Abstract:
:The effects of intravenous N-acetylcysteine on hepatic and systemic haemodynamics were investigated in 11 patients with stable cirrhosis (eight alcohol; two primary biliary cirrhosis; one cryptogenic). N-acetylcysteine administration had no effect on the mean heart rate or mean arterial blood pressure despite a significant fall in systemic and pulmonary vascular resistance. Cardiac index increased but estimated liver blood flow and portal venous pressure did not change significantly. Administration of N-acetylcysteine resulted in increased oxygen delivery to the tissues because of the increased cardiac index but this was not accompanied by a rise in either arteriovenous oxygen extraction ratio or mean tissue oxygen consumption. Therefore N-acetylcysteine administration seems to confer no haemodynamic benefit to patients with cirrhosis.
journal_name
Gutjournal_title
Gutauthors
Jones AL,Bangash IH,Bouchier IA,Hayes PCdoi
10.1136/gut.35.9.1290subject
Has Abstractpub_date
1994-09-01 00:00:00pages
1290-3issue
9eissn
0017-5749issn
1468-3288journal_volume
35pub_type
杂志文章相关文献
GUT文献大全abstract::A method not needing fluoroscopic control for positioning a manometric probe in the gastroduodenal tract is described. It is based on hydrostatic pressure variations occurring at each recording port of a multichannel perfused probe after changes in patient's position. The data are fed into a computer and the schematic...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.7.1007
更新日期:1988-07-01 00:00:00
abstract:OBJECTIVE:Gluten-free diet (GFD) is the only management for coeliac disease (CD). Available methods to assess GFD compliance are insufficiently sensitive to detect occasional dietary transgressions that may cause gut mucosal damage. We aimed to develop a method to determine gluten intake and monitor GFD compliance in p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-310148
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND AND AIMS:The detrimental impact of opioid agonist on the clinical management of inflammatory diseases remains elusive. Given the anti-inflammatory properties of the mu-opioid receptor (MOR) agonists at the intestinal barrier, we hypothesised that MOR activation might also dampen acute hepatic inflammation an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2006.105122
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND AND AIMS:Glucagon-like peptide 2 (GLP-2) may improve intestinal absorption in short bowel syndrome (SBS) patients with an end jejunostomy. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant GLP-2 analogue, prolongs the intestinotrophic properties of GLP-2 in animal models. The safety and effect of t...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1136/gut.2004.061440
更新日期:2005-09-01 00:00:00
abstract::Virulent Helicobacter pylori strains which have been clinically associated with severe outcome induce increased gastric mucosal immune responses. Although several bacterial pathogenic factors have been shown to have a considerable role in H pylori infection, variability in host immune responses may also contribute to ...
journal_title:Gut
pub_type: 杂志文章,评审
doi:
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:MicroRNAs (miRNAs) have been shown to offer great potential in the diagnosis of cancer. We investigated whether plasma miRNAs could discriminate between patients with and without colorectal cancer (CRC). METHODS:This study was divided into three phases: (1) marker discovery using real-time PCR-based miRNA pr...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.167817
更新日期:2009-10-01 00:00:00
abstract::The case of a 44-year-old woman is reported. The diagnosis after the appropriate tests and laparotomy was ACTH-secreting 'apudoma' of the gallbladder. This is a rare tumour and this case is believed to be the first reported of an ectopic hormone producing tumour from this side. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.16.6.473
更新日期:1975-06-01 00:00:00
abstract:OBJECTIVE:A high body mass index (BMI) is associated with an increased risk for severe liver disease. It is unclear if this risk differs across BMI categories, and if the association is partially attributed to development of type 2 diabetes mellitus (T2DM). DESIGN:We used register data from more than 1.2 million Swedi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-313622
更新日期:2018-08-01 00:00:00
abstract::The benzimidazole anthelmintics mebendazole and fenbendazole have been shown to be much less effective against Nippostrongylus brasiliensis infections in the rat on a combined iron and protein deficient diet. In the present experiments it was shown that the anthelmintic efficacy of mebendazole was significantly impair...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.4.305
更新日期:1979-04-01 00:00:00
abstract::Liver biopsy is required when clinically important information about the diagnosis, prognosis or management of a patient cannot be obtained by safer means, or for research purposes. There are several approaches to liver biopsy but predominantly percutaneous or transvenous approaches are used. A wide choice of needles ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-321299
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for cancer therapy through targeting SRSF6. DESIGN:We performed comprehensive analysis for the expression of SRSF6 in 311 CRC samples, The Cancer Genome Atlas and Gene Expres...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314983
更新日期:2019-01-01 00:00:00
abstract::Calcium palmitate occurred in 20% of the gallstones studied in this laboratory by x-ray diffraction and was the most important crystalline constituent after the different forms of cholesterol and calcium carbonate. Only one calculus contained alpha-palmitic acid. The gallstones came from America, England, Australia, S...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.7.618
更新日期:1970-07-01 00:00:00
abstract:BACKGROUND:Endoscopic diagnosis of short segments of Barrett's epithelium (SSBE)' is difficult and its meaning in terms of the presence of specialised columnar epithelium (SCE) has not been prospectively evaluated. AIMS:To evaluate the prevalence of SCE in patients with an endoscopic diagnosis of SSBE and in individua...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.5.659
更新日期:1998-05-01 00:00:00
abstract::Fasting serum gastrin has been measured by radioimmunoassay in 72 patients with duodenal ulcer and compared with that in normals, patients with gastric ulcer, and with the Zollinger-Ellison syndrome. The mean (+/- SEM) gastrin levels were 15.7 +/- 1.5 pg/ml in the duodenal ulcer group, 32.1 +/- 4.3 pg/ml in normals, 1...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.11.899
更新日期:1971-11-01 00:00:00
abstract::We have studied B-lymphocyte function in 39 patients with Crohn's disease and 35 normal individuals using a reverse haemolytic plaque assay as the effector system. Ten patients had active Crohn's disease, the others being in an inactive state of the disease. Compared with normal individuals, the Crohn's disease patien...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.11.1255
更新日期:1984-11-01 00:00:00
abstract::In an endoscopic study of 90 consecutive patients with more than one peptic ulcer, the ulcers in an individual were profoundly spatially clustered. Clustering of ulcer locations was shown using a non-parametric test of clustering (Kruskal-Wallis statistic with 89 degrees of freedom = 151.31, probability of observing t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.10.1329
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND AND AIMS:The 13C-Hiolein breath test (98% [U-13C] labelled long chain triglyceride mixture (highly labelled triolein) was evaluated as a non-invasive, non-radioactive test for exocrine pancreatic insufficiency. Accuracy and clinical validity were examined with reference to both the secretin pancreozymin test...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.39.5.668
更新日期:1996-11-01 00:00:00
abstract::The frequency of gastric Crohn's disease has been considered low. This study was undertaken to determine the prevalence of chronic gastritis and Helicobacter pylori infection in patients with Crohn's disease. Oesophagogastroduodenoscopy was performed on 62 consecutive patients suffering from ileocolonic Crohn's diseas...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.3.379
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Dietary lectins can alter the proliferation of colonic cells. Differentiation is regulated by adhesion molecules which, being glycosylated, are targets for lectin binding. AIMS:To examine the effects of dietary lectins on differentiation, adhesion, and proliferation of colorectal cancer cells. METHODS:Diff...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.5.709
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:Hippo signalling is a recently identified major oncosuppressive pathway that plays critical roles in inhibiting hepatocyte proliferation, survival and hepatocellular carcinoma (HCC) formation. Hippo kinase (Mst1 and Mst2) inhibits HCC proliferation by suppressing Yap/Taz transcription activities. As human HCC...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314061
更新日期:2018-09-01 00:00:00
abstract::Eight patients with traumatic transverse lesions of the spinal cord and eight healthy controls were examined with respect to the function of the anal sphincters. Continuous recordings of anal pressure and electromyograms from the striated sphincter muscles were obtained during gradual rectal distension by means of an ...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.16.8.638
更新日期:1975-08-01 00:00:00
abstract::Lactulose H2 breath tests are widely used for quantifying carbohydrate malabsorption, but the validity of the commonly used technique (interval sampling of H2 concentrations) has not been systematically investigated. In eight healthy adults we studied the reproducibility of the technique and the accuracy with which 5 ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.1.37
更新日期:1990-01-01 00:00:00
abstract:OBJECTIVES:Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in hu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300695
更新日期:2012-08-01 00:00:00
abstract::The influence of dehydrocholate on bromsulphtalein relative-storage capacity, bilary transport maximum (Tm), and fractional transfer rates between plasma, liver and bile have been studied in unanaesthetized dogs. In six dogs, storage capacity, Tm, and fractional transfer rates from plasma to liver, liver to bile, and ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.16.2.105
更新日期:1975-02-01 00:00:00
abstract:BACKGROUND:Tumour vascularisation is a determinant of the development of metastases. AIMS:To measure blood flow in normal stomach and gastric adenocarcinomas by laser Doppler flowmetry and correlate blood flow with vascularisation after immunohistochemical staining of resected specimens for CD31 and von Willebrand fac...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.45.3.341
更新日期:1999-09-01 00:00:00
abstract:OBJECTIVES:Gastric cancer is strongly associated with Helicobacter pylori (H. pylori). We conducted a previous systematic review and meta-analysis that suggested eradication therapy reduced future incidence of gastric cancer, but effect size was uncertain, and there was no reduction in gastric cancer-related mortality....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-320839
更新日期:2020-12-01 00:00:00
abstract::To determine the optimum bile acid regimen for rapid gall stone dissolution, 48 gall stone patients were divided into four groups of 12 according to stone diameter and were randomly allocated to receive one of four treatment regimens: bedtime or mealtime chenodeoxycholic acid (CDCA, 12 mg/kg/day) and bedtime or mealti...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.33.3.381
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Fer kinase is activated by a number of growth factors and cytokines, and phosphorylates cortactin during cell shape change induced cortical actin reorganisation. In addition, Fer participates in cytoskeletal interactions mediated by cadherins, platelet endothelial cell adhesion molecule 1 (PECAM-1),...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.061887
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:Natural history of paediatric-onset ulcerative proctitis (UP) is poorly described. Our aim was to describe the phenotype and disease course of incident UP in a population-based study of paediatric-onset UC. PATIENTS AND METHODS:All patients with UC diagnosed <17 years from 1988 to 2004, and followed during >...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-311970
更新日期:2017-11-01 00:00:00
abstract::Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin secretion were studied by using the isolated perfused rat stomach. [Asu1,7]-eel calcitonin (10(-9)--10(-7)M) caused a simultaneous dose-dependent increase of gastric somatostatin release and decrease of gastrin secretion, with a significant correla...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.2.94
更新日期:1980-02-01 00:00:00