Abstract:
:The oral administration of loxtidine to mice at doses of 600, 250, and 50 mg/kg/day for 746 days produced carcinoid tumours of the gastric fundus. The fundic mucosa also showed marked atypical hyperplasia with changes in foveolar cells similar to those seen in early incomplete metaplasia. These effects may be related to the prolonged achlorhydria produced by this potent unsurmountable histamine H2 receptor antagonist.
journal_name
Gutjournal_title
Gutauthors
Poynter D,Selway SA,Papworth SA,Riches SRdoi
10.1136/gut.27.11.1338subject
Has Abstractpub_date
1986-11-01 00:00:00pages
1338-46issue
11eissn
0017-5749issn
1468-3288journal_volume
27pub_type
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