Effect of secretogogues on mucosal blood flow in the antrum and corpus of the stomach.

abstract：:Management strategies for reflux disease are very different from those for dyspepsia and so differentiating between patients with "true" dyspepsia and those whose primary symptom is heartburn is a key step in their management. This separation has become more clear during the last decade as insights into reflux disease...

journal_title：Gut

authors： Dent J

更新日期：2002-05-01 00:00:00

abstract：:The prevalence of metabolic disease in a population of 68 postgastrectomy patients was assessed using histomorphometric evaluation of transiliac bone biopsy specimens after tetracycline double labelling. Trabecular bone volume was significantly lower in the postgastrectomy group (p less than 0.01): 62% of the patients...

journal_title：Gut

authors： Bisballe S,Eriksen EF,Melsen F,Mosekilde L,Sørensen OH,Hessov I

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVE:Assessment of disease extension and activity is crucial to guide treatment in Crohn's disease. The objective of the current cross-sectional study was to determine the accuracy of MR for this assessment. DESIGN:50 patients with clinically active (n = 35) or inactive (n = 15) Crohn's disease underwent ileocolo...

journal_title：Gut

authors： Rimola J,Rodriguez S,García-Bosch O,Ordás I,Ayala E,Aceituno M,Pellisé M,Ayuso C,Ricart E,Donoso L,Panés J

更新日期：2009-08-01 00:00:00

abstract：:The effect of peritoneal lavage with the addition of camostate to the lavage fluid on the outcome of taurocholate pancreatitis in rats was studied. Camostate is a low molecular weight protease inhibitor which has been developed recently. Peritoneal lavage was performed for 12 hours and camostate was added to the lavag...

journal_title：Gut

authors： Leonhardt U,Seidensticker F,Fussek M,Stöckmann F,Creutzfeldt W

更新日期：1990-08-01 00:00:00

abstract：:The extent to which defects in protein synthesis occurred in an experimental indomethacin induced rat model of nonsteroidal enteropathy has been examined. Male rats (nine) were fed indomethacin (8 mg/kg/day) for three days mixed with a powdered form of chow. The control group of rats (nine) were fed the same diet for ...

journal_title：Gut

authors： Banerjee AK,Marway JS,Preedy VR,Peters TJ

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD. DESIGN:Patient-level data of adult patie...

journal_title：Gut

authors： Lu TX,Dapas M,Lin E,Peters T,Sakuraba A

更新日期：2020-12-17 00:00:00

abstract：:The present study was undertaken to investigate the possibility that central nervous system monoaminergic pathways may play a role in the control of gastric acid and gastrin secretion in man. Submaximal pentagastrin stimulated (0.25 micrograms/kg/h) gastric acid secretion, as well as basal gastrin concentrations were ...

journal_title：Gut

authors： Caldara R,Barbieri C,Piepoli V,Borzio M,Masci E

更新日期：1985-10-01 00:00:00

abstract：:The nervous system in the intestine controls motility, secretion, sensory perception, and immune function. Peptidergic neurones with neurotransmitters such as substance P and nerve growth factors have been the main focus of neuroimmunomodulation research in the gut. This review summarises the present knowledge concern...

journal_title：Gut

authors： Straub RH,Wiest R,Strauch UG,Härle P,Schölmerich J

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVE:This phase II, randomised, double-blind, placebo-controlled clinical trial was designed to evaluate the efficacy and safety of PF-00547659, a fully human monoclonal antibody that binds to human mucosal addressin cell adhesion molecule (MAdCAM) to selectively reduce lymphocyte homing to the intestinal tract, i...

journal_title：Gut

authors： Sandborn WJ,Lee SD,Tarabar D,Louis E,Klopocka M,Klaus J,Reinisch W,Hébuterne X,Park DI,Schreiber S,Nayak S,Ahmad A,Banerjee A,Brown LS,Cataldi F,Gorelick KJ,Cheng JB,Hassan-Zahraee M,Clare R,D'Haens GR

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND:Hirschsprung's disease (HSCR) is a congenital disorder characterised by an absence of ganglion cells in the nerve plexuses of the lower digestive tract. Manifestation of the disease has been linked to mutations in genes that encode the crucial signals for the development of the enteric nervous system-the RET...

journal_title：Gut

authors： Garcia-Barceló M,Sham MH,Lui VC,Chen BL,Ott J,Tam PK

更新日期：2003-04-01 00:00:00

abstract：:p53 mutations are a common genetic finding in hepatocellular carcinoma from areas of high aflatoxin exposure. Recent small studies have shown that p53 gene mutations may be less common in areas with a low prevalence of hepatocellular carcinoma such as Great Britain. The protein product of mutant p53 can be detected im...

journal_title：Gut

authors： Collier JD,Carpenter M,Burt AD,Bassendine MF

更新日期：1994-01-01 00:00:00

abstract：:This study reports on the outcome of four patients having ileal pouch anal anastomosis after orthotopic liver transplantation for sclerosing cholangitis complicating ulcerative colitis. There were no deaths on follow up. Early postoperative bleeding was a complication of colectomy or rectal excision in three, one of w...

journal_title：Gut

authors： Rowley S,Candinas D,Mayer AD,Buckels JA,McMaster P,Keighley MR

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVE:The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC. The aim of this study was to determine the underlying compositional alterations, their molecular background and potential contribution to UC pathogenesis. DESIGN:In th...

journal_title：Gut

authors： van der Post S,Jabbar KS,Birchenough G,Arike L,Akhtar N,Sjovall H,Johansson MEV,Hansson GC

更新日期：2019-12-01 00:00:00

abstract：:The responses to deglutition of the lower oesophageal high pressure zone were studied in 13 healthy subjects. The recording assembly included three perfused pressure recording catheters, whose recording orifices were at the same axial level, and a more distally situated pH electrode. Relaxation and contraction progres...

journal_title：Gut

authors： Kaye MD,Showalter JP

更新日期：1972-05-01 00:00:00

abstract：OBJECTIVE:Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases. Given the prominence of dysbiosis and colonic dysfunction in patients with Parkinson's disease (PD), we pro...

journal_title：Gut

authors： Perez-Pardo P,Dodiya HB,Engen PA,Forsyth CB,Huschens AM,Shaikh M,Voigt RM,Naqib A,Green SJ,Kordower JH,Shannon KM,Garssen J,Kraneveld AD,Keshavarzian A

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Almost 4% of the population suffer from food allergy which is an adverse reaction to food with an underlying immunological mechanism. AIMS:To characterise one of the most frequent IgE defined food allergens, fish parvalbumin. METHODS:Tissue and subcellular distribution of carp parvalbumin was analysed by i...

journal_title：Gut

authors： Bugajska-Schretter A,Grote M,Vangelista L,Valent P,Sperr WR,Rumpold H,Pastore A,Reichelt R,Valenta R,Spitzauer S

更新日期：2000-05-01 00:00:00

abstract：:Studies have been made of mucus glycoprotein biosynthesis in different regions of the lower gastrointestinal tract in normal patients and those with ulcerative colitis (UC), active or inactive, by means of 3H-glucosamine (3H-GlcNH2)--35S-sulphate double labelling of epithelial biopsy specimens under culture conditions...

journal_title：Gut

authors： Morita H,Kettlewell MG,Jewell DP,Kent PW

更新日期：1993-07-01 00:00:00

abstract：:We have previously shown that rats fed raw soya flour (RSF) for more than four months develop hyperplastic foci of pancreatic acinar cells, which undergo malignant change if feeding RSF is continued throughout the life of the animals. The tendency to undergo malignant change is augmented by the additional use of a gen...

journal_title：Gut

authors： McGuinness EE,Morgan RG,Wormsley KG

更新日期：1987-01-01 00:00:00

abstract：:This case report describes the histological and macroscopic changes seen within a few months in the gastric mucosa of a 28 year old woman patient with upper abdominal symptoms. With hindsight these changes were the first signs of Sjögren's syndrome. ...

journal_title：Gut

authors： van Leeuwen ML,Tjiong HL,van Blankenstein M,Mulder AH,Bakker CM

更新日期：1993-08-01 00:00:00

abstract：:Bran, ispaghula (Fybogel), and lactulose were given to three groups of patients with diverticular disease for four weeks. Faecal weights, bile acids, fat and electrolytes, transit time, and colonic motility were estimated before and after treatment. Stool weight increased, notably with Fybogel. Cereal bran had the gre...

journal_title：Gut

authors： Eastwood MA,Smith AN,Brydon WG,Pritchard J

更新日期：1978-12-01 00:00:00

abstract：:Bile acid pool size and kinetics were determined in 17 patients with cirrhosis and 11 patients without liver disease and correlated with the severity of liver disease as determined by the usual clinical and laboratory criteria. In order to assess the severity of liver disease, a grading system was devised which assign...

journal_title：Gut

authors： McCormick WC 3rd,Bell CC Jr,Swell L,Vlahcevic ZR

更新日期：1973-11-01 00:00:00

abstract：:The staining of HLA class II antigens, the presence of cells positive for interleukin-2 receptors, the proportion of crypt cells in mitosis in the jejunal biopsy specimens, and the dose of coeliac disease marker HLA-DQ genes were studied in 75 healthy family members of coeliac disease patients. Eleven had silent coeli...

journal_title：Gut

authors： Holm K,Savilahti E,Koskimies S,Lipsanen V,Mäki M

更新日期：1994-01-01 00:00:00

abstract：:To assist in the prediction of variceal bleeding we examined 12 clinical, endoscopic and haemodynamic variables in 126 patients with portal hypertension (72 bleeders and 54 non-bleeders). Multiple regression and discriminant analysis were utilised for 101 patients. Stepwise regression among the 12 variables explained ...

journal_title：Gut

authors： Sarin SK,Sundaram KR,Ahuja RK

更新日期：1989-12-01 00:00:00

abstract：AIMS:To determine the sources of founding for UK gastroenterology research papers and the relative impact of papers funded by different groups and of unfunded ones. METHODS:UK gastroenterology papers from 1988-94 were selectively retrieved from the Science Citation Index by means of a specially constructed filter base...

journal_title：Gut

authors： Lewison G

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:Chronic pancreatitis (CP) is an inflammatory disease with progressive fibrosis leading to exocrine and endocrine dysfunction. Currently, there are no approved effective therapies for CP. Stimulator of interferon genes (STING) signalling is a key innate immune sensor of DNA. In this study, we evaluated the rol...

journal_title：Gut

authors： Zhao Q,Manohar M,Wei Y,Pandol SJ,Habtezion A

更新日期：2019-10-01 00:00:00

abstract：:It has been suggested that an intact vagal supply is essential for the normal function of the recptors in the duodenum and proximal small bowel, which influence the rate of gastric emptying. This paper reports the effect of vagal denervation on gastric emptying and also examines the site and mode of action of receptor...

journal_title：Gut

authors： Shahidullah M,Kennedy TL,Parks TG

更新日期：1975-05-01 00:00:00

abstract：OBJECTIVE:Lower GI bleeding (LGIB) is a common reason for emergency hospital admission, although there is paucity of data on presentations, interventions and outcomes. In this nationwide UK audit, we describe patient characteristics, interventions including endoscopy, radiology and surgery as well as clinical outcomes....

journal_title：Gut

authors： Oakland K,Guy R,Uberoi R,Hogg R,Mortensen N,Murphy MF,Jairath V,UK Lower GI Bleeding Collaborative.

更新日期：2018-04-01 00:00:00

abstract：:Liver biopsy is required when clinically important information about the diagnosis, prognosis or management of a patient cannot be obtained by safer means, or for research purposes. There are several approaches to liver biopsy but predominantly percutaneous or transvenous approaches are used. A wide choice of needles ...

journal_title：Gut

authors： Neuberger J,Patel J,Caldwell H,Davies S,Hebditch V,Hollywood C,Hubscher S,Karkhanis S,Lester W,Roslund N,West R,Wyatt JI,Heydtmann M

更新日期：2020-08-01 00:00:00

abstract：:All cases of Crohn's disease in the Nottingham area were ascertained and the date and place of domicile and work at the time of onset of symptoms noted. Applying the Knox and Pike and Smith tests for clustering of patients in time and space, no significant results were observed. Further analysis of differences in time...

journal_title：Gut

authors： Miller DS,Keighley A,Smith PG,Hughes AO,Langman MJ

更新日期：1975-06-01 00:00:00

abstract：:The motor activity of the transverse, descending, and sigmoid colon was recorded for 24 hours in 14 healthy volunteers with a colonoscope positioned catheter. During the study the patients ate two 1000 kcal mixed meals and one continental breakfast. Colonic motor activity was low before meals and minimal during sleep;...

journal_title：Gut

authors： Narducci F,Bassotti G,Gaburri M,Morelli A

更新日期：1987-01-01 00:00:00