Abstract:
:The present study was undertaken to investigate the possibility that central nervous system monoaminergic pathways may play a role in the control of gastric acid and gastrin secretion in man. Submaximal pentagastrin stimulated (0.25 micrograms/kg/h) gastric acid secretion, as well as basal gastrin concentrations were studied in two groups of subjects. The first group received oral administration of placebo and the catecholamine precursor L-dopa (500 mg); the second group was treated with placebo and the association of L-dopa (100 mg) plus carbidopa (35 mg) after pretreatment with carbidopa (50 mg every six hours for four doses), a schedule which is known to increase brain catecholamine concentrations. In comparison with placebo, stimulated gastric acid secretion was reduced by L-dopa alone, whereas was not modified by L-dopa plus carbidopa. Basal gastrin concentrations were increased after L-dopa and after L-dopa plus carbidopa. These data show that basal gastrin concentration is raised by central catecholamine augmentation; but gastric acid secretion seems to be influenced by changes of peripheral catecholamine concentrations. It is suggested that dopamine and perhaps noradrenaline, but not adrenaline, are important in these effects.
journal_name
Gutjournal_title
Gutauthors
Caldara R,Barbieri C,Piepoli V,Borzio M,Masci Edoi
10.1136/gut.26.10.1014subject
Has Abstractpub_date
1985-10-01 00:00:00pages
1014-7issue
10eissn
0017-5749issn
1468-3288journal_volume
26pub_type
临床试验,杂志文章相关文献
GUT文献大全abstract::A cohort of 123 patients with coeliac disease, diagnosed in the first three years of life and followed up for at least 10 years, was reevaluated during the teenage period in terms of compliance with the diet and clinical state. Mucosal structure and lymphocytes were assessed in small intestinal biopsy specimens obtain...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.8.881
更新日期:1991-08-01 00:00:00
abstract:BACKGROUND/AIMS:Transjugular intrahepatic portosystemic stent shunt (TIPSS) is effective in the prevention of variceal rebleeding but requires invasive portographic follow up. This randomised controlled trial aims to test the hypothesis that combining variceal band ligation (VBL) with TIPSS can obviate the need for lon...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.2003.013532
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Genetic predisposition and gliadin exposure are known to be crucial factors in the development of coeliac disease. Circumstantial evidence suggests that other unidentified environmental factors may also be of pathogenetic importance. AIM:To define the relation between cigarette smoking and the risk of devel...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.39.1.60
更新日期:1996-07-01 00:00:00
abstract:OBJECTIVE:In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD. DESIGN:Patient-level data of adult patie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-321609
更新日期:2020-12-17 00:00:00
abstract::The possibility that the mode of action of sulphasalazine and its active metabolite 5-amino-salicylic acid (5ASA) involves modification of toxic oxygen metabolite production by neutrophils has been investigated by measuring the effect of these drugs on luminol-dependent chemiluminescence, superoxide release and oxygen...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.11.1581
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:IgA class serum autoantibodies against type 2 (tissue) transglutaminase (TG2) bind to both intestinal and extraintestinal normal tissue sections in vitro, eliciting endomysial, reticulin, and jejunal antibody reactions. It is not known whether similar binding also occurs in coeliac patients in vivo, and may ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.024836
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND AND AIMS:A previous study suggested that the presence of myenteric plexitis in the proximal resection margins could be predictive of early endoscopic recurrence after ileocolonic or ileal resection for Crohn's disease (CD). The aim of the present study was to assess the predictive value of plexitis for early...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.177782
更新日期:2009-09-01 00:00:00
abstract::Bowel function was assessed in 51 subjects: 10 women and seven men who habitually consumed an omnivorous, vegetarian, or vegan diet. The subjects on these diets had a mean intake of fibre of 23 g, 37 g, and 47 g respectively. Mean transit times were variable and not significantly different between the groups. Vegans, ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.2.164
更新日期:1986-02-01 00:00:00
abstract:OBJECTIVES:National guidelines for the management of irritable bowel syndrome (IBS) recommend that psychological therapies should be considered, but their relative efficacy is unknown, because there have been few head-to-head trials. We performed a systematic review and network meta-analysis to try to resolve this unce...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-321191
更新日期:2020-08-01 00:00:00
abstract::Our life expectancy is increasing, leading to a rise in the ageing population. Ageing is associated with a decline in physiological function and adaptive capacity. Altered GI physiology can affect the amount and types of nutrients digested and absorbed as well as impact the intestinal microbiota. The intestinal microb...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2017-315542
更新日期:2018-12-01 00:00:00
abstract:BACKGROUND:Overexpression of tissue plasminogen activator (t-PA) in pancreatic cancer cells promotes invasion and proliferation in vitro and tumour growth and angiogenesis in vivo. AIMS:To understand the mechanisms by which t-PA favours cancer progression, we analysed the surface membrane proteins responsible for bind...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.026831
更新日期:2004-07-01 00:00:00
abstract::Nineteen healthy subjects were studied and 17 patients with gastric ulcer before and after ulcer healing with carbenoxolone. Gastric deoxytibonucleic acid (DNA) loss was measured as an index of epithelial cell turnover, and N-acetylneuraminic acid (NANA) content of gastric juice as an index of mucus secretion. In norm...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.10.817
更新日期:1977-10-01 00:00:00
abstract::CLINICAL PRESENTATION: A 51-year-old man, who had no previous disease, underwent a screening oesophagogastroduodenoscopy, which revealed multiple yellowish lesions in the middle thoracic oesophagus. All lesions were ≤3 mm in size and slightly elevated. Each lesion showed one or two white protrusions on the surface (fi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-315700
更新日期:2019-01-01 00:00:00
abstract::Jejunal absorption of sodium and water has been investigated in 10 normal Indians and 11 patients with chronic tropical sprue. Normal saline and solutions containing amino acids and dipeptides were studied. In both groups little absorption of sodium and water from normal saline was seen. Mean water and sodium absorpti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.6.480
更新日期:1977-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Many neuroendocrine gastrointestinal tumours express receptors for the regulatory peptide somatostatin. Among the five existing somatostatin receptor (sst) subtypes, sst2A is the most frequently expressed in these tumours. However, little information is available about the cellular location of sst2A...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.042002
更新日期:2004-10-01 00:00:00
abstract::The two major forms of inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated conditions characterised by an increased production of pro-inflammatory cytokines that act as critical drivers of intestinal inflammation. Anti-cytokine therapy has been s...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2019-318448
更新日期:2019-10-01 00:00:00
abstract:BACKGROUND:The phenotypic spectrum of familial adenomatous polyposis (FAP) varies from the classic appearance of hundreds of adenomatous colonic polyps in the young adult and early onset colorectal cancer, to the occurrence of sparse adenomas in the older adult, "attenuated" FAP, due to mutations at the 5' or 3' ends o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.6.829
更新日期:1999-12-01 00:00:00
abstract::'Tumour response', defined as clinical or radiological evidence of tumour shrinkage is frequently regarded as an objective of chemotherapy, rather than as a predictor of prolonged survival. This study has assessed whether a fall in the serum CEA concentration after chemotherapy for disseminated colorectal cancer is a ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.12.1625
更新日期:1987-12-01 00:00:00
abstract::It has been reported that intestinal permeability to polyethylene glycol 400 is increased in patients with Crohn's disease and their apparently unaffected first degree relatives. Because of the implications that these findings have for the aetiology of Crohn's disease these studies were repeated. Patients with Crohn's...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.3.320
更新日期:1992-03-01 00:00:00
abstract::The motility of the descending colon was studied in nine patients before and after resection of the rectum for cancer. This operation parasympathectomises and generally also sympathectomises the remaining left colon. Motor activity was significantly reduced by sleep before and after surgery. There was also a reduction...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.5.624
更新日期:1988-05-01 00:00:00
abstract::Two patients have been studied with a two and a half and nine year history of metastatic pancreatic apudoma. In both patients the main feature was chronic watery diarrhoea with remissions after partial tumour resection and streptozotocin therapy. Plasma levels of circulating VIP and neurotensin were persistently raise...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.5.448
更新日期:1983-05-01 00:00:00
abstract:BACKGROUND:Dyspepsia and irritable bowel syndrome are suitable conditions for assessment of quality of life. Their similarities justify the elaboration of a single specific questionnaire for the two conditions. AIMS:To examine the process leading to the validation of the psychometric properties of the functional diges...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.44.4.527
更新日期:1999-04-01 00:00:00
abstract::The prevalence of colorectal adenoma in 23 affected patients with hereditary non-polyposis colorectal cancer (HNPCC) was compared with that in an age matched forensic autopsy population. The mean ages at diagnosis of colorectal cancer in men (13) and women (10) were 39 and 37 years respectively. In HNPCC patients who ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.6.783
更新日期:1992-06-01 00:00:00
abstract::The value of lactulose treatment in hepatic encephalopathy is widely recognised but its mode of action remains controversial. Much evidence supports a role for gamma-aminobutyric acid in hepatic encephalopathy, and lactulose could alter its bacterial production in the gut. Using the rat synaptic membrane assay and gas...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.9.1007
更新日期:1991-09-01 00:00:00
abstract::This experimental study was undertaken to follow the influence of phenobarbital on bile chemistry and gallstone formation. Phenobarbital (400 mg/kg/day) was administered to golden hamsters receiving a diet known to induce cholesterol gallstones. After a 28-day period none of the control animals had gallstones whereas ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.12.956
更新日期:1973-12-01 00:00:00
abstract:OBJECTIVE:Helicobacter pylori (Hp) is a major risk factor for gastric cancer (GC). Hp promotes DNA damage and proteasomal degradation of p53, the guardian of genome stability. Hp reduces the expression of the transcription factor USF1 shown to stabilise p53 in response to genotoxic stress. We investigated whether Hp-me...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-318640
更新日期:2020-09-01 00:00:00
abstract::This study reports on a group of 20 patients with an initial diagnosis of primary biliary cirrhosis (PBC) whose serum tested negative for antimitochondrial antibodies by immunofluorescence. All had a clinical history compatible with primary biliary cirrhosis, and results of biochemical, histological, and radiological ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.2.260
更新日期:1994-02-01 00:00:00
abstract::Measurements of cell proliferation can be used as biomarkers of preneoplastic change. In this study, two immunocytochemical methods that measure different components of the cell cycle were compared to assess cell proliferation on biopsy samples from human colonic mucosa. These methods are based on a monoclonal antibod...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.11.1587
更新日期:1993-11-01 00:00:00
abstract:OBJECTIVE:Gut microbiota and diet are known to contribute to human metabolism. We investigated whether the metagenomic gut microbiota composition and function changes over pregnancy are related to gestational diabetes mellitus (GDM) and can be modified by dietary supplements, fish oil and/or probiotics. DESIGN:The gut...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-321643
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Lynch syndrome is caused by germline mismatch repair (MMR) gene mutations. The PREMM(1,2,6) model predicts the likelihood of a MMR gene mutation based on personal and family cancer history. OBJECTIVE:To compare strategies using PREMM(1,2,6) and tumour testing (microsatellite instability (MSI) and/or immunoh...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2011-301265
更新日期:2013-02-01 00:00:00