Abstract:
:The prevalence of colorectal adenoma in 23 affected patients with hereditary non-polyposis colorectal cancer (HNPCC) was compared with that in an age matched forensic autopsy population. The mean ages at diagnosis of colorectal cancer in men (13) and women (10) were 39 and 37 years respectively. In HNPCC patients who presented below the age of 50 years, at least one adenoma was found in 3 of 10 (30%) men and in 4 of 9 (44%) women. In the age matched autopsy specimens of large bowel, a solitary adenoma was found in 2/42 (5%) men (p = 0.015) and 1/21 (5%) women (p = 0.0075). Of the 11 adenomas from HNPCC patients, nine were greater than 1 cm and six showed a pure villous architecture. Contiguous adenocarcinoma was observed with six adenomas. Adenomas do not occur in large numbers in HNPCC, but develop at a young age, attain a large size, often show a villous configuration, and are more prone to malignant conversion than sporadic adenomas.
journal_name
Gutjournal_title
Gutauthors
Jass JR,Stewart SMdoi
10.1136/gut.33.6.783keywords:
subject
Has Abstractpub_date
1992-06-01 00:00:00pages
783-6issue
6eissn
0017-5749issn
1468-3288journal_volume
33pub_type
杂志文章相关文献
GUT文献大全abstract::In a double-blind controlled trial amylopectin sulphate (Depepsen) had no significant advantage over placebo in the symptomatic treatment of duodenal ulcer. ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.18.9.723
更新日期:1977-09-01 00:00:00
abstract:OBJECTIVE:MicroRNAs (miRNAs) have been shown to offer great potential in the diagnosis of cancer. We investigated whether plasma miRNAs could discriminate between patients with and without colorectal cancer (CRC). METHODS:This study was divided into three phases: (1) marker discovery using real-time PCR-based miRNA pr...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.167817
更新日期:2009-10-01 00:00:00
abstract:BACKGROUND:Colorectal carcinoids are often described as low-grade malignant. However, no study has compared the survival between patients with colorectal carcinoids and those with carcinomas, in a large series. In addition, no global consensus has been established on the crucial determinants of metastasis in colorectal...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2006.109157
更新日期:2007-06-01 00:00:00
abstract::Fasting insulin, lipids and lipoproteins were measured in 22 middle aged female non-insulin dependent diabetics with gall stone disease (cases) and in 22 non-insulin dependent diabetics without gall stone disease (controls). The groups were matched for sex, age, obesity, and fasting glucose concentrations. No differen...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.3.344
更新日期:1990-03-01 00:00:00
abstract::Four asymptomatic patients are described with raised serum alkaline phosphatase values and a positive serum mitochondrial antibody test. In all four needle liver biopsy showed destructive bile duct lesions. Lymphocyte transformation to phytohaemagglutinin was normal in three and impaired in one who also suffered from ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.6.444
更新日期:1973-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Fibrosis associated with chronic pancreatitis is an irreversible lesion that can disrupt pancreatic exocrine and endocrine function. Currently, there are no approved treatments for this disease. We previously showed that siRNA against collagen-specific chaperone protein gp46, encapsulated in vi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301746
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:Endoscopic surveillance for Barrett's oesophagus (BO) is under discussion given the overall low incidence of neoplastic progression and lack of evidence that it prevents advanced oesophageal adenocarcinoma (OAC). The aim of this study was to evaluate the impact of endoscopic BO surveillance on tumour stage an...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2014-308802
更新日期:2016-04-01 00:00:00
abstract::Faecal bile acid excretion was examined in 13 patients with adenomatous polyps of the large bowel and compared with a series of matched healthy subjects. Bile acids were analysed in detail with respect to the composition of individual bile acids and their mode of conjugation. The total excretion of bile acids by the p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.8.824
更新日期:1984-08-01 00:00:00
abstract::Intravenous glucose tolerance, insulin tolerance, tolbutamide, and glucagon tests were carried out in 21 patients with postnecrotic cirrhosis. Based arbitrarily on the bromsulphthalein retention they were divided into group A, nine patients with less impaired liver function, and group B, 12 patients with greater impai...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.11.907
更新日期:1974-11-01 00:00:00
abstract::Sex differences exist in the site specific incidences of colorectal cancer. The increased incidence of colonic cancer in women with breast cancer and the protective effect of increasing parity suggest a role for sex hormones. To explore the molecular basis, the expression of messenger RNA for oestrogen and progesteron...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.5.611
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Small intestinal epithelial cells (IEC) show apoptosis in physiological turnover of cells and in certain inflammatory diseases. AIMS:To investigate the role of caspases in the progression of IEC apoptosis in vivo. METHODS:IEC were separated along the villus-crypt axis from the jejunum of normal and Nippost...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.1.71
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:Most colorectal cancer (CRC) screening programmes are nowadays based on faecal immunochemical testing (FIT). Eligible subjects often use oral anticoagulants (OACs) or non-steroidal anti-inflammatory drugs (NSAIDs), which could possibly stimulate bleeding from both benign and premalignant lesions in the colon....
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316344
更新日期:2019-05-01 00:00:00
abstract::In order to investigate further the reported beneficial effect of deglycyrrhizinated liquorice in gastric ulcer, a trial with a double-blind, cross-over design was performed. The patients were treated during two consecutive periods of four weeks each with either liquorice extract during the first period and placebo du...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.14.9.711
更新日期:1973-09-01 00:00:00
abstract::Twenty-four patients who experienced 26 attacks of acute pancreatitis were studied. Endotoxaemia, as measured by the limulus lysate assay, was present in 13 of the attacks. Six out of seven patients with systemic complications of the disease had endotoxaemia. C3 catabolism was increased in all 26 attacks of pancreatit...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.8.656
更新日期:1982-08-01 00:00:00
abstract::Patients with primary biliary cirrhosis have a defect in the receptor mediated clearance of complement coated erythrocytes by fixed macrophages of the reticuloendothelial system. To investigate the probable mechanism of this defect peripheral blood monocytes were isolated from nine patients with primary biliary cirrho...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.3.324
更新日期:1986-03-01 00:00:00
abstract::This is a clinical study of 81 patients (32 male and 49 female), who are not alcoholics, with jaundice of hepato-cellular type lasting longer than three months. Forty-nine of these patients were under 21 years of age. The natural history of the condition and the response to corticosteroid therapy is described; good sy...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.4.4.378
更新日期:1963-12-01 00:00:00
abstract::Stimulation of the rectal mucosa with a bipolar electrode leads to relaxation of the internal anal sphincter. Intraoperative studies in two subjects showed that transmission of the impulse was independent of extrinsic nerves and was interrupted by circular myotomy. Characteristics of the reflex were studied in 11 heal...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.7.935
更新日期:1989-07-01 00:00:00
abstract::Peak plasma levels were reduced after an oral dose of 40 mg prednisolone in six patients with severe acute colitis as compared with six normal subjects, though total absorption appeared to be similar; the findings suggest that prednisolone absorption was delayed in acute colitis. A dilutional fall in plasma albumin wa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.1.49
更新日期:1980-01-01 00:00:00
abstract::To investigate the mechanisms underlying the hepatotoxicity induced by methyl dopa, we have examined sera from nine patients with liver damage following the use of the drug for evidence of sensitisation to drug altered liver cell membrane antigens using both immunofluorescence and antibody dependent cell mediated cyto...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.11.1233
更新日期:1985-11-01 00:00:00
abstract::The possible relationship between enteroglucagon and cellular proliferation in a rat model of intestinal adaptation after suppression and stimulation of enteroglucagon by somatostatin and bombesin has been investigated. Forty eight rats were divided into three groups of 16 animals, each group being further sub-divided...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.1.89
更新日期:1985-01-01 00:00:00
abstract::The amounts of lactase (EC 3.2.1.23), sucrase (EC 3.2.1.48), maltase (EC 3.2.1.20), microvillus aminopeptidase (microsomal EC3.4.11.2), and dipeptidyl peptidase IV (EC 3.4.14.X) in biopsies from proximal jejunum and distal ileum were studied by quantitative crossed immunoelectrophoresis and enzymatic assays in obese p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.8.662
更新日期:1980-08-01 00:00:00
abstract::The 13/14C-Urea breath test (UBT) is based on the simple principle that a solution of isotopically labelled urea will be rapidly hydrolysed by the abundantly expressed urease of H pylori. The released 13/14CO2 is absorbed across the mucus layer to the gastric mucosa and hence, via the systemic circulation, excreted in...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.43.2008.s47
更新日期:1998-07-01 00:00:00
abstract::Plasma- and erythrocyte-selenium concentrations were determined in five consecutive patients with Crohn's disease given preoperative total parenteral nutrition - nil per os - for a mean period of 34 days per patient. No blood components were administered during the total parenteral nutrition. Before the total parenter...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.1.50
更新日期:1985-01-01 00:00:00
abstract::The results of bile salt treatment in patients with radiolucent stones and a functioning gall bladder have been poor. In 42 of these patients awaiting cholecystectomy we determined the value of duodenal bile examination in predicting gall stone composition, and thus identifying those less likely to respond to bile sal...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.1.112
更新日期:1994-01-01 00:00:00
abstract::The synchronous change in the antral release of gastrin and somatostatin into a vein draining the stomach was studied during acidic and alkaline intragastric pH in six anaesthetised duodenal ulcer patients and six controls after atropinisation. No differences in the basal secretion of gastrin and somatostatin were obs...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.2.206
更新日期:1987-02-01 00:00:00
abstract:OBJECTIVE AND DESIGN:The goal of the study was to determine whether the mutational profile of early colorectal polyps correlated with growth behaviour. The growth of small polyps (6-9 mm) that were first identified during routine screening of patients was monitored over time by interval imaging with CT colonography. Mu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-312232
更新日期:2017-12-01 00:00:00
abstract::To investigate further the cause of the pancreatic enlargment induced by orally ingested soybean trypsin inhibitor (STI), antibodies raised against STI and purified by affinity chromatography were used to localise dietary STI in the rat gut by fluorescent immunocytochemical methods. This technique permitted the clear ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.4.260
更新日期:1978-04-01 00:00:00
abstract:OBJECTIVE:The intestinal microbiome affects the prevalence and pathophysiology of a variety of diseases ranging from inflammation to cancer. A reduced taxonomic or functional diversity of the microbiome was often observed in association with poorer health outcomes or disease in general. Conversely, factors or manifest ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-322753
更新日期:2020-11-09 00:00:00
abstract:OBJECTIVE:To develop gene expression profiles that characterise KRAS-, BRAF- or PIK3CA-activated- tumours, and to explore whether these profiles might be helpful in predicting the response to the epidermal growth factor receptor (EGFR) pathway inhibitors better than mutation status alone. DESIGN:Fresh frozen tumour sa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-302423
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Crohn's disease is one of the principal human chronic inflammatory bowel diseases. Although its aetiology is still unknown, its complex pathogenesis has environmental, immunological, and genetic determinants. CARD15 is the first susceptibility gene implicated in the predisposition to Crohn's disease and is k...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.6.840
更新日期:2003-06-01 00:00:00