Gastroenterology research in the United Kingdom: funding sources and impact.

abstract：BACKGROUND/AIMS:Replication deficient recombinant adenoviruses represent an efficient means of transferring genes in vivo into a wide variety of dividing and quiescent cells from many different organs. Although the gastrointestinal tract is a potentially attractive target for gene therapy approaches, only a few studies...

journal_title：Gut

authors： Wirtz S,Galle PR,Neurath MF

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:Faecal concentrations of the protein calprotectin have been found to be elevated in patients with colorectal neoplasia, suggesting that it might be used as a screening tool for colorectal cancer as well as adenomas. AIMS:To measure the sensitivity and specificity of faecal calprotectin for the detection of ...

journal_title：Gut

authors： Kronborg O,Ugstad M,Fuglerud P,Johne B,Hardcastle J,Scholefield JH,Vellacott K,Moshakis V,Reynolds JR

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:Adherent-invasive Escherichia coli (AIEC) are a leading candidate bacterial trigger for Crohn's disease (CD). The AIEC pathovar is defined by in vitro cell-line assays examining specific bacteria/cell interactions. No molecular marker exists for their identification. Our aim was to identify a molecular proper...

journal_title：Gut

authors： O'Brien CL,Bringer MA,Holt KE,Gordon DM,Dubois AL,Barnich N,Darfeuille-Michaud A,Pavli P

更新日期：2017-08-01 00:00:00

abstract：:The effects of corticotrophin and of cortisone, methyl prednisolone, and of aldosterone on the gastric secretion of dogs have been investigated. Juice was collected from dogs with denervated pouches under basal conditions and when stimulated with meat extract and with histamine. For each secretion the volume, viscosit...

journal_title：Gut

authors： CLARKE SD,NEILL DW,WELBOURN RB

更新日期：1960-03-01 00:00:00

abstract：BACKGROUND AND AIM:The treatment of ulcerative colitis (UC) with 5-aminosalicylic acid (5-ASA) does not have the same therapeutic effect in all patients. We tested the hypothesis that the effectiveness of the drug is related to its mucosal concentration. PATIENTS:Twenty one UC patients receiving oral 5-ASA (2.4-3.2 g/...

journal_title：Gut

authors： Frieri G,Giacomelli R,Pimpo M,Palumbo G,Passacantando A,Pantaleoni G,Caprilli R

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, may play a critical role in many chronic pain conditions. The possible involvement of BDNF in the altered gut sensation in patients with irritable bowel syndrome (IBS) was investigated in the present study. METHODS:Rectosigmoid bi...

journal_title：Gut

authors： Yu YB,Zuo XL,Zhao QJ,Chen FX,Yang J,Dong YY,Wang P,Li YQ

更新日期：2012-05-01 00:00:00

abstract：:The effect of rebamipide, a novel antiulcer compound, on Helicobacter pylori activated neutrophil dependent in vitro gastric epithelial cell injury was investigated. Luminol dependent chemiluminescence (ChL), which detects toxic oxidants from neutrophils exhibited a 12-fold increase when the bacterial suspension of H ...

journal_title：Gut

authors： Suzuki M,Miura S,Mori M,Kai A,Suzuki H,Fukumura D,Suematsu M,Tsuchiya M

更新日期：1994-10-01 00:00:00

abstract：:Fifty two patients with abnormal acid gastro-oesophageal reflux were studied by simultaneous oesophageal pH monitoring and continuous aspiration for 16 hours. Aspirates (from discrete two hour periods) were analysed for volume, pH, bile acids (conjugated and unconjugated), trypsin, and pepsin. The results were compare...

journal_title：Gut

authors： Gotley DC,Morgan AP,Ball D,Owen RW,Cooper MJ

更新日期：1991-10-01 00:00:00

abstract：:Completeness of vagotomy has been assessed by use of the electrical stimulation test and the insulin test in 50 patients suffering from chronic duodenal ulceration. A positive result from either was taken as evidence of incomplete vagotomy. The electrical stimulation test provided such evidence more often than the ins...

journal_title：Gut

authors： Hollanders D

更新日期：1971-08-01 00:00:00

abstract：BACKGROUND:Several pharmacological agents for the prevention of post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) have been studied. Clinical trials evaluating the protective effect of non-steroidal anti-inflammatory drugs (NSAIDs) have yielded inconclusive results. AIM:To perform a meta-an...

journal_title：Gut

authors： Elmunzer BJ,Waljee AK,Elta GH,Taylor JR,Fehmi SM,Higgins PD

更新日期：2008-09-01 00:00:00

abstract：:In a prospective study we compared the diagnostic accuracy of endoscopic fine needle aspiration cytology with that of brush cytology and forceps biopsy in relation to gross tumour pattern and site in 265 confirmed consecutive cases of malignancy of the oesophagus, stomach, colon, and rectum. Aspiration cytology gave t...

journal_title：Gut

authors： Zargar SA,Khuroo MS,Mahajan R,Jan GM,Dewani K,Koul V

更新日期：1991-07-01 00:00:00

abstract：OBJECTIVE:Eosinophilic oesophagitis (EoO) is a clinicopathological condition defined by proton pump inhibitor-refractory oesophageal symptoms combined with oesophageal eosinophilia. The pharmacodynamic effect of mepolizumab (a humanised anti-interleukin-5 monoclonal antibody) in EoO was evaluated. METHODS:Eleven adult...

journal_title：Gut

authors： Straumann A,Conus S,Grzonka P,Kita H,Kephart G,Bussmann C,Beglinger C,Smith DA,Patel J,Byrne M,Simon HU

更新日期：2010-01-01 00:00:00

abstract：:Ten patients in whom cystic dystrophy developed in a heterotopic pancreas of the duodenal (nine patients) or gastric (one patient) wall are reported. All were young or middle aged white men, only two of whom were alcoholic. The symptoms were caused by intestinal or biliary stenosis, or both, secondary to the inflammat...

journal_title：Gut

authors： Fléjou JF,Potet F,Molas G,Bernades P,Amouyal P,Fékété F

更新日期：1993-03-01 00:00:00

abstract：:Forty five patients with refractory oesophagitis, defined as persisting erosive changes or ulceration despite a minimum of three months' treatment with cimetidine 3.2 g daily or ranitidine 0.9 g daily, were treated in an open trial with omeprazole 40 mg daily for up to eight weeks. Endoscopically defined healing was o...

journal_title：Gut

authors： Bardhan KD,Morris P,Thompson M,Dhande DS,Hinchliffe RF,Jones RB,Daly MJ,Carroll NJ

更新日期：1990-07-01 00:00:00

abstract：:The present study was undertaken to investigate the possibility that central nervous system monoaminergic pathways may play a role in the control of gastric acid and gastrin secretion in man. Submaximal pentagastrin stimulated (0.25 micrograms/kg/h) gastric acid secretion, as well as basal gastrin concentrations were ...

journal_title：Gut

authors： Caldara R,Barbieri C,Piepoli V,Borzio M,Masci E

更新日期：1985-10-01 00:00:00

abstract：:We determined the ionic composition of faecal fluid from 13 patients with Crohn's disease limited to the colon, 10 with diffuse ulcerative colitis, and eight with ulcerative proctitis. The Crohn's and colitis groups had similar proportions of colon surface involved radiographically and similar 24 hour faecal weights. ...

journal_title：Gut

authors： Schilli R,Breuer RI,Klein F,Dunn K,Gnaedinger A,Bernstein J,Paige M,Kaufman M

更新日期：1982-04-01 00:00:00

abstract：OBJECTIVE:Young-onset colorectal cancer (YCRC) incidence is rising. Scant data exist on YCRC risk after presentation with concerning symptoms such as iron-deficiency anaemia (IDA) or haematochezia. We examined the association between IDA and YCRC, and haematochezia and YCRC. DESIGN:Cohort study of US Veterans aged 18-...

journal_title：Gut

authors： Demb J,Liu L,Murphy CC,Doubeni CA,Martínez ME,Gupta S

更新日期：2020-12-18 00:00:00

abstract：OBJECTIVE:In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD. DESIGN:Patient-level data of adult patie...

journal_title：Gut

authors： Lu TX,Dapas M,Lin E,Peters T,Sakuraba A

更新日期：2020-12-17 00:00:00

abstract：BACKGROUND AND AIMS:Helicobacter pylori infection and gastric atrophy are both risk factors for gastric cancer. We aimed to elucidate the natural history of gastric cancer development according to H pylori infection and gastric atrophy status. SUBJECTS AND METHODS:A total of 9293 participants in a mass health appraisa...

journal_title：Gut

authors： Watabe H,Mitsushima T,Yamaji Y,Okamoto M,Wada R,Kokubo T,Doi H,Yoshida H,Kawabe T,Omata M

更新日期：2005-06-01 00:00:00

abstract：INTRODUCTION:Recent data have suggested that specific haplotypic variants of the DLG5 gene on chromosome 10q23 may be associated with susceptibility to inflammatory bowel disease (IBD) in Germany. Haplotype D, notably characterised by the presence of a G-->A substitution at nucleotide 113, was associated with susceptib...

journal_title：Gut

authors： Noble CL,Nimmo ER,Drummond H,Smith L,Arnott ID,Satsangi J

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND AND AIMS:The early responses of the oesophageal mucosa to acid perfusion may predict subsequent pathology. Mucosal responses to luminal acid may result either from acid permeating through the mucosa or from other unknown transduction mechanisms. In order to better understand the dynamics of acid permeation i...

journal_title：Gut

authors： Tanaka S,Chu S,Hirokawa M,Montrose MH,Kaunitz JD

更新日期：2003-06-01 00:00:00

abstract：BACKGROUND AND AIMS:The gastrointestinal microflora exerts a barrier effect against enteropathogens. The aim of this study was to examine if bifidobacteria, a major species of the human colonic microflora, participates in the barrier effect by developing antimicrobial activity against enterovirulent bacteria. METHODS:...

journal_title：Gut

authors： Liévin V,Peiffer I,Hudault S,Rochat F,Brassart D,Neeser JR,Servin AL

更新日期：2000-11-01 00:00:00

abstract：:The hormones secretin and cholecystokinin-pancreozymin (CCK) have been shown to release brush-border alkaline phosphatase into the small-intestinal lumen in the human subject. In contrast to the disaccharidases, large amounts of alkaline phosphatase are present in human duodenal juice. The range has been established i...

journal_title：Gut

authors： Warnes TW,Hine P,Kay G

更新日期：1974-01-01 00:00:00

abstract：:By prolonged immunization of an inbred rat strain with isologous liver homogenate in Freund's complete adjuvant a low grade autoimmune ;cholangitis' with periductular fibrosis has been demonstrated. The lesion could be transferred to isogeneic animals by serial spleen cell injections and was associated with mild but v...

journal_title：Gut

authors： Maclaurin BP

更新日期：1971-06-01 00:00:00

abstract：BACKGROUND:There is considerable evidence indicating that the severity of hepatic damage in individuals with cholestatic liver disease is causally associated with the extent of intrahepatic oxidative stress. Increased levels or accelerated generation of reactive oxygen species and toxic degradative products of lipid pe...

journal_title：Gut

authors： Ljubuncic P,Tanne Z,Bomzon A

更新日期：2000-11-01 00:00:00

abstract：:Fasting serum gastrin has been measured by radioimmunoassay in 72 patients with duodenal ulcer and compared with that in normals, patients with gastric ulcer, and with the Zollinger-Ellison syndrome. The mean (+/- SEM) gastrin levels were 15.7 +/- 1.5 pg/ml in the duodenal ulcer group, 32.1 +/- 4.3 pg/ml in normals, 1...

journal_title：Gut

authors： Korman MG,Soveny C,Hansky J

更新日期：1971-11-01 00:00:00

abstract：:The barium enemas of 23 cases of end-to-end anastomosis following resection of a colonic carcinoma demonstrated that the normal anastomosis should be smooth, symmetrical, and have a regular mucosal pattern. In contrast the three patients reported with proven recurrent carcinoma at the anastomosis showed irregular asym...

journal_title：Gut

authors： Bartram C,Hale JE

更新日期：1970-09-01 00:00:00

abstract：:To investigate the basis of subclinical alveolitis in patients with primary biliary cirrhosis, 10 primary biliary cirrhosis patients were studied by bronchoalveolar lavage. Both bronchoalveolar lavage lymphoid and non-lymphoid cell populations were analysed using immunocytological methods to determine their proportion...

journal_title：Gut

authors： Spiteri MA,Johnson M,Epstein O,Sherlock S,Clarke SW,Poulter LW

更新日期：1990-02-01 00:00:00

abstract：BACKGROUND:Suicide gene therapy consists of the transfer into tumour cells of a "suicide" gene that can convert a non-toxic compound into a lethal drug. Expression of the cytosine deaminase gene leads to the conversion of the non-toxic compound 5-fluorocytosine to 5-fluorouracil. We have recently shown that "suicide ce...

journal_title：Gut

authors： Pierrefite-Carle V,Baqué P,Gavelli A,Brossette N,Benchimol D,Bourgeon A,Saint Paul MC,Staccini P,Rossi B

更新日期：2002-03-01 00:00:00

abstract：:Inflammatory mediators from intestinal mast cells may serve as initiators of acute and delayed inflammation. Mast cell histamine release was measured in 19 patients with inflammatory bowel diseases using gut mast cells from enzymatically dispersed endoscopic forceps biopsy specimens of macroscopically inflamed and nor...

journal_title：Gut

authors： Nolte H,Spjeldnaes N,Kruse A,Windelborg B

更新日期：1990-07-01 00:00:00