Abstract:
OBJECTIVE:Eosinophilic oesophagitis (EoO) is a clinicopathological condition defined by proton pump inhibitor-refractory oesophageal symptoms combined with oesophageal eosinophilia. The pharmacodynamic effect of mepolizumab (a humanised anti-interleukin-5 monoclonal antibody) in EoO was evaluated. METHODS:Eleven adults with active EoO (>20 peak eosinophil number/high power field (hpf) and dysphagia) were randomised to 750 mg of mepolizumab (n = 5) or placebo (n = 6) and received two intravenous infusions, 1 week apart. Those not in complete remission (<5 peak eosinophil number/hpf) after 8 weeks received two further doses 4 weeks apart, 1500 mg of mepolizumab or placebo. The effect of mepolizumab was assessed clinically, endoscopically, histologically, and via blood and tissue biomarkers. RESULTS:As assessed by immunofluorescence, a marked reduction of mean oesophageal eosinophilia (p = 0.03) was seen in the mepolizumab group (-54%) compared with the placebo group (-5%) 4 weeks after initiation of treatment. No further reduction of eosinophil numbers was observed in response to the two additional infusions in either group. Mepolizumab reduced tenascin C (p = 0.033) and transforming growth factor beta1 (p = 0.05) expression in the oesophageal epithelial layer 13 weeks after initiation of treatment. Clinically, limited improvement of symptoms was seen, although a trend was seen between 4 and 13 weeks after initiation of mepolizumab treatment. Mepolizumab was well tolerated. CONCLUSIONS:Mepolizumab significantly reduced eosinophil numbers in oesophageal tissues in adult patients with active EoO, and changes in the expression of molecules associated with oesophageal remodelling were reversed. Minimal clinical improvement was achieved in a subgroup of patients with EoO. Mepolizumab had an acceptable safety profile, even at the high 1500 mg dose level. TRIAL REGISTRATION NUMBER:NCT00274703.
journal_name
Gutjournal_title
Gutauthors
Straumann A,Conus S,Grzonka P,Kita H,Kephart G,Bussmann C,Beglinger C,Smith DA,Patel J,Byrne M,Simon HUdoi
10.1136/gut.2009.178558subject
Has Abstractpub_date
2010-01-01 00:00:00pages
21-30issue
1eissn
0017-5749issn
1468-3288pii
gut.2009.178558journal_volume
59pub_type
杂志文章,随机对照试验相关文献
GUT文献大全abstract:OBJECTIVE:To investigate the success rate of cold snare polypectomy (CSP) for complete resection of 4-9 mm colorectal adenomatous polyps compared with that of hot snare polypectomy (HSP). DESIGN:A prospective, multicentre, randomised controlled, parallel, non-inferiority trial conducted in 12 Japanese endoscopy units....
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2017-314215
更新日期:2018-11-01 00:00:00
abstract::Water and electrolyte balance has been studied in 39 patients with a permanent ileostomy, who had had a proctocolectomy for ulcerative colitis. The findings have been compared with those in 39 healthy subjects who were matched for age and sex. The ileostomists were found to lose excessive quantities of water and sodiu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.8.702
更新日期:1983-08-01 00:00:00
abstract::The feasibility of surgery in amoebic colitis is presented by illustrative case histories in two patients. Subtotal colectomy and ileostomy were carried out for fulminating colitis in the one and exteriorization, excision, and subsequent re-anastomosis of a localized perforated area of bowel in the other. It is sugges...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.11.941
更新日期:1970-11-01 00:00:00
abstract:BACKGROUND/AIMS:To investigate the prognostic values of putative hepatic stem/progenitor cell (HSC/HPC) biomarkers in patients with hepatocellular carcinoma (HCC). METHODS:Fourteen biomarkers related to HSCs/HPCs or tumour angiogenesis were assessed by qRT-PCR and then validated by tissue microarrays (TMAs) in three i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.176271
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Obstructive jaundice is associated with postoperative complications related to increased endotoxaemia and the inflammatory response. In animals obstructive jaundice is associated with endotoxaemia and cytokine induction, which are reversed by internal biliary drainage. AIMS:To study endotoxaemia and the sub...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.46.5.725
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:Hydrogen sulphide (H(2)S) is a potent toxin normally present in the colonic lumen which may play a role in ulcerative colitis (UC). Two enzymes, thiol methyltransferase (TMT) and rhodanese (RHOD), are thought to be responsible for sulphide removal but supportive evidence is lacking. AIMS:To determine the di...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.2.201
更新日期:2002-02-01 00:00:00
abstract::Cholecystokinin (CCK) release and gall bladder emptying in response to a fatty meal are completely abolished in coeliac disease. To determine the effect of lipid digestion on CCK release and gall bladder motility, six patients with untreated coeliac disease and a flat jejunal mucosa were studied on two separate days. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.1.17
更新日期:1995-01-01 00:00:00
abstract::Thirty two patients with active Crohn's disease were included in a controlled randomised trial to determine the efficacy and safety of polymeric enteral nutrition compared with steroids, to achieve and maintain clinical remission. The polymeric diet was administered through a fine bore nasogastric tube by continuous, ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.6.778
更新日期:1993-06-01 00:00:00
abstract::Two enzymes having lactase activity are present in the equine small intestine. The first, the digestive enzyme, neutral beta-galactosidase, declines in activity from birth to three years, disappearing completely between 3 and 4 years of age. The other, the soluble lysosomal enzyme, acid beta-galactosidase, having affi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.7.535
更新日期:1973-07-01 00:00:00
abstract::Levels of clotting factors II, V, and VII were measured on admission and then daily in 12 patients with grade IV hepatic coma due to fulminant hepatic failure. Factor VII levels obtained within 36 hours of the development of grade IV coma were not of value in predicting which patients would subsequently recover consci...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.7.489
更新日期:1976-07-01 00:00:00
abstract::A study of the function of the lower end of the oesophagus in the cat confirms that it behaves as a true physiological sphincter, even though histological evidence for such a structure is absent. Sphincteric action is a function of the circular muscle fibres in the lowest 2 cm. of the oesophagus. Reflex changes in ton...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2.3.252
更新日期:1961-09-01 00:00:00
abstract:BACKGROUND:It is presently not well understood to what extent peptic ulcer and gastric cancer represent related diseases. AIMS:The objective of this study was to assess past occurrence of gastric and duodenal ulcers in patients with cancer of the gastric cardia or other parts of the stomach. METHODS:The association b...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.40.2.247
更新日期:1997-02-01 00:00:00
abstract::Management strategies for reflux disease are very different from those for dyspepsia and so differentiating between patients with "true" dyspepsia and those whose primary symptom is heartburn is a key step in their management. This separation has become more clear during the last decade as insights into reflux disease...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.50.suppl_4.iv17
更新日期:2002-05-01 00:00:00
abstract::The amylase/creatinine clearance ratio (Cam/Ccr ratio) was determined in 239 subjects. In 87 hospitalised patients without pancreatic disease (controls) the Cam/Ccr ratio was 3.02 +/- 0.69 (mean +/- ISD). The ratio was above the normal range in all patients with acute pancreatitis but was normal in those with chronic ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.18.9.703
更新日期:1977-09-01 00:00:00
abstract:BACKGROUND:and aims: Positron emission tomography (PET) using (18)F labelled 2-fluoro-2-deoxy-D-glucose ((18)FDG) is an established imaging tool, although the recent development of a biologically stable thymidine analogue [18F] 3'-deoxy-3-fluorothymidine ((18)FLT) has allowed PET to image cellular proliferation by util...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.11.1602
更新日期:2003-11-01 00:00:00
abstract:BACKGROUND:Simple and inexpensive non-invasive fibrosis tests are highly needed but have been poorly studied in sub-Saharan Africa. METHODS:Using liver histology as a gold standard, we developed a novel index using routine laboratory tests to predict significant fibrosis in patients with chronic HBV infection in The G...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309260
更新日期:2016-08-01 00:00:00
abstract::Serum samples from 26 monozygotic twin pairs concordant or discordant with regard to inflammatory bowel disease, and rectal biopsies from 42 twins of the same subject group, were examined for IgG subclasses. They were all compared with normal controls. Almost all affected twins were in clinical remission. Paired immun...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.10.1358
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Gastric cancer remains a major cause of cancer mortality globally but no good prognostic tumour marker is available. Soluble fragment of E-cadherin protein has been reported to increase in the sera of patients with cancer and recently was found to be elevated in 67% of patients with gastric cancer. AIMS:To ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.6.808
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Despite the recent discovery of four genes responsible for up to 90% of all cases of hereditary non-polyposis colorectal cancer (HNPCC), there will still be families in whom predictive testing is not possible. A phenotypic biomarker would therefore be useful. An upwards shift of the proliferative compartment...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.1.85
更新日期:1998-07-01 00:00:00
abstract::Chronic idiopathic constipation may be the result of an autonomic neuropathy. This hypothesis was tested in 23 constipated patients and 17 age matched controls, using the acetylcholine sweat spot test devised to test autonomic integrity in diabetes. Acetylcholine (0.01%) was injected in the dorsum of the foot painted ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.11.1539
更新日期:1992-11-01 00:00:00
abstract:OBJECTIVE:As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a compelling way to tackle the disease. We aim to provide humanised mouse (humice) models for the understanding of the interaction between human cancer and immun...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-315201
更新日期:2018-10-01 00:00:00
abstract::The distribution of the endoplasmic reticulum in human hepatocytes is defined in quantitative terms using the techniques of morphometry. The subjects of the study are liver biopsies from normal, untreated subjects and patients being treated with various drugs. In contrast to rat hepatocytes, the amount of smooth endop...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.9.737
更新日期:1974-09-01 00:00:00
abstract::The investigation and treatment of 131 patients with 'obscure' gastrointestinal bleeding has been reviewed. One hundred and six patients were assessed electively for recurrent haemorrhage, 25 presented as emergencies. The major presenting feature was melaena (55 patients), anaemia (35), rectal bleeding (34), haemateme...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.1.47
更新日期:1987-01-01 00:00:00
abstract::A family is described in which eight members in three successive generations had a sliding type of oesophageal hiatus hernia (or partial thoracic stomach) as a sole anomaly. The trait in this family behaved as a strict dominant, manifesting the segregation of a single abnormal autosomal gene. Other possible aetiologie...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.1.51
更新日期:1970-01-01 00:00:00
abstract::Although the development of endoscopic methods of treatment for biliary obstruction has proceeded rapidly in recent years, endoscopic retrograde cholangiopancreatographic (ERCP) services are patchily distributed. A recent survey by the British Society of Gastroenterology has shown that almost half the district general...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.10.1150
更新日期:1990-10-01 00:00:00
abstract::We report two patients with periampullary cysts associated with recurrent attacks of acute pancreatitis. In both patients the diagnosis was made preoperatively by upper gastrointestinal endoscopy and ERCP, which was also useful in determining the relationship of the cysts to the biliary and pancreatic ductal systems. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.3.358
更新日期:1987-03-01 00:00:00
abstract:OBJECTIVE:We aimed at the identification of genetic alterations that may functionally substitute for CTNNB1 mutation in ß-catenin-activated hepatocellular adenomas (HCAs) and hepatocellular carcinoma (HCC). DESIGN:Large cohorts of HCA (n=185) and HCC (n=468) were classified using immunohistochemistry. The mutational s...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-317632
更新日期:2019-07-01 00:00:00
abstract::A 17 year old Asian patient with autoimmune chronic active hepatitis resistant to treatment with high dose corticosteroids and azathioprine was given cyclosporin at a dose of 5 mg/kg/day. Within two weeks of starting the cyclosporin treatment a favourable clinical and biochemical response was obtained and by one month...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.3.459
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is a frequent complication of morbid obesity, but its severity varies greatly and thus there is a strong need to better define its natural history in these patients. DESIGN:Liver biopsies were systematically performed in 798 consecutive patients with severe obesity u...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2016-312238
更新日期:2017-09-01 00:00:00
abstract::Acute fulminant pancreatitis is associated with significant morbidity and mortality. To examine the outcome of conservative and surgical treatment of this disorder, 36 patients who survived an initial episode were restudied after a mean of six years. Fifty three per cent had developed diabetes mellitus, half of whom r...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.6.843
更新日期:1992-06-01 00:00:00