Abstract:
BACKGROUND/AIMS:To investigate the prognostic values of putative hepatic stem/progenitor cell (HSC/HPC) biomarkers in patients with hepatocellular carcinoma (HCC). METHODS:Fourteen biomarkers related to HSCs/HPCs or tumour angiogenesis were assessed by qRT-PCR and then validated by tissue microarrays (TMAs) in three independent cohorts of patients with HCC undergoing curative resection (n=67, 314 and 73). RESULTS:Most of the biomarkers were found to be overexpressed in patients with recurrent HCC by quantitative reverse transcription-PCR (qRT-PCR). The HSC/HPC biomarkers cytokeratin 19, ATP-binding cassette subfamily G member 2 (ABCG2), CD133, Nestin and CD44, and the markers of angiogenesis microvessel density (MVD, determined by CD34 immunostaining), vascular endothelial growth factor (VEGF) and platelet-derived endothelial cell growth factor (PD-ECGF) were confirmed as significant predictors for overall survival (OS) and/or relapse-free survival (RFS) in TMA analysis. As compared with the low HSC/HPC profile group, patients with a high HSC/HPC profile who had higher VEGF levels (p=0.012) and MVD (p=0.030) in tumours had significantly lower OS and RFS (p<0.0001). Based on Cox regression, a simplified model including CD133, CD44, Nestin and MVD was constructed and confirmed as an independent predictor for OS (p<0.0001) and RFS (p<0.0001), regardless of alpha-fetoprotein level, tumour stage and recurrence time (p<0.0001 for all). CONCLUSION:High expression levels of HSC/HPC biomarkers are related to tumour angiogenesis and poor prognosis of HCC. The simplified model based on the HSC/HPC and tumour angiogenesis profile can be used to classify patients with HCC with a high risk of tumour recurrence after surgery.
journal_name
Gutjournal_title
Gutauthors
Yang XR,Xu Y,Yu B,Zhou J,Qiu SJ,Shi GM,Zhang BH,Wu WZ,Shi YH,Wu B,Yang GH,Ji Y,Fan Jdoi
10.1136/gut.2008.176271subject
Has Abstractpub_date
2010-07-01 00:00:00pages
953-62issue
7eissn
0017-5749issn
1468-3288pii
gut.2008.176271journal_volume
59pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND:To evaluate the relation between non-steroidal anti-inflammatory drugs (NSAIDs) and colitis due to inflammatory bowel disease. METHODS:A case-control study was conducted using a prospectively constructed, record linkage database containing hospital event and dispensed drug data (1989-93). The study populati...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.40.5.619
更新日期:1997-05-01 00:00:00
abstract::The aim of this study was to develop and validate an endoscopic index for assessing the severity of Crohn's disease. Endoscopic findings were prospectively collected by a multicentre group in 75 patients with Crohn's colitis according to a previously validated procedure. The presence of nine preselected lesions was re...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1136/gut.30.7.983
更新日期:1989-07-01 00:00:00
abstract:OBJECTIVE:Metabolic syndrome (MetS) arises from complex interactions between host genetic and environmental factors. Although it is now widely accepted that the gut microbiota plays a crucial role in host metabolism, current knowledge on the effect of host genetics on specific gut microbes related to MetS status remain...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-311326
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND AND AIMS:The choice of colorectal surgery in patients with familial adenomatous polyposis lies between the morbidity of proctocolectomy and ileum-pouch-anal anastomosis (IPAA) and the mortality from rectal cancer after total colectomy and ileorectal anastomosis (IRA). The aims of the present study were: (1) ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.2.231
更新日期:2001-08-01 00:00:00
abstract:OBJECTIVE:Functional gastrointestinal disorders (FGIDs) are diagnosed by the presence of a characteristic set of symptoms. However, the current criteria-based diagnostic approach is to some extent subjective and largely derived from observations in English-speaking Western patients. We aimed to identify latent symptom ...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2016-312852
更新日期:2018-06-01 00:00:00
abstract::All patients presenting with acute upper gastrointestinal bleeding between November 1986 and April 1988 were admitted to a centralised joint medical/surgical unit, with a policy of early clinical and endoscopic assessment and rapid surgical intervention in those at high risk. Of the 430 patients admitted 69.5% were ov...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.5.504
更新日期:1990-05-01 00:00:00
abstract:OBJECTIVE:Reports on the effects of bone marrow-derived cells on hepatic fibrosis are contradictory. Impaired fibrosis but increased inflammation has recently been demonstrated 10 weeks after bone marrow transplantation (BM-Tx) in Abcb4-/- mice. It is hypothesised that BM-Tx might have long-term therapeutic potential b...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300608
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:Hepatocellular adenomas (HCAs) classically develop in women who are taking oral contraceptives and have a risk of malignant transformation into hepatocellular carcinoma (HCC). HCA with malignant transformation is, however, an ill-defined entity thought to be an anecdotic pathway to HCC. The objective of this ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.222109
更新日期:2011-01-01 00:00:00
abstract::Gastric acid secretion, pepsin secretion, and fasting serum gastrin levels were measured in 23 patients with duodenal ulcer disease, divided into three groups which received either cimetidine 800 mg daily, cimetidine 1600 mg daily, or ranitidine hydrochloride 300 mg daily for eight weeks. Pentagastrin tests were carri...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.1.61
更新日期:1983-01-01 00:00:00
abstract::The mechanism by which intragastric balloons induce weight loss is not known, although they may act simply by reducing the amount of food needed to induce satiety. The knowledge that a balloon is present may influence the patients' eating patterns and reduce caloric intake and weight. In order to test whether the ball...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.30.8.1054
更新日期:1989-08-01 00:00:00
abstract::In a Danish multicentre trial we compared the relapse preventing effects of olsalazine and sulphasalazine in patients with ulcerative colitis over a 12 month treatment period. Two hundred and twenty seven patients (118 men) with at least two previous attacks of ulcerative colitis were randomly allocated according to a...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.33.2.252
更新日期:1992-02-01 00:00:00
abstract::A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and management of adult coeliac disease (CD). This paper presents the recommendations of the British Society of Gastroenterolo...
journal_title:Gut
pub_type: 杂志文章,实务指引
doi:10.1136/gutjnl-2013-306578
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Thrombosis may be an important effector mechanism in the pathogenesis of Crohn's disease. METHODS:This study therefore investigated the prevalence of independent thrombotic risk factors (factor VII coagulant activity, lipoprotein (a), fibrinogen, plasma triglycerides, and smoking) in patients with Crohn's d...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.5.733
更新日期:1996-05-01 00:00:00
abstract::Twenty one patients with diabetic peripheral neuropathy, 18 with idiopathic faecal incontinence and 11 normal controls were studied with techniques of mucosal electrosensitivity, rectal distension for the quantitative assessment of anorectal sensation, and manometric and electromyographic tests for the assessment of a...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.6.756
更新日期:1988-06-01 00:00:00
abstract:OBJECTIVE:Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in neurodegenerative diseases. Given the prominence of dysbiosis and colonic dysfunction in patients with Parkinson's disease (PD), we pro...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-316844
更新日期:2019-05-01 00:00:00
abstract:AIM:Recurrent bleeding after initial haemostasis is an important factor that directly relates to the outcome in the management of peptic ulcer bleeding. Conflicting reports have been published concerning the effectiveness of scheduled second therapeutic endoscopy on ulcer rebleeding. We investigate the use of scheduled...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.52.10.1403
更新日期:2003-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Both bile salts and glutathione participate in the generation of canalicular bile flow. In this work, we have investigated the effect of different bile salts on hepatic glutathione metabolism. METHODS:Using the isolated and perfused rat liver, we studied hepatic glutathione content, and metabolism ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.5.701
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND AND AIMS:Pancreatic cancer is among the most dismal of human malignancies. Current therapeutic strategies are virtually ineffective in controlling advanced, metastatic disease. Recent evidence suggests that the Hedgehog signalling pathway is aberrantly reactivated in the majority of pancreatic cancers, and t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.148189
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:Altered matrix degradation contributes to fibrosis in some liver diseases but the role of matrix degradation in fibrogenesis associated with genetic haemochromatosis has not previously been addressed. AIMS:To measure serum concentrations of tissue inhibitor of metalloproteinase 1 (TIMP-1) and matrix metallo...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.5.715
更新日期:1998-05-01 00:00:00
abstract::Carbachol and magnesium sulphate were used to increase the motility of the intestine in healthy volunteers. The effect was estimated by recording changes in abdominal sounds. Serum 5-hydroxytryptamine levels were assayed and found to be higher after gastrointestinal stimulation. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2.3.246
更新日期:1961-09-01 00:00:00
abstract::In a double-blind controlled trial amylopectin sulphate (Depepsen) had no significant advantage over placebo in the symptomatic treatment of duodenal ulcer. ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.18.9.723
更新日期:1977-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and efficacy of daclatasvir, an HCV NS5A inhibitor with pangenotypic activity, administered with peginterferon-alfa-2a/ribavirin. DESIGN:In this Phase 2b double-blind, placebo-controlled study, treatment-naive adults with HCV genotype 1 (N=365) or 4 (N=30) infection were randomly assig...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gutjnl-2014-307498
更新日期:2015-06-01 00:00:00
abstract:OBJECTIVES:Endothelial progenitor cells (EPCs) circulate with increased numbers in the peripheral blood of patients with highly-vascularised hepatocellular carcinoma (HCC) and contribute to angiogenesis and neovascularisation. We hypothesised that angiogenic EPCs, that is, colony forming unit-endothelial cells (CFU-ECs...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-306302
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:The intestinal microbiome affects the prevalence and pathophysiology of a variety of diseases ranging from inflammation to cancer. A reduced taxonomic or functional diversity of the microbiome was often observed in association with poorer health outcomes or disease in general. Conversely, factors or manifest ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-322753
更新日期:2020-11-09 00:00:00
abstract:BACKGROUND AND AIMS:Pigment epithelium-derived factor (PEDF), a non-inhibitory SERPIN with potent antiangiogenic activity, has been recently implicated in metabolism and adipogenesis, both of which are known to influence pancreatic cancer progression. Increased pancreatic fat in human pancreatic tumour correlates with ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300821
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Increased infertility in women has been reported after ileal pouch-anal anastomosis (IPAA) for ulcerative colitis but reported infertility rates vary substantially. AIMS:(1) To perform a systematic review and meta-analysis of the relative risk of infertility post-IPAA compared with medical management; (2) t...
journal_title:Gut
pub_type: 杂志文章,meta分析,评审
doi:10.1136/gut.2005.090316
更新日期:2006-11-01 00:00:00
abstract::A 69 year old woman developed chronic diarrhoea while being treated with ranitidine. Sigmoidoscopy was performed after six weeks and showed typical histological features of lymphocytic colitis. Ranitidine was withdrawn and the diarrhoea resolved. Eight months later, a 72 hour oral rechallenge period of ranitidine, was...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.5.708
更新日期:1995-11-01 00:00:00
abstract:OBJECTIVE:Hepatitis D virus (HDV) is a defective virus that completes its life cycle only with hepatitis B virus (HBV). The HBV with HDV super-infection has been considered as one of the most severe forms of the chronic viral hepatitis. However, there is a scarcity of data on the global burden of HDV infection. DESIGN...
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316601
更新日期:2019-03-01 00:00:00
abstract:BACKGROUND:Visceral hyperalgesia has been implicated as a factor contributing to symptom generation in irritable bowel syndrome (IBS). However, previous studies using intestinal balloon distension have used psychophysical procedures which do not provide adequate and unbiased measures of visceral sensitivity. METHODS:T...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.4.505
更新日期:1997-10-01 00:00:00
abstract::The effect of 28 days' continuous administration of oral indomethacin on gastroduodenal morphology, gastric mucosal blood flow, and gastric mucosal prostaglandin E2 (PGE2) metabolism in man was studied to define further the mechanisms of mucosal injury induced by indomethacin. Indomethacin caused acute gastroduodenal ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.2.164
更新日期:1992-02-01 00:00:00