Interferon alfa-2b for decompensated liver disease caused by either chronic hepatitis B or C: preliminary results of a pilot study.

Abstract:

:This pilot study was designed to assess the tolerance and effectiveness of interferon alfa-2b in patients with decompensated liver disease caused by chronic hepatitis B (n = 7) or C (n = 5). Preliminary results suggest that patients may benefit from small doses of interferon (improvement in liver function tests and reduction in alanine aminotransferase), although the decreased tolerance and dose dependent increase in side effects in these patients with liver disease underlines the need for close follow up and the dose adjustment of interferon treatment.

journal_name

Gut

journal_title

Gut

authors

Dimopoulou M,Fafoutis K,Basiliou K,Ketikoglou J,Karvountzis G

doi

10.1136/gut.34.2_suppl.s104

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

S104-5

issue

2 Suppl

eissn

0017-5749

issn

1468-3288

journal_volume

34

pub_type

杂志文章

相关文献

GUT文献大全
  • HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice.

    abstract:OBJECTIVE:HCV is a major cause of chronic liver disease worldwide, but the role of neutralising antibodies (nAbs) in its natural history remains poorly defined. We analysed the in vivo role of hypervariable region 1 (HVR1) for HCV virion properties, including nAb susceptibility. DESIGN:Analysis of HCV from human liver...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-310300

    authors: Prentoe J,Verhoye L,Velázquez Moctezuma R,Buysschaert C,Farhoudi A,Wang R,Alter H,Meuleman P,Bukh J

    更新日期:2016-12-01 00:00:00

  • Value of exfoliative cytology for investigating bile duct strictures.

    abstract::The cause of a biliary tract stricture may be difficult to determine radiologically. Exfoliative biliary cytology was evaluated in 62 patients (median age 65 years, range 30-94) with biliary tract strictures presenting to the Hepatobiliary Unit between January 1984 and December 1989. Bile samples were taken during end...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.33.10.1408

    authors: Davidson B,Varsamidakis N,Dooley J,Deery A,Dick R,Kurzawinski T,Hobbs K

    更新日期:1992-10-01 00:00:00

  • Global DNA hypomethylation occurs in the early stages of intestinal type gastric carcinoma.

    abstract:BACKGROUND:Global DNA hypomethylation has been found in the premalignant stages of some neoplasms and has been implicated as an important factor for tumour progression. AIMS:The aim of this study was to evaluate whether DNA hypomethylation occurs during the process of gastric carcinogenesis. METHODS:Gastric specimens...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.39.3.434

    authors: Cravo M,Pinto R,Fidalgo P,Chaves P,Glória L,Nobre-Leitão C,Costa Mira F

    更新日期:1996-09-01 00:00:00

  • Changes in oesophageal wall biomechanics after portal vein banding and variceal sclerotherapy measured by a new technique. An experimental study in rabbits.

    abstract::The biomechanical properties of the oesophageal wall were investigated in a rabbit model using a four electrode impedance technique. A specially designed probe with the electrodes inside a low pressure expandable insulating latex balloon was introduced in the oesophagus. Stepwise inflation and deflation was done for a...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.29.12.1699

    authors: Gregersen H,Jensen LS,Djurhuus JC

    更新日期:1988-12-01 00:00:00

  • Chemoprevention of colorectal cancer.

    abstract::Colorectal cancer is the fourth commonest form of cancer in men with 678 000 estimated new cases per year worldwide, representing 8.9% of all new cancers. The disease is most frequent in Occidental countries and particularly so in North America, Australia, New Zealand, and parts of Europe. Prospects for colorectal can...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.43.4.578

    authors: Langman M,Boyle P

    更新日期:1998-10-01 00:00:00

  • T cell-dependent protective effects of CpG motifs of bacterial DNA in experimental colitis are mediated by CD11c+ dendritic cells.

    abstract:BACKGROUND:Oligodeoxynucleotides (ODNs) containing unmethylated cytosine-guanosine (CpG) sequence motifs constitute the immunostimulatory components of bacterial DNA which potently activate innate immunity. Administration of CpG-ODNs before the onset of experimental colitis prevents intestinal inflammation by induction...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2009.193177

    authors: Hofmann C,Dunger N,Grunwald N,Hämmerling GJ,Hoffmann P,Schölmerich J,Falk W,Obermeier F

    更新日期:2010-10-01 00:00:00

  • Studies of the effect of metoclopramide and apomorphine on gastric emptying and secretion in man.

    abstract::With oral and intravenous doses of metoclopramide there was no constant effect on the gastric emptying of test meals of glucose or sodium citrate, nor was secretion of acid by the stomach in response to test meals of glucose or sodium citrate affected. Apomorphine, in subnauseous doses (0.25 mg intravenously) slowed t...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.11.12.989

    authors: Ramsbottom N,Hunt JN

    更新日期:1970-12-01 00:00:00

  • Laparoscopic biliary and gastric bypass: a useful adjunct in the treatment of carcinoma of the pancreas.

    abstract::Over 90% of patients with inoperable carcinoma of the pancreas are successfully palliated by endoscopic retrograde cholangiopancreatography and stent insertion. Treatment of the residual 10% of patients often entails a laparotomy, which is difficult to justify when median survival of these patients is only 150 days. L...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.36.5.778

    authors: Rhodes M,Nathanson L,Fielding G

    更新日期:1995-05-01 00:00:00

  • Visceral sensation and emotion: a study using hypnosis.

    abstract:BACKGROUND AND OBJECTIVES:We have previously shown that hypnosis can be used to study the effect of different emotions on the motility of the gastrointestinal tract. These studies demonstrated that both anger and excitement increased colonic motility while happiness led to a reduction. The purpose of this study was to ...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/gut.51.5.701

    authors: Houghton LA,Calvert EL,Jackson NA,Cooper P,Whorwell PJ

    更新日期:2002-11-01 00:00:00

  • Randomised placebo-controlled trial of teduglutide in reducing parenteral nutrition and/or intravenous fluid requirements in patients with short bowel syndrome.

    abstract:BACKGROUND AND AIMS:Teduglutide, a GLP-2 analogue, may restore intestinal structural and functional integrity by promoting repair and growth of the mucosa and reducing gastric emptying and secretion, thereby increasing fluid and nutrient absorption in patients with short bowel syndrome (SBS). This 24-week placebo-contr...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1136/gut.2010.218271

    authors: Jeppesen PB,Gilroy R,Pertkiewicz M,Allard JP,Messing B,O'Keefe SJ

    更新日期:2011-07-01 00:00:00

  • Peptic ulcer bleeding: accessory risk factors and interactions with non-steroidal anti-inflammatory drugs.

    abstract:AIMS:To determine risk factors for peptic ulcer bleeding other than non-steroidal anti-inflammatory drugs (NSAIDs). Methods-Data on possible antecedent risk factors obtained in a large case control study of 1121 patients admitted to hospitals in Glasgow, Newcastle, Nottingham, Oxford, and Portsmouth with bleeding pepti...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究

    doi:10.1136/gut.46.1.27

    authors: Weil J,Langman MJ,Wainwright P,Lawson DH,Rawlins M,Logan RF,Brown TP,Vessey MP,Murphy M,Colin-Jones DG

    更新日期:2000-01-01 00:00:00

  • Early gastric cancer in Europe.

    abstract::Despite mass population screening and an incidence of EGC in Japan that is at least double that of the West, there seem to be no genuine differences in the clinicopathological features of the disease between the two regions. The macroscopic appearance, size, depth of invasion, frequency of lymph node invasion, and his...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.41.2.142

    authors: Everett SM,Axon AT

    更新日期:1997-08-01 00:00:00

  • Role of visceral sensitivity in the pathophysiology of irritable bowel syndrome.

    abstract::Visceral hypersensitivity has been recognised as a characteristic of patients with irritable bowel syndrome (IBS). It may be involved in the pathogenesis of abdominal pain/discomfort, and seems to result from the sensitisation of nerve afferent pathways originating from the gastrointestinal tract. From a clinical poin...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.51.suppl_1.i67

    authors: Delvaux M

    更新日期:2002-07-01 00:00:00

  • Effect of toxin A and B of Clostridium difficile on rabbit ileum and colon.

    abstract::The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted flu...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.27.1.78

    authors: Mitchell TJ,Ketley JM,Haslam SC,Stephen J,Burdon DW,Candy DC,Daniel R

    更新日期:1986-01-01 00:00:00

  • Antibodies to Escherichia coli in chronic liver diseases.

    abstract::Patients with chronic active hepatitis or alcoholic cirrhosis have serum antibodies to many more serotypes of Escherichia coli than do patients with primary biliary cirrhosis or cryptogenic cirrhosis, or normal controls. They also have antibodies against more serotypes than cirrhotic patients with a portacaval shunt. ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.16.11.871

    authors: Simjee AE,Hamilton-Miller JM,Thomas HC,Brumfitt W,Sherlock S

    更新日期:1975-11-01 00:00:00

  • Risk factors for extensive ulcerative colitis and ulcerative proctitis: a population based case-control study.

    abstract::To examine socioeconomic factors, dietary and other personal habits, and medical history as risk factors for ulcerative colitis, we studied 167 (98%) of all prevalent cases of ulcerative colitis diagnosed in Uppsala county from 1945 to 1964 and 167 age and sex matched population controls. Ulcerative colitis patients w...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.32.12.1526

    authors: Samuelsson SM,Ekbom A,Zack M,Helmick CG,Adami HO

    更新日期:1991-12-01 00:00:00

  • Cancer surveillance in longstanding ulcerative colitis: endoscopic appearances help predict cancer risk.

    abstract:BACKGROUND AND AIMS:The risk of colorectal cancer is increased in ulcerative colitis (UC). Patients with UC have diverse colonoscopic appearances. Determining colonoscopic markers for cancer risk could allow patient risk stratification. PATIENTS AND METHODS:Following on from an earlier study which demonstrated a corre...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2003.038505

    authors: Rutter MD,Saunders BP,Wilkinson KH,Rumbles S,Schofield G,Kamm MA,Williams CB,Price AB,Talbot IC,Forbes A

    更新日期:2004-12-01 00:00:00

  • Influence of nutritional status on immune functions in patients with Crohn's disease.

    abstract::Nutritional status and immune function were correlated with clinical features in 56 patients with Crohn's disease. These were divided arbitrarily into either undernourished or well nourished groups according to whether their midarm circumference was below or above 90% of ideal standard. Results were also compared with...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.25.5.465

    authors: Harries AD,Danis VA,Heatley RV

    更新日期:1984-05-01 00:00:00

  • Association between antiviral treatment and extrahepatic outcomes in patients with hepatitis C virus infection.

    abstract:OBJECTIVE:To elucidate the association between antiviral therapy and extrahepatic outcomes in individuals infected with HCV. METHODS:This nationwide cohort study screened 293,480 Taiwanese residents with HCV infection and excluded those with substantial comorbidity. A total of 12,384 eligible patients who had received...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2014-308163

    authors: Hsu YC,Ho HJ,Huang YT,Wang HH,Wu MS,Lin JT,Wu CY

    更新日期:2015-03-01 00:00:00

  • Xylan-regulated delivery of human keratinocyte growth factor-2 to the inflamed colon by the human anaerobic commensal bacterium Bacteroides ovatus.

    abstract:BACKGROUND:Human growth factors are potential therapeutic agents for various inflammatory disorders affecting the gastrointestinal tract. However, they are unstable when administered orally and systemic administration requires high doses increasing the risk of unwanted side effects. Live microorganism-based delivery sy...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2008.176131

    authors: Hamady ZZ,Scott N,Farrar MD,Lodge JP,Holland KT,Whitehead T,Carding SR

    更新日期:2010-04-01 00:00:00

  • Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivo.

    abstract:BACKGROUND:Fresh fruit and vegetables exert multiple biological effects on the gastrointestinal mucosa. AIM:To assess whether apple extracts counteract oxidative or indomethacin induced damage to gastric epithelial cells in vitro and to rat gastric mucosa in vivo. METHODS:Apple extracts were obtained from freeze drie...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2004.046292

    authors: Graziani G,D'Argenio G,Tuccillo C,Loguercio C,Ritieni A,Morisco F,Del Vecchio Blanco C,Fogliano V,Romano M

    更新日期:2005-02-01 00:00:00

  • A search for persistent virus infection in Crohn's disease.

    abstract::Cell cultures derived from Crohn's disease and control tissues were subjected to a series of tests designed to detect persistent, non-cytocidal virus infection. No evidence for any such infection was found, and it is concluded that persistent viral infection of gut tissues is unlikely to play a significant role in the...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.21.3.202

    authors: Phillpotts RJ,Hermon-Taylor J,Teich NM,Brooke BN

    更新日期:1980-03-01 00:00:00

  • Computer aided positioning of manometric probe in the upper digestive tract.

    abstract::A method not needing fluoroscopic control for positioning a manometric probe in the gastroduodenal tract is described. It is based on hydrostatic pressure variations occurring at each recording port of a multichannel perfused probe after changes in patient's position. The data are fed into a computer and the schematic...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.29.7.1007

    authors: Bortolotti M,Bersani G

    更新日期:1988-07-01 00:00:00

  • Intraepithelial and lamina propria lymphocytes show distinct patterns of apoptosis whereas both populations are active in Fas based cytotoxicity in coeliac disease.

    abstract:BACKGROUND:Lamina propria (LPLs) and intraepithelial (IELs) lymphocytes are markedly increased in coeliac mucosa, and are thought to play a crucial role in the generation of villous atrophy in coeliac disease (CD). However, the mechanisms by which they mediate the killing of enterocytes in this condition are still poor...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.49.3.380

    authors: Di Sabatino A,Ciccocioppo R,D'Alò S,Parroni R,Millimaggi D,Cifone MG,Corazza GR

    更新日期:2001-09-01 00:00:00

  • Metabolism of 125I-labelled trypsin in man: evidence of recirculation.

    abstract::125I-labelled human trypsin metabolism has been investigated in man. Three subjects received 125I-trypsin and 131I-albumin intravenously. Against a background secretin infusion (1 U/kg/h), trypsin decayed biexponentially from the serum with half-lives of 17.5, 21, and 24 minutes for the rapid disappearance phase and 5...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.21.7.580

    authors: Lake-Bakaar G,Rubio CE,McKavanagh S,Potter BJ,Summerfield JA

    更新日期:1980-07-01 00:00:00

  • Inflammatory bowel disease: re-evaluation of the diagnosis in a prospective population based study in south eastern Norway.

    abstract:BACKGROUND:The incidence figures for ulcerative colitis (UC) and Crohn's disease (CD) have been difficult to interpret, and geographical variations may be due to differences in classification criteria and study design. Few studies have based the incidence on prospective systematic follow up to confirm the initial diagn...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.40.3.328

    authors: Moum B,Ekbom A,Vatn MH,Aadland E,Sauar J,Lygren I,Schulz T,Stray N,Fausa O

    更新日期:1997-03-01 00:00:00

  • A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma.

    abstract:OBJECTIVE:Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes. In human cancers, aberrant post-transcriptional modifications, such as alternative splicing and RNA editing, may lead to tumour specific transcriptome diversity. DESIGN:By utilising large ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2012-304037

    authors: Chan TH,Lin CH,Qi L,Fei J,Li Y,Yong KJ,Liu M,Song Y,Chow RK,Ng VH,Yuan YF,Tenen DG,Guan XY,Chen L

    更新日期:2014-05-01 00:00:00

  • Campylobacter pylori infection in Meckel's diverticula containing gastric mucosa.

    abstract::A retrospective survey was undertaken of 228 resected Meckel's diverticula to determine if there was any evidence of Campylobacter pylori infection in diverticula containing gastric mucosa. Among the 65 diverticula with gastric mucosa one was heavily infected with organisms having the morphological appearances of C py...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.30.9.1233

    authors: Morris A,Nicholson G,Zwi J,Vanderwee M

    更新日期:1989-09-01 00:00:00

  • Activation of caspases in intestinal villus epithelial cells of normal and nematode infected rats.

    abstract:BACKGROUND:Small intestinal epithelial cells (IEC) show apoptosis in physiological turnover of cells and in certain inflammatory diseases. AIMS:To investigate the role of caspases in the progression of IEC apoptosis in vivo. METHODS:IEC were separated along the villus-crypt axis from the jejunum of normal and Nippost...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.50.1.71

    authors: Hyoh Y,Ishizaka S,Horii T,Fujiwara A,Tegoshi T,Yamada M,Arizono N

    更新日期:2002-01-01 00:00:00

  • Radiographic evaluation of pancreatico-jejunal shunts.

    abstract::This paper describes opacification and identification of two surgically constructed pancreatico-jujunal shunts. A fibreoptic panendoscope was used with retrograde injection via the ampulla of Vater (ERCP). This procedure makes possible more accurate anatomical evaluation and so more precise clinical appraisal of both...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.17.6.439

    authors: Miller EW,Goldberg HI,Goldberg SB,Shapiro H

    更新日期:1976-06-01 00:00:00