Abstract:
:Basal serum gastrin in 40 patients with benign gastric ulcer was 103 +/- 10.7 pg/ml, a level significantly higher than corresponding estimations in normal subjects and patients with duodenal ulcer. Following stimulation by a protein meal, a mean rise of 124 pg/ml was achieved at 75 minutes and prior atropinization induced a rise of 208 pg/ml at 90 minutes. Insulin hypoglycaemia produced a rise of 63 pg/ml which was not significantly changed with concomitant neutralization of gastric contents. These results suggest that patients with gastric ulcer have higher basal gastrin levels than normal and this is probably related to the lowered antral acidity. In addition, the protein meal and insulin hypoglycaemia responses suggest an increased antral G cell mass and the possibility of additional gastrin release from sites outside the antrum. It is doubtful whether the relative hypergastrinaemia has an aetiological role in gastric ulcer but it may have a role in the maintenance of gastric ulcer.
journal_name
Gutjournal_title
Gutauthors
Korman MG,Soveny C,Hansky Jdoi
10.1136/gut.13.3.166subject
Has Abstractpub_date
1972-03-01 00:00:00pages
166-9issue
3eissn
0017-5749issn
1468-3288journal_volume
13pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND:Tumour necrosis factor (TNF) is a predominant cytokine produced in the gastric mucosa of patients with Helicobacter pylori infection. TNF induces apoptosis in a variety of cells. The soluble TNF receptors (sTNF-Rs) can be divided into sTNF-RI and sTNF-RII, both of which inhibit TNF activity. However, their p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.1.24
更新日期:1999-07-01 00:00:00
abstract:BACKGROUND:A long time goal of the medical research community has been the identification of a reliable and valid marker for Crohn's disease. AIM:To identify differences in the genetic expression patterns of healthy and diseased tissues. METHOD:The RNA arbitrarily primed polymerase chain reaction (RAP-PCR) procedure ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.6.878
更新日期:1998-06-01 00:00:00
abstract::On the basis of circumstantial clinical and experimental evidence, it has been suggested that enteroglucagon (EG) may act as an enterotrophic factor. This study was undertaken to evaluate the effects of long term in vivo immunoneutralisation of EG, using monoclonal antibodies to EG, on the hyperplastic ileal response ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.suppl.9
更新日期:1987-01-01 00:00:00
abstract::Big differences in the prevalence of peptic ulcer are known to exist in different parts of India. This paper reports a high incidence in Assam and records certain differences with peptic ulcers found in south India. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.5.4.355
更新日期:1964-08-01 00:00:00
abstract::The aim of this study is to assess the value of jejunal manometry in the diagnosis of subacute mechanical obstruction distal to the proximal small bowel. In a retrospective review of 850 manometric tracings carried out in patients with unexplained nausea, vomiting, abdominal pain or altered bowel movements, 16 tracing...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.4.468
更新日期:1989-04-01 00:00:00
abstract::An ileitis developing years or months after ileostomy was recognised and described many years ago but has rarely been mentioned since. We describe nine patients with a non-specific preanastomotic ileitis that developed years after colectomy in patients operated on for ulcerative colitis or carcinoma. The disease devel...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.3.373
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Patients with Crohn's disease suffer from intestinal bile acid malabsorption. Intestinal bile acid absorption is mediated by the apical sodium dependent bile acid transporter ASBT/IBAT (SLC10A2). In rats, ASBT is induced by glucocorticoids. AIMS:To study whether human ASBT is activated by glucocorticoids an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.53.1.78
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the most aggressive type of GI tumour, and it possesses deregulated cellular energetics. Although recent advances in PDAC biology have led to the discovery of recurrent genetic mutations in Kras, TP53 and SMAD4, which are related to this disease, clinical application...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2018-317163
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVE:MicroRNAs (miRNAs) have been shown to offer great potential in the diagnosis of cancer. We investigated whether plasma miRNAs could discriminate between patients with and without colorectal cancer (CRC). METHODS:This study was divided into three phases: (1) marker discovery using real-time PCR-based miRNA pr...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.167817
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:Treatments with sequential therapy (SEQ) or bismuth quadruple (QUAD) therapy have been proposed as empirical firstline regimens for Helicobacter pylori. We compared the efficacy and tolerability of 10 day SEQ with 10 day modified QUAD as both firstline and secondline treatments for H pylori in a randomised cr...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gutjnl-2013-306120
更新日期:2014-09-01 00:00:00
abstract::Three-day faecal collections were obtained from 87 patients with a variety of gastroenterological diagnoses and 12 control subjects while consuming normal diets. Faecal weight, total fatty acids, and the proportion of hydroxystearic (OHSA) acid were measured. All patients had some easily detectable hydroxystearic acid...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.8.614
更新日期:1974-08-01 00:00:00
abstract::Dysmotility of the duodenum and proximal jejunum has been reported in patients with irritable bowel syndrome. This study extended these findings by recording fasting ambulatory motility from electronic strain gauge sensors sited in the jejunum and ileum of eight diarrhoea predominant irritable bowel syndrome patients ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.2.203
更新日期:1994-02-01 00:00:00
abstract::An enema that contained a complex of bismuth citrate and polyacrylate was compared with 5-aminosalicylic acid (5-ASA) enemas for treatment of distal ulcerative colitis. The multicentre trial involving 63 patients was randomised and double blind with enemas given over four weeks; clinical, sigmoidoscopic, and histologi...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.34.5.676
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:In this study, we identify the nature of the immunological response of human peripheral blood mononuclear cells (PBMC) and lamina propria gastric lymphocytes (LPL) to two Helicobacter pylori antigens, the neutrophil activating protein (NapA) and alkyl hydroperoxide reductase (AphC). These antigens were ident...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.025494
更新日期:2005-01-01 00:00:00
abstract::Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and derma...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.8.929
更新日期:1986-08-01 00:00:00
abstract:BACKGROUND:"Probiotic" bacteria are effective in treating some inflammatory bowel diseases. However which bacteria confer benefit and mechanisms of action remain poorly defined. Dendritic cells, which are pivotal in early bacterial recognition, tolerance induction, and shaping of T cell responses, may be central in med...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.037325
更新日期:2004-11-01 00:00:00
abstract::Some patients with diarrhoea predominant irritable bowel syndrome have increased rectal sensitivity. It is uncertain, however, whether the diarrhoea is a consequence of the rectal sensitivity or if it is sensitising the rectum in some way. The aim of this study was to assess whether inducing diarrhoea in normal health...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.2.270
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:The effect of histamine H2 receptor antagonists on gastric emptying is controversial. AIMS:To determine the effects of ranitidine, famotidine, and omeprazole on gastric motility and emptying. PATIENTS AND METHODS:Fifteen normal subjects underwent simultaneous antroduodenal manometry, electrogastrography (E...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.42.2.243
更新日期:1998-02-01 00:00:00
abstract::We investigated the effects of medium (MCT) and long (LCT) chain triglyceride test meals on gall bladder contraction (using ultrasonography) and small intestinal bile acid concentrations and ileal flow rates (using intubation techniques) in normal individuals. Comparing the effects of ingesting medium chain triglyceri...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.4.405
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:Hereditary pancreatitis (HP) is a rare autosomal dominant disorder with variable expression and an overall lifetime penetrance of 80%. We hypothesised that (1) monozygotic twins within similar environments would develop the typical signs of HP at a similar age, and (2) if penetrance were due to modifier gene...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.4.542
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND AND AIMS:The diagnostic yield of capsule endoscopy (CE) compared with magnetic resonance imaging (MRI) in small bowel Crohn's disease is not well established. We prospectively investigated CE, MRI, and double contrast fluoroscopy in patients with suspected small bowel Crohn's disease. METHODS:Fifty two cons...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.069427
更新日期:2005-12-01 00:00:00
abstract::The effect of peritoneal lavage with the addition of camostate to the lavage fluid on the outcome of taurocholate pancreatitis in rats was studied. Camostate is a low molecular weight protease inhibitor which has been developed recently. Peritoneal lavage was performed for 12 hours and camostate was added to the lavag...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.8.934
更新日期:1990-08-01 00:00:00
abstract:OBJECTIVE:In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment domain 9 (CARD9), a key innate immunity gene, is required to shape a normal gut microbiota. Card9-/- mice are more susceptible to the enteric mouse pathogen C...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314195
更新日期:2018-10-01 00:00:00
abstract::This study reports on a group of 20 patients with an initial diagnosis of primary biliary cirrhosis (PBC) whose serum tested negative for antimitochondrial antibodies by immunofluorescence. All had a clinical history compatible with primary biliary cirrhosis, and results of biochemical, histological, and radiological ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.2.260
更新日期:1994-02-01 00:00:00
abstract::Sera from patients with Crohn's disease have been reported to show positive immunofluorescence with lymph nodes of nude mice primed with a filtrate of intestinal tissue affected with Crohn's disease. An indirect immunofluorescence assay was used to test sera of 63 unrelated patients with Crohn's disease, 21 with ulcer...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.12.1426
更新日期:1986-12-01 00:00:00
abstract:OBJECTIVE:The gut-brain axis is considered as a major regulatory checkpoint in the control of glucose homeostasis. The detection of nutrients and/or hormones in the duodenum informs the hypothalamus of the host's nutritional state. This process may occur via hypothalamic neurons modulating central release of nitric oxi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-310230
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.066100
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND:Hereditary forms of chronic idiopathic intestinal pseudo-obstruction (CIIP) are well described but the aetiology of most cases of sporadic CIIP is unknown. AIM:To determines whether herpes viruses can persist in the gastrointestinal tract, thereby implicating them in the pathogenesis of CIIP. METHODS:Twent...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.1.100
更新日期:1997-07-01 00:00:00
abstract:BACKGROUND:Global DNA hypomethylation has been found in the premalignant stages of some neoplasms and has been implicated as an important factor for tumour progression. AIMS:The aim of this study was to evaluate whether DNA hypomethylation occurs during the process of gastric carcinogenesis. METHODS:Gastric specimens...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.39.3.434
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:Genetic predisposition and gliadin exposure are known to be crucial factors in the development of coeliac disease. Circumstantial evidence suggests that other unidentified environmental factors may also be of pathogenetic importance. AIM:To define the relation between cigarette smoking and the risk of devel...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.39.1.60
更新日期:1996-07-01 00:00:00