Abstract:
:On the basis of circumstantial clinical and experimental evidence, it has been suggested that enteroglucagon (EG) may act as an enterotrophic factor. This study was undertaken to evaluate the effects of long term in vivo immunoneutralisation of EG, using monoclonal antibodies to EG, on the hyperplastic ileal response after small bowel resection. Nineteen rats had a 70% proximal resection. A group of 10 rats was given iv 0.5 ml of undiluted hybridoma ascites immediately after the operation and on the 7th day postoperatively. Furthermore 0.025 ml/day of the same hybridoma ascitic fluid was continuously delivered ip for 14 days via mini-osmotic pumps. The hybridoma ascites was prepared from the clone 23.6B4 synthesising a monoclonal antibody directed toward the N-terminal to central region of the glucagon molecule which showed a marked crossreaction with EG. A control group of 9 rats was given a corresponding amount of antibody-free plasmacytoma ascites (Ag 8.653) by the same technique. Seven and 14 days postoperatively there was a plasma anti-EG-antibody excess with an excess binding capacity of 84.9 glucagon eq nM and 88.5 glucagon eq nM respectively. The three dimensional architecture and the proliferative activity of the ileal remnant were evaluated two weeks postoperatively. Despite a continuous immunoneutralisation of circulating endogenous EG by monoclonal antibodies, the adaptive response of the ileal remnants was of the same magnitude as that seen in the control group. These data do not support the hypothesis that EG is a circulating enterotrophic regulatory peptide.
journal_name
Gutjournal_title
Gutauthors
Gregor M,Menge H,Stössel R,Riecken EOdoi
10.1136/gut.28.suppl.9subject
Has Abstractpub_date
1987-01-01 00:00:00pages
9-14eissn
0017-5749issn
1468-3288journal_volume
28 Supplpub_type
杂志文章相关文献
GUT文献大全abstract::The relationship between physical activity and risk of symptomatic diverticular disease has not been investigated directly. This association was examined in a prospective cohort of 47,678 American men, 40 to 75 years of age, and free of diagnosed diverticular disease, colon or rectal polyp, ulcerative colitis, and can...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.2.276
更新日期:1995-02-01 00:00:00
abstract::The isoenzyme pattern of lactic dehydrogenase was measured in rectal biopsies from six patients with ulcerative colitis in whom precancerous histological changes had been independently recognized. There was a highly significant increase in the ratio of isoenzymes IV + V to I + II. This suggests that lactic dehydrogena...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.1.16
更新日期:1971-01-01 00:00:00
abstract::The prevalence of metabolic disease in a population of 68 postgastrectomy patients was assessed using histomorphometric evaluation of transiliac bone biopsy specimens after tetracycline double labelling. Trabecular bone volume was significantly lower in the postgastrectomy group (p less than 0.01): 62% of the patients...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.11.1303
更新日期:1991-11-01 00:00:00
abstract::Forty six patients with endoscopically diagnosed duodenal ulceration were randomly allocated to treatment with either sucralfate 1 g qds (n = 24) or cimetidine 200 mg tds and 400 mg nocte (n = 22). When the ulcers healed, a maintenance dose of sucralfate 1 g bd or cimetidine 400 mg nocte was given for one year (or unt...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.30.5.586
更新日期:1989-05-01 00:00:00
abstract:OBJECTIVE:The gut microbiota, which is considered a causal factor in metabolic diseases as shown best in animals, is under the dual influence of the host genome and nutritional environment. This study investigated whether the gut microbiota per se, aside from changes in genetic background and diet, could sign different...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301012
更新日期:2012-04-01 00:00:00
abstract::The epithelial-mesenchymal interface of the intestinal mucosa obviously plays an important role in supporting the mucosal architecture. Its significance for the process of migration and differentiation of the epithelial cells remains to be resolved. It consists of a basement membrane, the anchoring zone and the subepi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.suppl.143
更新日期:1987-01-01 00:00:00
abstract::A simple and reliable radioimmunoassay has been developed for a new gut hormone, HPP. In the primate 93% of the total PP was found in the pancreas with a small amount throughout the remaining gastrointestinal tract. HPP has been shown to be produced by a number of pancreatic apudomas and their metastases. The immunore...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.12.940
更新日期:1976-12-01 00:00:00
abstract::Management strategies for reflux disease are very different from those for dyspepsia and so differentiating between patients with "true" dyspepsia and those whose primary symptom is heartburn is a key step in their management. This separation has become more clear during the last decade as insights into reflux disease...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.50.suppl_4.iv17
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:Exogenous use of the intestinal hormone glucagon-like peptide 1 (GLP-1) lowers glycaemia by stimulation of insulin, inhibition of glucagon, and delay of gastric emptying. AIMS:To assess the effects of endogenous GLP-1 on endocrine pancreatic secretion and antro-pyloro-duodenal motility by utilising the GLP-...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.059741
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:Corticosteroid has been established as the standard therapy for autoimmune pancreatitis (AIP), but the requirement for maintenance corticosteroid therapy is controversial. We conducted a randomised controlled trial to clarify the efficacy of maintenance corticosteroid therapy in patients with AIP. DESIGN:We ...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2016-312049
更新日期:2017-03-01 00:00:00
abstract:BACKGROUND:Dietary lectins can alter the proliferation of colonic cells. Differentiation is regulated by adhesion molecules which, being glycosylated, are targets for lectin binding. AIMS:To examine the effects of dietary lectins on differentiation, adhesion, and proliferation of colorectal cancer cells. METHODS:Diff...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.5.709
更新日期:1999-05-01 00:00:00
abstract::Electrical activity of the colon was investigated in six healthy volunteers and 22 patients presenting functional colonic disorders associated with pain, constipation, or diarrhoea. Myoelectrical activity during 10 hours, including two daily meals, was recorded from eight groups of nickel-chrome electrodes using a 1.5...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.6.480
更新日期:1980-06-01 00:00:00
abstract:BACKGROUND:Chronic pancreatitis is a known risk factor for pancreatic adenocarcinoma. Recent work has pointed to a role for bone marrow-derived progenitor cells (BMDCs) in chronic inflammation-based carcinogenesis. Consequently, the role of BMDCs in chronic pancreatitis was investigated. METHODS:The fate of BMDCs was ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.143271
更新日期:2008-08-01 00:00:00
abstract::A 90 year old woman with alveolar rhabdomyosarcoma of the gall bladder is described. The patient died with tumour metastasis four months after diagnosis despite complete excision of the tumour. The histological, immunohistochemical, and ultrastructural features of the tumour are summarised and published works are revi...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.35.6.854
更新日期:1994-06-01 00:00:00
abstract:BACKGROUND:Increased serum antibodies against carbonic anhydrase II (CA-II Ab) or IgG4 levels have been reported in cases of autoimmune chronic pancreatitis (ACP). AIM:To assess the relevance of serum CA-II Ab and IgG4 levels for the diagnosis of ACP in idiopathic CP (ICP) versus alcoholic CP and Sjogren's syndrome (S...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2004.047142
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:The intestinal epithelium is covered by a continuous layer of mucus which is secreted by well differentiated epithelial cells. Disregulation of the expression of mucins has been reported to have possible implications in the neoplastic process which affects intestinal mucosae. It is well known that preneoplas...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.4.519
更新日期:1998-10-01 00:00:00
abstract:OBJECTIVE:Gastric cancer (GC) remains difficult to cure due to heterogeneity in a clinical challenge and the molecular mechanisms underlying this disease are complex and not completely understood. Accumulating evidence suggests that microRNAs (miRNAs) play an important role in GC, but the role of specific miRNAs involv...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-306640
更新日期:2015-02-01 00:00:00
abstract::4-Aminosalicylic acid (4-ASA) has been suggested as an effective treatment for both active and quiescent ulcerative colitis. 5-Aminosalicylic acid (5-ASA) is well accepted for the maintenance treatment of inactive ulcerative colitis. Moreover, recent studies suggest that 5-ASA may also be effective in maintaining remi...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.35.8.1081
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Portal systemic encephalopathy (PSE) is a complex neuropsychiatric syndrome associated with hepatic failure. Small scale studies have shown the benzodiazepine receptor antagonist flumazenil to be effective in ameliorating PSE. AIMS:To determine the efficacy of flumazenil in patients with non-comatous mild t...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.39.2.319
更新日期:1996-08-01 00:00:00
abstract::Serum zinc concentrations and urine zinc excretion have been studied in 10 patients with severe Crohn's disease before and during 59 patient-weeks of intravenous nutrition. Before serum zinc concentrations (9.9 +/- 1.0 mumol/l: mean +/- SEM) and urine zinc excretion (3-3 +/- 0.6 mumol/24h) were less than controls (p l...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.11.984
更新日期:1982-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Helicobacter pylori (H pylori) infection is a major risk factor in the development of distal gastric adenocarcinoma. Development of the invasive phenotype is associated with the phenomenon of epithelial:mesenchymal transition (EMT). Soluble heparin-binding epidermal growth factor (HB-EGF) has been i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.199794
更新日期:2010-08-01 00:00:00
abstract::Previous reports have shown that both Crohn's disease and ulcerative colitis affect people in white collar occupations associated with higher income and higher social class more frequently than other groups in the population. This study sought to carry these analyses one step further and investigate the distribution o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.9.1037
更新日期:1990-09-01 00:00:00
abstract::The host's humoral immune response to Helicobacter pylori has been used in the diagnosis of active infection with these organisms. Several commercial tests are available but there are few and unconfirmed reports of their efficacy. This study aimed to assess and compare the efficacy of the following H pylori serologica...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.4.461
更新日期:1993-04-01 00:00:00
abstract::A dodecapeptide of A-gliadin, which shares amino acid homologies with the E1b protein of adenovirus 12, was used to produce murine monoclonal antibodies. Five monoclonal antibodies were produced and were screened by enzyme linked immunosorbant assay, immunodot assay, and immunoblotting. The antibodies were tested agai...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.11.1504
更新日期:1992-11-01 00:00:00
abstract::The gastric secretory response to insulin changes in many patients between ;immediate' tests, within two weeks of vagotomy, and ;delayed' tests, done at least six months later. Patients who develop recurrent duodenal ulceration after vagotomy and pyloroplasty show highly significant increases in peak and rise in conce...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.4.303
更新日期:1971-04-01 00:00:00
abstract::A method is described for measuring transit time through the gut which requires the collection of only one stool. A dose of 20 radio-opaque markers is given to the subject on each of three consecutive days with breakfast, each dose of marker being of a different type. The first stool passed after rising on the fourth ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.3.219
更新日期:1976-03-01 00:00:00
abstract::Ranitidine bismuth citrate was compared with an equipotent dose of ranitidine, to determine whether the former, by an anti-Helicobacter pylori activity, would counteract the rise of gastrin resulting from ranitidine's gastric acid antisecretory activity. Twenty four men with duodenal ulcers were studied before and on ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.3.338
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Many lines of evidence suggest that T helper cell type 1 (Th1) immune responses predominate in Crohn's disease (CD). Recently, a novel transcription factor T-box expressed in T cells (T-bet) has been reported as the master regulator of Th1 development. This study was designed to investigate the role...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.024190
更新日期:2004-09-01 00:00:00
abstract::The important issue of whether Heliobacter pylori eradication leads to increased reflux has been the subject of many apparently contradictory publications, but when we asked two leading authorities to give us their views, there turned out to be considerable consensus, as you can read below. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.019844
更新日期:2004-02-01 00:00:00
abstract:BACKGROUND:In a previous hospital based study, we suggested that undiagnosed coeliac disease has a prevalence, among pregnant women, of 1:80, and is a cause of unfavourable outcome of pregnancy. AIMS:In order to confirm or dismiss this hypothesis, which has significant public health implications, we carried out a larg...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.53.1.149
更新日期:2004-01-01 00:00:00