MicroRNA-29c mediates initiation of gastric carcinogenesis by directly targeting ITGB1.

abstract：BACKGROUND:Suicide gene therapy consists of the transfer into tumour cells of a "suicide" gene that can convert a non-toxic compound into a lethal drug. Expression of the cytosine deaminase gene leads to the conversion of the non-toxic compound 5-fluorocytosine to 5-fluorouracil. We have recently shown that "suicide ce...

journal_title：Gut

authors： Pierrefite-Carle V,Baqué P,Gavelli A,Brossette N,Benchimol D,Bourgeon A,Saint Paul MC,Staccini P,Rossi B

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND/AIMS:Replication deficient recombinant adenoviruses represent an efficient means of transferring genes in vivo into a wide variety of dividing and quiescent cells from many different organs. Although the gastrointestinal tract is a potentially attractive target for gene therapy approaches, only a few studies...

journal_title：Gut

authors： Wirtz S,Galle PR,Neurath MF

更新日期：1999-06-01 00:00:00

abstract：:This prospective study aimed to determine the prevalence of Helicobacter pylori infection in relation to the occurrence and severity of NSAIDs induced gastropathy. A total of 111 patients were studied-66 were taking NSAIDs and 45 were control patients. All patients underwent endoscopy during which antral biopsy specim...

journal_title：Gut

authors： Heresbach D,Raoul JL,Bretagne JF,Minet J,Donnio PY,Ramée MP,Siproudhis L,Gosselin M

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Monocyte chemoattractant protein 1 (MCP-1) is increased transmurally in inflammatory bowel disease (IBD). Although MCP-1 is considered to play an important role in fibrotic disease in other organs, the role of MCP-1 in gut fibrosis is unknown. We investigated the fibrotic potential of MCP-1 in the g...

journal_title：Gut

authors： Motomura Y,Khan WI,El-Sharkawy RT,Verma-Gandhu M,Verdu EF,Gauldie J,Collins SM

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer. Cancer-associated thrombosis/thromboembolism (CAT), frequently observed in PDAC, is known as a poor prognostic factor. Here, we investigated the underlying mechanisms between PDAC and CAT, and performed a trial of therapeutic approach for PDAC u...

journal_title：Gut

authors： Sano M,Takahashi R,Ijichi H,Ishigaki K,Yamada T,Miyabayashi K,Kimura G,Mizuno S,Kato H,Fujiwara H,Nakatsuka T,Tanaka Y,Kim J,Masugi Y,Morishita Y,Tanaka M,Ushiku T,Nakai Y,Tateishi K,Ishii Y,Isayama H,Moses HL,

更新日期：2020-10-21 00:00:00

abstract：:A method of in vivo calculation of liver volume using a gamma camera and a 1600 or 4096 channel analyser is described. Topographically, the maximum thickness giving the highest counts in matrix data in the right anterior oblique projection is measured as the maximum breadth in the right posterior oblique projection. T...

journal_title：Gut

authors： Fujii M,Mukai T,Yamamoto T,Wakisaka G

更新日期：1976-04-01 00:00:00

abstract：BACKGROUND:This is a consensus developed by a group of expert endoscopists aiming to standardise the preparation, process and endoscopic procedural steps for diagnosis of early upper gastrointestinal (GI) cancers. METHOD:The Delphi method was used to develop consensus statements through identification of clinical ques...

journal_title：Gut

authors： Chiu PWY,Uedo N,Singh R,Gotoda T,Ng EKW,Yao K,Ang TL,Ho SH,Kikuchi D,Yao F,Pittayanon R,Goda K,Lau JYW,Tajiri H,Inoue H

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Autoantibodies against transglutaminase 2 (TG2) are thought to be responsible for the endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) tissue binding of serum samples from coeliac patients but the exclusive role of TG2 in these staining patterns has not yet been established. AIMS:To evaluate wh...

journal_title：Gut

authors： Korponay-Szabó IR,Laurila K,Szondy Z,Halttunen T,Szalai Z,Dahlbom I,Rantala I,Kovács JB,Fésüs L,Mäki M

更新日期：2003-02-01 00:00:00

abstract：:Motilin is a hormonal peptide found in the duodenum and jejunum which potently influences gastrointestinal tract motility. Its role in human physiology is not yet established. After a standard hospital lunch the plasma concentration of motilin showed a small, transient, but significant rise in 28 healthy subjects. Ind...

journal_title：Gut

authors： Christofides ND,Bloom SR,Besterman HS,Adrian TE,Ghatei MA

更新日期：1979-02-01 00:00:00

abstract：:Four young Chinese women took daily doses of an unidentified 'Indian' herbal tea as treatment for psoriasis. Three (one of whom died), developed ascites, hepatomegaly and biochemical abnormalities within 19-45 days. The fourth patient discontinued herbal tea after 21 days when she developed a skin rash. Two patients h...

journal_title：Gut

authors： Kumana CR,Ng M,Lin HJ,Ko W,Wu PC,Todd D

更新日期：1985-01-01 00:00:00

abstract：:Heartburn is a common symptom affecting 21-44% of the adult population on a monthly basis. Oesophagitis is less common, affecting 2% of individuals. Epidemiological studies have shown that patients with gastro-oesophageal reflux disease (GORD) have similar incidence rates of Helicobacter pylori infection as do control...

journal_title：Gut

authors： McNamara D,O'Morain C

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Lamina propria (LPLs) and intraepithelial (IELs) lymphocytes are markedly increased in coeliac mucosa, and are thought to play a crucial role in the generation of villous atrophy in coeliac disease (CD). However, the mechanisms by which they mediate the killing of enterocytes in this condition are still poor...

journal_title：Gut

authors： Di Sabatino A,Ciccocioppo R,D'Alò S,Parroni R,Millimaggi D,Cifone MG,Corazza GR

更新日期：2001-09-01 00:00:00

abstract：OBJECTIVE:Vedolizumab is a gut-selective antibody to α4β7 integrin for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). We report an integrated summary of the safety of vedolizumab. DESIGN:Safety data (May 2009-June 2013) from six trials of vedolizumab were integrated. Adverse events were evaluated i...

journal_title：Gut

authors： Colombel JF,Sands BE,Rutgeerts P,Sandborn W,Danese S,D'Haens G,Panaccione R,Loftus EV Jr,Sankoh S,Fox I,Parikh A,Milch C,Abhyankar B,Feagan BG

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVE:The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC. The aim of this study was to determine the underlying compositional alterations, their molecular background and potential contribution to UC pathogenesis. DESIGN:In th...

journal_title：Gut

authors： van der Post S,Jabbar KS,Birchenough G,Arike L,Akhtar N,Sjovall H,Johansson MEV,Hansson GC

更新日期：2019-12-01 00:00:00

abstract：:Colorectal cancer is the fourth commonest form of cancer in men with 678 000 estimated new cases per year worldwide, representing 8.9% of all new cancers. The disease is most frequent in Occidental countries and particularly so in North America, Australia, New Zealand, and parts of Europe. Prospects for colorectal can...

journal_title：Gut

authors： Langman M,Boyle P

更新日期：1998-10-01 00:00:00

abstract：:Primary oesophageal involvement by lymphoma in two patients, one with Hodgkin's disease and one with non-Hodgkin's lymphoma is reported. In both, there were no manifestations of the disease outside the oesophagus, which is exceptionally rare. In the patient with non-Hodgkin's lymphoma, the oesophageal tumour was the f...

journal_title：Gut

authors： Taal BG,Van Heerde P,Somers R

更新日期：1993-07-01 00:00:00

abstract：BACKGROUND:Simple and inexpensive non-invasive fibrosis tests are highly needed but have been poorly studied in sub-Saharan Africa. METHODS:Using liver histology as a gold standard, we developed a novel index using routine laboratory tests to predict significant fibrosis in patients with chronic HBV infection in The G...

journal_title：Gut

authors： Lemoine M,Shimakawa Y,Nayagam S,Khalil M,Suso P,Lloyd J,Goldin R,Njai HF,Ndow G,Taal M,Cooke G,D'Alessandro U,Vray M,Mbaye PS,Njie R,Mallet V,Thursz M

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:Shortage of organ donors, a critical challenge for treatment of end-stage organ failure, has motivated the development of alternative strategies to generate organs in vitro. Here, we aim to describe the hepatorganoids, which is a liver tissue model generated by three-dimensional (3D) bioprinting of HepaRG cel...

journal_title：Gut

authors： Yang H,Sun L,Pang Y,Hu D,Xu H,Mao S,Peng W,Wang Y,Xu Y,Zheng YC,Du S,Zhao H,Chi T,Lu X,Sang X,Zhong S,Wang X,Zhang H,Huang P,Sun W,Mao Y

更新日期：2020-05-20 00:00:00

abstract：:Partial gastrectomy and intestinal resection significantly impaired glucose tolerance (p < 0.05) and significantly decreased the release of insulin by intravenous glucose (p < 0.05) or a meal of minced beef (p < 0.01). There was a significantly greater release of insulin one hour after oral glucose in the gastrectomy ...

journal_title：Gut

authors： Wapnick S,Jones JJ

更新日期：1972-11-01 00:00:00

abstract：BACKGROUND:The role of the recently discovered GB virus C (GBV-C)/hepatitis G virus in fulminant hepatic failure (FHF) has been debated. Although GBV-C RNA has been detected in many cases of FHF, recent data suggest that the relation between GBV-C and FHF may be accidental. AIMS:To retrospectively investigate the poss...

journal_title：Gut

authors： Halasz R,Barkholt L,Lara C,Hultgren C,Ando Y,Broomé U,Fischler B,Nemeth A,Ericzon BG,Sönnerborg A,Sällberg M

更新日期：1999-02-01 00:00:00

abstract：:The aims of the present study were to determine the relative amplitudes of intragastric motor responses evoked by different vagal branches and to establish whether the effects of acute or chronic vagotomy could be predicted from these data. Intragastric pressure responses to electrical stimulation of the vagus were me...

journal_title：Gut

authors： Andrews PL,Lawes IN,Bower AJ

更新日期：1980-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Progression of a colorectal adenoma to invasive cancer occurs in a minority of adenomas and is the most crucial step in colorectal cancer pathogenesis. In the majority of cases, this is associated with gain of a substantial part of chromosome 20q, indicating that multiple genes on the 20q ampli...

journal_title：Gut

authors： Sillars-Hardebol AH,Carvalho B,Tijssen M,Beliën JA,de Wit M,Delis-van Diemen PM,Pontén F,van de Wiel MA,Fijneman RJ,Meijer GA

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Colorectal carcinoids are often described as low-grade malignant. However, no study has compared the survival between patients with colorectal carcinoids and those with carcinomas, in a large series. In addition, no global consensus has been established on the crucial determinants of metastasis in colorectal...

journal_title：Gut

authors： Konishi T,Watanabe T,Kishimoto J,Kotake K,Muto T,Nagawa H,Japanese Society for Cancer of the Colon and Rectum.

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:The aetiology of Crohn's disease (CD) has been related to nucleotide-binding oligomerisation domain containing 2 (NOD2) and ATG16L1 gene variants. The observation of bacterial DNA translocation in patients with CD led us to hypothesise that this process may be facilitated in patients with NOD2/ATG16L1-variant...

journal_title：Gut

authors： Gutiérrez A,Scharl M,Sempere L,Holler E,Zapater P,Almenta I,González-Navajas JM,Such J,Wiest R,Rogler G,Francés R

更新日期：2014-02-01 00:00:00

abstract：:Intestinal folate absorption was assessed in six normal subjects and in four patients with coeliac sprue who were studied before and after treatment by dietary gluten exclusion. Comparisons were made of the luminal disappearance from the perfused jejunum of 3H-pteroylmonoglutamate and pteroyl 14C-glutamylhexaglutamate...

journal_title：Gut

authors： Halsted CH,Reisenauer AM,Shane B,Tamura T

更新日期：1978-10-01 00:00:00

abstract：:Glycosylation is a key modification of proteins and lipids and is involved in most intermolecular and intercellular interactions. The gastrointestinal mucus gel is continuous and can be divided into two layers: a secreted loosely associated layer and a layer firmly attached to the mucosa. In addition, the membrane-bou...

journal_title：Gut

authors： Moran AP,Gupta A,Joshi L

更新日期：2011-10-01 00:00:00

abstract：:Four different dosage regimens of interferon (IFN) alfa-2b (3 million units (MU) three times weekly for three months, 3 MU three times weekly for six months, 6 MU two times weekly for six months, and 6 MU three times weekly for six months) were compared in patients with chronic hepatitis C. There was no significant di...

journal_title：Gut

authors： De Bac C,Grimaldi F,Clementi C,Duca F,Livoli D,Taliani G

更新日期：1993-01-01 00:00:00

abstract：:Both carbachol (10(-4)-10(-3) mol/l) and cholecystokinin octapeptide (CCK-8) (10(-8)-10(-6) mol/l) significantly stimulated the release of pepsinogen from rabbit gastric mucosa maintained in organ culture (213-216% and 143-261% of control, respectively, p less than 0.05-0.01). The secretion was not affected by removin...

journal_title：Gut

authors： Miyamoto T,Itoh M,Noguchi Y,Yokochi K

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND:Patients with chronic hepatitis B (CHB) infection are at an increased risk of developing hepatocellular carcinoma (HCC). Risk scores have been developed in Asian populations to predict HCC risk over time. AIM:To assess the performance of HCC risk prediction models in a heterogeneous population of patients w...

journal_title：Gut

authors： Abu-Amara M,Cerocchi O,Malhi G,Sharma S,Yim C,Shah H,Wong DK,Janssen HL,Feld JJ

更新日期：2016-08-01 00:00:00

abstract：CLINICAL PRESENTATION:A 28-year-old woman presented with a 3-year history of chronic watery diarrhoea along with abdominal pain and bloating, which could mostly be alleviated after defecation. Her symptom of diarrhoea, at least three times a day, could be relieved by neither probiotics nor antidiarrhoeal agents. She ha...

journal_title：Gut

authors： Zhou CB,Lu H,Chen YX,Fang JY

更新日期：2019-03-01 00:00:00