Coeliac disease: characterisation of monoclonal antibodies raised against a synthetic peptide corresponding to amino acid residues 206-217 of A-gliadin.

abstract：BACKGROUND:Lipids may exacerbate symptoms induced by gut stimuli. AIM:To determine the mechanism whereby fat exerts this effect. SUBJECTS:Twenty four healthy subjects were studied during fasting. METHODS:We measured perception (0-6 scale) in response to jejunal balloon distension and transmucosal electrical nerve st...

journal_title：Gut

authors： Accarino AM,Azpiroz F,Malagelada JR

更新日期：2001-05-01 00:00:00

abstract：:A single oral dose of 4-46 mmol calcium gluconate at pH 5-6 was administered intragastrically to 15 male volunteers without gastrointestinal disease. There was a significant rise in acid output from 30-90 minutes after the calcium was given compared with the basal hourly collection. The serum gastrin level 30 minutes ...

journal_title：Gut

authors： Brodie MJ,Ganguli PC,Fine A,Thomson TJ

更新日期：1977-02-01 00:00:00

abstract：:One hundred patients who had undergone operation for duodenal ulcer (68 vagotomy and gastroenterostomy; seven vagotomy and pyloroplasty; 22 gastrectomy and three gastroenterostomy) 10 or more years previously each underwent endoscopy. Biopsies were taken and gastric juice aspirated for measurement of pH and nitrite co...

journal_title：Gut

authors： Watt PC,Sloan JM,Donaldson JD,Patterson CC,Kennedy TL

更新日期：1984-03-01 00:00:00

abstract：INTRODUCTION:Recently, we showed that the length of cardiac mucosa in healthy volunteers correlated with age and obesity. We have now examined the immunohistological characteristics of this expanded cardia to determine whether it may be due to columnar metaplasia of the distal oesophagus. METHODS:We used the squamocol...

journal_title：Gut

authors： Derakhshan MH,Robertson EV,Yeh Lee Y,Harvey T,Ferrier RK,Wirz AA,Orange C,Ballantyne SA,Hanvey SL,Going JJ,McColl KE

更新日期：2015-11-01 00:00:00

abstract：AIMS:To determine the sources of founding for UK gastroenterology research papers and the relative impact of papers funded by different groups and of unfunded ones. METHODS:UK gastroenterology papers from 1988-94 were selectively retrieved from the Science Citation Index by means of a specially constructed filter base...

journal_title：Gut

authors： Lewison G

更新日期：1998-08-01 00:00:00

abstract：OBJECTIVE:Serrated polyps (SPs) are an important cause of postcolonoscopy colorectal cancers (PCCRCs), which is likely the result of suboptimal SP detection during colonoscopy. We assessed the long-term effect of a simple educational intervention focusing on optimising SP detection. DESIGN:An educational intervention,...

journal_title：Gut

authors： Bleijenberg AGC,van Leerdam ME,Bargeman M,Koornstra JJ,van Herwaarden YJ,Spaander MC,Sanduleanu S,Bastiaansen BAJ,Schoon EJ,van Lelyveld N,Dekker E,IJspeert JEG

更新日期：2020-12-01 00:00:00

abstract：:There are sex differences in large bowel cancer rates and a variety of other gastrointestinal disorders possibly because of differences in gut biology. To determine whether men and women have different gastrointestinal responses when consuming identical intakes of dietary fibre, 16 women and 18 men consumed liquid for...

journal_title：Gut

authors： Lampe JW,Fredstrom SB,Slavin JL,Potter JD

更新日期：1993-04-01 00:00:00

abstract：BACKGROUND:Patients with Crohn's disease suffer from intestinal bile acid malabsorption. Intestinal bile acid absorption is mediated by the apical sodium dependent bile acid transporter ASBT/IBAT (SLC10A2). In rats, ASBT is induced by glucocorticoids. AIMS:To study whether human ASBT is activated by glucocorticoids an...

journal_title：Gut

authors： Jung D,Fantin AC,Scheurer U,Fried M,Kullak-Ublick GA

更新日期：2004-01-01 00:00:00

abstract：:Prostaglandins (PGs) are synthesised by gastric mucosa, and have been shown to inhibit gastric acid secretion and ulcer formation in man and experimental animals. Recently exogenous PGs, mainly of the E group, have been used for the treatment of peptic ulcer disease. We therefore searched for a drug that would stimula...

journal_title：Gut

authors： Ligumsky M,Rachmilewitz D,Zor U

更新日期：1979-10-01 00:00:00

abstract：:A fifth instance of Crohn's disease in identical twins is reported. The evidence for genetic expression of the disease is considered and the possible mechanisms involved are reviewed. ...

journal_title：Gut

authors： Hislop IG,Grant AK

更新日期：1969-12-01 00:00:00

abstract：OBJECTIVE:Contrary to the long-standing prerequisite of inducing selective (ie, bifidogenic) effects, recent findings suggest that prebiotic interventions lead to ecosystem-wide microbiota shifts. Yet, a comprehensive characterisation of this process is still lacking. Here, we apply 16S rDNA microbiota profiling and ma...

journal_title：Gut

authors： Vandeputte D,Falony G,Vieira-Silva S,Wang J,Sailer M,Theis S,Verbeke K,Raes J

更新日期：2017-11-01 00:00:00

abstract：:The amounts of lactase (EC 3.2.1.23), sucrase (EC 3.2.1.48), maltase (EC 3.2.1.20), microvillus aminopeptidase (microsomal EC3.4.11.2), and dipeptidyl peptidase IV (EC 3.4.14.X) in biopsies from proximal jejunum and distal ileum were studied by quantitative crossed immunoelectrophoresis and enzymatic assays in obese p...

journal_title：Gut

authors： Skovbjerg H,Gudmand-Høyer E,Norén O,Sjöström H

更新日期：1980-08-01 00:00:00

abstract：:An investigation of immunological parameters was conducted in 38 patients with Crohn's disease. The immunological tests employed included skin tests with dinitrochlorobenzene and a battery of common skin test antigens, lymphocyte transformation with phytohaemagglutinin and pokeweed mitogen, serum immunoglobulins, and ...

journal_title：Gut

authors： MacPherson BR,Albertini RJ,Beeken WL

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:Portal systemic encephalopathy (PSE) is a complex neuropsychiatric syndrome associated with hepatic failure. Small scale studies have shown the benzodiazepine receptor antagonist flumazenil to be effective in ameliorating PSE. AIMS:To determine the efficacy of flumazenil in patients with non-comatous mild t...

journal_title：Gut

authors： Gyr K,Meier R,Häussler J,Boulétreau P,Fleig WE,Gatta A,Holstege A,Pomier-Layrargues G,Schalm SW,Groeneweg M,Scollo-Lavizzari G,Ventura E,Zeneroli ML,Williams R,Yoo Y,Amrein R

更新日期：1996-08-01 00:00:00

abstract：:THE SMOOTH MUSCLE SPHINCTERIC ACTIVITY OF THE ANUS IN CATS IS BASED ON TWO DISTINCT MECHANISMS: a typical anal component, characterized by anal slow pressure waves not related to spike potentials in the internal anal sphincter, and an intestinal-like pressure component related to spiking activity in the internal sphin...

journal_title：Gut

authors： Kerremans R,Penninckx F

更新日期：1970-08-01 00:00:00

abstract：:Six of 25 renal transplant recipients had a duodenal ulcer at endoscopy. Histamine concentration and the activity of histamine methyltransferase, the degrading enzyme of histamine, were measured in gastric mucosal biopsies obtained at endoscopy and compared with patients with duodenal ulcer but not undergoing transpla...

journal_title：Gut

authors： Timoney AG,Man WK,Spencer J,Taylor H,Williams G

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:There is considerable evidence indicating that the severity of hepatic damage in individuals with cholestatic liver disease is causally associated with the extent of intrahepatic oxidative stress. Increased levels or accelerated generation of reactive oxygen species and toxic degradative products of lipid pe...

journal_title：Gut

authors： Ljubuncic P,Tanne Z,Bomzon A

更新日期：2000-11-01 00:00:00

abstract：BACKGROUND:The diagnosis and classification of oesophageal motility disorders is currently based on assessment of the phasic contractile activity of the oesophagus. Tonic muscular contraction of the oesophageal body (oesophageal tone) has not been well characterised. AIM:To quantify oesophageal tonic activity in healt...

journal_title：Gut

authors： González M,Mearin F,Vasconez C,Armengol JR,Malagelada JR

更新日期：1997-09-01 00:00:00

abstract：:Chronic idiopathic constipation may be the result of an autonomic neuropathy. This hypothesis was tested in 23 constipated patients and 17 age matched controls, using the acetylcholine sweat spot test devised to test autonomic integrity in diabetes. Acetylcholine (0.01%) was injected in the dorsum of the foot painted ...

journal_title：Gut

authors： Altomare D,Pilot MA,Scott M,Williams N,Rubino M,Ilincic L,Waldron D

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:Liver fibrosis and cirrhosis resulting from chronic liver injury represent a major healthcare burden worldwide. Growth differentiation factor (GDF) 11 has been recently investigated for its role in rejuvenation of ageing organs, but its role in chronic liver diseases has remained unknown. Here, we investigate...

journal_title：Gut

authors： Dai Z,Song G,Balakrishnan A,Yang T,Yuan Q,Möbus S,Weiss AC,Bentler M,Zhu J,Jiang X,Shen X,Bantel H,Jaeckel E,Kispert A,Vogel A,Saborowski A,Büning H,Manns M,Cantz T,Ott M,Sharma AD

更新日期：2020-06-01 00:00:00

abstract：:The synchronous change in the antral release of gastrin and somatostatin into a vein draining the stomach was studied during acidic and alkaline intragastric pH in six anaesthetised duodenal ulcer patients and six controls after atropinisation. No differences in the basal secretion of gastrin and somatostatin were obs...

journal_title：Gut

authors： Jensen SL,Holst JJ,Christiansen LA,Shokouh-Amiri MH,Lorentsen M,Beck H,Jensen HE

更新日期：1987-02-01 00:00:00

abstract：OBJECTIVE:In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD. DESIGN:Patient-level data of adult patie...

journal_title：Gut

authors： Lu TX,Dapas M,Lin E,Peters T,Sakuraba A

更新日期：2020-12-17 00:00:00

abstract：:The effect of a new complex oligosaccharide exhibiting potent inhibitory action on alpha-glucoside hydrolases on intestinal absorption of sucrose in man was tested by constant in vivo perfusion of the jejunum. At concentrations of 4.65 or 15.5 X 10(-6)M the alpha-glucosidehydrolase inhibitor (alpha-GHI) markedly inhib...

journal_title：Gut

authors： Caspary WF,Kalisch H

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Fatigue is a frequent and disabling symptom reported by patients with chronic hepatitis C (CHC). Its mechanism is poorly understood. Recent attention has focused on the role of leptin and energy expenditure in CHC. Our aims were to analyse fatigue in CHC and to determine its relationship with diseas...

journal_title：Gut

authors： Piche T,Gelsi E,Schneider SM,Hébuterne X,Giudicelli J,Ferrua B,Laffont C,Benzaken S,Hastier P,Montoya ML,Longo F,Rampal P,Tran A

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:A high prevalence of osteoporosis is reported in Crohn's disease. The pathogenesis is not completely understood but is probably multifactorial. Longstanding Crohn's disease is associated with a deficiency of fat soluble vitamins, among them vitamin K. Vitamin K is a cofactor in the carboxylation of osteocalc...

journal_title：Gut

authors： Schoon EJ,Müller MC,Vermeer C,Schurgers LJ,Brummer RJ,Stockbrügger RW

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Glucagon-like peptide 2 (GLP-2) may improve intestinal absorption in short bowel syndrome (SBS) patients with an end jejunostomy. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant GLP-2 analogue, prolongs the intestinotrophic properties of GLP-2 in animal models. The safety and effect of t...

journal_title：Gut

authors： Jeppesen PB,Sanguinetti EL,Buchman A,Howard L,Scolapio JS,Ziegler TR,Gregory J,Tappenden KA,Holst J,Mortensen PB

更新日期：2005-09-01 00:00:00

abstract：:We have reviewed the outcome of all patients undergoing their first intestinal resection for Crohn's disease at this hospital between 1970 and 1987. Recurrence rates, defined by recurrent intestinal symptoms and radiological confirmation of mucosal disease, were calculated using survival analysis. Age, sex, anatomical...

journal_title：Gut

authors： Griffiths AM,Wesson DE,Shandling B,Corey M,Sherman PM

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND:Based on equivocal clinical data, intravenous antioxidant therapy has been used for the treatment of severe acute pancreatitis. To date there is no randomised comparison of this therapy in severe acute pancreatitis. METHODS:We conducted a randomised, double blind, placebo controlled trial of intravenous ant...

journal_title：Gut

authors： Siriwardena AK,Mason JM,Balachandra S,Bagul A,Galloway S,Formela L,Hardman JG,Jamdar S

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:Screening colonoscopy to monitor for early colitis-associated colon cancer (CAC) is difficult due to the aberrant mucosal patterns associated with long-standing colitis. The aim of this study was to develop a rapid fluorescent detection method for use during colonoscopy for improving the detection of CAC uti...

journal_title：Gut

authors： Mitsunaga M,Kosaka N,Choyke PL,Young MR,Dextras CR,Saud SM,Colburn NH,Sakabe M,Nagano T,Asanuma D,Urano Y,Kobayashi H

更新日期：2013-08-01 00:00:00

abstract：BACKGROUND AND AIM:To clarify the roles of Helicobacter pylori cytotoxin in gastric atrophy, the cytotoxin positive rate and cytotoxin activity in Fukui and Okinawa, where the prevalence of atrophic gastritis and gastric cancer risk are quite different, were studied. MATERIALS:Seventy three strains from Fukui and 51 f...

journal_title：Gut

authors： Ito S,Azuma T,Murakita H,Hirai M,Miyaji H,Ito Y,Ohtaki Y,Yamazaki Y,Kuriyama M,Keida Y,Kohli Y

更新日期：1996-12-01 00:00:00