Immunological studies in patients with Crohn's disease.

abstract：BACKGROUND:Familial adenomatous polyposis (FAP) is a clinically well defined hereditary disease caused by germline mutations within the adenomatous polyposis coli (APC) gene. Although several techniques are applied in the mutation analysis of FAP kindreds about 20-50% of cases remain unclear, with no APC mutation ident...

journal_title：Gut

authors： Heinimann K,Müllhaupt B,Weber W,Attenhofer M,Scott RJ,Fried M,Martinoli S,Müller H,Dobbie Z

更新日期：1998-11-01 00:00:00

abstract：:In this study a perfusion technique has been used to investigate jejunal secretion in response to the dibasic amino acid L-arginine. L-arginine at 5, 15, and 40 mmol/l in isotonic saline solutions induced net intestinal secretion of water and Na+. The structurally similar dibasic amino acid L-lysine caused net absorpt...

journal_title：Gut

authors： Hegarty JE,Fairclough PD,Clark ML,Dawson AM

更新日期：1981-02-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori strains possessing the cagA gene are thought to induce interleukin 8 (IL-8) in gastric mucosa. However, it is still unclear whether a relation exists between the cagA gene and the expression patterns of cytokines other than IL-8. AIMS:To investigate the relation between the cagA gene and...

journal_title：Gut

authors： Yamaoka Y,Kita M,Kodama T,Sawai N,Kashima K,Imanishi J

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVE:Hepatitis D virus (HDV) is a defective virus that completes its life cycle only with hepatitis B virus (HBV). The HBV with HDV super-infection has been considered as one of the most severe forms of the chronic viral hepatitis. However, there is a scarcity of data on the global burden of HDV infection. DESIGN...

journal_title：Gut

authors： Chen HY,Shen DT,Ji DZ,Han PC,Zhang WM,Ma JF,Chen WS,Goyal H,Pan S,Xu HG

更新日期：2019-03-01 00:00:00

abstract：:Using 24 hour pH monitoring as a reference standard, the usefulness of the acid perfusion (AP) test in predicting gastro-oesophageal reflux disease (GORD) was assessed in 71 non-cardiac chest pain (NCCP) patients and 23 endoscopic oesophagitis patients. Of the 71 NCCP patients, 35 had a positive AP test (of whom 20 ha...

journal_title：Gut

authors： Hewson EG,Sinclair JW,Dalton CB,Wu WC,Castell DO,Richter JE

更新日期：1989-03-01 00:00:00

abstract：:This experimental study was undertaken to follow the influence of phenobarbital on bile chemistry and gallstone formation. Phenobarbital (400 mg/kg/day) was administered to golden hamsters receiving a diet known to induce cholesterol gallstones. After a 28-day period none of the control animals had gallstones whereas ...

journal_title：Gut

authors： Lagarriga J,Bouchier IA

更新日期：1973-12-01 00:00:00

abstract：OBJECTIVE:Endoscopic surveillance for Barrett's oesophagus (BO) is under discussion given the overall low incidence of neoplastic progression and lack of evidence that it prevents advanced oesophageal adenocarcinoma (OAC). The aim of this study was to evaluate the impact of endoscopic BO surveillance on tumour stage an...

journal_title：Gut

authors： Kastelein F,van Olphen SH,Steyerberg EW,Spaander MC,Bruno MJ,ProBar-Study Group.

更新日期：2016-04-01 00:00:00

abstract：:The isoenzyme pattern of lactic dehydrogenase was measured in rectal biopsies from six patients with ulcerative colitis in whom precancerous histological changes had been independently recognized. There was a highly significant increase in the ratio of isoenzymes IV + V to I + II. This suggests that lactic dehydrogena...

journal_title：Gut

authors： Lewis B,Morson BC,February AW,Jones JH,Misiewicz JJ

更新日期：1971-01-01 00:00:00

abstract：:Gastric cancer is a major health burden worldwide and prevention is the most promising strategy to control the disease. The available scientific evidence indicates that curing Helicobacter pylori infection results in a modest retardation of the precancerous process but does not prevent all cancers. Individuals at the ...

journal_title：Gut

authors： Correa P

更新日期：2004-09-01 00:00:00

abstract：:Heat shock proteins (HSPs) are a highly conserved family of proteins which inhabit almost all subcellular locations and cellular membranes. Depending on their location, these proteins perform a variety of chaperoning functions including folding of newly synthesised polypeptides. HSPs also play a major role in the prot...

journal_title：Gut

authors： Dudeja V,Vickers SM,Saluja AK

更新日期：2009-07-01 00:00:00

abstract：:A 22 year old woman presenting with recurrent intestinal pseudo-obstruction is reported. Jejunal biopsy showed subtotal villous atrophy which improved markedly during a period of total parenteral nutrition and with steroid treatment. It did not relapse on a gluten free diet. The reasons why this patient represents a c...

journal_title：Gut

authors： Dawson DJ,Sciberras CM,Whitwell H

更新日期：1984-09-01 00:00:00

abstract：:Possible mechanisms by which liver antigen presenting cells (APC) may facilitate tolerance induction are discussed. Tolerance may be facilitated by a distinctive combination of factors, linked to the unique anatomical and microenvironmental features of the liver. ...

journal_title：Gut

authors： Lau AH,de Creus A,Lu L,Thomson AW

更新日期：2003-08-01 00:00:00

abstract：:This paper describes the results of transproctoscopic fine needle aspiration cytology in the diagnosis of rectal lesions. Fifty one consecutive patients referred with a presumptive diagnosis of rectal mass were subjected to proctoscopic examination when fine needle aspiration cytology, brush cytology and biopsy sample...

journal_title：Gut

authors： Kochhar R,Rajwanshi A,Wig JD,Gupta NM,Kesiezie V,Bhasin DK,Malik AK,Gupta SK,Mehta SK

更新日期：1990-03-01 00:00:00

abstract：OBJECTIVE:Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35%-80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterise the natural history of AAV ...

journal_title：Gut

authors： La Bella T,Imbeaud S,Peneau C,Mami I,Datta S,Bayard Q,Caruso S,Hirsch TZ,Calderaro J,Morcrette G,Guettier C,Paradis V,Amaddeo G,Laurent A,Possenti L,Chiche L,Bioulac-Sage P,Blanc JF,Letouze E,Nault JC,Zucman-Rossi

更新日期：2020-04-01 00:00:00

abstract：AIMS:To compare jejunal mucosal morphometry in HIV infected patients resident in London and Uganda. PATIENTS:Twenty HIV positive patients from London and 16 from Uganda were studied, and compared with HIV negative control subjects from both sites. METHODS:Stools and biopsy specimens were examined for enteropathogens....

journal_title：Gut

authors： Batman PA,Kapembwa MS,Miller AR,Sedgwick PM,Lucas S,Sewankambo NK,Serwadda D,Pudney J,Moody A,Harris JR,Griffin GE

更新日期：1998-09-01 00:00:00

abstract：:ABO and Rhesus blood group data have been examined for 1,680 patients treated for gastric cancer in four London hospitals. The risk of developing gastric cancer was estimated to be 16% higher for group A subjects than for group O subjects, in close agreement with many previous reports throughout the world. More detail...

journal_title：Gut

authors： Glober GA,Cantrell EG,Doll R,Peto R

更新日期：1971-07-01 00:00:00

abstract：OBJECTIVE:The number of colonoscopies required to reach competency is not well established. The primary aim of this study was to determine the number of colonoscopies trainees need to perform to attain competency, defined by a caecal intubation rate (CIR) ≥90%. As competency depends on completion, we also investigated ...

journal_title：Gut

authors： Ward ST,Mohammed MA,Walt R,Valori R,Ismail T,Dunckley P

更新日期：2014-11-01 00:00:00

abstract：:Spirits from areas of high and low incidence of cancer of the oesophagus were examined for volatile nitrosamines using a chemiluminescent detector. No nitrosamines were found, the detection limit being 0.001 microng/ml. ...

journal_title：Gut

authors： Gough TA

更新日期：1977-04-01 00:00:00

abstract：:To test the hypothesis that Helicobacter pylori infection is associated with a decreased intragastric acidity during omeprazole therapy, ambulatory 24 hour dual point gastric pH recordings were performed in 18 H pylori positive and 14 H pylori negative subjects. There was a four to six week washout period between the ...

journal_title：Gut

authors： Verdú EF,Armstrong D,Fraser R,Viani F,Idström JP,Cederberg C,Blum AL

更新日期：1995-04-01 00:00:00

abstract：:Increased arachidonic acid concentrations in experimental rodent colonic cancer have been described recently. In humans, a reduced erythrocyte stearic acid to oleic acid ratio has been reported in patients with colorectal cancer and it has been proposed that similar changes exist in the cancer tissue. The long chain f...

journal_title：Gut

authors： Neoptolemos JP,Husband D,Imray C,Rowley S,Lawson N

更新日期：1991-03-01 00:00:00

abstract：:Three cases are presented of lymphocytic colitis with chronic diarrhoea concurrent with longterm use of Cyclo 3 Fort, a phlebotonic drug used in France. The histological and immunopathological features of lymphocytic colitis are described. We show that lymphocytic colitis is drug induced, particularly in one patient w...

journal_title：Gut

authors： Beaugerie L,Luboinski J,Brousse N,Cosnes J,Chatelet FP,Gendre JP,Le Quintrec Y

更新日期：1994-03-01 00:00:00

abstract：:Carbenoxolone (Biogastrone, Berk) has been shown to reduce the peptic activity and total acidity of gastric juice obtained from anaesthetized pylorus-ligated rats without affecting significantly the volume of gastric juice secreted or the K(+) concentration. Glycyrrhetinic acid was less potent in reducing peptic activ...

journal_title：Gut

authors： Henman FD

更新日期：1970-04-01 00:00:00

abstract：OBJECTIVE:Silibinin is a flavonolignan that is well established for its robust antiviral activity against HCV infection and has undergone several clinical trials for the management of hepatitis C. Despite its potency, silibinin suffers from poor solubility and bioavailability, restricting its clinical use. To overcome ...

journal_title：Gut

authors： Liu CH,Lin CC,Hsu WC,Chung CY,Lin CC,Jassey A,Chang SP,Tai CJ,Tai CJ,Shields J,Richardson CD,Yen MH,Tyrrell DLJ,Lin LT

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:Dietary lectins can alter the proliferation of colonic cells. Differentiation is regulated by adhesion molecules which, being glycosylated, are targets for lectin binding. AIMS:To examine the effects of dietary lectins on differentiation, adhesion, and proliferation of colorectal cancer cells. METHODS:Diff...

journal_title：Gut

authors： Jordinson M,El-Hariry I,Calnan D,Calam J,Pignatelli M

更新日期：1999-05-01 00:00:00

abstract：:Patients with primary biliary cirrhosis have a defect in the receptor mediated clearance of complement coated erythrocytes by fixed macrophages of the reticuloendothelial system. To investigate the probable mechanism of this defect peripheral blood monocytes were isolated from nine patients with primary biliary cirrho...

journal_title：Gut

authors： Minuk GY,Vergalla J,Hanson RG,Hoofnagle JH,Frank MM,Jones EA

更新日期：1986-03-01 00:00:00

abstract：BACKGROUND:Micrometastases within bone marrow have been shown to indicate a poor prognosis in patients with epithelial tumours. However, the degree to which micrometastases represent true residual disease or cell shedding and metastatic potential, is unclear. AIM:To explore whether micrometastases represent residual d...

journal_title：Gut

authors： O'Sullivan GC,Collins JK,Kelly J,Morgan J,Madden M,Shanahan F

更新日期：1997-04-01 00:00:00

abstract：:The synchronous change in the antral release of gastrin and somatostatin into a vein draining the stomach was studied during acidic and alkaline intragastric pH in six anaesthetised duodenal ulcer patients and six controls after atropinisation. No differences in the basal secretion of gastrin and somatostatin were obs...

journal_title：Gut

authors： Jensen SL,Holst JJ,Christiansen LA,Shokouh-Amiri MH,Lorentsen M,Beck H,Jensen HE

更新日期：1987-02-01 00:00:00

abstract：:Lymphangiomas are rare tumours of lymphatic vessels, most commonly found in children. We present the unusual case of small bowel obstruction caused by benign lymphangioma in a middle aged woman. ...

journal_title：Gut

authors： Campbell WJ,Irwin ST,Biggart JD

更新日期：1991-12-01 00:00:00

abstract：:There is no satisfactory biomarker yet available for predicting the likelihood of premalignant changes or carcinoma developing in Barrett's or columnar lined oesophagus. In this study we have evaluated the proliferation of squamous epithelium, columnar epithelium from columnar lined oesophagus and gastric columnar epi...

journal_title：Gut

authors： Iftikhar SY,Steele RJ,Watson S,James PD,Dilks K,Hardcastle JD

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVE:Persistent colonisation by Helicobacter pylori, and especially by cagA-positive strains, has been related to several health outcomes with effects in opposite directions. Thus, it is important to evaluate its influence on total and category-specific mortality. DESIGN:We conducted prospective cohort analyses i...

journal_title：Gut

authors： Chen Y,Segers S,Blaser MJ

更新日期：2013-09-01 00:00:00