Abstract:
:A simple and reliable radioimmunoassay has been developed for a new gut hormone, HPP. In the primate 93% of the total PP was found in the pancreas with a small amount throughout the remaining gastrointestinal tract. HPP has been shown to be produced by a number of pancreatic apudomas and their metastases. The immunoreactive PP from these tumours and from normal pancreas was chromatographically indistinguishable from the pure peptide. The plasma PP concentration rose rapidly after a meal in normal subjects and was still raised six hours later. Fasting plasma PP levels in patients with PP cell containing pancreatic endocrine tumours were higher than even the postprandial level in normal subjects. PP measurements is thus useful in diagnosis of pancreatic endocrine tumours.
journal_name
Gutjournal_title
Gutauthors
Adrian TE,Bloom SR,Bryant MG,Polak JM,Heitz PH,Barnes AJdoi
10.1136/gut.17.12.940subject
Has Abstractpub_date
1976-12-01 00:00:00pages
940-44issue
12eissn
0017-5749issn
1468-3288journal_volume
17pub_type
杂志文章相关文献
GUT文献大全abstract::Gastric adaptation was impaired immediately after the performance of complete vagotomy in a series of 20 acute experiments in the dog. Preliminary isolation of the intact vagi in 10 of these animals produced alterations in adaptation similar to those seen after vagal division. It is concluded that alterations in gastr...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.11.874
更新日期:1972-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Many lines of evidence suggest that T helper cell type 1 (Th1) immune responses predominate in Crohn's disease (CD). Recently, a novel transcription factor T-box expressed in T cells (T-bet) has been reported as the master regulator of Th1 development. This study was designed to investigate the role...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.024190
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:"Probiotic" bacteria are effective in treating some inflammatory bowel diseases. However which bacteria confer benefit and mechanisms of action remain poorly defined. Dendritic cells, which are pivotal in early bacterial recognition, tolerance induction, and shaping of T cell responses, may be central in med...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.037325
更新日期:2004-11-01 00:00:00
abstract::Amino acid induced acid and gastrin responses during intragastric titration at pH 2.5 and 5.5 were compared in normal subjects and duodenal ulcer patients with G-cell hyperfunction. The latter were identified on the basis of raised basal or maximal acid outputs and increased gastrin responses to feeding. In normal sub...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.3.232
更新日期:1985-03-01 00:00:00
abstract::This trial was undertaken to establish the long term biochemical and serological outcome of patients with acute post-transfusion hepatitis C virus infection after treatment with interferon alfa-2b. After 12 months, 12 patients (eight treated, four controls) had self limited disease and 16 patients (seven treated, nine...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.2_suppl.s62
更新日期:1993-01-01 00:00:00
abstract::Hydrogen breath tests are widely used to explore the pathophysiology of functional gastrointestinal disorders. Small intestinal bacterial overgrowth and carbohydrate malabsorption are disorders detected by these tests that have been proposed to be of great importance for symptoms in, for instance, irritable bowel synd...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.2005.075127
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Surgical management of extrahepatic cholestasis is frequently complicated by bacterial translocation and severe liver injury. The aim of this study was to clarify the involvement of Toll-like receptors (TLRs) in the pathogenesis of bacterial translocation and liver injury in obstructive cholestasis....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.065318
更新日期:2006-01-01 00:00:00
abstract::A manometric method was developed to study the motor activity in the unprepared human colon, and the results in eight healthy subjects were compared with those obtained in the same subjects after bowel cleansing with a non-absorbable solution containing polyethylene glycol 4000 (PEG). A tube assembly (4.5 m long, 12 l...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.5.649
更新日期:1995-11-01 00:00:00
abstract:BACKGROUND:Experimental, clinical, and epidemiological studies have implicated mitogenic metabolites of arachidonic acid such as prostaglandin E(2) (PGE(2)) in colorectal carcinogenesis. Recently, cyclooxygenase 2 (COX-2) which catalyses the conversion of arachidonic acid to PGE(2), has displayed increased levels in hu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.5.730
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVE:Osteopontin (OPN) has been found to be valuable in diagnosis and predicting the prognosis of a variety of malignancies. The aims of the present study are to evaluate the usefulness of plasma OPN level for predicting gastric cancer development, invasion and survival. PATIENTS AND METHODS:One hundred and thirt...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2006.109868
更新日期:2007-06-01 00:00:00
abstract::The behaviour of basal and stimulated acid secretion, gastrin release, serum pepsinogen I, and gastric emptying of liquids was studied in 19 consecutive patients with Helicobacter pylori positive duodenal ulcer, over a follow up period of six months. Eleven patients were studied before and at three and six months afte...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.2.210
更新日期:1995-08-01 00:00:00
abstract:BACKGROUND:Nitric oxide is a major neurotransmitter in non-adrenergic, non-cholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined. AIMS:To study the effect of glyceryl trinitrate, a nitr...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.42.3.410
更新日期:1998-03-01 00:00:00
abstract:AIM:Recurrent bleeding after initial haemostasis is an important factor that directly relates to the outcome in the management of peptic ulcer bleeding. Conflicting reports have been published concerning the effectiveness of scheduled second therapeutic endoscopy on ulcer rebleeding. We investigate the use of scheduled...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.52.10.1403
更新日期:2003-10-01 00:00:00
abstract::We determined the ionic composition of faecal fluid from 13 patients with Crohn's disease limited to the colon, 10 with diffuse ulcerative colitis, and eight with ulcerative proctitis. The Crohn's and colitis groups had similar proportions of colon surface involved radiographically and similar 24 hour faecal weights. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.4.326
更新日期:1982-04-01 00:00:00
abstract::Earlier studies have reported that faecal pH is more alkaline in patients with colonic cancer, indicating a reduction in colonic carbohydrate fermentation to organic acids. The pH of faeces from 11 pre and 14 postoperative, selected colonic cancer patients without intestinal obstruction, major loss of appetite or weig...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.5.625
更新日期:1993-05-01 00:00:00
abstract::A simple evocative test has been used to study pancreatic function. Serial estimations of amylase and lipase in blood serum are made at intervals up to six hours and again at 24 hours after injecting intravenously standard doses of secretin and pancreozymin. The results of 213 tests on a normal group, in pancreatic di...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.1.2.125
更新日期:1960-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Progression of a colorectal adenoma to invasive cancer occurs in a minority of adenomas and is the most crucial step in colorectal cancer pathogenesis. In the majority of cases, this is associated with gain of a substantial part of chromosome 20q, indicating that multiple genes on the 20q ampli...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301153
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND AND AIMS:Emerging evidence suggests that highly treatment-resistant tumour-initiating cells (TICs) play a central role in the pathogenesis of pancreatic cancer. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered to be a novel anticancer agent; however, recent studies have shown th...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.149039
更新日期:2009-07-01 00:00:00
abstract:BACKGROUND AND AIMS:The incidence of oesophageal adenocarcinoma (OAC) has been increasing rapidly with a dismal survival rate of less than 20%. Understanding the genomic aberrations and biology of this cancer may enhance disease interventions. This study aimed to use genome-wide genomic and expression data to enhance t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.234179
更新日期:2011-10-01 00:00:00
abstract::Colonic biopsy specimens were obtained from patients undergoing surgery for carcinoma of the rectum. Colonic resistance arteries (internal diameter 178-345 microns) were dissected out under the microscope and mounted in a microvascular myograph capable of measuring isometric tension development. Experiments were desig...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.12.1391
更新日期:1990-12-01 00:00:00
abstract:OBJECTIVE:To elucidate the association between antiviral therapy and extrahepatic outcomes in individuals infected with HCV. METHODS:This nationwide cohort study screened 293,480 Taiwanese residents with HCV infection and excluded those with substantial comorbidity. A total of 12,384 eligible patients who had received...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308163
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:We have previously shown that hypnosis can be used to study the effect of different emotions on the motility of the gastrointestinal tract. These studies demonstrated that both anger and excitement increased colonic motility while happiness led to a reduction. The purpose of this study was to ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.51.5.701
更新日期:2002-11-01 00:00:00
abstract:BACKGROUND:Hereditary pancreatitis (HP) is a rare autosomal dominant disorder with variable expression and an overall lifetime penetrance of 80%. We hypothesised that (1) monozygotic twins within similar environments would develop the typical signs of HP at a similar age, and (2) if penetrance were due to modifier gene...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.4.542
更新日期:2001-04-01 00:00:00
abstract::Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin secretion were studied by using the isolated perfused rat stomach. [Asu1,7]-eel calcitonin (10(-9)--10(-7)M) caused a simultaneous dose-dependent increase of gastric somatostatin release and decrease of gastrin secretion, with a significant correla...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.2.94
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:The effect of histamine H2 receptor antagonists on gastric emptying is controversial. AIMS:To determine the effects of ranitidine, famotidine, and omeprazole on gastric motility and emptying. PATIENTS AND METHODS:Fifteen normal subjects underwent simultaneous antroduodenal manometry, electrogastrography (E...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.42.2.243
更新日期:1998-02-01 00:00:00
abstract::Over 90% of patients with inoperable carcinoma of the pancreas are successfully palliated by endoscopic retrograde cholangiopancreatography and stent insertion. Treatment of the residual 10% of patients often entails a laparotomy, which is difficult to justify when median survival of these patients is only 150 days. L...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.5.778
更新日期:1995-05-01 00:00:00
abstract::The metabolism of tauroursodeoxycholic acid orally administered and its effects on the bile acid pool of patients with asymptomatic/mildly symptomatic primary biliary cirrhosis is described. Patients were randomly assigned 500, 1000, or 1500 mg/day of tauroursodeoxycholate for six months. Biliary and serum bile acids ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.38.3.439
更新日期:1996-03-01 00:00:00
abstract::Clinically significant liver involvement in systemic amyloidosis, especially with cholestasis, is rare. We report a case of primary amyloidosis with severe intrahepatic cholestasis leading to terminal liver failure. The present case is the first of its kind reported involving Lambda light chains only as the associated...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.7.903
更新日期:1987-07-01 00:00:00
abstract::The oral administration of loxtidine to mice at doses of 600, 250, and 50 mg/kg/day for 746 days produced carcinoid tumours of the gastric fundus. The fundic mucosa also showed marked atypical hyperplasia with changes in foveolar cells similar to those seen in early incomplete metaplasia. These effects may be related ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.11.1338
更新日期:1986-11-01 00:00:00
abstract:BACKGROUND:Recently, non-invasive techniques such as 3 dimensional ultrasonography (3DUS) have been developed to assess gastric wall characteristics and to investigate their relationship with upper gastrointestinal sensations. To date, no head-to-head comparison has been carried out between the barostat and the 3DUS te...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.062836
更新日期:2006-12-01 00:00:00