Hepatitis C virus markers in patients with acute post-transfusion hepatitis treated with interferon alfa-2b.

abstract：:All patients presenting with acute upper gastrointestinal bleeding between November 1986 and April 1988 were admitted to a centralised joint medical/surgical unit, with a policy of early clinical and endoscopic assessment and rapid surgical intervention in those at high risk. Of the 430 patients admitted 69.5% were ov...

journal_title：Gut

authors： Holman RA,Davis M,Gough KR,Gartell P,Britton DC,Smith RB

更新日期：1990-05-01 00:00:00

abstract：:Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination. Its use may be complicated by the development of peripheral neuropathy and liver damage. The majority of patients with perhexiline neuropathy have an impaired ability to effect metabolic drug oxidation which is genetica...

journal_title：Gut

authors： Morgan MY,Reshef R,Shah RR,Oates NS,Smith RL,Sherlock S

更新日期：1984-10-01 00:00:00

abstract：BACKGROUND:Invasion of the intestinal mucosa by leucocytes is a characteristic of intestinal inflammation but the role of the epithelium in orchestrating this recruitment has not been examined in vivo. Cultured intestinal epithelial cells secrete a wide variety of chemokines, often in response to agents present in the ...

journal_title：Gut

authors： Ohtsuka Y,Lee J,Stamm DS,Sanderson IR

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Colonoscopy is the current reference standard for the detection of colorectal neoplasia, but nevertheless adenomas remain undetected. The Endocuff, an endoscopic cap with plastic projections, may improve colonic visualisation and adenoma detection. The aim of this study was to compare the mean numbe...

journal_title：Gut

authors： van Doorn SC,van der Vlugt M,Depla A,Wientjes CA,Mallant-Hent RC,Siersema PD,Tytgat K,Tuynman H,Kuiken SD,Houben G,Stokkers P,Moons L,Bossuyt P,Fockens P,Mundt MW,Dekker E

更新日期：2017-03-01 00:00:00

abstract：:In six healthy subjects serum concentrations of 5 amino salicylic acid (5ASA) and acetyl 5ASA were measured for up to 24 hours, and urinary excretion over 48 hours. After an intravenous injection of 3.26 mmol 5ASA serum concentrations fell rapidly with a distribution half-life of 17 +/- 2 min and an elimination half-l...

journal_title：Gut

authors： Myers B,Evans DN,Rhodes J,Evans BK,Hughes BR,Lee MG,Richens A,Richards D

更新日期：1987-02-01 00:00:00

abstract：:A clinical, biochemical, and pathological study is recorded of 50 patients in whom a diagnosis of idiopathic steatorrhea had been made and who had ;flat' jejunal biopsies. It is suggested that there is an underlying constitutional defect, not yet clearly defined, and that possibly secondary intestinal infection allows...

journal_title：Gut

authors： COOKE WT,FONE DJ,COX EV,MEYNELL MJ,GADDIE R

更新日期：1963-09-01 00:00:00

abstract：:This experimental study was undertaken to follow the influence of phenobarbital on bile chemistry and gallstone formation. Phenobarbital (400 mg/kg/day) was administered to golden hamsters receiving a diet known to induce cholesterol gallstones. After a 28-day period none of the control animals had gallstones whereas ...

journal_title：Gut

authors： Lagarriga J,Bouchier IA

更新日期：1973-12-01 00:00:00

abstract：OBJECTIVE:Young-onset colorectal cancer (YCRC) incidence is rising. Scant data exist on YCRC risk after presentation with concerning symptoms such as iron-deficiency anaemia (IDA) or haematochezia. We examined the association between IDA and YCRC, and haematochezia and YCRC. DESIGN:Cohort study of US Veterans aged 18-...

journal_title：Gut

authors： Demb J,Liu L,Murphy CC,Doubeni CA,Martínez ME,Gupta S

更新日期：2020-12-18 00:00:00

abstract：:Intestinal protein loss in chronic inflammatory bowel diseases may be easily determined by measurement of alpha-1-antitrypsin (alpha 1-AT) stool concentration and alpha 1-AT clearance. Both parameters were significantly raised in 36 and 34 patients respectively with chronic inflammatory bowel diseases, compared with e...

journal_title：Gut

authors： Fischbach W,Becker W,Mössner J,Koch W,Reiners C

更新日期：1987-04-01 00:00:00

abstract：OBJECTIVE:To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for cancer therapy through targeting SRSF6. DESIGN:We performed comprehensive analysis for the expression of SRSF6 in 311 CRC samples, The Cancer Genome Atlas and Gene Expres...

journal_title：Gut

authors： Wan L,Yu W,Shen E,Sun W,Liu Y,Kong J,Wu Y,Han F,Zhang L,Yu T,Zhou Y,Xie S,Xu E,Zhang H,Lai M

更新日期：2019-01-01 00:00:00

abstract：:Sulphasalazine (salicyl-azo-sulphapyridine) was ingested by 27 healthy subjects for five days at a dosage of 4 g daily. The acetylator phenotype of each subject had been established previously. The serum concentrations of the parent drug and its sulphapyridine-metabolites were determined and the adverse effects were r...

journal_title：Gut

authors： Schröder H,Evans DA

更新日期：1972-04-01 00:00:00

abstract：:A case is described of a life threatening vasculitis of the small bowel leading to massive gastrointestinal haemorrhage which was apparently due to cytomegalovirus inclusion disease. Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine. This ...

journal_title：Gut

authors： Sackier JM,Kelly SB,Clarke D,Rees AJ,Wood CB

更新日期：1991-11-01 00:00:00

abstract：:Two consecutive trials of out-patient treatment for mild cases of active ulcerative colitis are described. In the first trial oral prednisone gave significantly better results than a placebo. In the second trial "salazopyrin" gave final results approaching those of prednisone, although over a longer time and with a hi...

journal_title：Gut

authors： LENNARD-JONES JE,LONGMORE AJ,NEWELL AC,WILSON CW,JONES FA

更新日期：1960-09-01 00:00:00

abstract：:This prospective study was undertaken to evaluate the correlation between densitometric values of gall stones assessed by computed tomography and the success rate of litholytic therapy in 28 patients eligible for oral treatment. A densitometric study of the stones was performed in all patients before treatment. A cut ...

journal_title：Gut

authors： Caroli A,Del Favero G,Di Mario F,Spigariol F,Scalon P,Meggiato T,Zambelli C,Naccarato R

更新日期：1992-05-01 00:00:00

abstract：:An investigation of immunological parameters was conducted in 38 patients with Crohn's disease. The immunological tests employed included skin tests with dinitrochlorobenzene and a battery of common skin test antigens, lymphocyte transformation with phytohaemagglutinin and pokeweed mitogen, serum immunoglobulins, and ...

journal_title：Gut

authors： MacPherson BR,Albertini RJ,Beeken WL

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:It has been suggested that Mycobacterium paratuberculosis is the cause of Crohn's disease. In a previous report the immediate effect of two years treatment with antituberculous chemotherapy showed no clinical benefit. AIMS:To assess both the immediate and longer term effect of treatment on the disease. MET...

journal_title：Gut

authors： Thomas GA,Swift GL,Green JT,Newcombe RG,Braniff-Mathews C,Rhodes J,Wilkinson S,Strohmeyer G,Kreuzpainter G

更新日期：1998-04-01 00:00:00

abstract：:It has been found that a ;gastric' type of epithelium tends to develop in the first part of the duodenum in patients with duodenal ulceration and is found in the second part of the duodenum in a patient with the Zollinger-Ellison syndrome. It is likely that ;gastric' epithelium appears when the duodenal acidity is hig...

journal_title：Gut

authors： JAMES AH

更新日期：1964-08-01 00:00:00

abstract：BACKGROUND:Linkage data have now identified several inflammatory bowel disease (IBD) susceptibility loci but these data have not been consistently replicated in independent studies. One potential explanation for this is the possibility that patients enrolled in such studies may have been erroneously classified with res...

journal_title：Gut

authors： Silverberg MS,Daly MJ,Moskovitz DN,Rioux JD,McLeod RS,Cohen Z,Greenberg GR,Hudson TJ,Siminovitch KA,Steinhart AH

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:During development, the homeobox gene Cdx2 exerts a homeotic function, providing the positional information necessary for correct specification of the midgut endoderm. This is illustrated by the non-neoplastic gastric-type heteroplasias present at birth in the pericaecal region of Cdx2(+/-) mice. Furthermore...

journal_title：Gut

authors： Bonhomme C,Duluc I,Martin E,Chawengsaksophak K,Chenard MP,Kedinger M,Beck F,Freund JN,Domon-Dell C

更新日期：2003-10-01 00:00:00

abstract：BACKGROUND:A long time goal of the medical research community has been the identification of a reliable and valid marker for Crohn's disease. AIM:To identify differences in the genetic expression patterns of healthy and diseased tissues. METHOD:The RNA arbitrarily primed polymerase chain reaction (RAP-PCR) procedure ...

journal_title：Gut

authors： Lafontaine DA,Mercure S,Perreault JP

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:Cyclooxygenase 2 (COX-2) and matrix metalloproteinases (MMPs) have been implicated in tissue injury and fibrogenesis in animal models but little is known regarding their role in hepatitis C virus (HCV) related liver disease in humans. AIMS:To characterise the intrahepatic expression pattern of COX-2 and MMP...

journal_title：Gut

authors： Núñez O,Fernández-Martínez A,Majano PL,Apolinario A,Gómez-Gonzalo M,Benedicto I,López-Cabrera M,Boscá L,Clemente G,García-Monzón C,Martín-Sanz P

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Increased expression of proinflammatory cytokines, including tumour necrosis factor alpha, interleukin 6, and interferon gamma, as well as activation of proinflammatory signalling molecules such as nuclear factor kappa B, is characteristic of inflammatory bowel disease (IBD). AIMS:To investigate expression ...

journal_title：Gut

authors： Schreiber S,Rosenstiel P,Hampe J,Nikolaus S,Groessner B,Schottelius A,Kühbacher T,Hämling J,Fölsch UR,Seegert D

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Emerging evidence suggests that highly treatment-resistant tumour-initiating cells (TICs) play a central role in the pathogenesis of pancreatic cancer. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered to be a novel anticancer agent; however, recent studies have shown th...

journal_title：Gut

authors： Kallifatidis G,Rausch V,Baumann B,Apel A,Beckermann BM,Groth A,Mattern J,Li Z,Kolb A,Moldenhauer G,Altevogt P,Wirth T,Werner J,Schemmer P,Büchler MW,Salnikov AV,Herr I

更新日期：2009-07-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA) levels have been measured in the serum of 490 patients and 93 normal controls using the double antibody radioimmunoassay technique. Levels were elevated in 71 of patients with carcinomata of the gastrointestinal tract and in 42% with other types of malignancy. In patients with non-neopla...

journal_title：Gut

authors： Booth SN,King JP,Leonard JC,Dykes PW

更新日期：1973-10-01 00:00:00

abstract：:We report on clinical, nutritional, and hepatic histological findings in 50 non-selected obese subjects (mean overweight +74%; range +21-138%). The pathogenesis of the liver damage was assessed with the help of multidimensional analysis of a number of clinical variables. According to the severity of the hepatic lesion...

journal_title：Gut

authors： Braillon A,Capron JP,Hervé MA,Degott C,Quenum C

更新日期：1985-02-01 00:00:00

abstract：:Intestinal adaptation (small intestinal weight and length, weight of the caecum and of the residual colon) to feeding different doses (0-5-50-500 mg/kg bw) of the absorbable, competitive alpha-glucosidase inhibitors BAY m 1099 and BAY o 1248 for three, seven, or 28 days was studied in rats. With the highest dose of ei...

journal_title：Gut

authors： Lembcke B,Löser C,Fölsch UR,Wöhler J,Creutzfeldt W

更新日期：1987-01-01 00:00:00

abstract：OBJECTIVE:Reports on the effects of bone marrow-derived cells on hepatic fibrosis are contradictory. Impaired fibrosis but increased inflammation has recently been demonstrated 10 weeks after bone marrow transplantation (BM-Tx) in Abcb4-/- mice. It is hypothesised that BM-Tx might have long-term therapeutic potential b...

journal_title：Gut

authors： Roderfeld M,Rath T,Pasupuleti S,Zimmermann M,Neumann C,Churin Y,Dierkes C,Voswinckel R,Barth PJ,Zahner D,Graf J,Roeb E

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:Silibinin is a flavonolignan that is well established for its robust antiviral activity against HCV infection and has undergone several clinical trials for the management of hepatitis C. Despite its potency, silibinin suffers from poor solubility and bioavailability, restricting its clinical use. To overcome ...

journal_title：Gut

authors： Liu CH,Lin CC,Hsu WC,Chung CY,Lin CC,Jassey A,Chang SP,Tai CJ,Tai CJ,Shields J,Richardson CD,Yen MH,Tyrrell DLJ,Lin LT

更新日期：2017-10-01 00:00:00

abstract：:Clinical data and histology from the oesophagus, gastric antrum, and duodenum were collected from 36 patients undergoing surgery for duodenal ulcer. Gastritis was present in 94% of the patients (25% of atrophic type), oesophagitis in 72% and duodenitis in 39%. Abnormal biopsies were present from all three sites in 33%...

journal_title：Gut

authors： Earlam RJ,Amerigo J,Kakavoulis T,Pollock DJ

更新日期：1985-01-01 00:00:00

abstract：:By prolonged immunization of an inbred rat strain with isologous liver homogenate in Freund's complete adjuvant a low grade autoimmune ;cholangitis' with periductular fibrosis has been demonstrated. The lesion could be transferred to isogeneic animals by serial spleen cell injections and was associated with mild but v...

journal_title：Gut

authors： Maclaurin BP

更新日期：1971-06-01 00:00:00