Abstract:
BACKGROUND:Experimental, clinical, and epidemiological studies have implicated mitogenic metabolites of arachidonic acid such as prostaglandin E(2) (PGE(2)) in colorectal carcinogenesis. Recently, cyclooxygenase 2 (COX-2) which catalyses the conversion of arachidonic acid to PGE(2), has displayed increased levels in human colorectal cancer. AIMS:To evaluate whether there is differential COX-2 expression from different locations (caecum, ascending, transverse, descending, or sigmoid colon, and rectum) in human colorectal cancer. METHODS:Protein levels of COX-2 were determined by western blot analysis in tumours and adjacent normal mucosa of 39 patients with colorectal cancer. RESULTS:There was a notable overexpression of COX-2 protein in tumours located in the rectum (p<0.001) compared with other locations in the colon. Rectal tumours revealed elevated COX-2 protein levels in 18/20 cases compared with 4/19 colonic cases. No association between enhanced COX-2 protein expression in tumour tissue and Dukes's stages was found. CONCLUSIONS:Results suggest that the differential COX-2 expression may be due to differences in gene regulatory factors affecting COX-2 expression and/or reflect secondary changes in tumour progression which may have clinical implications.
journal_name
Gutjournal_title
Gutauthors
Dimberg J,Samuelsson A,Hugander A,Söderkvist Pdoi
10.1136/gut.45.5.730keywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
730-2issue
5eissn
0017-5749issn
1468-3288journal_volume
45pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND:An endoscopic procedure that uses a pH indicator called phenol red to assess Helicobacter pylori infected gastric mucosa has recently been developed. This test makes it possible to take biopsy specimens from H pylori infected areas. AIM:This test was applied to patients with early gastric cancers to clarify...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.1.20
更新日期:1998-01-01 00:00:00
abstract::The size of the related lymph nodes and their histology has been correlated in 34 specimens of Crohn's disease. Granulomata were shown not to affect the maximum diameter of the lymph nodes nor to be more frequent in large nodes. The enlargement of lymph nodes appeared to be due to simple, non-specific, reactive change...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.12.970
更新日期:1972-12-01 00:00:00
abstract::Chronic alcohol consumption induces cytochrome P450IIE1, enabling habitual abusers to consume far greater quantities of alcohol than normal subjects. This pathway of metabolism leads to the production of free radical species, which cause tissue damage through peroxidation of cell membranes. Groups of Wistar rats of eq...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.11.1644
更新日期:1994-11-01 00:00:00
abstract:OBJECTIVE:Guidelines mandate expert pathology review of Barrett's oesophagus (BO) biopsies that reveal dysplasia, but there are no evidence-based standards to corroborate expert reviewer status. We investigated BO concordance rates and pathologist features predictive of diagnostic discordance. DESIGN:Pathologists (n=5...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2019-318985
更新日期:2020-05-01 00:00:00
abstract::Pancreatic secretion of lipase and chymotrypsin in response to elemental diets and a crushed food homogenate was studied in normal subjects. The solutions were infused at constant flow rates at the ligament of Treitz with polyethylene glycol as a nonabsorbable marker. A triple lumen tube was used, enabling collection ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.3.194
更新日期:1978-03-01 00:00:00
abstract:BACKGROUND:Endoscopic diagnosis of short segments of Barrett's epithelium (SSBE)' is difficult and its meaning in terms of the presence of specialised columnar epithelium (SCE) has not been prospectively evaluated. AIMS:To evaluate the prevalence of SCE in patients with an endoscopic diagnosis of SSBE and in individua...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.5.659
更新日期:1998-05-01 00:00:00
abstract::The investigation and treatment of 131 patients with 'obscure' gastrointestinal bleeding has been reviewed. One hundred and six patients were assessed electively for recurrent haemorrhage, 25 presented as emergencies. The major presenting feature was melaena (55 patients), anaemia (35), rectal bleeding (34), haemateme...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.1.47
更新日期:1987-01-01 00:00:00
abstract:OBJECTIVE:Assessment of disease extension and activity is crucial to guide treatment in Crohn's disease. The objective of the current cross-sectional study was to determine the accuracy of MR for this assessment. DESIGN:50 patients with clinically active (n = 35) or inactive (n = 15) Crohn's disease underwent ileocolo...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2008.167957
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND AND AIMS:Monocyte chemoattractant protein 1 (MCP-1) is increased transmurally in inflammatory bowel disease (IBD). Although MCP-1 is considered to play an important role in fibrotic disease in other organs, the role of MCP-1 in gut fibrosis is unknown. We investigated the fibrotic potential of MCP-1 in the g...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.068429
更新日期:2006-05-01 00:00:00
abstract::One hundred patients who had undergone operation for duodenal ulcer (68 vagotomy and gastroenterostomy; seven vagotomy and pyloroplasty; 22 gastrectomy and three gastroenterostomy) 10 or more years previously each underwent endoscopy. Biopsies were taken and gastric juice aspirated for measurement of pH and nitrite co...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.3.246
更新日期:1984-03-01 00:00:00
abstract::The relationship between the adaptive response and plasma PYY concentrations after small bowel resection has been investigated. Seventy five per cent proximal small bowel resection resulted in a rise in plasma PYY at six days from 28 +/- 3.1 to 85 +/- 12.3 pmol/l (p less than 0.001) and this difference was maintained ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.12.1353
更新日期:1985-12-01 00:00:00
abstract::Fasting serum gastrin has been measured by radioimmunoassay in 72 patients with duodenal ulcer and compared with that in normals, patients with gastric ulcer, and with the Zollinger-Ellison syndrome. The mean (+/- SEM) gastrin levels were 15.7 +/- 1.5 pg/ml in the duodenal ulcer group, 32.1 +/- 4.3 pg/ml in normals, 1...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.11.899
更新日期:1971-11-01 00:00:00
abstract:BACKGROUND:There is a widespread notion that obesity leads to gastro-oesophageal reflux but scientific evidence of an association is limited and inconsistent. AIMS:To estimate the strength of the association between body mass and reflux symptoms, we performed a population based cross sectional interview study. SUBJEC...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.47.1.26
更新日期:2000-07-01 00:00:00
abstract:BACKGROUND:Autoantibodies against transglutaminase 2 (TG2) are thought to be responsible for the endomysial (EMA), reticulin (ARA), and jejunal antibody (JEA) tissue binding of serum samples from coeliac patients but the exclusive role of TG2 in these staining patterns has not yet been established. AIMS:To evaluate wh...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.2.199
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVES:COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear. DESIGN:This Italian prosp...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-321411
更新日期:2020-07-01 00:00:00
abstract::Acute fulminant pancreatitis is associated with significant morbidity and mortality. To examine the outcome of conservative and surgical treatment of this disorder, 36 patients who survived an initial episode were restudied after a mean of six years. Fifty three per cent had developed diabetes mellitus, half of whom r...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.6.843
更新日期:1992-06-01 00:00:00
abstract::These consensus guidelines were jointly commissioned by the British Society of Gastroenterology (BSG), the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and Public Health England (PHE). They provide an evidence-based framework for the use of surveillance colonoscopy and non-colonoscopic colorecta...
journal_title:Gut
pub_type: 杂志文章,实务指引
doi:10.1136/gutjnl-2019-319858
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Sulfhydryl (SH) compounds are essential in maintaining mucosal integrity in the gastrointestinal tract. A decrease in colonic mucosal SH compounds affects the redox status of the mucosa, resulting in vulnerability to further attacks. Therefore, there is a strong need for in vivo evaluation of SH compounds in...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.9.1291
更新日期:2003-09-01 00:00:00
abstract::Daytime intragastric pH, fasting and meal stimulated serum gastrin and nocturnal acid output were studied in eight male duodenal ulcer patients before, during and two days after completing nizatidine 300 mg nocte (20:00 h) for four weeks. Median nocturnal acid output (mmol/10 h) decreased during treatment to 11.6 (ran...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.4.449
更新日期:1989-04-01 00:00:00
abstract::In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes using electron microscopy and immunohistochemistry showed certain unusual features: the microorganisms were observed within ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.5.588
更新日期:1987-05-01 00:00:00
abstract::The purpose of this single blind controlled multicentre trial was to compare the relative effectiveness of pirenzepine and cimetidine in healing endoscopically proven duodenal ulcers. One hundred and twenty six patients with duodenal ulcer were treated with a daily dose of 100 mg pirenzepine (50 mg each before breakfa...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.25.2.206
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND:Thrombosis may be an important effector mechanism in the pathogenesis of Crohn's disease. METHODS:This study therefore investigated the prevalence of independent thrombotic risk factors (factor VII coagulant activity, lipoprotein (a), fibrinogen, plasma triglycerides, and smoking) in patients with Crohn's d...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.5.733
更新日期:1996-05-01 00:00:00
abstract::The effects of luminal instillation of 16,16 dimethyl PGE2 (dmPGE2) on gastric acid secretion and back diffusion of H+ were studied in anaesthetised dogs which were prepared with a segment of the greater curvature of the stomach mounted in a double lumen chamber. This model permitted simultaneous evaluation of two seg...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.9.775
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:In liver regeneration after portal branch ligation we previously showed that early cellular changes are observed in both the proliferating and atrophying liver lobes. They are therefore not indicative of future proliferative response. In this study we attempted to define precisely, in the same model, the tim...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.1.119
更新日期:2001-07-01 00:00:00
abstract:BACKGROUND:Colorectal carcinoids are often described as low-grade malignant. However, no study has compared the survival between patients with colorectal carcinoids and those with carcinomas, in a large series. In addition, no global consensus has been established on the crucial determinants of metastasis in colorectal...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2006.109157
更新日期:2007-06-01 00:00:00
abstract:AIMS:To evaluate the clinical utility of two new tests for serum trypsinogen 2 and trypsin 2-alpha 1 antitrypsin complex (trypsin 2-AAT) in diagnosing and assessing the severity of acute pancreatitis (AP) induced by endoscopic retrograde cholangiopancreatography (ERCP). PATIENTS:Three hundred and eight consecutive pat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.5.690
更新日期:1997-11-01 00:00:00
abstract::Following a prolonged period of relative inertia, real progress has been made in the past few years in understanding the pathogenesis of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis. Clinical experience, epidemiological studies, and molecular genetics have provided strong evidence th...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.50.suppl_3.iii31
更新日期:2002-05-01 00:00:00
abstract::Aspirin administration to normal subjects resulted in a reduction in gastric prostaglandin E (PGE) output. Both PGE concentration and gastric juice volume were decreased. Gastric acid output also decreased, although the difference was not statistically significant. An increased sensitivity of the PGE system to inhibit...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.1.54
更新日期:1976-01-01 00:00:00
abstract::In man, the main pancreatic duct is normally derived from ventral and dorsal embryological buds of the pancreas. In a minority of people, failure of fusion of the two buds results in separate drainage of the dorsal and ventral pancreas, so that the accessory duct provides the main drainage for the gland. Patients with...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.12.1066
更新日期:1979-12-01 00:00:00
abstract::The distribution of mucosal PGE2-like activity was determined by bioassay technique in the body and antrum of the stomach and in the duodenum of healthy subjects and duodenal ulcer patients before and after administration of aspirin, paracetamol, or histamine. In healthy subjects, the oxyntic, antral and duodenal muco...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.22.4.283
更新日期:1981-04-01 00:00:00