Peptic ulcer and non-steroidal anti-inflammatory agents.

Abstract:

:Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and dermatology outpatient clinics. There were 95 gastric ulcer and 85 duodenal ulcer patients. A statistically and clinically association (relative risk = 5) was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. There was also evidence of positive associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. By contrast, duodenal ulcer was unrelated to these drugs. Too few patients used paracetamol for any conclusion to be drawn on its role.

journal_name

Gut

journal_title

Gut

authors

Duggan JM,Dobson AJ,Johnson H,Fahey P

doi

10.1136/gut.27.8.929

subject

Has Abstract

pub_date

1986-08-01 00:00:00

pages

929-33

issue

8

eissn

0017-5749

issn

1468-3288

journal_volume

27

pub_type

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