Abstract:
:Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and dermatology outpatient clinics. There were 95 gastric ulcer and 85 duodenal ulcer patients. A statistically and clinically association (relative risk = 5) was found between the regular use of non-steroidal anti-inflammatory agents and gastric ulcer. There was also evidence of positive associations between gastric ulcer and aspirin containing preparations with or without non-steroidal anti-inflammatory agents. By contrast, duodenal ulcer was unrelated to these drugs. Too few patients used paracetamol for any conclusion to be drawn on its role.
journal_name
Gutjournal_title
Gutauthors
Duggan JM,Dobson AJ,Johnson H,Fahey Pdoi
10.1136/gut.27.8.929subject
Has Abstractpub_date
1986-08-01 00:00:00pages
929-33issue
8eissn
0017-5749issn
1468-3288journal_volume
27pub_type
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