Molecular characterisation of non-absorptive and absorptive enterocytes in human small intestine.

abstract：:Calcium in milk products stimulates gastric acid secretion and inhibits the cytolytic activity of intestinal contents. Based on these effects, it was hypothesised that calcium might lessen the severity of food borne intestinal infections. The possible differential effects of a low calcium milk and normal milk products...

journal_title：Gut

authors： Bovee-Oudenhoven I,Termont D,Dekker R,Van der Meer R

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Interleukin-6 (IL-6) is a well-recognised mediator of liver disease and regeneration. However, the in vivo effects of IL-6 on enterocytes and the intestinal tract have not been elucidated. We sought to determine the in vivo effects of IL-6 on enterocytes. METHODS:Murine models of increased or absen...

journal_title：Gut

authors： Jin X,Zimmers TA,Zhang Z,Pierce RH,Koniaris LG

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Portal systemic encephalopathy (PSE) is a complex neuropsychiatric syndrome associated with hepatic failure. Small scale studies have shown the benzodiazepine receptor antagonist flumazenil to be effective in ameliorating PSE. AIMS:To determine the efficacy of flumazenil in patients with non-comatous mild t...

journal_title：Gut

authors： Gyr K,Meier R,Häussler J,Boulétreau P,Fleig WE,Gatta A,Holstege A,Pomier-Layrargues G,Schalm SW,Groeneweg M,Scollo-Lavizzari G,Ventura E,Zeneroli ML,Williams R,Yoo Y,Amrein R

更新日期：1996-08-01 00:00:00

abstract：:Forty patients with endoscopically proven persistent duodenal ulcer who had been treated for six weeks with cimetidine (1 g/day) were randomly allocated to receive a further six weeks' treatment with cimetidine (1 g/day) or ranitidine (300 mg/day). Ulcers healed in 12 of 19 patients given cimetidine (63%) and in 13 of...

journal_title：Gut

authors： Quatrini M,Basilisco G,Bianchi PA

更新日期：1984-10-01 00:00:00

abstract：:A retrospective study was undertaken to investigate how endoscopies yielding positive findings differ a priori from those yielding negative findings: and how those judged 'helpful' (in the sense of influencing management) differ a priori from those judged 'unhelpful'. A total of 483 patients undergoing endoscopy was s...

journal_title：Gut

authors： Naji SA,Brunt PW,Hagen S,Mowat NA,Russell IT,Sinclair TS,Tang TM

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy. METHODS:A population-based case-control study was conducted in Southern Germany in 2003-...

journal_title：Gut

authors： Brenner H,Chang-Claude J,Seiler CM,Hoffmeister M

更新日期：2012-11-01 00:00:00

abstract：:It has been demonstrated that cardiac output and pulmonary, gastroduodenal, pancreatic, and splenic blood flow increases after portacaval shunt operations. This report concerns a study of cerebral haemodynamics and metabolism in eight patients with cirrhosis of the liver, examined both before and after portacaval surg...

journal_title：Gut

authors： Bianchi Porro G,Maiolo AT,Della Porta P

更新日期：1969-11-01 00:00:00

abstract：:We have determined the relative importance of day and night time gastric acid inhibition for duodenal ulcer healing by comparing the anti-ulcer efficacy of a single morning with that of a single bedtime dose of ranitidine. One hundred and thirty patients with active duodenal ulcer were randomly assigned to a double-bl...

journal_title：Gut

authors： Bianchi Porro G,Parente F,Sangaletti O

更新日期：1990-04-01 00:00:00

abstract：:TNM (tumour, node, metastases) staging has thus far been the most important guide to prognosis in patients with gastric cancer. Histological grading, in contrast, has not provided any additional information. Recently a novel grading system based on tubular differentiation and mucus production has been proposed, which ...

journal_title：Gut

authors： Martin IG,Dixon MF,Sue-Ling H,Axon AT,Johnston D

更新日期：1994-06-01 00:00:00

abstract：:The behaviour of basal and stimulated acid secretion, gastrin release, serum pepsinogen I, and gastric emptying of liquids was studied in 19 consecutive patients with Helicobacter pylori positive duodenal ulcer, over a follow up period of six months. Eleven patients were studied before and at three and six months afte...

journal_title：Gut

authors： Parente F,Maconi G,Sangaletti O,Minguzzi M,Vago L,Bianchi Porro G

更新日期：1995-08-01 00:00:00

abstract：:The leakiness of the cell membranes of colonic epithelial cells isolated by the collagenase/Dispase technique from normal or diseased colons was assessed in a 4 h 51Cr release assay. Cells from normal, adenoma bearing or cancer bearing colons showed 51Cr release of 8% or less in almost all of 46 cell populations teste...

journal_title：Gut

authors： Gibson PR,van de Pol E,Barratt PJ,Doe WF

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:The diagnosis and classification of oesophageal motility disorders is currently based on assessment of the phasic contractile activity of the oesophagus. Tonic muscular contraction of the oesophageal body (oesophageal tone) has not been well characterised. AIM:To quantify oesophageal tonic activity in healt...

journal_title：Gut

authors： González M,Mearin F,Vasconez C,Armengol JR,Malagelada JR

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND AND AIMS:A previous study suggested that the presence of myenteric plexitis in the proximal resection margins could be predictive of early endoscopic recurrence after ileocolonic or ileal resection for Crohn's disease (CD). The aim of the present study was to assess the predictive value of plexitis for early...

journal_title：Gut

authors： Sokol H,Polin V,Lavergne-Slove A,Panis Y,Treton X,Dray X,Bouhnik Y,Valleur P,Marteau P

更新日期：2009-09-01 00:00:00

abstract：:During a four hour observation period vasoactive intestinal polypeptide (VIP) is released in increasing amounts from the feline small intestine exposed to cholera toxin. As VIP is known to be located almost exclusively in the intestinal nerves, the present findings strongly suggest that cholera toxin activates the ent...

journal_title：Gut

authors： Cassuto J,Fahrenkrug J,Jodal M,Tuttle R,Lundgren O

更新日期：1981-11-01 00:00:00

abstract：:Earlier studies regarding possible primary immune disturbances participating in the pathogenesis of Crohn's disease yielded conflicting results. Peripheral blood lymphocyte subsets and lymphocyte proliferative responses to five soluble recall antigens and to the polyclonal stimulator phythaemagglutinin were therefore ...

journal_title：Gut

authors： D'Haens G,Hiele M,Rutgeerts P,Geboes K,Ceuppens JL

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:The efficacy of a levofloxacin-based regimen as the first-line treatment and a clarithromycin-based regimen as the second-line treatment for Helicobacter pylori infection remains unknown. The aim of this study was to assess the eradication rates of these two regimens using different administration sequences....

journal_title：Gut

authors： Liou JM,Lin JT,Chang CY,Chen MJ,Cheng TY,Lee YC,Chen CC,Sheng WH,Wang HP,Wu MS

更新日期：2010-05-01 00:00:00

abstract：:The value of lactulose treatment in hepatic encephalopathy is widely recognised but its mode of action remains controversial. Much evidence supports a role for gamma-aminobutyric acid in hepatic encephalopathy, and lactulose could alter its bacterial production in the gut. Using the rat synaptic membrane assay and gas...

journal_title：Gut

authors： al Mardini H,al Jumaili B,Record CO,Burke D

更新日期：1991-09-01 00:00:00

abstract：:The epithelial-mesenchymal interface of the intestinal mucosa obviously plays an important role in supporting the mucosal architecture. Its significance for the process of migration and differentiation of the epithelial cells remains to be resolved. It consists of a basement membrane, the anchoring zone and the subepi...

journal_title：Gut

authors： Hahn U,Schuppan D,Hahn EG,Merker HJ,Riecken EO

更新日期：1987-01-01 00:00:00

abstract：:Eighteen patients with fulminant liver failure were studied, 10 with normal renal function (group A) and eight with renal failure (group B, plasma creatinine greater than 200 mumol/l). Renal function was assessed by standard clearance techniques and patients in group B had a marked reduction compared with group A in b...

journal_title：Gut

authors： Guarner F,Hughes RD,Gimson AE,Williams R

更新日期：1987-12-01 00:00:00

abstract：BACKGROUND:Oligodeoxynucleotides (ODNs) containing unmethylated cytosine-guanosine (CpG) sequence motifs constitute the immunostimulatory components of bacterial DNA which potently activate innate immunity. Administration of CpG-ODNs before the onset of experimental colitis prevents intestinal inflammation by induction...

journal_title：Gut

authors： Hofmann C,Dunger N,Grunwald N,Hämmerling GJ,Hoffmann P,Schölmerich J,Falk W,Obermeier F

更新日期：2010-10-01 00:00:00

abstract：:We report a seven year history of a 23 year old woman born in the Antilles, with pseudotumoral enterocolitis and massive eosinophilia. In 1973 she developed a haemorrhagic colitis with massive peripheral eosinophilia of up to 60000/mm3. Medical treatment, mainly corticosteroids, failed to control the disease. The pati...

journal_title：Gut

authors： Malè PJ,de Toledo F,Widgren S,de Peyer R,Berthoud S

更新日期：1983-04-01 00:00:00

abstract：:This case report describes the histological and macroscopic changes seen within a few months in the gastric mucosa of a 28 year old woman patient with upper abdominal symptoms. With hindsight these changes were the first signs of Sjögren's syndrome. ...

journal_title：Gut

authors： van Leeuwen ML,Tjiong HL,van Blankenstein M,Mulder AH,Bakker CM

更新日期：1993-08-01 00:00:00

abstract：:Relatives of patients with colorectal cancer have on average a two to threefold increased risk for developing bowel neoplasia although in some families the risk is much higher. This study examined the compliance for endoscopic screening and faecal occult blood testing among first degree relatives of patients with colo...

journal_title：Gut

authors： Stephenson BM,Murday VA,Finan PJ,Quirke P,Dixon MF,Bishop DT

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND AND AIMS:It is not known why some reflux episodes evoke symptoms and others do not. We investigated the determinants of perception of gastro-oesophageal reflux. METHODS:In 32 patients with symptoms suggestive of gastro-oesophageal reflux, 24 hour ambulatory pH and impedance monitoring was performed after ce...

journal_title：Gut

authors： Bredenoord AJ,Weusten BL,Curvers WL,Timmer R,Smout AJ

更新日期：2006-03-01 00:00:00

abstract：:The epidemiology of hepatitis C virus (HCV) infection was studied in an English teaching hospital over an 18 month period. A total of 104 HCV antibody positive patients were referred for further investigation. They were divided into those diagnosed through screening (blood donors and intravenous drug abusers) and thos...

journal_title：Gut

authors： Watson JP,Brind AM,Chapman CE,Bates CL,Gould FK,Johnson SJ,Burt AD,Ferguson J,Simmonds P,Bassendine MF

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:It is postulated that high serum levels of insulin and insulin growth factor 1 (IGF-1) mediate obesity-associated carcinogenesis. The relationship of insulin, IGF-1 and IGF binding proteins (IGFBP) with Barrett's oesophagus (BO) has not been well examined. METHODS:Serum levels of insulin and IGFBPs in patie...

journal_title：Gut

authors： Greer KB,Thompson CL,Brenner L,Bednarchik B,Dawson D,Willis J,Grady WM,Falk GW,Cooper GS,Li L,Chak A

更新日期：2012-05-01 00:00:00

abstract：BACKGROUND:Lipids may exacerbate symptoms induced by gut stimuli. AIM:To determine the mechanism whereby fat exerts this effect. SUBJECTS:Twenty four healthy subjects were studied during fasting. METHODS:We measured perception (0-6 scale) in response to jejunal balloon distension and transmucosal electrical nerve st...

journal_title：Gut

authors： Accarino AM,Azpiroz F,Malagelada JR

更新日期：2001-05-01 00:00:00

abstract：:Both carbachol (10(-4)-10(-3) mol/l) and cholecystokinin octapeptide (CCK-8) (10(-8)-10(-6) mol/l) significantly stimulated the release of pepsinogen from rabbit gastric mucosa maintained in organ culture (213-216% and 143-261% of control, respectively, p less than 0.05-0.01). The secretion was not affected by removin...

journal_title：Gut

authors： Miyamoto T,Itoh M,Noguchi Y,Yokochi K

更新日期：1992-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Transforming growth factor beta (TGF-beta) is frequently involved in gastrointestinal carcinogenesis although its contribution to oesophageal adenocarcinoma (AC) and its precursor Barrett's oesophageal epithelium (BE) metaplasia are unclear. METHODS:Expression of TGF-beta signalling components was ...

journal_title：Gut

authors： Onwuegbusi BA,Aitchison A,Chin SF,Kranjac T,Mills I,Huang Y,Lao-Sirieix P,Caldas C,Fitzgerald RC

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:The phenotypic spectrum of familial adenomatous polyposis (FAP) varies from the classic appearance of hundreds of adenomatous colonic polyps in the young adult and early onset colorectal cancer, to the occurrence of sparse adenomas in the older adult, "attenuated" FAP, due to mutations at the 5' or 3' ends o...

journal_title：Gut

authors： Rozen P,Samuel Z,Shomrat R,Legum C

更新日期：1999-12-01 00:00:00