Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis.

abstract：BACKGROUND:TFF1 is a 6.5 kDa secreted protein that is expressed predominantly in normal gastric mucosa. It is coexpressed with mucins and it can form dimers via a free carboxy terminal cysteine residue. AIMS:To investigate the molecular forms of TFF1 that are present in normal human stomach and the association of the ...

journal_title：Gut

authors： Newton JL,Allen A,Westley BR,May FE

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVE:Tumour-associated macrophages (TAMs) play key roles in tumour progression. Recent evidence suggests that TAMs critically modulate the efficacy of anticancer therapies, raising the prospect of their targeting in human cancer. DESIGN:In a large retrospective cohort study involving 110 patients with pancreatic ...

journal_title：Gut

authors： Di Caro G,Cortese N,Castino GF,Grizzi F,Gavazzi F,Ridolfi C,Capretti G,Mineri R,Todoric J,Zerbi A,Allavena P,Mantovani A,Marchesi F

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Lynch syndrome is caused by germline mutations in DNA mismatch repair genes leading to microsatellite instability (MSI) and colorectal cancer. Mesalazine, commonly used for the treatment of UC, reduces MSI in vitro. Here, we tested natural compounds for such activity and applied mesalazine and thymoquinone in...

journal_title：Gut

authors： Kortüm B,Campregher C,Lang M,Khare V,Pinter M,Evstatiev R,Schmid G,Mittlböck M,Scharl T,Kucherlapati MH,Edelmann W,Gasche C

更新日期：2015-12-01 00:00:00

abstract：:Lymphangiomas are rare tumours of lymphatic vessels, most commonly found in children. We present the unusual case of small bowel obstruction caused by benign lymphangioma in a middle aged woman. ...

journal_title：Gut

authors： Campbell WJ,Irwin ST,Biggart JD

更新日期：1991-12-01 00:00:00

abstract：:Some patients with diarrhoea predominant irritable bowel syndrome have increased rectal sensitivity. It is uncertain, however, whether the diarrhoea is a consequence of the rectal sensitivity or if it is sensitising the rectum in some way. The aim of this study was to assess whether inducing diarrhoea in normal health...

journal_title：Gut

authors： Houghton LA,Wych J,Whorwell PJ

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Diabetes has been associated with an increased risk of hepatocellular carcinoma (HCC) in studies of referred patients. This is the first population based case control study in the USA to examine this association while adjusting for other major risk factors related to HCC. METHODS:We used the Surveillance Ep...

journal_title：Gut

authors： Davila JA,Morgan RO,Shaib Y,McGlynn KA,El-Serag HB

更新日期：2005-04-01 00:00:00

abstract：BACKGROUND:A long time goal of the medical research community has been the identification of a reliable and valid marker for Crohn's disease. AIM:To identify differences in the genetic expression patterns of healthy and diseased tissues. METHOD:The RNA arbitrarily primed polymerase chain reaction (RAP-PCR) procedure ...

journal_title：Gut

authors： Lafontaine DA,Mercure S,Perreault JP

更新日期：1998-06-01 00:00:00

abstract：:To investigate the effects of supplemental oxygen on cardiac rhythm during gastroscopy, 103 patients aged over 60 were randomised to receive either supplemental oxygen or air at 2 litres/minute during the procedure. Pulse rate, blood pressure, oxygen saturation, and a Holter cardiac trace were monitored before, during...

journal_title：Gut

authors： Bowling TE,Hadjiminas CL,Polson RJ,Baron JH,Foale RA

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVES:Serous cystic neoplasm (SCN) is a cystic neoplasm of the pancreas whose natural history is poorly known. The purpose of the study was to attempt to describe the natural history of SCN, including the specific mortality. DESIGN:Retrospective multinational study including SCN diagnosed between 1990 and 2014. ...

journal_title：Gut

authors： Jais B,Rebours V,Malleo G,Salvia R,Fontana M,Maggino L,Bassi C,Manfredi R,Moran R,Lennon AM,Zaheer A,Wolfgang C,Hruban R,Marchegiani G,Fernández Del Castillo C,Brugge W,Ha Y,Kim MH,Oh D,Hirai I,Kimura W,Jang JY

更新日期：2016-02-01 00:00:00

abstract：:This study reports on the outcome of four patients having ileal pouch anal anastomosis after orthotopic liver transplantation for sclerosing cholangitis complicating ulcerative colitis. There were no deaths on follow up. Early postoperative bleeding was a complication of colectomy or rectal excision in three, one of w...

journal_title：Gut

authors： Rowley S,Candinas D,Mayer AD,Buckels JA,McMaster P,Keighley MR

更新日期：1995-12-01 00:00:00

abstract：:Transiliac biopsies from 34 female patients with corticosteroid treated chronic active hepatitis have been examined to determine the contributions made by decreased bone formation and increased bone resorption to bone loss associated with this condition and to determine the structural basis of the bone loss. Mean wall...

journal_title：Gut

authors： Stellon AJ,Webb A,Compston JE

更新日期：1988-03-01 00:00:00

abstract：:The investigation and treatment of 131 patients with 'obscure' gastrointestinal bleeding has been reviewed. One hundred and six patients were assessed electively for recurrent haemorrhage, 25 presented as emergencies. The major presenting feature was melaena (55 patients), anaemia (35), rectal bleeding (34), haemateme...

journal_title：Gut

authors： Thompson JN,Salem RR,Hemingway AP,Rees HC,Hodgson HJ,Wood CB,Allison DJ,Spencer J

更新日期：1987-01-01 00:00:00

abstract：:A histochemical study of conjugated and total bilirubin was made on liver biopsies of 150 patients. Three types of cholestasis were defined: type I, characterized by the presence of intracellular pigment granules in the hepatocytes; type II, showing intracellular granules and extracellular thrombi (this group may be s...

journal_title：Gut

authors： Desmet VJ,Bullens AM,De Groote J

更新日期：1970-06-01 00:00:00

abstract：OBJECTIVE:Dietary fibre has beneficial effects on energy metabolism, and the majority of studies have focused on short-chain fatty acids produced by gut microbiota. Ginseng has been reported to aid in body weight management, however, its mechanism of action is not yet clear. In this study, we focused on the potential m...

journal_title：Gut

authors： Quan LH,Zhang C,Dong M,Jiang J,Xu H,Yan C,Liu X,Zhou H,Zhang H,Chen L,Zhong FL,Luo ZB,Lam SM,Shui G,Li D,Jin W

更新日期：2020-07-01 00:00:00

abstract：:A case of adenocarcinoma of the ileum, occurring in an area concomitantly the site of Crohn's disease, is described. Examination of the literature suggests that there are certain characteristics of the small bowel carcinoma which arises in Crohn's disease. These include invisibility of the tumour on macroscopic inspec...

journal_title：Gut

authors： Fleming KA,Pollock AC

更新日期：1975-07-01 00:00:00

abstract：OBJECTIVES:COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear. DESIGN:This Italian prosp...

journal_title：Gut

authors： Bezzio C,Saibeni S,Variola A,Allocca M,Massari A,Gerardi V,Casini V,Ricci C,Zingone F,Amato A,Caprioli F,Lenti MV,Viganò C,Ascolani M,Bossa F,Castiglione F,Cortelezzi C,Grossi L,Milla M,Morganti D,Pastorelli L,R

更新日期：2020-07-01 00:00:00

abstract：:The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted flu...

journal_title：Gut

authors： Mitchell TJ,Ketley JM,Haslam SC,Stephen J,Burdon DW,Candy DC,Daniel R

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Hephaestin is a multicopper ferroxidase required for basolateral transport of iron from enterocytes. Sex linked anaemia (sla) mice have a defect in the release of iron from intestinal enterocytes into the circulation due to an interstitial deletion in the hephaestin gene (heph). RESULTS:We have demonstrated...

journal_title：Gut

authors： Kuo YM,Su T,Chen H,Attieh Z,Syed BA,McKie AT,Anderson GJ,Gitschier J,Vulpe CD

更新日期：2004-02-01 00:00:00

abstract：:Circulating immune complexes were determined in 59 consecutive patients with Crohn's disease and 100 blood donors by a double method based on the inhibition of the agglutinating activity of CIq and/or rheumatoid factor on the IgG-coated polystyrene particles. In patients, the incidence of positive immune complexes was...

journal_title：Gut

authors： Fiasse R,Lurhuma AZ,Cambiaso CL,Masson PL,Dive C

更新日期：1978-07-01 00:00:00

abstract：BACKGROUND AND AIMS:The authors' goal was to measure pH at the gastric surface (pH₀) to understand how acid secretion affects the repair of microscopic injury to the gastric epithelium. METHODS:Microscopic gastric damage was induced by laser light, during confocal/two-photon imaging of pH-sensitive dyes (Cl-NERF, BCEC...

journal_title：Gut

authors： Demitrack ES,Aihara E,Kenny S,Varro A,Montrose MH

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation and increased epithelial permeability. Both tumour necrosis factor alpha (TNF-alpha) and interferon gamma (IFN-gamma) have been implicated in IBD. AIMS:To understand better the effects of these cytokines on epithelial cell ...

journal_title：Gut

authors： Fish SM,Proujansky R,Reenstra WW

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:Early events in the progression of 90% of sporadic colorectal cancers depend on constitutive activation of Wnt signalling. Recent data also indicate a close association between the Hedgehog (Hh) and Wnt pathways in colonic epithelial cell differentiation. AIMS:To investigate whether expression of Gli1, a tr...

journal_title：Gut

authors： Akiyoshi T,Nakamura M,Koga K,Nakashima H,Yao T,Tsuneyoshi M,Tanaka M,Katano M

更新日期：2006-07-01 00:00:00

abstract：:It has been suggested, on the basis of impaired granulocyte migration to skin windows, that there is a fundamental granulocyte defect in Crohn's disease. In vitro tests of granulocyte function have, however, failed to confirm this. We have studied granulocyte migration to inflamed bowel in Crohn's disease using a new ...

journal_title：Gut

authors： Saverymuttu SH,Peters AM,Lavender JP,Chadwick VS,Hodgson HJ

更新日期：1985-04-01 00:00:00

abstract：BACKGROUND:Sodium butyrate, a product of colonic bacterial fermentation, is able to inhibit cell proliferation and to stimulate cell differentiation of colonic epithelial cell lines. It has been proposed that these cellular effects could be linked to its ability to cause hyperacetylation of histone through the inhibiti...

journal_title：Gut

authors： Siavoshian S,Segain JP,Kornprobst M,Bonnet C,Cherbut C,Galmiche JP,Blottière HM

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Despite intent to cure surgery with negative resection margins, locoregional recurrence is common in pancreatic cancer. AIMS:To determine whether detection of K-ras gene mutation in the histologically negative surgical margins of pancreatic cancer reflects unrecognised disease. PATIENTS:Seventy patients wh...

journal_title：Gut

authors： Kim J,Reber HA,Dry SM,Elashoff D,Chen SL,Umetani N,Kitago M,Hines OJ,Kazanjian KK,Hiramatsu S,Bilchik AJ,Yong S,Shoup M,Hoon DS

更新日期：2006-11-01 00:00:00

abstract：:Seven patients with hypoalbuminaemia and extensive jejunoileal Crohn's disease were treated with an elemental diet for 28 to 56 days. Over this time there was an increase in total plasma proteins from mean of 49.1 to 59.0 g/l and a mean rise in serum albumin from 20.7 to 30.0 g/l (P less than 0.05). In addition, there...

journal_title：Gut

authors： Logan RF,Gillon J,Ferrington C,Ferguson A

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND:The development of endocrine tumours of the duodenopancreatic area (ETDP) is thought to be slow, but their natural history is not well known. The aim of this study was to determine the factors that influence survival of patients with ETDP. PATIENTS/METHODS:Eighty two patients with ETDP (44 non-functioning t...

journal_title：Gut

authors： Madeira I,Terris B,Voss M,Denys A,Sauvanet A,Flejou JF,Vilgrain V,Belghiti J,Bernades P,Ruszniewski P

更新日期：1998-09-01 00:00:00

abstract：:A study of HLA-DR antigen in 75 patients with primary biliary cirrhosis has been carried out in order to test the hypothesis that genetic factors related to genes controlling immune responses might be important in the pathogenesis of primary biliary cirrhosis. The frequencies of HLA-DR locus antigens was not significa...

journal_title：Gut

authors： Bassendine MF,Dewar PJ,James OF

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Coeliac disease (CD) is triggered by an abnormal reaction to gluten. Peptides resulting from partially digested gluten of wheat, barley or rye cause inflammation of the small intestinal mucosa. Previous contradictory studies suggest that oats may trigger the abnormal immunological response in patien...

journal_title：Gut

authors： Comino I,Real A,de Lorenzo L,Cornell H,López-Casado MÁ,Barro F,Lorite P,Torres MI,Cebolla A,Sousa C

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:Current strategies to guide selection of neoadjuvant therapy in oesophageal adenocarcinoma (OAC) are inadequate. We assessed the ability of a DNA damage immune response (DDIR) assay to predict response following neoadjuvant chemotherapy in OAC. DESIGN:Transcriptional profiling of 273 formalin-fixed paraffin-...

journal_title：Gut

authors： Turkington RC,Knight LA,Blayney JK,Secrier M,Douglas R,Parkes EE,Sutton EK,Stevenson L,McManus D,Halliday S,McCavigan AM,Logan GE,Walker SM,Steele CJ,Perner J,Bornschein J,MacRae S,Miremadi A,McCarron E,McQuaid S,

更新日期：2019-11-01 00:00:00