Effects of one year's treatment with ranitidine and of truncal vagotomy on gastric contents.

Abstract:

:Fifteen patients with peptic ulcer underwent 24 hour studies of gastric contents: before and on completing six weeks' treatment with oral ranitidine 150 mg bd, twice on maintenance treatment for nine to 12 months and one month after stopping the drug. For comparison, 11 patients underwent identical 24 hour studies three to 38 months after truncal vagotomy for duodenal ulcer. During treatment with ranitidine median 24 hour intragastric pH, nitrate concentration, and counts of total and nitrate reducing bacteria increased significantly regardless of dietary nitrate content; there was no significant increase in the median day time concentration of N-nitroso compounds. Despite these changes, an acid tide at some point in each 24 hour study period prevented persistent bacterial colonisation of the stomach. There were no significant differences between the biochemical and microbiological changes recorded during one year of treatment with ranitidine, and the observations on patients after truncal vagotomy. One month after stopping one year's treatment with ranitidine all variables examined returned to pretreatment levels. Treatment with ranitidine or vagotomy was associated with significant positive correlations among pH, nitrate concentration and bacterial counts. Correlations between pH and N-nitroso compound concentration and between concentrations of nitrite and N-nitroso compounds were not significant.

journal_name

Gut

journal_title

Gut

authors

Thomas JM,Misiewicz JJ,Cook AR,Hill MJ,Smith PL,Walters CL,Forster JK,Martin LE,Woodings DF

doi

10.1136/gut.28.6.726

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

726-38

issue

6

eissn

0017-5749

issn

1468-3288

journal_volume

28

pub_type

杂志文章

相关文献

GUT文献大全
  • Prednisolone absorption in acute colitis.

    abstract::Peak plasma levels were reduced after an oral dose of 40 mg prednisolone in six patients with severe acute colitis as compared with six normal subjects, though total absorption appeared to be similar; the findings suggest that prednisolone absorption was delayed in acute colitis. A dilutional fall in plasma albumin wa...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.21.1.49

    authors: Elliott PR,Powell-Tuck J,Gillespie PE,Laidlow JM,Lennard-Jones JE,English J,Chakraborty J,Marks V

    更新日期:1980-01-01 00:00:00

  • Induction of various cytokines and development of severe mucosal inflammation by cagA gene positive Helicobacter pylori strains.

    abstract:BACKGROUND:Helicobacter pylori strains possessing the cagA gene are thought to induce interleukin 8 (IL-8) in gastric mucosa. However, it is still unclear whether a relation exists between the cagA gene and the expression patterns of cytokines other than IL-8. AIMS:To investigate the relation between the cagA gene and...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.41.4.442

    authors: Yamaoka Y,Kita M,Kodama T,Sawai N,Kashima K,Imanishi J

    更新日期:1997-10-01 00:00:00

  • U.K. guidelines on the management of variceal haemorrhage in cirrhotic patients.

    abstract::These updated guidelines on the management of variceal haemorrhage have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines which this document supersedes were written in 2...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-309262

    authors: Tripathi D,Stanley AJ,Hayes PC,Patch D,Millson C,Mehrzad H,Austin A,Ferguson JW,Olliff SP,Hudson M,Christie JM,Clinical Services and Standards Committee of the British Society of Gastroenterology.

    更新日期:2015-11-01 00:00:00

  • Computed tomography, ultrasound, and cholestatic jaundice.

    abstract::Computed tomography detected the presence of dilated ducts in 15 of 18 cases with extrahepatic obstructive jaundice and demonstrated the obstructing lesion in 18 out of 25. The cause of the obstruction was detected in the absence of duct dilatation, and calculi which were radiolucent on conventional radiographs were d...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.19.8.685

    authors: Morris A,Fawcitt RA,Wood R,Forbes WS,Isherwood I,Marsh MN

    更新日期:1978-08-01 00:00:00

  • Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer.

    abstract:PURPOSE:Despite recent advances in colorectal cancer (CRC) treatment, the prognosis of patients suffering from this malignancy still remains substandard, and metastatic recurrence following curative surgery is the leading cause of mortality. Therefore, it is imperative to identify prognostic markers to predict the clin...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-309359

    authors: Okugawa Y,Toiyama Y,Toden S,Mitoma H,Nagasaka T,Tanaka K,Inoue Y,Kusunoki M,Boland CR,Goel A

    更新日期:2017-01-01 00:00:00

  • The effect of phenobarbital on cholesterol gallstones in hamsters.

    abstract::This experimental study was undertaken to follow the influence of phenobarbital on bile chemistry and gallstone formation. Phenobarbital (400 mg/kg/day) was administered to golden hamsters receiving a diet known to induce cholesterol gallstones. After a 28-day period none of the control animals had gallstones whereas ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.14.12.956

    authors: Lagarriga J,Bouchier IA

    更新日期:1973-12-01 00:00:00

  • Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma.

    abstract:OBJECTIVE:Hippo signalling is a recently identified major oncosuppressive pathway that plays critical roles in inhibiting hepatocyte proliferation, survival and hepatocellular carcinoma (HCC) formation. Hippo kinase (Mst1 and Mst2) inhibits HCC proliferation by suppressing Yap/Taz transcription activities. As human HCC...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2017-314061

    authors: Kim W,Khan SK,Liu Y,Xu R,Park O,He Y,Cha B,Gao B,Yang Y

    更新日期:2018-09-01 00:00:00

  • Acetylator phenotype and adverse effects of sulphasalazine in healthy subjects.

    abstract::Sulphasalazine (salicyl-azo-sulphapyridine) was ingested by 27 healthy subjects for five days at a dosage of 4 g daily. The acetylator phenotype of each subject had been established previously. The serum concentrations of the parent drug and its sulphapyridine-metabolites were determined and the adverse effects were r...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.13.4.278

    authors: Schröder H,Evans DA

    更新日期:1972-04-01 00:00:00

  • Early cancer of the gastric remnant.

    abstract::Early carcinoma of the gastric remnant was diagnosed in 19 patients between January 1976 and January 1986. In all patients early cancer was suspected at endoscopy and confirmed by biopsy and histology. The main reason for endoscopic examination was diffuse epigastric pain suggestive of stump gastritis. The surgical pr...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.29.3.298

    authors: Pointner R,Schwab G,Königsrainer A,Bodner E,Schmid KW

    更新日期:1988-03-01 00:00:00

  • Concentration of selenium in plasma and erythrocytes during total parenteral nutrition in Crohn's disease.

    abstract::Plasma- and erythrocyte-selenium concentrations were determined in five consecutive patients with Crohn's disease given preoperative total parenteral nutrition - nil per os - for a mean period of 34 days per patient. No blood components were administered during the total parenteral nutrition. Before the total parenter...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.26.1.50

    authors: Jacobson S,Plantin LO

    更新日期:1985-01-01 00:00:00

  • Portal and peripheral blood short chain fatty acid concentrations after caecal lactulose instillation at surgery.

    abstract::The major end products of fermentation, short chain fatty acids (acetate, propionate, butyrate) were measured in portal and peripheral venous blood after the caecal instillation of lactulose at surgery in patients undergoing elective cholecystectomy. Blood samples for short chain fatty acid measurement were taken befo...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.33.9.1249

    authors: Peters SG,Pomare EW,Fisher CA

    更新日期:1992-09-01 00:00:00

  • Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function.

    abstract:OBJECTIVE:The intestinal microbiome affects the prevalence and pathophysiology of a variety of diseases ranging from inflammation to cancer. A reduced taxonomic or functional diversity of the microbiome was often observed in association with poorer health outcomes or disease in general. Conversely, factors or manifest ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-322753

    authors: Frost F,Kacprowski T,Rühlemann M,Pietzner M,Bang C,Franke A,Nauck M,Völker U,Völzke H,Dörr M,Baumbach J,Sendler M,Schulz C,Mayerle J,Weiss FU,Homuth G,Lerch MM

    更新日期:2020-11-09 00:00:00

  • Regulation of tumour necrosis factor (TNF) induced apoptosis by soluble TNF receptors in Helicobacter pylori infection.

    abstract:BACKGROUND:Tumour necrosis factor (TNF) is a predominant cytokine produced in the gastric mucosa of patients with Helicobacter pylori infection. TNF induces apoptosis in a variety of cells. The soluble TNF receptors (sTNF-Rs) can be divided into sTNF-RI and sTNF-RII, both of which inhibit TNF activity. However, their p...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.45.1.24

    authors: Shibata J,Goto H,Arisawa T,Niwa Y,Hayakawa T,Nakayama A,Mori N

    更新日期:1999-07-01 00:00:00

  • In healthy volunteers, immunohistochemistry supports squamous to columnar metaplasia as mechanism of expansion of cardia, aggravated by central obesity.

    abstract:INTRODUCTION:Recently, we showed that the length of cardiac mucosa in healthy volunteers correlated with age and obesity. We have now examined the immunohistological characteristics of this expanded cardia to determine whether it may be due to columnar metaplasia of the distal oesophagus. METHODS:We used the squamocol...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2014-308914

    authors: Derakhshan MH,Robertson EV,Yeh Lee Y,Harvey T,Ferrier RK,Wirz AA,Orange C,Ballantyne SA,Hanvey SL,Going JJ,McColl KE

    更新日期:2015-11-01 00:00:00

  • Oesophageal hiatus hernia in three generations of one family.

    abstract::A family is described in which eight members in three successive generations had a sliding type of oesophageal hiatus hernia (or partial thoracic stomach) as a sole anomaly. The trait in this family behaved as a strict dominant, manifesting the segregation of a single abnormal autosomal gene. Other possible aetiologie...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.11.1.51

    authors: Carré IJ,Froggatt P

    更新日期:1970-01-01 00:00:00

  • Induction of a fibrogenic response in mouse colon by overexpression of monocyte chemoattractant protein 1.

    abstract:BACKGROUND AND AIMS:Monocyte chemoattractant protein 1 (MCP-1) is increased transmurally in inflammatory bowel disease (IBD). Although MCP-1 is considered to play an important role in fibrotic disease in other organs, the role of MCP-1 in gut fibrosis is unknown. We investigated the fibrotic potential of MCP-1 in the g...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2005.068429

    authors: Motomura Y,Khan WI,El-Sharkawy RT,Verma-Gandhu M,Verdu EF,Gauldie J,Collins SM

    更新日期:2006-05-01 00:00:00

  • Comparison of the hepatic clearances of campesterol, sitosterol, and cholesterol in healthy subjects suggests that efflux transporters controlling intestinal sterol absorption also regulate biliary secretion.

    abstract:BACKGROUND:Recently identified ABCG5/8 transporters are responsible in part for the different absorption rates of campesterol, sitosterol, and cholesterol. These transporters are also expressed in the liver and might regulate biliary sterol secretion. AIMS:This study was therefore conducted to determine the biliary se...

    journal_title:Gut

    pub_type: 临床试验,杂志文章

    doi:10.1136/gut.51.6.860

    authors: Sudhop T,Sahin Y,Lindenthal B,Hahn C,Lüers C,Berthold HK,von Bergmann K

    更新日期:2002-12-01 00:00:00

  • A study of carbohydrate metabolism in postnecrotic cirrhosis liver.

    abstract::Intravenous glucose tolerance, insulin tolerance, tolbutamide, and glucagon tests were carried out in 21 patients with postnecrotic cirrhosis. Based arbitrarily on the bromsulphthalein retention they were divided into group A, nine patients with less impaired liver function, and group B, 12 patients with greater impai...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.15.11.907

    authors: Yeung RT,Wang CC

    更新日期:1974-11-01 00:00:00

  • Evaluation of the trophic effect of longterm treatment with the histamine H2 receptor antagonist loxtidine on rat oxyntic mucosa by differential counting of dispersed cells.

    abstract::To evaluate whether the general trophic effect of gastrin on the oxyntic mucosa is an indirect effect mediated by histamine H2 receptors, sustained 24 hour hypergastrinaemia was induced in Sprague-Dawley rats by treatment with the long acting and potent histamine H2 antagonist loxtidine for five months. The trophic ef...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.35.11.1547

    authors: Brenna E,Swarts HG,Klaassen CH,de Pont JJ,Waldum HL

    更新日期:1994-11-01 00:00:00

  • Vicia faba agglutinin, the lectin present in broad beans, stimulates differentiation of undifferentiated colon cancer cells.

    abstract:BACKGROUND:Dietary lectins can alter the proliferation of colonic cells. Differentiation is regulated by adhesion molecules which, being glycosylated, are targets for lectin binding. AIMS:To examine the effects of dietary lectins on differentiation, adhesion, and proliferation of colorectal cancer cells. METHODS:Diff...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.44.5.709

    authors: Jordinson M,El-Hariry I,Calnan D,Calam J,Pignatelli M

    更新日期:1999-05-01 00:00:00

  • Prophylactic effects of olsalazine v sulphasalazine during 12 months maintenance treatment of ulcerative colitis. The Danish Olsalazine Study Group.

    abstract::In a Danish multicentre trial we compared the relapse preventing effects of olsalazine and sulphasalazine in patients with ulcerative colitis over a 12 month treatment period. Two hundred and twenty seven patients (118 men) with at least two previous attacks of ulcerative colitis were randomly allocated according to a...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/gut.33.2.252

    authors: Kiilerich S,Ladefoged K,Rannem T,Ranløv PJ

    更新日期:1992-02-01 00:00:00

  • The risks of screening: data from the Nottingham randomised controlled trial of faecal occult blood screening for colorectal cancer.

    abstract:AIMS:To determine the harm that ensues from faecal occult blood (FOB) screening for colorectal cancer. METHODS:150 251 people were randomly allocated either to receive biennial Haemoccult FOB tests (n =75 253) or not to be contacted (n=74 998). Study group patients returning positive tests were offered colonic investi...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/gut.45.4.588

    authors: Robinson MH,Hardcastle JD,Moss SM,Amar SS,Chamberlain JO,Armitage NC,Scholefield JH,Mangham CM

    更新日期:1999-10-01 00:00:00

  • Association between antiviral treatment and extrahepatic outcomes in patients with hepatitis C virus infection.

    abstract:OBJECTIVE:To elucidate the association between antiviral therapy and extrahepatic outcomes in individuals infected with HCV. METHODS:This nationwide cohort study screened 293,480 Taiwanese residents with HCV infection and excluded those with substantial comorbidity. A total of 12,384 eligible patients who had received...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2014-308163

    authors: Hsu YC,Ho HJ,Huang YT,Wang HH,Wu MS,Lin JT,Wu CY

    更新日期:2015-03-01 00:00:00

  • Peripheral functional organisation of vagally evoked gastric motor responses in the ferret.

    abstract::The aims of the present study were to determine the relative amplitudes of intragastric motor responses evoked by different vagal branches and to establish whether the effects of acute or chronic vagotomy could be predicted from these data. Intragastric pressure responses to electrical stimulation of the vagus were me...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.21.10.811

    authors: Andrews PL,Lawes IN,Bower AJ

    更新日期:1980-10-01 00:00:00

  • Bone marrow transplantation improves hepatic fibrosis in Abcb4-/- mice via Th1 response and matrix metalloproteinase activity.

    abstract:OBJECTIVE:Reports on the effects of bone marrow-derived cells on hepatic fibrosis are contradictory. Impaired fibrosis but increased inflammation has recently been demonstrated 10 weeks after bone marrow transplantation (BM-Tx) in Abcb4-/- mice. It is hypothesised that BM-Tx might have long-term therapeutic potential b...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2011-300608

    authors: Roderfeld M,Rath T,Pasupuleti S,Zimmermann M,Neumann C,Churin Y,Dierkes C,Voswinckel R,Barth PJ,Zahner D,Graf J,Roeb E

    更新日期:2012-06-01 00:00:00

  • ACTH-secreting 'apudoma' of gallbladder.

    abstract::The case of a 44-year-old woman is reported. The diagnosis after the appropriate tests and laparotomy was ACTH-secreting 'apudoma' of the gallbladder. This is a rare tumour and this case is believed to be the first reported of an ectopic hormone producing tumour from this side. ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.16.6.473

    authors: Spence RW,Burns-Cox CJ

    更新日期:1975-06-01 00:00:00

  • The relevance of gastrointestinal fistulae in clinical practice: a review.

    abstract::Gastrointestinal fistulae most frequently occur as complications after abdominal surgery (75-85%) although they can also occur spontaneously--for example, in patients with inflammatory bowel disease (IBD) such as diverticulitis or following radiation therapy. Abdominal trauma can also lead to fistula formation althoug...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.49.suppl_4.iv2

    authors: Falconi M,Pederzoli P

    更新日期:2001-12-01 00:00:00

  • Availability of monoglutamyl and polyglutamyl folates in normal subjects and in patients with coeliac sprue.

    abstract::Intestinal folate absorption was assessed in six normal subjects and in four patients with coeliac sprue who were studied before and after treatment by dietary gluten exclusion. Comparisons were made of the luminal disappearance from the perfused jejunum of 3H-pteroylmonoglutamate and pteroyl 14C-glutamylhexaglutamate...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.19.10.886

    authors: Halsted CH,Reisenauer AM,Shane B,Tamura T

    更新日期:1978-10-01 00:00:00

  • Spirochaetosis of the human rectum associated with an intraepithelial mast cell and IgE plasma cell response.

    abstract::In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes using electron microscopy and immunohistochemistry showed certain unusual features: the microorganisms were observed within ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.28.5.588

    authors: Gebbers JO,Ferguson DJ,Mason C,Kelly P,Jewell DP

    更新日期:1987-05-01 00:00:00

  • Green tea consumption and gastric cancer in Japanese: a pooled analysis of six cohort studies.

    abstract:BACKGROUND:Previous experimental studies have suggested many possible anti-cancer mechanisms for green tea, but epidemiological evidence for the effect of green tea consumption on gastric cancer risk is conflicting. OBJECTIVE:To examine the association between green tea consumption and gastric cancer. METHODS:We anal...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2008.166710

    authors: Inoue M,Sasazuki S,Wakai K,Suzuki T,Matsuo K,Shimazu T,Tsuji I,Tanaka K,Mizoue T,Nagata C,Tamakoshi A,Sawada N,Tsugane S,Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.

    更新日期:2009-10-01 00:00:00