Abstract:
BACKGROUND:Previous experimental studies have suggested many possible anti-cancer mechanisms for green tea, but epidemiological evidence for the effect of green tea consumption on gastric cancer risk is conflicting. OBJECTIVE:To examine the association between green tea consumption and gastric cancer. METHODS:We analysed original data from six cohort studies that measured green tea consumption using validated questionnaires at baseline. Hazard ratios (HRs) in the individual studies were calculated, with adjustment for a common set of variables, and combined using a random-effects model. RESULTS:During 2 285 968 person-years of follow-up for a total of 219 080 subjects, 3577 cases of gastric cancer were identified. Compared with those drinking <1 cup/day, no significant risk reduction for gastric cancer was observed with increased green tea consumption in men, even in stratified analyses by smoking status and subsite. In women, however, a significantly decreased risk was observed for those with consumption of > or =5 cups/day (multivariate-adjusted pooled HR = 0.79, 95% confidence interval (CI) = 0.65 to 0.96). This decrease was also significant for the distal subsite (HR = 0.70, 95% CI = 0.50 to 0.96). In contrast, a lack of association for proximal gastric cancer was consistently seen in both men and women. CONCLUSIONS:Green tea may decrease the risk of distal gastric cancer in women.
journal_name
Gutjournal_title
Gutauthors
Inoue M,Sasazuki S,Wakai K,Suzuki T,Matsuo K,Shimazu T,Tsuji I,Tanaka K,Mizoue T,Nagata C,Tamakoshi A,Sawada N,Tsugane S,Research Group for the Development and Evaluation of Cancer Prevention Strategies in Japan.doi
10.1136/gut.2008.166710subject
Has Abstractpub_date
2009-10-01 00:00:00pages
1323-32issue
10eissn
0017-5749issn
1468-3288pii
gut.2008.166710journal_volume
58pub_type
杂志文章相关文献
GUT文献大全abstract:OBJECTIVE:As pathogen sensors, Toll-like receptors (TLR) play a role in the first defence line during HCV infection. However, the impact of the DNA sensor TLR9 on the natural course of HCV infection is unknown. To address this, TLR9 promoter polymorphisms (single nucleotide polymorphisms (SNPs)) rs187084 and rs5743836 ...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gutjnl-2015-310239
更新日期:2017-10-01 00:00:00
abstract::Progress in the management of hepatocellular carcinoma (HCC) has been slow and has limited impact on outcome. Most patients with HCC have two diseases--chronic liver disease and HCC--and complex interactions between the two have major implications for diagnosis and prognosis as well as the management of HCC. The disea...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.51.4.459
更新日期:2002-10-01 00:00:00
abstract::The most reliable method of making a specific aetiological diagnosis of chronic viral hepatitis would be to identify virus specific cytotoxic T lymphocytes responsible for the killing of virus infected hepatocytes in each patient's liver. Unfortunately, this can not be proposed for routine diagnosis and surrogate test...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.2_suppl.s36
更新日期:1993-01-01 00:00:00
abstract::Overtubes are short sleeves designed to fit over the shaft of fibrescopes. Several home made overtubes have been described. We have reviewed design principles and many potential applications, which are not widely appreciated. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.9.863
更新日期:1983-09-01 00:00:00
abstract::A group of 80 patients with diseases of the small intestine were given a standardized psychiatric assessment every time they attended the outpatients' department over a period of a year. Forty-six patients with idiopathic steatorrhoea, 23 patients with Crohn's disease, and 11 patients with alactasia were interviewed o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.6.459
更新日期:1970-06-01 00:00:00
abstract::Peptide histidine isoleucine, a 27 amino acid peptide with close amino acid sequence homology to vasoactive intestinal peptide and secretin, is distributed throughout the mammalian intestinal tract, where it has been localised to intramural neurones. An intestinal perfusion technique has been used to study the effect ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.6.624
更新日期:1984-06-01 00:00:00
abstract:BACKGROUND:Motor disturbances are sometimes associated with diarrhoea by unknown mechanisms. AIM:To determine if there is a quantitative link between intestinal motility and epithelial secretion. SUBJECTS:Experiments were performed in 21 healthy volunteers and three patients with villus atrophy. METHODS:Duodenal and...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.46.3.376
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:Early detection and early treatment are of vital importance to the successful treatment of various cancers. The development of a novel screening method that is as economical and non-invasive as the faecal occult blood test (FOBT) for early detection of colorectal cancer (CRC) is needed. A study was undertaken...
journal_title:Gut
pub_type: 杂志文章,随机对照试验
doi:10.1136/gut.2010.218305
更新日期:2011-06-01 00:00:00
abstract::Following a prolonged period of relative inertia, real progress has been made in the past few years in understanding the pathogenesis of the chronic inflammatory bowel diseases, Crohn's disease and ulcerative colitis. Clinical experience, epidemiological studies, and molecular genetics have provided strong evidence th...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.50.suppl_3.iii31
更新日期:2002-05-01 00:00:00
abstract:BACKGROUND:Recent reports have described a modulating influence of nitric oxide (NO) on intestinal mucosal permeability and have implicated a role for mast cells in this NO mediated process. AIMS:To assess further the contribution of mast cells to the mucosal permeability changes elicited by the NO synthase (NOS) inhi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.5.636
更新日期:1997-11-01 00:00:00
abstract::Although a high prevalence of antibodies to Helicobacter pylori has been documented within families, culture and DNA typing of strains from infected children and their parents has not been evaluated. This study aimed to analyse H pylori infection within family groups. Endoscopy, gastric biopsy, and H pylori culture we...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.10.1348
更新日期:1993-10-01 00:00:00
abstract::To explore the role played by beta adrenoreceptor mediated pathways on human upper gut function a series of studies were conducted into the effects of beta adrenoreceptor agonists and antagonists on orocaecal and duodenocaecal transit and on antral and duodenal motor activity. Under control conditions orocaecal transi...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.33.8.1062
更新日期:1992-08-01 00:00:00
abstract:BACKGROUND:Activated hepatic stellate cells (HSCs) are an attractive target for antifibrotic therapy based on their key role in extracellular matrix accumulation during liver injury. AIM:: To develop a system for regulable and cell-specific gene expression in HSCs to enable targeted delivery of therapeutic genes. MET...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.085704
更新日期:2007-03-01 00:00:00
abstract::Computed tomography detected the presence of dilated ducts in 15 of 18 cases with extrahepatic obstructive jaundice and demonstrated the obstructing lesion in 18 out of 25. The cause of the obstruction was detected in the absence of duct dilatation, and calculi which were radiolucent on conventional radiographs were d...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.8.685
更新日期:1978-08-01 00:00:00
abstract::Heat shock proteins (HSPs) are a highly conserved family of proteins which inhabit almost all subcellular locations and cellular membranes. Depending on their location, these proteins perform a variety of chaperoning functions including folding of newly synthesised polypeptides. HSPs also play a major role in the prot...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.2007.140194
更新日期:2009-07-01 00:00:00
abstract:AIM:This prospective study aimed to compare the accuracy of echo enhanced ultrasound with spiral computed tomography (CT) in assessing acute pancreatitis and to explore the correlation between ultrasound findings and clinical outcome. METHODS:Thirty one patients (24 men and 7 women, median age 39 years, range 19-67 ye...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.070276
更新日期:2006-01-01 00:00:00
abstract::This study reports on a group of 20 patients with an initial diagnosis of primary biliary cirrhosis (PBC) whose serum tested negative for antimitochondrial antibodies by immunofluorescence. All had a clinical history compatible with primary biliary cirrhosis, and results of biochemical, histological, and radiological ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.2.260
更新日期:1994-02-01 00:00:00
abstract::'Tumour response', defined as clinical or radiological evidence of tumour shrinkage is frequently regarded as an objective of chemotherapy, rather than as a predictor of prolonged survival. This study has assessed whether a fall in the serum CEA concentration after chemotherapy for disseminated colorectal cancer is a ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.12.1625
更新日期:1987-12-01 00:00:00
abstract::A simple evocative test has been used to study pancreatic function. Serial estimations of amylase and lipase in blood serum are made at intervals up to six hours and again at 24 hours after injecting intravenously standard doses of secretin and pancreozymin. The results of 213 tests on a normal group, in pancreatic di...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.1.2.125
更新日期:1960-06-01 00:00:00
abstract::The size of the related lymph nodes and their histology has been correlated in 34 specimens of Crohn's disease. Granulomata were shown not to affect the maximum diameter of the lymph nodes nor to be more frequent in large nodes. The enlargement of lymph nodes appeared to be due to simple, non-specific, reactive change...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.12.970
更新日期:1972-12-01 00:00:00
abstract::The prevalence of antibodies against hepatitis C virus (anti-HCV) among intravenous drug users (IVDU) has consistently been very high. Cross challenge studies in chimpanzees provide evidence that reinfection with different HCV strains may occur. In humans, reinfection with different HCV strains has been reported in mu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.6.900
更新日期:2003-06-01 00:00:00
abstract::Steatorrhoea has been found in a large proportion of patients with inflammatory dermatoses, especially eczema and psoriasis. It is due to the rash itself and disappears rapidly after topical treatment of the skin. This particular enteropathy, unlike that associated with dermatitis herpetiformis, is not accompanied by ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.4.292
更新日期:1970-04-01 00:00:00
abstract:BACKGROUND:Tumour vascularisation is a determinant of the development of metastases. AIMS:To measure blood flow in normal stomach and gastric adenocarcinomas by laser Doppler flowmetry and correlate blood flow with vascularisation after immunohistochemical staining of resected specimens for CD31 and von Willebrand fac...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.45.3.341
更新日期:1999-09-01 00:00:00
abstract:BACKGROUND:Suicide gene therapy consists of the transfer into tumour cells of a "suicide" gene that can convert a non-toxic compound into a lethal drug. Expression of the cytosine deaminase gene leads to the conversion of the non-toxic compound 5-fluorocytosine to 5-fluorouracil. We have recently shown that "suicide ce...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.3.387
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Gastric cancer remains a major cause of cancer mortality globally but no good prognostic tumour marker is available. Soluble fragment of E-cadherin protein has been reported to increase in the sera of patients with cancer and recently was found to be elevated in 67% of patients with gastric cancer. AIMS:To ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.6.808
更新日期:2001-06-01 00:00:00
abstract::Seventy six patients with dysphagia caused by malignant tumours of the oesophagus or gastric cardia have been treated using the Neodymium Yttrium Aluminium Garnet (NdYag) laser. The laser was set to deliver 80-100 watts of power for 0.5-1 second pulses. To obtain improvement, patients on average needed four treatment ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.7.792
更新日期:1987-07-01 00:00:00
abstract::Partial gastrectomy and intestinal resection significantly impaired glucose tolerance (p < 0.05) and significantly decreased the release of insulin by intravenous glucose (p < 0.05) or a meal of minced beef (p < 0.01). There was a significantly greater release of insulin one hour after oral glucose in the gastrectomy ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.11.871
更新日期:1972-11-01 00:00:00
abstract:OBJECTIVE:The colonic inner mucus layer protects us from pathogens and commensal-induced inflammation, and has been shown to be defective in active UC. The aim of this study was to determine the underlying compositional alterations, their molecular background and potential contribution to UC pathogenesis. DESIGN:In th...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-317571
更新日期:2019-12-01 00:00:00
abstract::Forty patients with endoscopically proven persistent duodenal ulcer who had been treated for six weeks with cimetidine (1 g/day) were randomly allocated to receive a further six weeks' treatment with cimetidine (1 g/day) or ranitidine (300 mg/day). Ulcers healed in 12 of 19 patients given cimetidine (63%) and in 13 of...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.25.10.1113
更新日期:1984-10-01 00:00:00
abstract::Fifteen patients with severe intractable irritable bowel syndrome previously reported as successfully treated with hypnotherapy, have now been followed up for a mean duration of 18 months. All patients remain in remission although two have experienced a single relapse overcome by an additional session of hypnotherapy....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.4.423
更新日期:1987-04-01 00:00:00