Abstract:
OBJECTIVE:Osteoporosis and fractures are frequently encountered in patients with Crohn's disease. In order to prevent fractures, treatment with bone protecting drugs appears warranted early in the course of bone disease when bone loss is not yet prominent. We therefore aimed to demonstrate a beneficial effect on bone density of the bisphosphonate risedronate in osteopenic Crohn's disease patients. METHODS:This double-blind, placebo-controlled randomised trial of risedronate with calcium and vitamin D supplementation was performed in osteopenic Crohn's disease patients. Patients were treated for 2 years with follow-up after 3 and after every 6 months. Disease characteristics and activity and bone turnover markers were assessed at all visits; dual x-ray absorptiometry was performed at baseline, 12 and 24 months; radiographs of the spine at baseline and 24 months. RESULTS:Of 132 consenting patients, 131 were randomised (67 placebo and 64 risedronate). Patient characteristics were similar in both groups, although the risedronate group was slightly heavier (body mass index 24.3 vs 23.0 kg/m(2)). Bone mineral density at lumbar spine increased 0.04 g/cm(2) on average in the risedronate group versus 0.01 g/cm(2) in the placebo group (p=0.007). The mean increase in total hip bone mineral density was 0.03 versus 0.01 g/cm(2), respectively (p=0.071). Fracture prevalence and incidence were similar. Change of T-scores and concentrations of bone turnover markers were consistent with a beneficial effect of risedronate when compared with placebo. The effect of risedronate was primarily demonstrated in the first 12 months of treatment. No serious unexpected suspected adverse events were observed. CONCLUSIONS:A 24-month treatment course with risedronate 35 mg once weekly, concomitant with calcium and vitamin D supplementation, in osteopenic Crohn's disease patients improved bone density at lumbar spine. NTR 163 Dutch Trial Register.
journal_name
Gutjournal_title
Gutauthors
van Bodegraven AA,Bravenboer N,Witte BI,Dijkstra G,van der Woude CJ,Stokkers PC,Russel MG,Oldenburg B,Pierik M,Roos JC,van Hogezand RA,Dik VK,Oostlander AE,Netelenbos JC,van de Langerijt L,Hommes DW,Lips P,Dutch Initiatdoi
10.1136/gutjnl-2013-305523subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1424-30issue
9eissn
0017-5749issn
1468-3288pii
gutjnl-2013-305523journal_volume
63pub_type
杂志文章,多中心研究,随机对照试验相关文献
GUT文献大全abstract:BACKGROUND AND AIMS:Insulin-like growth factor (IGF) I receptor (IGF-Ir) signalling is required for carcinogenicity and proliferation of many tumours but this pathway has not been studied in detail in gastric cancer. We have previously shown successful therapy for colorectal, pancreatic, and lung cancer using recombina...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.048926
更新日期:2005-05-01 00:00:00
abstract::Since pancreatobiliary diversion probably stimulates pancreatic growth by increasing cholecystokinin secretion, the effect of the cholecystokinin antagonist CR-1409 on this adaptive response was tested. Male Wistar rats (n = 108) weighing 220-250g were randomised to receive either pancreatobiliary diversion (n = 60) o...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.9.1049
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:The identification of gastric superficial cancerous lesions based on conventional white-light endoscopy (WLE) is challenging, and histological analysis remains the 'gold standard' for the final diagnosis. Confocal laser endomicroscopy (CLE) can provide in vivo histological observation without the need for bi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.223586
更新日期:2011-03-01 00:00:00
abstract::The medication history of patients presenting with benign oesophageal stricture is compared with an age and sex matched control population selected from the community. Fifty five out of 151 consecutive admissions to a dysphagia clinic were found to have benign oesophageal stricture. Twenty six out of 53 (49%) had been...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.5.478
更新日期:1984-05-01 00:00:00
abstract::Lymphocytes obtained after enzymatic digestion of intestinal biopsies from patients with coeliac disease were examined for the presence of gliadin specific antibody secreting cells by means of the ELISPOT technique. This technique permits enumeration of gliadin antibody secreting immunocytes, differentiated with regar...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.1.72
更新日期:1989-01-01 00:00:00
abstract::The role of biliary deoxycholate as an endogenous colon carcinogen and the possible association between cholelithiasis and/or cholecystectomy and the subsequent development of large bowel cancer is unclear. This paper describes biliary bile acids analysis performed on 13 patients undergoing cholecystectomy for gall st...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.6.860
更新日期:1989-06-01 00:00:00
abstract::An ileitis developing years or months after ileostomy was recognised and described many years ago but has rarely been mentioned since. We describe nine patients with a non-specific preanastomotic ileitis that developed years after colectomy in patients operated on for ulcerative colitis or carcinoma. The disease devel...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.3.373
更新日期:1994-03-01 00:00:00
abstract::The problems associated with recurrent Crohn's disease were examined in a series of 168 patients who had undergone primary resection for this condition at the General Infirmary at Leeds from 1939 to 1968 inclusive. The overall recurrence rate was 34.2%. The risk of recurrence was less in patients with involvement main...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.7.519
更新日期:1971-07-01 00:00:00
abstract:OBJECTIVE:Hepatocellular carcinoma (HCC) is a heterogeneous tumour displaying a complex variety of genetic and epigenetic changes. In human cancers, aberrant post-transcriptional modifications, such as alternative splicing and RNA editing, may lead to tumour specific transcriptome diversity. DESIGN:By utilising large ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-304037
更新日期:2014-05-01 00:00:00
abstract::Overtubes are short sleeves designed to fit over the shaft of fibrescopes. Several home made overtubes have been described. We have reviewed design principles and many potential applications, which are not widely appreciated. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.9.863
更新日期:1983-09-01 00:00:00
abstract::Infection with the delta agent can only occur in the context of coexistent hepatitis B virus infection. We describe a patient in whom the clinical features of acute delta hepatitis developed when seroconversion from hepatitis B surface antigen to antibody had already occurred and diagnosis of recent acute hepatitis B ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.2.212
更新日期:1985-02-01 00:00:00
abstract::The hormones secretin and cholecystokinin-pancreozymin (CCK) have been shown to release brush-border alkaline phosphatase into the small-intestinal lumen in the human subject. In contrast to the disaccharidases, large amounts of alkaline phosphatase are present in human duodenal juice. The range has been established i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.1.39
更新日期:1974-01-01 00:00:00
abstract::The sample population in this initial case control study of the adenosine diphosphate ribosyl transferase (ADPRT) response of inflammatory bowel disease patients included: 23 patients with ulcerative colitis (UC)-active and inactive, 13 patients with Crohn's disease (CD)-active and inactive, 14 first degree relatives ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.12.1680
更新日期:1988-12-01 00:00:00
abstract::The aim of this study is to assess the value of jejunal manometry in the diagnosis of subacute mechanical obstruction distal to the proximal small bowel. In a retrospective review of 850 manometric tracings carried out in patients with unexplained nausea, vomiting, abdominal pain or altered bowel movements, 16 tracing...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.4.468
更新日期:1989-04-01 00:00:00
abstract:BACKGROUND:5-Lipoxygenase products play a part in inflammatory response. AIMS:The effect of intracolonic administration of zileuton (a 5-lipoxygenase inhibitor) on colonic damage and eicosanoid local release was assessed in a rat model of colitis. METHODS:Ninety rats with trinitrobenzenesulphonic acid induced colitis...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.38.6.899
更新日期:1996-06-01 00:00:00
abstract::Because previous studies have suggested that red cell membrane sialic acid might be a determinant of survival in vivo, we examined the relationship between haemolysis, erythrocyte membrane sialic acid, and hepatic neuraminidase (sialidase) levels in experimental cholestatic jaundice in rats. Treatment of normal rat er...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.10.794
更新日期:1974-10-01 00:00:00
abstract:BACKGROUND:The prevalence of duodenal carcinoma is much higher in familial adenomatous polyposis (FAP) than in the background population, and duodenal adenomatosis is found in most polyposis patients. AIMS:To describe the long term natural history of duodenal adenomatosis in FAP and evaluate if cancer prophylactic sur...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2003.027771
更新日期:2004-03-01 00:00:00
abstract::In 18 patients intermediary anabolic metabolites of 5-FU were measured in normal colonic mucosa and colorectal cancer tissue of intravenous bolus injection or continuous infusion. Higher total concentrations of 5-FU products were found in the cancers when compared with normal colonic tissue. There appeared to be no ev...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.2.176
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Different acid and peptic related gastroduodenal diseases are associated with both increased gastric secretion and Helicobacter pylori infection. Patients with H pylori associated gastritis or duodenal ulcer have increased serum pepsinogen levels which decrease after eradication. The mechanisms of H pylori i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.50.1.13
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:In this study, we identify the nature of the immunological response of human peripheral blood mononuclear cells (PBMC) and lamina propria gastric lymphocytes (LPL) to two Helicobacter pylori antigens, the neutrophil activating protein (NapA) and alkyl hydroperoxide reductase (AphC). These antigens were ident...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.025494
更新日期:2005-01-01 00:00:00
abstract::A 45 year old man is described with Whipple's disease who presented with weight loss, lethargy, and ascites. He subsequently developed fever and a mass in the neck, but died despite antibiotic treatment and nutritional support. Necropsy showed extraintestinal lymphoma. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.11.1627
更新日期:1993-11-01 00:00:00
abstract::Levels of clotting factors II, V, and VII were measured on admission and then daily in 12 patients with grade IV hepatic coma due to fulminant hepatic failure. Factor VII levels obtained within 36 hours of the development of grade IV coma were not of value in predicting which patients would subsequently recover consci...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.7.489
更新日期:1976-07-01 00:00:00
abstract::TNM (tumour, node, metastases) staging has thus far been the most important guide to prognosis in patients with gastric cancer. Histological grading, in contrast, has not provided any additional information. Recently a novel grading system based on tubular differentiation and mucus production has been proposed, which ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.6.758
更新日期:1994-06-01 00:00:00
abstract::Ranitidine bismuth citrate was compared with an equipotent dose of ranitidine, to determine whether the former, by an anti-Helicobacter pylori activity, would counteract the rise of gastrin resulting from ranitidine's gastric acid antisecretory activity. Twenty four men with duodenal ulcers were studied before and on ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.34.3.338
更新日期:1993-03-01 00:00:00
abstract::The effect of the unconjugated bile acids, cholic, deoxycholic, chenodeoxycholic, and ursodeoxycholic acids, and of the conjugated bile acid taurocholic acid on the mucosal-to-serosal transport and tissue uptake of the naturally occurring folate derivative, 5-methyltetrahydrofolate (5-CH3H4PteGlu) was examined in ever...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.12.1376
更新日期:1984-12-01 00:00:00
abstract::This report assesses the value of cholinesterase (ChE) activity as an indicator of liver function and analyses its usefulness in the diagnosis of jaundice. A rapid method of determination has been used, and alterations in ChE activity in conditions other than liver disease have been studied to permit a fuller and more...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.1.4.294
更新日期:1960-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Progression of a colorectal adenoma to invasive cancer occurs in a minority of adenomas and is the most crucial step in colorectal cancer pathogenesis. In the majority of cases, this is associated with gain of a substantial part of chromosome 20q, indicating that multiple genes on the 20q ampli...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301153
更新日期:2012-11-01 00:00:00
abstract::In duodenal ulceration the Alcian blue staining acid mucosubstances in goblet cells are reduced and the goblet cells themselves disappear. At the same time periodic acid-Schiff (PAS) staining neutral mucosubstances appear in the cells of the surface epithelium. These changes have been measured quantitatively with the ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.10.909
更新日期:1983-10-01 00:00:00
abstract::The actions of hydrochloric acid, natural PGE1, PGE2 and a synthetic commercial PGE1 preparation, Enisoprost (Searle) on pepsinogen synthesis and secretion were studied in canine chief cell monolayer cultures. Hydrochloric acid, applied directly to the apical surface of chief cells using culture plate inserts (Millipo...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.6.774
更新日期:1989-06-01 00:00:00
abstract:BACKGROUND AND AIMS:Assessing the presence and degree of intestinal inflammation objectively, simply, and reliably is a significant problem in gastroenterology. We assessed faecal excretion of calprotectin, a stable neutrophil specific marker, as an index of intestinal inflammation and its potential use as a screening ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.47.4.506
更新日期:2000-10-01 00:00:00