Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome.

abstract：:To evaluate whether the general trophic effect of gastrin on the oxyntic mucosa is an indirect effect mediated by histamine H2 receptors, sustained 24 hour hypergastrinaemia was induced in Sprague-Dawley rats by treatment with the long acting and potent histamine H2 antagonist loxtidine for five months. The trophic ef...

journal_title：Gut

authors： Brenna E,Swarts HG,Klaassen CH,de Pont JJ,Waldum HL

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:Vedolizumab is a gut-selective antibody to α4β7 integrin for the treatment of ulcerative colitis (UC) and Crohn's disease (CD). We report an integrated summary of the safety of vedolizumab. DESIGN:Safety data (May 2009-June 2013) from six trials of vedolizumab were integrated. Adverse events were evaluated i...

journal_title：Gut

authors： Colombel JF,Sands BE,Rutgeerts P,Sandborn W,Danese S,D'Haens G,Panaccione R,Loftus EV Jr,Sankoh S,Fox I,Parikh A,Milch C,Abhyankar B,Feagan BG

更新日期：2017-05-01 00:00:00

abstract：:Helicobacter pylori causes chronic (type B) gastritis. The 'intestinal' form of gastric cancer arises against a background of chronic gastritis, and prospective epidemiological studies have shown that H pylori is a major risk factor for this. An increase in mucosal cell proliferation increases the likelihood of a neop...

journal_title：Gut

authors： Lynch DA,Mapstone NP,Clarke AM,Sobala GM,Jackson P,Morrison L,Dixon MF,Quirke P,Axon AT

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:Colorectal cancer (CRC) leads to significant morbidity/mortality worldwide. Defining critical research gaps (RG), their prioritisation and resolution, could improve patient outcomes. DESIGN:RG analysis was conducted by a multidisciplinary panel of patients, clinicians and researchers (n=71). Eight working gr...

journal_title：Gut

authors： Lawler M,Alsina D,Adams RA,Anderson AS,Brown G,Fearnhead NS,Fenwick SW,Halloran SP,Hochhauser D,Hull MA,Koelzer VH,McNair AGK,Monahan KJ,Näthke I,Norton C,Novelli MR,Steele RJC,Thomas AL,Wilde LM,Wilson RH,Tomlins

更新日期：2018-01-01 00:00:00

abstract：:There are sex differences in large bowel cancer rates and a variety of other gastrointestinal disorders possibly because of differences in gut biology. To determine whether men and women have different gastrointestinal responses when consuming identical intakes of dietary fibre, 16 women and 18 men consumed liquid for...

journal_title：Gut

authors： Lampe JW,Fredstrom SB,Slavin JL,Potter JD

更新日期：1993-04-01 00:00:00

abstract：:The staining of HLA class II antigens, the presence of cells positive for interleukin-2 receptors, the proportion of crypt cells in mitosis in the jejunal biopsy specimens, and the dose of coeliac disease marker HLA-DQ genes were studied in 75 healthy family members of coeliac disease patients. Eleven had silent coeli...

journal_title：Gut

authors： Holm K,Savilahti E,Koskimies S,Lipsanen V,Mäki M

更新日期：1994-01-01 00:00:00

abstract：:Carbenoxolone (Biogastrone, Berk) has been shown to reduce the peptic activity and total acidity of gastric juice obtained from anaesthetized pylorus-ligated rats without affecting significantly the volume of gastric juice secreted or the K(+) concentration. Glycyrrhetinic acid was less potent in reducing peptic activ...

journal_title：Gut

authors： Henman FD

更新日期：1970-04-01 00:00:00

abstract：OBJECTIVE:Current strategies to guide selection of neoadjuvant therapy in oesophageal adenocarcinoma (OAC) are inadequate. We assessed the ability of a DNA damage immune response (DDIR) assay to predict response following neoadjuvant chemotherapy in OAC. DESIGN:Transcriptional profiling of 273 formalin-fixed paraffin-...

journal_title：Gut

authors： Turkington RC,Knight LA,Blayney JK,Secrier M,Douglas R,Parkes EE,Sutton EK,Stevenson L,McManus D,Halliday S,McCavigan AM,Logan GE,Walker SM,Steele CJ,Perner J,Bornschein J,MacRae S,Miremadi A,McCarron E,McQuaid S,

更新日期：2019-11-01 00:00:00

abstract：:Clinical history, questionnaire data and response to antisecretory therapy are insufficient to make a conclusive diagnosis of GERD in isolation, but are of value in determining need for further investigation. Conclusive evidence for reflux on oesophageal testing include advanced grade erosive oesophagitis (LA grades C...

journal_title：Gut

authors： Gyawali CP,Kahrilas PJ,Savarino E,Zerbib F,Mion F,Smout AJPM,Vaezi M,Sifrim D,Fox MR,Vela MF,Tutuian R,Tack J,Bredenoord AJ,Pandolfino J,Roman S

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:It has been suggested that slow transit constipation (STC) may be part of a panenteric motor disorder. AIM:To evaluate motility of an upper gastrointestinal organ, the gall bladder, in 16 patients with STC and 20 healthy controls. METHODS:Gall bladder emptying (ultrasonography) was studied in response to n...

journal_title：Gut

authors： Penning C,Gielkens HA,Delemarre JB,Lamers CB,Masclee AA

更新日期：1999-08-01 00:00:00

abstract：BACKGROUND:The aim of the study was to test the hypothesis that in the fasting state, proximal intestinal HCO3- absorption, which depends on villus Na+/H+ exchanger activity, is tonically inhibited by a cholinergic atropine sensitive mechanism. SUBJECTS:The experiments were performed in 34 healthy volunteers and in ei...

journal_title：Gut

authors： Mellander A,Sjövall H

更新日期：1999-03-01 00:00:00

abstract：:Cell cultures derived from Crohn's disease and control tissues were subjected to a series of tests designed to detect persistent, non-cytocidal virus infection. No evidence for any such infection was found, and it is concluded that persistent viral infection of gut tissues is unlikely to play a significant role in the...

journal_title：Gut

authors： Phillpotts RJ,Hermon-Taylor J,Teich NM,Brooke BN

更新日期：1980-03-01 00:00:00

abstract：:Lymphocytic gastritis and primary gastric lymphoma are rare conditions with unknown aetiology. It has recently been suggested that Helicobacter pylori has a role in the pathogenesis of both of them. The occurrence of lymphocytic gastritis and H pylori was studied in a series of patients with primary gastric lymphoma. ...

journal_title：Gut

authors： Miettinen A,Karttunen TJ,Alavaikko M

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Whole body catabolism as the result of intrahepatic metabolic derangement is common in liver transplant candidates. However, individual nutritional assessment parameters lack sensitivity and specificity in determining energy status of these patients. Recently, serum hepatocyte growth factor (HGF) has been sh...

journal_title：Gut

authors： Miki C,Mayer AD,Buckels JA,Iriyama K,Suzuki H,McMaster P

更新日期：1999-06-01 00:00:00

abstract：:A simple method based on atomic absorption spectrophotometry and using protein concentration as the reference standard was used for measuring the total tissue iron concentration in needle liver biopsy specimens from 47 patients with varying levels of body iron stores. The values obtained showed a close correlation ove...

journal_title：Gut

authors： Walker RJ,Miller JP,Dymock IW,Shilkin KB,Williams R

更新日期：1971-12-01 00:00:00

abstract：:Salivary amylase output in man increases after injection of synthetic human calcitonin. This effect is dose dependent. ...

journal_title：Gut

authors： Drack GT,Koelz HR,Blum AL

更新日期：1976-08-01 00:00:00

abstract：OBJECTIVE:Gastric carcinoma development is triggered by Helicobacter pylori. Chronic H. pylori infection leads to reduced acid secretion, which may allow the growth of a different gastric bacterial community. This change in the microbiome may increase aggression to the gastric mucosa and contribute to malignancy. Our a...

journal_title：Gut

authors： Ferreira RM,Pereira-Marques J,Pinto-Ribeiro I,Costa JL,Carneiro F,Machado JC,Figueiredo C

更新日期：2018-02-01 00:00:00

abstract：:The secretory response of gastric acid to pure ethanol and alcoholic beverages may be different because the action of the non-ethanolic contents of the beverage may overwhelm that of ethanol. Pure ethanol in low concentrations (< 5% vol/vol) is a mild stimulant of acid secretion whereas at higher concentrations it has...

journal_title：Gut

authors： Chari S,Teyssen S,Singer MV

更新日期：1993-06-01 00:00:00

abstract：:Seven patients with hypoalbuminaemia and extensive jejunoileal Crohn's disease were treated with an elemental diet for 28 to 56 days. Over this time there was an increase in total plasma proteins from mean of 49.1 to 59.0 g/l and a mean rise in serum albumin from 20.7 to 30.0 g/l (P less than 0.05). In addition, there...

journal_title：Gut

authors： Logan RF,Gillon J,Ferrington C,Ferguson A

更新日期：1981-05-01 00:00:00

abstract：BACKGROUND:Nitric oxide is a major neurotransmitter in non-adrenergic, non-cholinergic (NANC) pathways. NANC inhibitory innervation has been shown in human gall bladder muscle in vitro; the role of nitric oxide in human gall bladder emptying however is undefined. AIMS:To study the effect of glyceryl trinitrate, a nitr...

journal_title：Gut

authors： Greaves R,Miller J,O'Donnell L,McLean A,Farthing MJ

更新日期：1998-03-01 00:00:00

abstract：:Central reading, that is, independent, off-site, blinded review or reading of imaging endpoints, has been identified as a crucial component in the conduct and analysis of inflammatory bowel disease clinical trials. Central reading is the final step in a workflow that has many parts, all of which can be improved. Furth...

journal_title：Gut

authors： Gottlieb K,Daperno M,Usiskin K,Sands BE,Ahmad H,Howden CW,Karnes W,Oh YS,Modesto I,Marano C,Stidham RW,Reinisch W

更新日期：2021-02-01 00:00:00

abstract：:Intravenous glucose tolerance, insulin tolerance, tolbutamide, and glucagon tests were carried out in 21 patients with postnecrotic cirrhosis. Based arbitrarily on the bromsulphthalein retention they were divided into group A, nine patients with less impaired liver function, and group B, 12 patients with greater impai...

journal_title：Gut

authors： Yeung RT,Wang CC

更新日期：1974-11-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a human pathogen responsible for acute and chronic liver disease, infecting an estimated 130-170 million persons worldwide. An intriguing feature of HCV infection is its peculiar relationship with lipids: (1) HCV virions circulate in serum bound to lipoproteins; (2) lipids have been shown to...

journal_title：Gut

authors： Negro F

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Abdominal pain and discomfort are common symptoms in functional disorders and are attributed to visceral hypersensitivity. These symptoms fluctuate over time but the basis for this is unknown. Here we examine the impact of changes in gut flora and gut inflammatory cell activity on visceral sensitivi...

journal_title：Gut

authors： Verdú EF,Bercik P,Verma-Gandhu M,Huang XX,Blennerhassett P,Jackson W,Mao Y,Wang L,Rochat F,Collins SM

更新日期：2006-02-01 00:00:00

abstract：:Twenty one patients with diabetic peripheral neuropathy, 18 with idiopathic faecal incontinence and 11 normal controls were studied with techniques of mucosal electrosensitivity, rectal distension for the quantitative assessment of anorectal sensation, and manometric and electromyographic tests for the assessment of a...

journal_title：Gut

authors： Rogers J,Levy DM,Henry MM,Misiewicz JJ

更新日期：1988-06-01 00:00:00

abstract：:Peptide histidine isoleucine, a 27 amino acid peptide with close amino acid sequence homology to vasoactive intestinal peptide and secretin, is distributed throughout the mammalian intestinal tract, where it has been localised to intramural neurones. An intestinal perfusion technique has been used to study the effect ...

journal_title：Gut

authors： Moriarty KJ,Hegarty JE,Tatemoto K,Mutt V,Christofides ND,Bloom SR,Wood JR

更新日期：1984-06-01 00:00:00

abstract：:Clinical data and histology from the oesophagus, gastric antrum, and duodenum were collected from 36 patients undergoing surgery for duodenal ulcer. Gastritis was present in 94% of the patients (25% of atrophic type), oesophagitis in 72% and duodenitis in 39%. Abnormal biopsies were present from all three sites in 33%...

journal_title：Gut

authors： Earlam RJ,Amerigo J,Kakavoulis T,Pollock DJ

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) have been reported to protect against the development of colon cancer. However, the mechanism(s) by which NSAIDs exert their effects is not clear. AIMS:The aim of this study was to examine the effects of NSAIDs on mRNA expression of tumour suppressor adenomatou...

journal_title：Gut

authors： Kishimoto Y,Takata N,Jinnai T,Morisawa T,Shiota G,Kawasaki H,Hasegawa J

更新日期：2000-12-01 00:00:00

abstract：AIMS:To determine the sources of founding for UK gastroenterology research papers and the relative impact of papers funded by different groups and of unfunded ones. METHODS:UK gastroenterology papers from 1988-94 were selectively retrieved from the Science Citation Index by means of a specially constructed filter base...

journal_title：Gut

authors： Lewison G

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree of the defect may be associated with risk in some types of cancer, especially cancers associated with chronic inflammation. OBJECTIVE:To d...

journal_title：Gut

authors： Asada K,Nakajima T,Shimazu T,Yamamichi N,Maekita T,Yokoi C,Oda I,Ando T,Yoshida T,Nanjo S,Fujishiro M,Gotoda T,Ichinose M,Ushijima T

更新日期：2015-03-01 00:00:00