Potential difference across the normal and the abnormal gastric mucosa in man.

abstract：:The purpose of this single blind controlled multicentre trial was to compare the relative effectiveness of pirenzepine and cimetidine in healing endoscopically proven duodenal ulcers. One hundred and twenty six patients with duodenal ulcer were treated with a daily dose of 100 mg pirenzepine (50 mg each before breakfa...

journal_title：Gut

authors： Brunner H,Dittrich H,Kratochvil P,Brandstätter G,Hentschel E,Schütze K,Tragl KH,Kern H,Löffelmann K,Zeiler H

更新日期：1984-02-01 00:00:00

abstract：:Both experimental cholecystitis and luminal distension inhibit fluid absorption and stimulate motor activity in the gall bladder. These functional alterations are mimicked by exogenous prostaglandins (PGs) and inhibited by potent cyclooxygenase inhibitors, but direct evidence of a primary role of endogenous PGs is not...

journal_title：Gut

authors： Thornell E,Jivegård L,Bukhave K,Rask-Madsen J,Svanvik J

更新日期：1986-04-01 00:00:00

abstract：OBJECTIVES:Lipid mediators in the GI tract regulate satiation and satiety. Bile acids (BAs) regulate the absorption and metabolism of dietary lipid in the intestine, but their effects on lipid-regulated satiation and satiety are completely unknown. Investigating this is challenging because introducing excessive BAs or ...

journal_title：Gut

authors： Higuchi S,Ahmad TR,Argueta DA,Perez PA,Zhao C,Schwartz GJ,DiPatrizio NV,Haeusler RA

更新日期：2020-09-01 00:00:00

abstract：AIMS:To compare jejunal mucosal morphometry in HIV infected patients resident in London and Uganda. PATIENTS:Twenty HIV positive patients from London and 16 from Uganda were studied, and compared with HIV negative control subjects from both sites. METHODS:Stools and biopsy specimens were examined for enteropathogens....

journal_title：Gut

authors： Batman PA,Kapembwa MS,Miller AR,Sedgwick PM,Lucas S,Sewankambo NK,Serwadda D,Pudney J,Moody A,Harris JR,Griffin GE

更新日期：1998-09-01 00:00:00

abstract：BACKGROUND:Dyspepsia is a chronic disease with significant impact on the use of health care resources. A management strategy based on Helicobacter pylori testing has been recommended but the long term effect is unknown. AIM:To investigate the long term effect of a test and treat strategy compared with prompt endoscopy...

journal_title：Gut

authors： Lassen AT,Hallas J,Schaffalitzky de Muckadell OB

更新日期：2004-12-01 00:00:00

abstract：BACKGROUND AND AIM:There are few data on the course of Helicobacter pylori infection in asymptomatic subjects. The aim of this study was to assess the effect of eradication therapy on the development of dyspeptic and gastro-oesophageal reflux disease in a cohort of asymptomatic individuals observed over a prolonged per...

journal_title：Gut

authors： Vaira D,Vakil N,Rugge M,Gatta L,Ricci C,Menegatti M,Leandro G,Holton J,Russo VM,Miglioli M

更新日期：2003-11-01 00:00:00

abstract：BACKGROUND:Sodium butyrate, a product of colonic bacterial fermentation, is able to inhibit cell proliferation and to stimulate cell differentiation of colonic epithelial cell lines. It has been proposed that these cellular effects could be linked to its ability to cause hyperacetylation of histone through the inhibiti...

journal_title：Gut

authors： Siavoshian S,Segain JP,Kornprobst M,Bonnet C,Cherbut C,Galmiche JP,Blottière HM

更新日期：2000-04-01 00:00:00

abstract：BACKGROUND:Patients with chronic hepatitis B (CHB) infection are at an increased risk of developing hepatocellular carcinoma (HCC). Risk scores have been developed in Asian populations to predict HCC risk over time. AIM:To assess the performance of HCC risk prediction models in a heterogeneous population of patients w...

journal_title：Gut

authors： Abu-Amara M,Cerocchi O,Malhi G,Sharma S,Yim C,Shah H,Wong DK,Janssen HL,Feld JJ

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:The aim of the study was to test the hypothesis that in the fasting state, proximal intestinal HCO3- absorption, which depends on villus Na+/H+ exchanger activity, is tonically inhibited by a cholinergic atropine sensitive mechanism. SUBJECTS:The experiments were performed in 34 healthy volunteers and in ei...

journal_title：Gut

authors： Mellander A,Sjövall H

更新日期：1999-03-01 00:00:00

abstract：OBJECTIVE:Chronic pancreatitis is a progressive inflammatory disorder of the pancreas characterised by permanent destruction of acinar cells. Mutations in the chymotrypsinogen C (CTRC) gene have been linked to the development of chronic pancreatitis. The aim of the present study was to explore whether CTRC mutants indu...

journal_title：Gut

authors： Szmola R,Sahin-Tóth M

更新日期：2010-03-01 00:00:00

abstract：:Nutritional status and immune function were correlated with clinical features in 56 patients with Crohn's disease. These were divided arbitrarily into either undernourished or well nourished groups according to whether their midarm circumference was below or above 90% of ideal standard. Results were also compared with...

journal_title：Gut

authors： Harries AD,Danis VA,Heatley RV

更新日期：1984-05-01 00:00:00

abstract：:Gastroparesis is defined by the presence of delayed gastric emptying (GE) in the absence of mechanical obstruction. Symptoms that have been attributed to gastroparesis include postprandial fullness, early satiation nausea and vomiting. Gastroprokinetic drugs are the preferred treatment option. A number of problems wit...

journal_title：Gut

authors： Stanghellini V,Tack J

更新日期：2014-12-01 00:00:00

abstract：:Colonic biopsy specimens were obtained from patients undergoing surgery for carcinoma of the rectum. Colonic resistance arteries (internal diameter 178-345 microns) were dissected out under the microscope and mounted in a microvascular myograph capable of measuring isometric tension development. Experiments were desig...

journal_title：Gut

authors： Mortensen FV,Nielsen H,Mulvany MJ,Hessov I

更新日期：1990-12-01 00:00:00

abstract：:The effects of drugs which change the bile-salt-independent fraction of bile flow on Na(+)K(a+) and Mg(2+) activated ATPases were studied in membrane fractions rich in bile canaliculi. The administration of phenobarbital caused no induction of these enzymes which could explain the increased bile flow observed in the r...

journal_title：Gut

authors： Laperche Y,Launay A,Oudéa P

更新日期：1972-11-01 00:00:00

abstract：:Results from a recent, new assay suggest that omeprazole, a potent inhibitor of gastric acid secretion, is genotoxic. The principle of this assay is that the non-proliferating zone of surface gastric epithelial cells can be selectively removed by controlled digestion so that any incorporation of tritiated thymidine in...

journal_title：Gut

authors： Goodlad RA,Lee CY,Alison MR,Sarraf CE,Ghatei MA,Bloom SR,Wright NA

更新日期：1993-02-01 00:00:00

abstract：:The leakiness of the cell membranes of colonic epithelial cells isolated by the collagenase/Dispase technique from normal or diseased colons was assessed in a 4 h 51Cr release assay. Cells from normal, adenoma bearing or cancer bearing colons showed 51Cr release of 8% or less in almost all of 46 cell populations teste...

journal_title：Gut

authors： Gibson PR,van de Pol E,Barratt PJ,Doe WF

更新日期：1988-04-01 00:00:00

abstract：BACKGROUND:Thrombosis may be an important effector mechanism in the pathogenesis of Crohn's disease. METHODS:This study therefore investigated the prevalence of independent thrombotic risk factors (factor VII coagulant activity, lipoprotein (a), fibrinogen, plasma triglycerides, and smoking) in patients with Crohn's d...

journal_title：Gut

authors： Hudson M,Chitolie A,Hutton RA,Smith MS,Pounder RE,Wakefield AJ

更新日期：1996-05-01 00:00:00

abstract：:Serum gastrin levels have been studied in 70 patients with chronically reduced glomerular filtration rate (GFR) as estimated by 51Cr-EDTA clearance, creatinine, and beta2-microglobulin values. A strong dependence upon GFR was found, although the correlation between gastrin levels and GFR was not as high as that betwee...

journal_title：Gut

authors： Hällgren R,Karlsson FA,Lundqvist G

更新日期：1978-03-01 00:00:00

abstract：:Carriers of beta amino acids and imino acids in the small intestine of rabbits and guinea pigs are chloride dependent, and a cotransport of chloride, sodium, and 2-methyl-aminoisobutyric acid has been shown. This study examines the chloride dependence of amino acid transport in the human small intestine. The steady st...

journal_title：Gut

authors： Munck LK

更新日期：1995-02-01 00:00:00

abstract：:Duodenal function was studied in 11 healthy volunteers after intragastric instillation of a mixed semi-elemental meal. The duodenum accepted chyme of varying pH, osmolality, and nutrient concentration; and, as a result of biliary, pancreatic, and enteric secretion as well as absorption, it delivered chyme with nearly ...

journal_title：Gut

authors： Miller LJ,Malagelada JR,Go VL

更新日期：1978-08-01 00:00:00

abstract：:This paper describes four patients whose chief symptoms were steatorrhoea and loss of weight. Despite the absence of a history of abdominal pain investigations showed that these patients had chronic pancreatitis, which responded to medical treatment. The pathological findings in two of these cases and in six which cam...

journal_title：Gut

authors： GOULSTON SJ,GALLAGHER ND

更新日期：1962-09-01 00:00:00

abstract：BACKGROUND:The intestinal microbiota plays a critical role in the pathophysiology of pouchitis, a major complication after ileal pouch anal anastomosis in patients with ulcerative colitis. Recently, controlled trials have demonstrated that probiotics are effective in maintenance of remission in pouchitis patients. Howe...

journal_title：Gut

authors： Kühbacher T,Ott SJ,Helwig U,Mimura T,Rizzello F,Kleessen B,Gionchetti P,Blaut M,Campieri M,Fölsch UR,Kamm MA,Schreiber S

更新日期：2006-06-01 00:00:00

abstract：:Serumfolate folate levels and the bacteriology of the small intestine were studied in 13 patients with jejunal diverticulosis, 29 patients with partial gastrectomy, and five patients with ileal disease. The mean serum folate level in the patients with partial gastrectomy (7.2 mmug/ml) was similar to that of control su...

journal_title：Gut

authors： Hoffbrand AV,Tabaqchali S,Booth CC,Mollin DL

更新日期：1971-01-01 00:00:00

abstract：:The highest prevalence rates of hepatitis C virus infection in the world have been recently reported among Egyptian blood donors and frequent recipients of transfusions and other blood products. This is the first report, however, demonstrating hepatitis C as the most frequent association with chronic liver disease in ...

journal_title：Gut

authors： Waked IA,Saleh SM,Moustafa MS,Raouf AA,Thomas DL,Strickland GT

更新日期：1995-07-01 00:00:00

abstract：BACKGROUND:A decrease in arterial isoleucine values after intragastric blood administration in pigs has been observed. This contrasted with increased values of most other amino acids, ammonia, and urea. After an isonitrogenous control meal in these pigs all amino acids including isoleucine increased, and urea increased...

journal_title：Gut

authors： Dejong CH,Meijerink WJ,van Berlo CL,Deutz NE,Soeters PB

更新日期：1996-07-01 00:00:00

abstract：OBJECTIVE:Lower GI bleeding (LGIB) is a common reason for emergency hospital admission, although there is paucity of data on presentations, interventions and outcomes. In this nationwide UK audit, we describe patient characteristics, interventions including endoscopy, radiology and surgery as well as clinical outcomes....

journal_title：Gut

authors： Oakland K,Guy R,Uberoi R,Hogg R,Mortensen N,Murphy MF,Jairath V,UK Lower GI Bleeding Collaborative.

更新日期：2018-04-01 00:00:00

abstract：:Rosetting techniques were used to estimate T and B cell subpopulations in the peripheral blood in patients with treated and untreated adult coeliac disease and in control subjects. In patients with untreated coeliac disease, T cell numbers were significantly lower than in controls or treated patients, although there w...

journal_title：Gut

authors： Bullen AW,Losowsky MS

更新日期：1978-10-01 00:00:00

abstract：BACKGROUND:Whole body catabolism as the result of intrahepatic metabolic derangement is common in liver transplant candidates. However, individual nutritional assessment parameters lack sensitivity and specificity in determining energy status of these patients. Recently, serum hepatocyte growth factor (HGF) has been sh...

journal_title：Gut

authors： Miki C,Mayer AD,Buckels JA,Iriyama K,Suzuki H,McMaster P

更新日期：1999-06-01 00:00:00

abstract：BACKGROUND:The ground squirrel on a high cholesterol diet exhibits prolonged intestinal transit, a pathogenetic factor in cholesterol gallstone formation. AIMS:To examine the effect of a high cholesterol diet on the characteristics of the migrating myoelectrical complex (MMC) and the potential benefit of erythromycin....

journal_title：Gut

authors： Xu QW,Scott RB,Tan DT,Shaffer EA

更新日期：1998-12-01 00:00:00

abstract：:Carbenoxolone (Biogastrone, Berk) has been shown to reduce the peptic activity and total acidity of gastric juice obtained from anaesthetized pylorus-ligated rats without affecting significantly the volume of gastric juice secreted or the K(+) concentration. Glycyrrhetinic acid was less potent in reducing peptic activ...

journal_title：Gut

authors： Henman FD

更新日期：1970-04-01 00:00:00