Dietary polyamines are essential luminal growth factors for small intestinal and colonic mucosal growth and development.

abstract：BACKGROUND/AIM:The reliability of a quantitative method for the non-invasive assessment of intestinal disaccharide hydrolysis was assessed. METHODS:Differential excretion of intact disaccharide, expressed as ratios of lactulose to appropriate hydrolysable disaccharides in urine collected following combined ingestion, ...

journal_title：Gut

authors： Bjarnason I,Batt R,Catt S,Macpherson A,Maxton D,Menzies IS

更新日期：1996-09-01 00:00:00

abstract：OBJECTIVE:Crohn's disease (CD) is associated with increased risk of small bowel cancer (SBC), but previous studies have been small. We aimed to examine the risk of incident SBC and death from SBC in patients with inflammatory bowel disease (IBD). DESIGN:In a binational, population-based cohort study from Sweden and De...

journal_title：Gut

authors： Axelrad JE,Olén O,Sachs MC,Erichsen R,Pedersen L,Halfvarson J,Askling J,Ekbom A,Sørensen HT,Ludvigsson JF

更新日期：2021-02-01 00:00:00

abstract：:An elderly woman with chronic ulcerative colitis who developed proximal muscle weakness, increased serum creatine phosphokinase activity, and histological and electromyographic abnormalities characteristic of polymyositis is described. Treatment with corticosteroids and 5-acetylsalicylic acid was followed by a remissi...

journal_title：Gut

authors： Chugh S,Dilawari JB,Sawhney IM,Dang N,Radotra BD,Chawla YK

更新日期：1993-04-01 00:00:00

abstract：:Hydrogen breath tests are widely used to explore the pathophysiology of functional gastrointestinal disorders. Small intestinal bacterial overgrowth and carbohydrate malabsorption are disorders detected by these tests that have been proposed to be of great importance for symptoms in, for instance, irritable bowel synd...

journal_title：Gut

authors： Simrén M,Stotzer PO

更新日期：2006-03-01 00:00:00

abstract：BACKGROUND:Lamina propria (LPLs) and intraepithelial (IELs) lymphocytes are markedly increased in coeliac mucosa, and are thought to play a crucial role in the generation of villous atrophy in coeliac disease (CD). However, the mechanisms by which they mediate the killing of enterocytes in this condition are still poor...

journal_title：Gut

authors： Di Sabatino A,Ciccocioppo R,D'Alò S,Parroni R,Millimaggi D,Cifone MG,Corazza GR

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:The role of intestinal transporter regulation in optimising nutrient absorption has been studied extensively in rodent and cell line models but not in human subjects. AIMS:The aim of the present study was to investigate the response in vivo of zinc transporters in the human enterocyte to dietary zinc supple...

journal_title：Gut

authors： Cragg RA,Phillips SR,Piper JM,Varma JS,Campbell FC,Mathers JC,Ford D

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVE:Exposure of the oesophageal mucosa to gastric acid and bile acids leads to the accumulation of reactive oxygen species (ROS), a known risk factor for Barrett's oesophagus and progression to oesophageal adenocarcinoma (OAC). This study investigated the functions of glutathione peroxidase 7 (GPX7), frequently s...

journal_title：Gut

authors： Peng D,Belkhiri A,Hu T,Chaturvedi R,Asim M,Wilson KT,Zaika A,El-Rifai W

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND AND AIMS:The role of GATA factors in cancer has gained increasing attention recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is controversial. GATA6 is amplified in a subset of tumours and was proposed to be oncogenic, but high GATA6 levels are found in well-differentiated tumou...

journal_title：Gut

authors： Martinelli P,Carrillo-de Santa Pau E,Cox T,Sainz B Jr,Dusetti N,Greenhalf W,Rinaldi L,Costello E,Ghaneh P,Malats N,Büchler M,Pajic M,Biankin AV,Iovanna J,Neoptolemos J,Real FX

更新日期：2017-09-01 00:00:00

abstract：:We report massive acute haemolysis associated with hepatitis A in a 36 year old Irish woman. Although mild anaemia is not uncommon during viral hepatitis, haemolysis of the severity observed in this patient has previously been reported only in patients with glucose-6-phosphate dehydrogenase deficiency. ...

journal_title：Gut

authors： Lyons DJ,Gilvarry JM,Fielding JF

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:In association with innate and adaptive immunity, the microbiota controls the colonisation resistance against intestinal pathogens. Caspase recruitment domain 9 (CARD9), a key innate immunity gene, is required to shape a normal gut microbiota. Card9-/- mice are more susceptible to the enteric mouse pathogen C...

journal_title：Gut

authors： Lamas B,Michel ML,Waldschmitt N,Pham HP,Zacharioudaki V,Dupraz L,Delacre M,Natividad JM,Costa GD,Planchais J,Sovran B,Bridonneau C,Six A,Langella P,Richard ML,Chamaillard M,Sokol H

更新日期：2018-10-01 00:00:00

abstract：BACKGROUND AND AIMS:Biliary lipid absorption by the gall bladder mucosa and the cholesterol content of the gall bladder wall appear to play a role in cholesterol gall stone formation. As the scavenger receptor class B type I (SR- BI) regulates cellular cholesterol uptake, we studied its expression in human and murine g...

journal_title：Gut

authors： Miquel JF,Moreno M,Amigo L,Molina H,Mardones P,Wistuba II,Rigotti A

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is associated with cardiovascular risk. The aim of this study was to determine the role of fatty liver in predicting coronary artery disease and clinical outcomes in patients undergoing coronary angiogram. METHOD...

journal_title：Gut

authors： Wong VW,Wong GL,Yip GW,Lo AO,Limquiaco J,Chu WC,Chim AM,Yu CM,Yu J,Chan FK,Sung JJ,Chan HL

更新日期：2011-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Large numbers of plasma cells (PC) localise in the intestinal lamina propria (LP) where they play a critical role in the defence against pathogens. This study analyses the level of maturation reached by normal human colon LPPC in comparison with that of bone marrow (BM) PC. METHODS:A technique was ...

journal_title：Gut

authors： Medina F,Segundo C,Campos-Caro A,Salcedo I,García-Poley A,Brieva JA

更新日期：2003-03-01 00:00:00

abstract：BACKGROUND:An increasing number of case reports indicate potential nephrotoxicity of 5-aminosalicylic acid (5-ASA), which shares similarities with the chemical structures of both phenacetin and acetylsalicylic acid. AIM:In a point prevalence study the occurrence of sensitive indices indicative of early kidney malfunct...

journal_title：Gut

authors： Schreiber S,Hämling J,Zehnter E,Howaldt S,Daerr W,Raedler A,Kruis W

更新日期：1997-06-01 00:00:00

abstract：:Possible mechanisms by which liver antigen presenting cells (APC) may facilitate tolerance induction are discussed. Tolerance may be facilitated by a distinctive combination of factors, linked to the unique anatomical and microenvironmental features of the liver. ...

journal_title：Gut

authors： Lau AH,de Creus A,Lu L,Thomson AW

更新日期：2003-08-01 00:00:00

abstract：:Acute fulminant pancreatitis is associated with significant morbidity and mortality. To examine the outcome of conservative and surgical treatment of this disorder, 36 patients who survived an initial episode were restudied after a mean of six years. Fifty three per cent had developed diabetes mellitus, half of whom r...

journal_title：Gut

authors： Eriksson J,Doepel M,Widén E,Halme L,Ekstrand A,Groop L,Höckerstedt K

更新日期：1992-06-01 00:00:00

abstract：:Gastric antral vascular ectasia ('water melon stomach') is a poorly documented cause of occult upper gastrointestinal blood loss. We describe a case which emphasises the clinical and pathological difficulties that can be encountered in making this elusive diagnosis. ...

journal_title：Gut

authors： Gouldesbrough DR,Pell AC

更新日期：1991-08-01 00:00:00

abstract：OBJECTIVES:Gastric cancer is strongly associated with Helicobacter pylori (H. pylori). We conducted a previous systematic review and meta-analysis that suggested eradication therapy reduced future incidence of gastric cancer, but effect size was uncertain, and there was no reduction in gastric cancer-related mortality....

journal_title：Gut

authors： Ford AC,Yuan Y,Moayyedi P

更新日期：2020-12-01 00:00:00

abstract：:Synchronous cancers of the oesophagus and stomach diagnosed in a patient showing pronounced leucocytosis were examined for production of granulocyte colony stimulating factor (G-CSF) and expression of G-CSF receptor. Whereas enzyme immunoassay of tissue extracts showed that the oesophageal carcinoma produced G-CSF, th...

journal_title：Gut

authors： Ichiishi E,Yoshikawa T,Kogawa T,Yoshida N,Kondo M

更新日期：2000-03-01 00:00:00

abstract：:Three methods for dispensing nutritional solutions are compared in 48 patients with gastrointestinal diseases on intravenous nutrition during 3582 days. The protocol for intravenous nutrition applied by the nursing team and the solutions used were the same in the three groups. In group A standard bottles were used, wh...

journal_title：Gut

authors： Messing B,Beliah M,Girard-Pipau F,Leleve D,Bernier JJ

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:We previously described hepatitis reactivation in two carriers of the hepatitis C virus (HCV) genotype 2c. AIM:To assess the relationship between HCV genotypes and risk of hepatitis reactivation, we studied the course of aminotransferases in patients infected with the two relevant genotypes in Italy. PATIE...

journal_title：Gut

authors： Rumi MG,De Filippi F,La Vecchia C,Donato MF,Gallus S,Del Ninno E,Colombo M

更新日期：2005-03-01 00:00:00

abstract：:Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination. Its use may be complicated by the development of peripheral neuropathy and liver damage. The majority of patients with perhexiline neuropathy have an impaired ability to effect metabolic drug oxidation which is genetica...

journal_title：Gut

authors： Morgan MY,Reshef R,Shah RR,Oates NS,Smith RL,Sherlock S

更新日期：1984-10-01 00:00:00

abstract：:To investigate factors which predispose to relapse in patients with ulcerative colitis, we conducted a survey to compare the events occurring in the four weeks preceding the clinic attendance of 62 outpatients in remission with those taking place in the same period before the onset of relapse in 21 patients attending ...

journal_title：Gut

authors： Rampton DS,McNeil NI,Sarner M

更新日期：1983-03-01 00:00:00

abstract：BACKGROUND:Most colon cancers start with dysregulated Wnt/β-catenin signalling and remain a major therapeutic challenge. Examining whether HAMLET (human α-lactalbumin made lethal to tumour cells) may be used for colon cancer treatment is logical, based on the properties of the complex and its biological context. OBJEC...

journal_title：Gut

authors： Puthia M,Storm P,Nadeem A,Hsiung S,Svanborg C

更新日期：2014-01-01 00:00:00

abstract：:We have determined the relative importance of day and night time gastric acid inhibition for duodenal ulcer healing by comparing the anti-ulcer efficacy of a single morning with that of a single bedtime dose of ranitidine. One hundred and thirty patients with active duodenal ulcer were randomly assigned to a double-bl...

journal_title：Gut

authors： Bianchi Porro G,Parente F,Sangaletti O

更新日期：1990-04-01 00:00:00

abstract：OBJECTIVE:In treating patients with inflammatory bowel disease (IBD), how concomitant medications influence the response to infliximab is largely unexplored. We aim to evaluate whether proton pump inhibitors (PPIs) affect the response to infliximab therapy in patients with IBD. DESIGN:Patient-level data of adult patie...

journal_title：Gut

authors： Lu TX,Dapas M,Lin E,Peters T,Sakuraba A

更新日期：2020-12-17 00:00:00

abstract：OBJECTIVE:To investigate the success rate of cold snare polypectomy (CSP) for complete resection of 4-9 mm colorectal adenomatous polyps compared with that of hot snare polypectomy (HSP). DESIGN:A prospective, multicentre, randomised controlled, parallel, non-inferiority trial conducted in 12 Japanese endoscopy units....

journal_title：Gut

authors： Kawamura T,Takeuchi Y,Asai S,Yokota I,Akamine E,Kato M,Akamatsu T,Tada K,Komeda Y,Iwatate M,Kawakami K,Nishikawa M,Watanabe D,Yamauchi A,Fukata N,Shimatani M,Ooi M,Fujita K,Sano Y,Kashida H,Hirose S,Iwagami H,

更新日期：2018-11-01 00:00:00

abstract：OBJECTIVES:No trial has compared non-bismuth quadruple 'sequential' and 'concomitant' regimens in settings with increasing clarithromycin rates. The study aims to compare the effectiveness and safety of these therapies for Helicobacter pylori treatment. DESIGN:Prospective randomised clinical trial in 11 Spanish hospit...

journal_title：Gut

authors： McNicholl AG,Marin AC,Molina-Infante J,Castro M,Barrio J,Ducons J,Calvet X,de la Coba C,Montoro M,Bory F,Perez-Aisa A,Forné M,Gisbert JP,Participant Centres.

更新日期：2014-02-01 00:00:00

abstract：:Jejunal absorption of sodium and water has been investigated in 10 normal Indians and 11 patients with chronic tropical sprue. Normal saline and solutions containing amino acids and dipeptides were studied. In both groups little absorption of sodium and water from normal saline was seen. Mean water and sodium absorpti...

journal_title：Gut

authors： Hellier MD,Bhat P,Albert J,Baker SJ

更新日期：1977-06-01 00:00:00

abstract：OBJECTIVE:MicroRNAs (miRNAs) have been shown to offer great potential in the diagnosis of cancer. We investigated whether plasma miRNAs could discriminate between patients with and without colorectal cancer (CRC). METHODS:This study was divided into three phases: (1) marker discovery using real-time PCR-based miRNA pr...

journal_title：Gut

authors： Ng EK,Chong WW,Jin H,Lam EK,Shin VY,Yu J,Poon TC,Ng SS,Sung JJ

更新日期：2009-10-01 00:00:00