Abstract:
:Small bowel enteropathies that are associated with an autoimmune process are often resistant to treatment. Two children with autoimmune enteropathy were treated with cyclosporin A for eight months. Both improved, as assessed by growth, small intestinal mucosal morphology, and carbohydrate absorption. Cyclosporin A is useful in the treatment of autoimmune enteropathy. This report also suggests that T cell activation (which is suppressed by cyclosporin A) is important in the pathogenesis of this condition.
journal_name
Gutjournal_title
Gutauthors
Sanderson IR,Phillips AD,Spencer J,Walker-Smith JAdoi
10.1136/gut.32.11.1421subject
Has Abstractpub_date
1991-11-01 00:00:00pages
1421-5issue
11eissn
0017-5749issn
1468-3288journal_volume
32pub_type
杂志文章相关文献
GUT文献大全abstract:BACKGROUND:In transplant recipients with choledococholedocostomy (CDCD), endoscopic retrograde cholangiopancreatography (ERCP) remains the gold standard for the diagnosis of biliary leak or strictures. Transabdominal ultrasonography (TAUS) has been used to screen patients with suspected biliary tract complications, pri...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.6.900
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:The normal intestinal microflora plays an important role in host metabolism and provides a natural defence mechanism against invading pathogens. Although the microbiota in adults has been extensively studied, little is known of the changes that occur in the microflora with aging. These may have important con...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.2.198
更新日期:2001-02-01 00:00:00
abstract::Three pH electrodes in clinical use were examined--(1) antimony electrode with remote reference electrode (Synectics 0011), (2) glass electrode with remote reference electrode (Microelectrodes Inc. MI 506) and (3) combined glass electrode with integral reference electrode (Radiometer GK2801C). In vitro studies showed ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.8.935
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:Simple and inexpensive non-invasive fibrosis tests are highly needed but have been poorly studied in sub-Saharan Africa. METHODS:Using liver histology as a gold standard, we developed a novel index using routine laboratory tests to predict significant fibrosis in patients with chronic HBV infection in The G...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309260
更新日期:2016-08-01 00:00:00
abstract::To determine the optimum bile acid regimen for rapid gall stone dissolution, 48 gall stone patients were divided into four groups of 12 according to stone diameter and were randomly allocated to receive one of four treatment regimens: bedtime or mealtime chenodeoxycholic acid (CDCA, 12 mg/kg/day) and bedtime or mealti...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.33.3.381
更新日期:1992-03-01 00:00:00
abstract:BACKGROUND:Several inflammatory disorders of the intestine are characterised by enhanced expression of tumour necrosis factor alpha (TNF-alpha). Monocytes and macrophages have been suggested as a major cellular source of TNF-alpha in human gut, whereas mast cells, although known to be capable of producing TNF-alpha, ha...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.44.5.643
更新日期:1999-05-01 00:00:00
abstract::In an effort to assess connective tissue biosynthetic activity in human liver disease, collagen proline hydroxylase (a key enzyme in collagen biosynthesis) and the uptake of (35)S sulphate (a precursor of sulphated mucopolysaccharides) were measured in hepatic tissue obtained mainly by percutaneous biopsy.A procedure ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.4.260
更新日期:1974-04-01 00:00:00
abstract:BACKGROUND:Crohn's disease is one of the principal human chronic inflammatory bowel diseases. Although its aetiology is still unknown, its complex pathogenesis has environmental, immunological, and genetic determinants. CARD15 is the first susceptibility gene implicated in the predisposition to Crohn's disease and is k...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.6.840
更新日期:2003-06-01 00:00:00
abstract::Alkaline phosphatase has been extracted from human pancreas with n-butanol and has been shown to have distinctive isoenzyme characteristics when compared with the enzymes of small intestine and of normal serum. The enzyme has been demonstrated histochemically in a carcinoma of the pancreas and also in an islet cell tu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.13.7.513
更新日期:1972-07-01 00:00:00
abstract::When there is villus atrophy in a jejunal biopsy, intraepithelial lymphocyte (IEL) mitosis correlates with a diagnosis of coeliac disease. We have examined the significance of IEL mitosis in jejunal biopsies with normal villi. Counts of IEL per 100 villus enterocytes, and IEL mitosis per 1000 IEL, were carried out in ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.6.675
更新日期:1986-06-01 00:00:00
abstract::The secretory response of gastric acid to pure ethanol and alcoholic beverages may be different because the action of the non-ethanolic contents of the beverage may overwhelm that of ethanol. Pure ethanol in low concentrations (< 5% vol/vol) is a mild stimulant of acid secretion whereas at higher concentrations it has...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.34.6.843
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND:Portal systemic encephalopathy (PSE) is a complex neuropsychiatric syndrome associated with hepatic failure. Small scale studies have shown the benzodiazepine receptor antagonist flumazenil to be effective in ameliorating PSE. AIMS:To determine the efficacy of flumazenil in patients with non-comatous mild t...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.39.2.319
更新日期:1996-08-01 00:00:00
abstract:OBJECTIVES:To determine the therapeutic equivalence and safety of once daily (OD) versus three times daily (TID) dosing of a total daily dose of 3 g Salofalk (mesalazine) granules in patients with active ulcerative colitis. DESIGN:A randomised, double-blind, double-dummy, parallel group, multicentre, international, ph...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.2008.154302
更新日期:2009-02-01 00:00:00
abstract::This study determined the location and tissue density of cells immunoreactive for tumour necrosis factor alpha (TNF alpha) in intestinal specimens from 24 patients with chronic inflammatory bowel disease (15 with Crohn's disease, nine with ulcerative colitis) and 11 controls. There was significantly increased density ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.12.1705
更新日期:1993-12-01 00:00:00
abstract:OBJECTIVE:The risk of colorectal cancer after a previous negative colonoscopy is very low. Nevertheless, interval cancers occur. We aimed to assess the characteristics and predictors of interval cancers after negative colonoscopy. METHODS:A population-based case-control study was conducted in Southern Germany in 2003-...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301531
更新日期:2012-11-01 00:00:00
abstract::Small intestinal mucosa obtained from six fasting patients with cholera by a peroral biopsy technique was studied with the electron microscope. The cultures of their rectal swabs were all positive for Vibrio cholerae. In the absorptive cells, large pseudopod-like cytoplasmic processes with deformed microvilli or witho...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.7.531
更新日期:1974-07-01 00:00:00
abstract:BACKGROUND:Shanghai fever, a community-acquired enteric illness associated with sepsis caused by Pseudomonas aeruginosa, was first described in 1918. The understanding of Shanghai fever is incomplete. OBJECTIVE:To delineate the clinical features and to examine the host and microbial factors associated with Shanghai fe...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-304786
更新日期:2014-05-01 00:00:00
abstract::Gastroparesis is defined by the presence of delayed gastric emptying (GE) in the absence of mechanical obstruction. Symptoms that have been attributed to gastroparesis include postprandial fullness, early satiation nausea and vomiting. Gastroprokinetic drugs are the preferred treatment option. A number of problems wit...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-306084
更新日期:2014-12-01 00:00:00
abstract::Visceral hypersensitivity has been recognised as a characteristic of patients with irritable bowel syndrome (IBS). It may be involved in the pathogenesis of abdominal pain/discomfort, and seems to result from the sensitisation of nerve afferent pathways originating from the gastrointestinal tract. From a clinical poin...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.51.suppl_1.i67
更新日期:2002-07-01 00:00:00
abstract::The behaviour of basal and stimulated acid secretion, gastrin release, serum pepsinogen I, and gastric emptying of liquids was studied in 19 consecutive patients with Helicobacter pylori positive duodenal ulcer, over a follow up period of six months. Eleven patients were studied before and at three and six months afte...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.2.210
更新日期:1995-08-01 00:00:00
abstract::Several methods for the preparation of cell suspensions from human gastrointestinal mucosa were investigated. Satisfactory suspensions were obtained by incubating tissue fragments in a solution of collagenase and hyaluronidase overnight at 4 degrees C followed by 30 minutes at 37 degrees C. The resulting suspension co...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.10.898
更新日期:1978-10-01 00:00:00
abstract:BACKGROUND AND AIMS:Helicobacter pylori (H pylori) infection is a major risk factor in the development of distal gastric adenocarcinoma. Development of the invasive phenotype is associated with the phenomenon of epithelial:mesenchymal transition (EMT). Soluble heparin-binding epidermal growth factor (HB-EGF) has been i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.199794
更新日期:2010-08-01 00:00:00
abstract::The problems associated with recurrent Crohn's disease were examined in a series of 168 patients who had undergone primary resection for this condition at the General Infirmary at Leeds from 1939 to 1968 inclusive. The overall recurrence rate was 34.2%. The risk of recurrence was less in patients with involvement main...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.7.519
更新日期:1971-07-01 00:00:00
abstract::The effect of a new complex oligosaccharide exhibiting potent inhibitory action on alpha-glucoside hydrolases on intestinal absorption of sucrose in man was tested by constant in vivo perfusion of the jejunum. At concentrations of 4.65 or 15.5 X 10(-6)M the alpha-glucosidehydrolase inhibitor (alpha-GHI) markedly inhib...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.9.750
更新日期:1979-09-01 00:00:00
abstract::We report two patients with periampullary cysts associated with recurrent attacks of acute pancreatitis. In both patients the diagnosis was made preoperatively by upper gastrointestinal endoscopy and ERCP, which was also useful in determining the relationship of the cysts to the biliary and pancreatic ductal systems. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.3.358
更新日期:1987-03-01 00:00:00
abstract::A fifth instance of Crohn's disease in identical twins is reported. The evidence for genetic expression of the disease is considered and the possible mechanisms involved are reviewed. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.10.12.994
更新日期:1969-12-01 00:00:00
abstract::This pilot study was designed to assess the tolerance and effectiveness of interferon alfa-2b in patients with decompensated liver disease caused by chronic hepatitis B (n = 7) or C (n = 5). Preliminary results suggest that patients may benefit from small doses of interferon (improvement in liver function tests and re...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.2_suppl.s104
更新日期:1993-01-01 00:00:00
abstract::Upper gastrointestinal function in response to a mixed nutrient meal was evaluated in hyperthyroid patients, both before and after therapy, and in healthy controls. Gastric secretion, gastric emptying, and pancreatic secretion were all normal and normally integrated postprandially in the hyperthyroid patients. Bile ac...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.8.695
更新日期:1980-08-01 00:00:00
abstract::The host's humoral immune response to Helicobacter pylori has been used in the diagnosis of active infection with these organisms. Several commercial tests are available but there are few and unconfirmed reports of their efficacy. This study aimed to assess and compare the efficacy of the following H pylori serologica...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.4.461
更新日期:1993-04-01 00:00:00
abstract::Six of 25 renal transplant recipients had a duodenal ulcer at endoscopy. Histamine concentration and the activity of histamine methyltransferase, the degrading enzyme of histamine, were measured in gastric mucosal biopsies obtained at endoscopy and compared with patients with duodenal ulcer but not undergoing transpla...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.30.1.65
更新日期:1989-01-01 00:00:00