Sulindac and a cyclooxygenase-2 inhibitor, etodolac, increase APC mRNA in the colon of rats treated with azoxymethane.

abstract：OBJECTIVE:Chronic HBV infection affects more than 250 million people worldwide and remains a global healthcare problem in part because we lack curative treatment. Sustained viral control requires HBV-specific T cells, but these become functionally impaired in chronic infection. Clinical evidence indicates that function...

journal_title：Gut

authors： Hoogeveen RC,Robidoux MP,Schwarz T,Heydmann L,Cheney JA,Kvistad D,Aneja J,Melgaço JG,Fernandes CA,Chung RT,Boonstra A,Kim AY,Baumert TF,Timm J,Lewis-Ximenez LL,Tonnerre P,Lauer GM

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:Gluten-free diet (GFD) is the only management for coeliac disease (CD). Available methods to assess GFD compliance are insufficiently sensitive to detect occasional dietary transgressions that may cause gut mucosal damage. We aimed to develop a method to determine gluten intake and monitor GFD compliance in p...

journal_title：Gut

authors： Moreno ML,Cebolla Á,Muñoz-Suano A,Carrillo-Carrion C,Comino I,Pizarro Á,León F,Rodríguez-Herrera A,Sousa C

更新日期：2017-02-01 00:00:00

abstract：:Recent evidence suggests that the production of colorectal carcinogens is facilitated when the pH of the colonic contents is alkaline. It follows that the colonic intraluminal pH of patients with colorectal neoplasms should be higher than in normal subjects. Gastrointestinal pH has been measured in 30 patients with co...

journal_title：Gut

authors： Pye G,Evans DF,Ledingham S,Hardcastle JD

更新日期：1990-12-01 00:00:00

abstract：:Some patients with diarrhoea predominant irritable bowel syndrome have increased rectal sensitivity. It is uncertain, however, whether the diarrhoea is a consequence of the rectal sensitivity or if it is sensitising the rectum in some way. The aim of this study was to assess whether inducing diarrhoea in normal health...

journal_title：Gut

authors： Houghton LA,Wych J,Whorwell PJ

更新日期：1995-08-01 00:00:00

abstract：BACKGROUND:Interleukin 8 (IL-8) has recently been proposed to have an important role in mediating the development of the systemic sequelae associated with severe acute pancreatitis. AIMS:To define the role of IL-8 in acute pancreatitis by neutralising its effects with a monoclonal anti-IL-8 antibody (WS-4), in a rabbi...

journal_title：Gut

authors： Osman MO,Kristensen JU,Jacobsen NO,Lausten SB,Deleuran B,Deleuran M,Gesser B,Matsushima K,Larsen CG,Jensen SL

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND:There is a widespread notion that obesity leads to gastro-oesophageal reflux but scientific evidence of an association is limited and inconsistent. AIMS:To estimate the strength of the association between body mass and reflux symptoms, we performed a population based cross sectional interview study. SUBJEC...

journal_title：Gut

authors： Lagergren J,Bergström R,Nyrén O

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:Gut microbiota and diet are known to contribute to human metabolism. We investigated whether the metagenomic gut microbiota composition and function changes over pregnancy are related to gestational diabetes mellitus (GDM) and can be modified by dietary supplements, fish oil and/or probiotics. DESIGN:The gut...

journal_title：Gut

authors： Mokkala K,Paulin N,Houttu N,Koivuniemi E,Pellonperä O,Khan S,Pietilä S,Tertti K,Elo LL,Laitinen K

更新日期：2021-02-01 00:00:00

abstract：:To assess whether dietary antigens play a role in inflammatory bowel disease, 26 monozygotic twin pairs with inflammatory bowel disease and 52 healthy controls were investigated for serum antibodies (IgA, IgG, IgM) against ovalbumin, betalactoglobulin, gliadin, whole yeast (Saccharomyces cerevisiae) and yeast cell wal...

journal_title：Gut

authors： Lindberg E,Magnusson KE,Tysk C,Järnerot G

更新日期：1992-07-01 00:00:00

abstract：:Colonic exfoliated epithelial cells in faecal material provide a source of human DNA which has been analysed for the presence of the tumour marker ras, in order to detect early tumour cells. The stool samples were subjected to a preliminary sample preparation step followed by centrifugation. DNA was extracted from bot...

journal_title：Gut

authors： Smith-Ravin J,England J,Talbot IC,Bodmer W

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:Exposure of the oesophageal mucosa to gastric acid and bile acids leads to the accumulation of reactive oxygen species (ROS), a known risk factor for Barrett's oesophagus and progression to oesophageal adenocarcinoma (OAC). This study investigated the functions of glutathione peroxidase 7 (GPX7), frequently s...

journal_title：Gut

authors： Peng D,Belkhiri A,Hu T,Chaturvedi R,Asim M,Wilson KT,Zaika A,El-Rifai W

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Dietary lectins can alter the proliferation of colonic cells. Differentiation is regulated by adhesion molecules which, being glycosylated, are targets for lectin binding. AIMS:To examine the effects of dietary lectins on differentiation, adhesion, and proliferation of colorectal cancer cells. METHODS:Diff...

journal_title：Gut

authors： Jordinson M,El-Hariry I,Calnan D,Calam J,Pignatelli M

更新日期：1999-05-01 00:00:00

abstract：:Pectin has been shown to minimise the fall in blood glucose seen in patients who are troubled by hypoglycaemia attacks after gastric surgery. We therefore performed 50 g glucose tolerance tests with and without 14.5 g pectin on 11 post-gastric surgery patients. After pectin, the high postprandial levels of glucose, in...

journal_title：Gut

authors： Jenkins DJ,Bloom SR,Albuquerque RH,Leeds AR,Sarson DL,Metz GL,Alberti KG

更新日期：1980-07-01 00:00:00

abstract：:Though amoebic liver abscess and liver cirrhosis occur very commonly in hospital practice in the tropics, they have not to the knowledge of the present authors hitherto been reported to occur simultaneously in the same patient. The patient described here, who had clear-cut clinical and histological features of chronic...

journal_title：Gut

authors： Falaiye JM,Okeke GC,Fregene AO

更新日期：1980-02-01 00:00:00

abstract：:This trial was undertaken to establish the long term biochemical and serological outcome of patients with acute post-transfusion hepatitis C virus infection after treatment with interferon alfa-2b. After 12 months, 12 patients (eight treated, four controls) had self limited disease and 16 patients (seven treated, nine...

journal_title：Gut

authors： Genesca J,Esteban JI,Quer J,Viladomiu LL,Gonzalez A,Esteban R,Guardia J

更新日期：1993-01-01 00:00:00

abstract：:Studies have been made of mucus glycoprotein biosynthesis in different regions of the lower gastrointestinal tract in normal patients and those with ulcerative colitis (UC), active or inactive, by means of 3H-glucosamine (3H-GlcNH2)--35S-sulphate double labelling of epithelial biopsy specimens under culture conditions...

journal_title：Gut

authors： Morita H,Kettlewell MG,Jewell DP,Kent PW

更新日期：1993-07-01 00:00:00

abstract：:Forty five patients with refractory oesophagitis, defined as persisting erosive changes or ulceration despite a minimum of three months' treatment with cimetidine 3.2 g daily or ranitidine 0.9 g daily, were treated in an open trial with omeprazole 40 mg daily for up to eight weeks. Endoscopically defined healing was o...

journal_title：Gut

authors： Bardhan KD,Morris P,Thompson M,Dhande DS,Hinchliffe RF,Jones RB,Daly MJ,Carroll NJ

更新日期：1990-07-01 00:00:00

abstract：:The amylase/creatinine clearance ratio (Cam/Ccr ratio) was determined in 239 subjects. In 87 hospitalised patients without pancreatic disease (controls) the Cam/Ccr ratio was 3.02 +/- 0.69 (mean +/- ISD). The ratio was above the normal range in all patients with acute pancreatitis but was normal in those with chronic ...

journal_title：Gut

authors： Marten A,Beales D,Elias E

更新日期：1977-09-01 00:00:00

abstract：:To investigate the mechanisms underlying the hepatotoxicity induced by methyl dopa, we have examined sera from nine patients with liver damage following the use of the drug for evidence of sensitisation to drug altered liver cell membrane antigens using both immunofluorescence and antibody dependent cell mediated cyto...

journal_title：Gut

authors： Neuberger J,Kenna JG,Nouri Aria K,Williams R

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVE:Current diagnostic methods for gastro-oesophageal reflux disease (GORD) have moderate sensitivity/specificity and can be invasive and expensive. Pepsin detection in saliva has been proposed as an 'office-based' method for GORD diagnosis. The aims of this study were to establish normal values of salivary pepsi...

journal_title：Gut

authors： Hayat JO,Gabieta-Somnez S,Yazaki E,Kang JY,Woodcock A,Dettmar P,Mabary J,Knowles CH,Sifrim D

更新日期：2015-03-01 00:00:00

abstract：:This presentation describes interim findings in a series of 319 patients referred from 41 hospitals on the basis of histopathological findings of 'early gastric cancer', 'dysplasia', or 'worrying mucosal appearances'. Data were recorded using a predefined proforma, and histopathological material circulated amongst a '...

journal_title：Gut

authors： de Dombal FT,Price AB,Thompson H,Williams GT,Morgan AG,Softley A,Clamp SE,Unwin BJ

更新日期：1990-01-01 00:00:00

abstract：:The prevalence of methane production in an adult population of 256 subjects was 41%, but it was significantly higher in females (49%), than males (33%). When the population was subdivided into ethnic groups. Caucasians (48%) and Black (45%) had significantly more methane producers than Orientals (24%) and Indians (32%...

journal_title：Gut

authors： Pitt P,de Bruijn KM,Beeching MF,Goldberg E,Blendis LM

更新日期：1980-11-01 00:00:00

abstract：BACKGROUND:Patients with irritable bowel syndrome (IBS) have reduced pain thresholds for rectal distension. In addition, the prevalence of sexual/physical abuse in referred IBS patients is high and is associated with greater pain reporting, poorer health status, and poorer outcome. This lead to a hypothesis that abuse ...

journal_title：Gut

authors： Ringel Y,Whitehead WE,Toner BB,Diamant NE,Hu Y,Jia H,Bangdiwala SI,Drossman DA

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND AND AIMS:In acute liver failure (ALF), the brain is exposed to high levels of ammonia. Human studies defining the clinical significance of ammonia in ALF are lacking. This prospective study evaluated the relationship of arterial ammonia levels at admission to complications and survival among patients with AL...

journal_title：Gut

authors： Bhatia V,Singh R,Acharya SK

更新日期：2006-01-01 00:00:00

abstract：:Small bowel enteropathies that are associated with an autoimmune process are often resistant to treatment. Two children with autoimmune enteropathy were treated with cyclosporin A for eight months. Both improved, as assessed by growth, small intestinal mucosal morphology, and carbohydrate absorption. Cyclosporin A is ...

journal_title：Gut

authors： Sanderson IR,Phillips AD,Spencer J,Walker-Smith JA

更新日期：1991-11-01 00:00:00

abstract：:A cohort of 123 patients with coeliac disease, diagnosed in the first three years of life and followed up for at least 10 years, was reevaluated during the teenage period in terms of compliance with the diet and clinical state. Mucosal structure and lymphocytes were assessed in small intestinal biopsy specimens obtain...

journal_title：Gut

authors： Mayer M,Greco L,Troncone R,Auricchio S,Marsh MN

更新日期：1991-08-01 00:00:00

abstract：:Large numbers of cells are shed from small intestinal mucosa but they are so rapidly destroyed that there is little direct information about their morphological types. Material obtained by washing the human and rat small intestine was immediately processed and examined by light and electron microscopy. Small intestina...

journal_title：Gut

authors： Pink IJ,Croft DN,Creamer B

更新日期：1970-03-01 00:00:00

abstract：:Fifty two patients with abnormal acid gastro-oesophageal reflux were studied by simultaneous oesophageal pH monitoring and continuous aspiration for 16 hours. Aspirates (from discrete two hour periods) were analysed for volume, pH, bile acids (conjugated and unconjugated), trypsin, and pepsin. The results were compare...

journal_title：Gut

authors： Gotley DC,Morgan AP,Ball D,Owen RW,Cooper MJ

更新日期：1991-10-01 00:00:00

abstract：BACKGROUND:Patients with Crohn's disease suffer from intestinal bile acid malabsorption. Intestinal bile acid absorption is mediated by the apical sodium dependent bile acid transporter ASBT/IBAT (SLC10A2). In rats, ASBT is induced by glucocorticoids. AIMS:To study whether human ASBT is activated by glucocorticoids an...

journal_title：Gut

authors： Jung D,Fantin AC,Scheurer U,Fried M,Kullak-Ublick GA

更新日期：2004-01-01 00:00:00

abstract：:Fasting and postprandial plasma concentrations of glycine and taurine conjugates of cholic, chenodeoxycholic, and deoxycholic acid were measured by a high pressure liquid chromatography-enzymatic assay in nine healthy subjects. The mean value of each bile acid concentration increased significantly (2.4-4.7 times) in t...

journal_title：Gut

authors： Linnet K

更新日期：1983-03-01 00:00:00

abstract：AIM:The aim of this study was to implement an imaging protocol for positron emission tomography/computed tomography (PET/CT) colonography and to combine this protocol with whole body PET/CT tumour staging for a single whole body examination for routine clinical use. SUBJECTS AND METHODS:A whole body PET/CT protocol fo...

journal_title：Gut

authors： Veit P,Kühle C,Beyer T,Kuehl H,Herborn CU,Börsch G,Stergar H,Barkhausen J,Bockisch A,Antoch G

更新日期：2006-01-01 00:00:00