Methylation of the oestrogen receptor gene in non-neoplastic epithelium as a marker of colorectal neoplasia risk in longstanding and extensive ulcerative colitis.

abstract：INTRODUCTION:The use of patient reported outcome measures to support routine inflammatory bowel disease (IBD) care is not widespread and suggests that existing questionnaires lack relevance to day-to-day decisions or are too cumbersome to administer. We developed a simple, generic tool for capturing disease control fro...

journal_title：Gut

authors： Bodger K,Ormerod C,Shackcloth D,Harrison M,IBD Control Collaborative.

更新日期：2014-07-01 00:00:00

abstract：:We have studied B-lymphocyte function in 39 patients with Crohn's disease and 35 normal individuals using a reverse haemolytic plaque assay as the effector system. Ten patients had active Crohn's disease, the others being in an inactive state of the disease. Compared with normal individuals, the Crohn's disease patien...

journal_title：Gut

authors： Sieber G,Herrmann F,Zeitz M,Teichmann H,Rühl H

更新日期：1984-11-01 00:00:00

abstract：:This report assesses the value of cholinesterase (ChE) activity as an indicator of liver function and analyses its usefulness in the diagnosis of jaundice. A rapid method of determination has been used, and alterations in ChE activity in conditions other than liver disease have been studied to permit a fuller and more...

journal_title：Gut

authors： BURNETT W

更新日期：1960-12-01 00:00:00

abstract：:The human gut microbiome is a complex ecosystem, densely colonised by thousands of microbial species. It varies among individuals and depends on host genotype and environmental factors, such as diet and antibiotics. In this review, we focus on stability and resilience as essential ecological characteristics of the gut...

journal_title：Gut

authors： Fassarella M,Blaak EE,Penders J,Nauta A,Smidt H,Zoetendal EG

更新日期：2020-10-13 00:00:00

abstract：:A case is described of a life threatening vasculitis of the small bowel leading to massive gastrointestinal haemorrhage which was apparently due to cytomegalovirus inclusion disease. Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine. This ...

journal_title：Gut

authors： Sackier JM,Kelly SB,Clarke D,Rees AJ,Wood CB

更新日期：1991-11-01 00:00:00

abstract：:This report is of a patient with long-term small bowel regional enteritis who presented with a perforation of an adenocarcinoma involving a diseased portion of ileum. Adenocarcinoma of the small bowel is rare. The incidence of small bowel adenocarcinoma may be higher in patients with regional enteritis, but a definite...

journal_title：Gut

authors： Heathcote J,Knauer CM,Oakes D,Archibald RW

更新日期：1980-12-01 00:00:00

abstract：:Colonic biopsy specimens were obtained from patients undergoing surgery for carcinoma of the rectum. Colonic resistance arteries (internal diameter 178-345 microns) were dissected out under the microscope and mounted in a microvascular myograph capable of measuring isometric tension development. Experiments were desig...

journal_title：Gut

authors： Mortensen FV,Nielsen H,Mulvany MJ,Hessov I

更新日期：1990-12-01 00:00:00

abstract：:The effect of a new complex oligosaccharide exhibiting potent inhibitory action on alpha-glucoside hydrolases on intestinal absorption of sucrose in man was tested by constant in vivo perfusion of the jejunum. At concentrations of 4.65 or 15.5 X 10(-6)M the alpha-glucosidehydrolase inhibitor (alpha-GHI) markedly inhib...

journal_title：Gut

authors： Caspary WF,Kalisch H

更新日期：1979-09-01 00:00:00

abstract：:A series of experiments has been performed in healthy male volunteers to investigate the disposition of orally administered disodium azodisalicylate, a potentially useful drug for the treatment of ulcerative colitis. The drug was given by mouth in doses of up to 2 g a day for six weeks and there were no adverse effect...

journal_title：Gut

authors： Willoughby CP,Aronson JK,Agback H,Bodin NO,Truelove SC

更新日期：1982-12-01 00:00:00

abstract：:Recent reports have indicated a possible role for 111Indium leucocyte scintigraphy in the management of patients with acute inflammatory bowel disease. Our experience with this technique in 15 patients (nine with ulcerative colitis, six with Crohn's disease) is described. Perfect agreement was not obtained between sci...

journal_title：Gut

authors： Buxton-Thomas MS,Dickinson RJ,Maltby P,Hunter JO,Wraight EP

更新日期：1984-12-01 00:00:00

abstract：:Blood ethanol concentrations after separate oral dosing and intravenous infusion of ethanol (0.15 g/kg) were measured in 16 control subjects and 13 subjects treated with ranitidine. All subjects underwent routine upper gastrointestinal endoscopy. Peak blood ethanol concentrations, and area under the blood ethanol/time...

journal_title：Gut

authors： Brown AS,Fiaterone JR,Day CP,Bennett MK,Kelly PJ,James OF

更新日期：1995-09-01 00:00:00

abstract：BACKGROUND:Impaired iron handling in riboflavin deficiency is thought to be partially a result of significant morphological and cytokinetic changes within the small intestine. AIMS:The aim of the study was to find out if the responses of the rat small intestine to riboflavin deficiency induced at weaning could be reve...

journal_title：Gut

authors： Williams EA,Rumsey RD,Powers HJ

更新日期：1996-08-01 00:00:00

abstract：:The cause of a biliary tract stricture may be difficult to determine radiologically. Exfoliative biliary cytology was evaluated in 62 patients (median age 65 years, range 30-94) with biliary tract strictures presenting to the Hepatobiliary Unit between January 1984 and December 1989. Bile samples were taken during end...

journal_title：Gut

authors： Davidson B,Varsamidakis N,Dooley J,Deery A,Dick R,Kurzawinski T,Hobbs K

更新日期：1992-10-01 00:00:00

abstract：:In a randomised clinical trial, patients with moderately active Crohn's disease received either prednisolone 0.5 mg/kg/day plus a normal diet, or an elemental diet plus oral framycetin, colistin and nystatin. Patients were assessed using the Crohn's disease activity index (CDAI), ESR, and faecal granulocyte excretion ...

journal_title：Gut

authors： Saverymuttu S,Hodgson HJ,Chadwick VS

更新日期：1985-10-01 00:00:00

abstract：OBJECTIVES:Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in hu...

journal_title：Gut

authors： Kiesslich R,Duckworth CA,Moussata D,Gloeckner A,Lim LG,Goetz M,Pritchard DM,Galle PR,Neurath MF,Watson AJ

更新日期：2012-08-01 00:00:00

abstract：:Glucosamine synthetase, the first enzyme in glycoprotein synthesis, has been measured in serial rectal biopsies in four patients with membranous colitis. In two of the patients the levels of the enzyme were very high initially and in the other two patients the enzyme levels rose to a peak above the normal range after ...

journal_title：Gut

authors： Goodman MJ,Kent PW,Truelove SC

更新日期：1977-03-01 00:00:00

abstract：:The relationship between the adaptive response and plasma PYY concentrations after small bowel resection has been investigated. Seventy five per cent proximal small bowel resection resulted in a rise in plasma PYY at six days from 28 +/- 3.1 to 85 +/- 12.3 pmol/l (p less than 0.001) and this difference was maintained ...

journal_title：Gut

authors： Savage AP,Gornacz GE,Adrian TE,Ghatei MA,Goodlad RA,Wright NA,Bloom SR

更新日期：1985-12-01 00:00:00

abstract：:Dysphagia in a 79 year old lady was caused by a giant polypoid tumour in mid-oesophagus. Surgery was not appropriate. Shrinkage of the tumour and its eventual detachment were achieved by stopping its blood supply by YAG laser photocoagulation of the tumour stalk. Good, temporary palliation of the dysphagia was achieve...

journal_title：Gut

authors： Richardson D,Wyatt JI,Miloszewski KJ

更新日期：1992-08-01 00:00:00

abstract：:This study was done to determine the severity and extent of abnormalities of duodenal mucosal architecture in non-specific (non-ulcerative) and ulcer-associated duodenitis. The effect of successful treatment with cimetidine on these changes has also been assessed. A method of microdissection and measurement of villus ...

journal_title：Gut

authors： Hasan M,Sircus W,Ferguson A

更新日期：1981-08-01 00:00:00

abstract：BACKGROUND:Insulin resistance is a frequent feature of chronic hepatitis C. Whether insulin resistance could be the cause or consequence of steatosis and fibrosis is unknown. The ability of HCV genotype 3 to promote steatosis by itself provides an unique opportunity to answer this question. AIMS:The aim of the present...

journal_title：Gut

authors： Fartoux L,Poujol-Robert A,Guéchot J,Wendum D,Poupon R,Serfaty L

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Intrahepatic cholestasis of pregnancy (ICP) has a complex aetiology with a significant genetic component. ABCB11 encodes the bile salt export pump (BSEP); mutations cause a spectrum of cholestatic disease, and are implicated in the aetiology of ICP. METHODS:ABCB11 variation in ICP was investigated by screen...

journal_title：Gut

authors： Dixon PH,van Mil SW,Chambers J,Strautnieks S,Thompson RJ,Lammert F,Kubitz R,Keitel V,Glantz A,Mattsson LA,Marschall HU,Molokhia M,Moore GE,Linton KJ,Williamson C

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Melanoma inhibitory activity 2 (MIA2) is a novel gene of the MIA gene family. The selective expression of MIA2 in hepatocytes is controlled by hepatocyte nuclear factor (HNF) 1 binding sites in the MIA2 promotor. In contrast, in most hepatocellular carcinomas (HCC) MIA2 expression is down-regulated or lost. ...

journal_title：Gut

authors： Hellerbrand C,Amann T,Schlegel J,Wild P,Bataille F,Spruss T,Hartmann A,Bosserhoff AK

更新日期：2008-02-01 00:00:00

abstract：:Evidence is presented which indicates a possible reduction in recognition capacity for tumour cell antigens (EB(2) Burkitt lymphoma cell line) by lymphocytes from some patients with longstanding but inactive Crohn's disease. Three out of seven patients tested also showed diminished or absent lymphocytotoxicity when th...

journal_title：Gut

authors： Maclaurin BP,Cooke WT,Ling NR

更新日期：1972-08-01 00:00:00

abstract：BACKGROUND:Although polypoid lesions of the gall bladder are frequently observed in asymptomatic subjects, the natural history of these lesions has never been studied using ultrasonography. AIM:The natural history of polypoid lesions of the gall bladder was investigated using ultrasonography. SUBJECTS:Among 4343 pati...

journal_title：Gut

authors： Moriguchi H,Tazawa J,Hayashi Y,Takenawa H,Nakayama E,Marumo F,Sato C

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:Intraluminal acid evokes reflex contraction of oesophageal longitudinal smooth muscle (LSM) and consequent oesophageal shortening. This reflex may play a role in the pathophysiology of oesophageal pain syndromes and hiatus hernia formation. The aim of the current study was to elucidate further the mechanisms ...

journal_title：Gut

authors： Paterson WG,Miller DV,Dilworth N,Assini JB,Lourenssen S,Blennerhassett MG

更新日期：2007-10-01 00:00:00

abstract：:The sample population in this initial case control study of the adenosine diphosphate ribosyl transferase (ADPRT) response of inflammatory bowel disease patients included: 23 patients with ulcerative colitis (UC)-active and inactive, 13 patients with Crohn's disease (CD)-active and inactive, 14 first degree relatives ...

journal_title：Gut

authors： Markowitz MM,Rozen P,Pero RW,Tobi M,Miller DG

更新日期：1988-12-01 00:00:00

abstract：:In a prospective survey positive antimitochondrial antibodies have been detected in 69/4200 (1.64%) of all sera submitted to a routine immunology laboratory. Of the 69, only nine patients had uniquivocal primary biliary cirrhosis, six others had chronic active hepatitis, 10 had abnormal liver function tests without ev...

journal_title：Gut

authors： Triger DR,Charlton CA,Ward AM

更新日期：1982-10-01 00:00:00

abstract：:Histocompatibility (HLA) antigen phenotypes have been studied in 100 patients with ulcerative colitis, 100 with Crohn's disease, and 283 normal controls. In addition the incidence of ankylosing spondylitis, sacroiliitis, and "enteropathic" peripheral arthropathy was determined in the patients with inflammatory bowel d...

journal_title：Gut

authors： Mallas EG,Mackintosh P,Asquith P,Cooke WT

更新日期：1976-11-01 00:00:00

abstract：:Seventeen patients with proven systemic sclerosis had a peroral jejunal biopsy performed. Four biopsies were regarded as showing abnormalities, which were mostly confined to the deeper structures, although in two there was a minimal degree of villous atrophy without epithelial cell changes. Passive intestinal permeabi...

journal_title：Gut

authors： Cobden I,Rothwell J,Axon AT,Dixon MF,Lintott DJ,Rowell NR

更新日期：1980-04-01 00:00:00

abstract：BACKGROUND AND AIM:The aim of this study was to unravel the mechanisms responsible for the increased risk of gall stone disease in hypertriglyceridaemia (HTG) and to compare the effects of triglyceride lowering therapy by bezafibrate and fish oil on determinants of cholelithiasis (biliary lipid composition and gall bla...

journal_title：Gut

authors： Jonkers IJ,Smelt AH,Ledeboer M,Hollum ME,Biemond I,Kuipers F,Stellaard F,Boverhof R,Meinders AE,Lamers CH,Masclee AA

更新日期：2003-01-01 00:00:00