Perforation of an adenocarcinoma of the small bowel affected by regional enteritis.

abstract：:Typical 'pouchitis' is a well recognised complication of ileal pouches in ulcerative colitis. Infrequently, a refractory pouchitis (RP) presents with certain clinical, endoscopic, and pathological features resembling Crohn's disease and is often ascribed to misdiagnosis of the initial colitis. To test that hypothesis ...

journal_title：Gut

authors： Subramani K,Harpaz N,Bilotta J,Bodian C,Rubin PH,Janowitz HD,Gelernt IM,Sachar DB

更新日期：1993-11-01 00:00:00

abstract：:Despite mass population screening and an incidence of EGC in Japan that is at least double that of the West, there seem to be no genuine differences in the clinicopathological features of the disease between the two regions. The macroscopic appearance, size, depth of invasion, frequency of lymph node invasion, and his...

journal_title：Gut

authors： Everett SM,Axon AT

更新日期：1997-08-01 00:00:00

abstract：:The benzimidazole anthelmintics mebendazole and fenbendazole have been shown to be much less effective against Nippostrongylus brasiliensis infections in the rat on a combined iron and protein deficient diet. In the present experiments it was shown that the anthelmintic efficacy of mebendazole was significantly impair...

journal_title：Gut

authors： Duncombe VM,Bolin TD,Davis AE,Fagan MR,Kelly JD

更新日期：1979-04-01 00:00:00

abstract：:Previous studies have suggested that profound inhibition of gastric acid secretion may increase exposure to potentially carcinogenic N-nitroso compounds. The aim of this study was to find out if the proton pump inhibitor omeprazole (20 mg daily) is associated with increased concentrations of potentially carcinogenic N...

journal_title：Gut

authors： Verdu E,Viani F,Armstrong D,Fraser R,Siegrist HH,Pignatelli B,Idström JP,Cederberg C,Blum AL,Fried M

更新日期：1994-04-01 00:00:00

abstract：:Faecal stream diversion may induce inflammatory changes in the defunctioned segment of the large intestine. These changes are predominantly mucosal, although confusing histological features including granulomas may be present. The pathology of 15 defunctioned rectal stumps has been studied. All patients had previously...

journal_title：Gut

authors： Warren BF,Shepherd NA,Bartolo DC,Bradfield JW

更新日期：1993-04-01 00:00:00

abstract：:The role of vasoactive intestinal polypeptide in the control of gastric corpus tone and motility was investigated using auto-antibodies to neutralise endogenous vasoactive intestinal polypeptide. Six ferrets were immunised with vasoactive intestinal polypeptide thyroglobulin conjugate in Freund's complete adjuvant whi...

journal_title：Gut

authors： Grundy D,Gharib-Naseri MK,Hutson D

更新日期：1992-11-01 00:00:00

abstract：METHODS:Four patients with clinicopathological features suggesting a new distinct entity defining extensive small intestinal CD4 T cell infiltration were observed. RESULTS:All four patients presented with chronic diarrhoea, malabsorption, and weight loss. Biopsy specimens of the small intestine disclosed extensive and...

journal_title：Gut

authors： Carbonnel F,d'Almagne H,Lavergne A,Matuchansky C,Brouet JC,Sigaux F,Beaugerie L,Nemeth J,Coffin B,Cosnes J,Gendre JP,Rambaud JC

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Both bile salts and glutathione participate in the generation of canalicular bile flow. In this work, we have investigated the effect of different bile salts on hepatic glutathione metabolism. METHODS:Using the isolated and perfused rat liver, we studied hepatic glutathione content, and metabolism ...

journal_title：Gut

authors： Rodríguez-Ortigosa CM,Cincu RN,Sanz S,Ruiz F,Quiroga J,Prieto J

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Patients with Crohn's disease suffer from intestinal bile acid malabsorption. Intestinal bile acid absorption is mediated by the apical sodium dependent bile acid transporter ASBT/IBAT (SLC10A2). In rats, ASBT is induced by glucocorticoids. AIMS:To study whether human ASBT is activated by glucocorticoids an...

journal_title：Gut

authors： Jung D,Fantin AC,Scheurer U,Fried M,Kullak-Ublick GA

更新日期：2004-01-01 00:00:00

abstract：BACKGROUND:Crohn's disease is one of the principal human chronic inflammatory bowel diseases. Although its aetiology is still unknown, its complex pathogenesis has environmental, immunological, and genetic determinants. CARD15 is the first susceptibility gene implicated in the predisposition to Crohn's disease and is k...

journal_title：Gut

authors： Berrebi D,Maudinas R,Hugot JP,Chamaillard M,Chareyre F,De Lagausie P,Yang C,Desreumaux P,Giovannini M,Cézard JP,Zouali H,Emilie D,Peuchmaur M

更新日期：2003-06-01 00:00:00

abstract：:The effect of purified toxin A and partially purified toxin B on rabbit ileum and colon was investigated. Toxin A caused tissue damage which was followed by permeability changes and fluid accumulation in both tissues. Toxin A did not increase the permeability of the colon to the extent observed for ileum; secreted flu...

journal_title：Gut

authors： Mitchell TJ,Ketley JM,Haslam SC,Stephen J,Burdon DW,Candy DC,Daniel R

更新日期：1986-01-01 00:00:00

abstract：:In two patients presenting with mild intestinal symptoms, rectal spirochaetosis was the only morphological abnormality diagnosed by light microscopy. A re-evaluation of the morphological changes using electron microscopy and immunohistochemistry showed certain unusual features: the microorganisms were observed within ...

journal_title：Gut

authors： Gebbers JO,Ferguson DJ,Mason C,Kelly P,Jewell DP

更新日期：1987-05-01 00:00:00

abstract：:These updated guidelines on the management of variceal haemorrhage have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines which this document supersedes were written in 2...

journal_title：Gut

authors： Tripathi D,Stanley AJ,Hayes PC,Patch D,Millson C,Mehrzad H,Austin A,Ferguson JW,Olliff SP,Hudson M,Christie JM,Clinical Services and Standards Committee of the British Society of Gastroenterology.

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:Gastric carcinoma development is triggered by Helicobacter pylori. Chronic H. pylori infection leads to reduced acid secretion, which may allow the growth of a different gastric bacterial community. This change in the microbiome may increase aggression to the gastric mucosa and contribute to malignancy. Our a...

journal_title：Gut

authors： Ferreira RM,Pereira-Marques J,Pinto-Ribeiro I,Costa JL,Carneiro F,Machado JC,Figueiredo C

更新日期：2018-02-01 00:00:00

abstract：:Gastrointestinal fistulae most frequently occur as complications after abdominal surgery (75-85%) although they can also occur spontaneously--for example, in patients with inflammatory bowel disease (IBD) such as diverticulitis or following radiation therapy. Abdominal trauma can also lead to fistula formation althoug...

journal_title：Gut

authors： Falconi M,Pederzoli P

更新日期：2001-12-01 00:00:00

abstract：BACKGROUND:In transplant recipients with choledococholedocostomy (CDCD), endoscopic retrograde cholangiopancreatography (ERCP) remains the gold standard for the diagnosis of biliary leak or strictures. Transabdominal ultrasonography (TAUS) has been used to screen patients with suspected biliary tract complications, pri...

journal_title：Gut

authors： Hussaini SH,Sheridan MB,Davies M

更新日期：1999-12-01 00:00:00

abstract：:Evidence is presented of a higher than normal incidence both of clinical coeliac disease and of small-intestinal mucosal abnormalities in relatives of children with coeliac disease. In such relatives the incidence of mucosal abnormality may differ from the incidence of clinical coeliac disease. The data show an absenc...

journal_title：Gut

authors： Robinson DC,Watson AJ,Wyatt EH,Marks JM,Roberts DF

更新日期：1971-10-01 00:00:00

abstract：:To investigate further the cause of the pancreatic enlargment induced by orally ingested soybean trypsin inhibitor (STI), antibodies raised against STI and purified by affinity chromatography were used to localise dietary STI in the rat gut by fluorescent immunocytochemical methods. This technique permitted the clear ...

journal_title：Gut

authors： Wilson PA,Melmed RN,Hampe MM,Holt SJ

更新日期：1978-04-01 00:00:00

abstract：BACKGROUND AND AIMS:We followed a population based cohort of patients with inflammatory bowel disease (IBD) from Olmsted County, Minnesota, in order to analyse long term survival and cause specific mortality. MATERIAL AND METHODS:A total of 692 patients were followed for a median of 14 years. Standardised mortality ra...

journal_title：Gut

authors： Jess T,Loftus EV Jr,Harmsen WS,Zinsmeister AR,Tremaine WJ,Melton LJ 3rd,Munkholm P,Sandborn WJ

更新日期：2006-09-01 00:00:00

abstract：:A histological study of peroral jejunal biopsies and resection specimens from patients with malignant histiocytosis of the intestine (MHI) has revealed characteristic lesions consisting of intramucosal histiocytic aggregations which invade surface and crypt epithelium. These lesions are found in 'uninvolved' jejunal m...

journal_title：Gut

authors： Isaacson P

更新日期：1980-05-01 00:00:00

abstract：:The possible relationship between enteroglucagon and cellular proliferation in a rat model of intestinal adaptation after suppression and stimulation of enteroglucagon by somatostatin and bombesin has been investigated. Forty eight rats were divided into three groups of 16 animals, each group being further sub-divided...

journal_title：Gut

authors： Sagor GR,Ghatei MA,O'Shaughnessy DJ,Al-Mukhtar MY,Wright NA,Bloom SR

更新日期：1985-01-01 00:00:00

abstract：BACKGROUND:The major potential site of acid nitrosation is the proximal stomach, an anatomical site prone to a rising incidence of metaplasia and adenocarcinoma. Nitrite, a pre-carcinogen present in saliva, can be converted to nitrosating species and N-nitroso compounds by acidification at low gastric pH in the presenc...

journal_title：Gut

authors： Combet E,Paterson S,Iijima K,Winter J,Mullen W,Crozier A,Preston T,McColl KE

更新日期：2007-12-01 00:00:00

abstract：:An elderly woman with chronic ulcerative colitis who developed proximal muscle weakness, increased serum creatine phosphokinase activity, and histological and electromyographic abnormalities characteristic of polymyositis is described. Treatment with corticosteroids and 5-acetylsalicylic acid was followed by a remissi...

journal_title：Gut

authors： Chugh S,Dilawari JB,Sawhney IM,Dang N,Radotra BD,Chawla YK

更新日期：1993-04-01 00:00:00

abstract：OBJECTIVE:Tumour-associated macrophages (TAMs) play key roles in tumour progression. Recent evidence suggests that TAMs critically modulate the efficacy of anticancer therapies, raising the prospect of their targeting in human cancer. DESIGN:In a large retrospective cohort study involving 110 patients with pancreatic ...

journal_title：Gut

authors： Di Caro G,Cortese N,Castino GF,Grizzi F,Gavazzi F,Ridolfi C,Capretti G,Mineri R,Todoric J,Zerbi A,Allavena P,Mantovani A,Marchesi F

更新日期：2016-10-01 00:00:00

abstract：:The effect of increasing the calcium, magnesium and sodium concentration in gall bladder bile samples from 21 patients with gall stones and nine controls on the in vitro rate of formation of cholesterol microcrystals and numbers of cholesterol microcrystals formed was examined. Addition of these cations to raise the m...

journal_title：Gut

authors： Neithercut WD

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Firm recommendations about the way thiopurine drugs are introduced and the use of thiopurine methyltransferase (TPMT) and metabolite measurements during treatment in inflammatory bowel disease (IBD) are lacking. AIM:To evaluate pharmacokinetics and tolerance after initiation of thiopurine treatment with a f...

journal_title：Gut

authors： Hindorf U,Lindqvist M,Peterson C,Söderkvist P,Ström M,Hjortswang H,Pousette A,Almer S

更新日期：2006-10-01 00:00:00

abstract：:Although changes in T lymphocyte subset distribution in the peripheral blood of patients infected with human immunodeficiency virus (HIV) are well defined it is not known whether these changes reflect changes in lymphoid compartments clearly involved in HIV related disease like the intestinal mucosa. This study analys...

journal_title：Gut

authors： Schneider T,Jahn HU,Schmidt W,Riecken EO,Zeitz M,Ullrich R

更新日期：1995-10-01 00:00:00

abstract：:Stimulation of the rectal mucosa with a bipolar electrode leads to relaxation of the internal anal sphincter. Intraoperative studies in two subjects showed that transmission of the impulse was independent of extrinsic nerves and was interrupted by circular myotomy. Characteristics of the reflex were studied in 11 heal...

journal_title：Gut

authors： Kamm MA,Lennard-Jones JE,Nicholls RJ

更新日期：1989-07-01 00:00:00

abstract：:Upper gastrointestinal function in response to a mixed nutrient meal was evaluated in hyperthyroid patients, both before and after therapy, and in healthy controls. Gastric secretion, gastric emptying, and pancreatic secretion were all normal and normally integrated postprandially in the hyperthyroid patients. Bile ac...

journal_title：Gut

authors： Miller LJ,Owyang C,Malagelada JR,Gorman CA,Go VL

更新日期：1980-08-01 00:00:00

abstract：BACKGROUND AND AIMS:A subset of functional dyspepsia (FD) patients report meal-related symptoms, possibly representing a pathophysiologically homogeneous subgroup. The aim of the present study was to establish the time-course of symptoms in relation to meal ingestion, and to assess the relationship between self-reporte...

journal_title：Gut

authors： Bisschops R,Karamanolis G,Arts J,Caenepeel P,Verbeke K,Janssens J,Tack J

更新日期：2008-11-01 00:00:00