Abstract:
:The effect of increasing the calcium, magnesium and sodium concentration in gall bladder bile samples from 21 patients with gall stones and nine controls on the in vitro rate of formation of cholesterol microcrystals and numbers of cholesterol microcrystals formed was examined. Addition of these cations to raise the mean maximum concentration of calcium ions to 19.8 mmol/l, of magnesium ions to 20 mmol/l and sodium ions to 998 mmol/l did not trigger nucleation in control bile samples or samples from patients with gall stones. Increasing the mean concentration of calcium ions to 8.6 mmol/l and of sodium to 320 mmol/l increased the numbers of cholesterol monohydrate crystals/0.1 mm3 counted by light polarisation phase contrast microscopy at the time of nucleation in samples from patients with gall stones from a median of 2 (range 1-10) in control portions to 18 (range 2-128) for calcium ions and 10 (range 2-141) for sodium ions (p less than 0.001). Calcium and magnesium ions were more effective than sodium ions, and calcium ions could increase crystal numbers at concentrations found in samples from patients with gall stones, median 4.6 mmol/l (range 2.7-16.9 mmol/l). The concentrations of calcium and magnesium present in bile may therefore influence the rate of development of gall stones.
journal_name
Gutjournal_title
Gutauthors
Neithercut WDdoi
10.1136/gut.30.5.665subject
Has Abstractpub_date
1989-05-01 00:00:00pages
665-70issue
5eissn
0017-5749issn
1468-3288journal_volume
30pub_type
杂志文章相关文献
GUT文献大全abstract::The effect of 28 days' continuous administration of oral indomethacin on gastroduodenal morphology, gastric mucosal blood flow, and gastric mucosal prostaglandin E2 (PGE2) metabolism in man was studied to define further the mechanisms of mucosal injury induced by indomethacin. Indomethacin caused acute gastroduodenal ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.2.164
更新日期:1992-02-01 00:00:00
abstract:AIMS:To determine the sources of founding for UK gastroenterology research papers and the relative impact of papers funded by different groups and of unfunded ones. METHODS:UK gastroenterology papers from 1988-94 were selectively retrieved from the Science Citation Index by means of a specially constructed filter base...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.2.288
更新日期:1998-08-01 00:00:00
abstract::Clinically significant liver involvement in systemic amyloidosis, especially with cholestasis, is rare. We report a case of primary amyloidosis with severe intrahepatic cholestasis leading to terminal liver failure. The present case is the first of its kind reported involving Lambda light chains only as the associated...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.7.903
更新日期:1987-07-01 00:00:00
abstract:OBJECTIVES:The postinfectious irritable bowel syndrome (PI-IBS) suggests that impaired resolution of inflammation could cause IBS symptoms. The authors hypothesised that polymorphisms in genes whose expression were altered by gastroenteritis might be linked to IBS with diarrhoea (IBS-D) which closely resembles PI-IBS. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-301213
更新日期:2013-07-01 00:00:00
abstract::Infection with the delta agent can only occur in the context of coexistent hepatitis B virus infection. We describe a patient in whom the clinical features of acute delta hepatitis developed when seroconversion from hepatitis B surface antigen to antibody had already occurred and diagnosis of recent acute hepatitis B ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.2.212
更新日期:1985-02-01 00:00:00
abstract::Evidence is presented of a higher than normal incidence both of clinical coeliac disease and of small-intestinal mucosal abnormalities in relatives of children with coeliac disease. In such relatives the incidence of mucosal abnormality may differ from the incidence of clinical coeliac disease. The data show an absenc...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.10.789
更新日期:1971-10-01 00:00:00
abstract::In a search for past or present infection with herpes viruses, serum antibody titres to herpes simplex type 1 virus, cytomegalovirus, and varicella-zoster virus were measured by complement fixation test in 58 patients with achalasia. Serum was also taken from 40 age and sex matched patients without oesophageal symptom...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.3.299
更新日期:1993-03-01 00:00:00
abstract::Severe watery diarrhoea in a patient with medullary thryoid carcinoma and high calcitonin levels was associated with increased distal ileal flow. Plasma from the patient inhibited small intestinal fluid absorption in dogs without affecting mucosal cyclic AMP levels. When calcitonin was removed from the plasma, the eff...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.7.629
更新日期:1979-07-01 00:00:00
abstract:BACKGROUND:Because hepatic cirrhosis is a major risk factor for hepatocellular carcinoma, recent guidelines by the European Association for the Study of the Liver (EASL) on clinical management of hepatocellular carcinoma recommend periodic ultrasound surveillance of cirrhotic patients with immediate workup for nodules ...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2003.032359
更新日期:2004-09-01 00:00:00
abstract::For the first time the endoscopist has more than one option for the management of gastro-oesophageal varices. It is now feasible to select the appropriate therapy on the basis of the clinical setting. Acute injection sclerotherapy remains a quick and simple technique for the control of active bleeding from oesophageal...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.36.5.647
更新日期:1995-05-01 00:00:00
abstract::Aspirin administration to normal subjects resulted in a reduction in gastric prostaglandin E (PGE) output. Both PGE concentration and gastric juice volume were decreased. Gastric acid output also decreased, although the difference was not statistically significant. An increased sensitivity of the PGE system to inhibit...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.17.1.54
更新日期:1976-01-01 00:00:00
abstract::This experimental study was undertaken to follow the influence of phenobarbital on bile chemistry and gallstone formation. Phenobarbital (400 mg/kg/day) was administered to golden hamsters receiving a diet known to induce cholesterol gallstones. After a 28-day period none of the control animals had gallstones whereas ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.14.12.956
更新日期:1973-12-01 00:00:00
abstract::The effect of sodium taurocholate instillation on the stimulated stomachs of patients with duodenal ulceration has been investigated. Instillation into the stomach of sodium taurocholate significantly reduced pentagastrin stimulated volume and outputs of both acid and sodium, with no change in the calculated volume of...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.1.28
更新日期:1983-01-01 00:00:00
abstract::These consensus guidelines were jointly commissioned by the British Society of Gastroenterology (BSG), the Association of Coloproctology of Great Britain and Ireland (ACPGBI) and Public Health England (PHE). They provide an evidence-based framework for the use of surveillance colonoscopy and non-colonoscopic colorecta...
journal_title:Gut
pub_type: 杂志文章,实务指引
doi:10.1136/gutjnl-2019-319858
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:The reported cumulative risk of developing pouchitis in ulcerative colitis (UC) patients undergoing ileal pouch-anal anastomosis (IPAA) approaches 50% after 10 years. To date, no preoperative serological predictor of pouchitis has been found. AIMS:To assess whether preoperative perinuclear antineutrophil cy...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.5.671
更新日期:2001-11-01 00:00:00
abstract::Fifty two patients with abnormal acid gastro-oesophageal reflux were studied by simultaneous oesophageal pH monitoring and continuous aspiration for 16 hours. Aspirates (from discrete two hour periods) were analysed for volume, pH, bile acids (conjugated and unconjugated), trypsin, and pepsin. The results were compare...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.10.1093
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:Surveillance colonoscopy is widely recommended in patients with longstanding and extensive ulcerative colitis (UC) in order to detect colorectal neoplasia at an early stage. However, it still remains questionable whether surveillance colonoscopy effectively enables early detection of UC associated neoplasia....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.062059
更新日期:2005-09-01 00:00:00
abstract::Patients with Crohn's disease commonly develop ileal and less commonly colonic strictures, containing various degrees of inflammation and fibrosis. While predominantly inflammatory strictures may benefit from a medical anti-inflammatory treatment, predominantly fibrotic strictures currently require endoscopic balloon ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2018-318081
更新日期:2019-06-01 00:00:00
abstract:OBJECTIVES:To compare performance measures across all three rounds of the English bowel cancer screening faecal occult blood test pilot and their relation to social deprivation and ethnicity. METHODS:In each round in three primary care trusts, data for a restricted population of over 48,500 aged 60-69 years were analy...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.236430
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Diabetes has been associated with an increased risk of hepatocellular carcinoma (HCC) in studies of referred patients. This is the first population based case control study in the USA to examine this association while adjusting for other major risk factors related to HCC. METHODS:We used the Surveillance Ep...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2004.052167
更新日期:2005-04-01 00:00:00
abstract::Faecal stream diversion may induce inflammatory changes in the defunctioned segment of the large intestine. These changes are predominantly mucosal, although confusing histological features including granulomas may be present. The pathology of 15 defunctioned rectal stumps has been studied. All patients had previously...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.4.514
更新日期:1993-04-01 00:00:00
abstract::Faecal bile acid excretion was examined in 13 patients with adenomatous polyps of the large bowel and compared with a series of matched healthy subjects. Bile acids were analysed in detail with respect to the composition of individual bile acids and their mode of conjugation. The total excretion of bile acids by the p...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.8.824
更新日期:1984-08-01 00:00:00
abstract::To investigate further the cause of the pancreatic enlargment induced by orally ingested soybean trypsin inhibitor (STI), antibodies raised against STI and purified by affinity chromatography were used to localise dietary STI in the rat gut by fluorescent immunocytochemical methods. This technique permitted the clear ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.4.260
更新日期:1978-04-01 00:00:00
abstract::An ileitis developing years or months after ileostomy was recognised and described many years ago but has rarely been mentioned since. We describe nine patients with a non-specific preanastomotic ileitis that developed years after colectomy in patients operated on for ulcerative colitis or carcinoma. The disease devel...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.3.373
更新日期:1994-03-01 00:00:00
abstract:OBJECTIVES:Loss of intestinal barrier function plays an important role in the pathogenesis of inflammatory bowel disease (IBD). Shedding of intestinal epithelial cells is a potential cause of barrier loss during inflammation. The objectives of the study were (1) to determine whether cell shedding and barrier loss in hu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300695
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE AND DESIGN:The goal of the study was to determine whether the mutational profile of early colorectal polyps correlated with growth behaviour. The growth of small polyps (6-9 mm) that were first identified during routine screening of patients was monitored over time by interval imaging with CT colonography. Mu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-312232
更新日期:2017-12-01 00:00:00
abstract::Spontaneous basal rectal activity, recorded after resection of the sigmoid colon for diverticular disease, was more than twice the normal. The rectum of post-resection cases yielded a markedly exaggerated overall response to prostigmine, in addition to producing abundant fast wave patterns. The response to stretch of ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.2.121
更新日期:1970-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Surgical management of extrahepatic cholestasis is frequently complicated by bacterial translocation and severe liver injury. The aim of this study was to clarify the involvement of Toll-like receptors (TLRs) in the pathogenesis of bacterial translocation and liver injury in obstructive cholestasis....
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2005.065318
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Dietary fibre has beneficial effects on energy metabolism, and the majority of studies have focused on short-chain fatty acids produced by gut microbiota. Ginseng has been reported to aid in body weight management, however, its mechanism of action is not yet clear. In this study, we focused on the potential m...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-319114
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:Shortage of organ donors, a critical challenge for treatment of end-stage organ failure, has motivated the development of alternative strategies to generate organs in vitro. Here, we aim to describe the hepatorganoids, which is a liver tissue model generated by three-dimensional (3D) bioprinting of HepaRG cel...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-319960
更新日期:2020-05-20 00:00:00