Abstract:
:Three cases of apparent primary villous atrophy of the terminal ileum in women with chronic diarrhoea are reported. Eight cases have previously been reported in the literature. Clinical characteristics are the presence of severe chronic secretory diarrhoea with episodes of hypokalaemia combined with signs of ileal malabsorption and/or efficacy of cholestyramine. Diagnosis is based on ileoscopy and histology. An association with microscopic colitis was present in the three patients and in four cases in the literature. The pathogenesis of primary ileal villous atrophy remains unknown and may involve dysimmunity. Its association with microscopic colitis may indicate a common pathogenesis or support the hypothesis that the faecal stream or bile salts play a role in the pathogenesis of microscopic colitis.
journal_name
Gutjournal_title
Gutauthors
Marteau P,Lavergne-Slove A,Lemann M,Bouhnik Y,Bertheau P,Becheur H,Galian A,Rambaud JCdoi
10.1136/gut.41.4.561subject
Has Abstractpub_date
1997-10-01 00:00:00pages
561-4issue
4eissn
0017-5749issn
1468-3288journal_volume
41pub_type
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