Primary ileal villous atrophy is often associated with microscopic colitis.

Abstract:

:Three cases of apparent primary villous atrophy of the terminal ileum in women with chronic diarrhoea are reported. Eight cases have previously been reported in the literature. Clinical characteristics are the presence of severe chronic secretory diarrhoea with episodes of hypokalaemia combined with signs of ileal malabsorption and/or efficacy of cholestyramine. Diagnosis is based on ileoscopy and histology. An association with microscopic colitis was present in the three patients and in four cases in the literature. The pathogenesis of primary ileal villous atrophy remains unknown and may involve dysimmunity. Its association with microscopic colitis may indicate a common pathogenesis or support the hypothesis that the faecal stream or bile salts play a role in the pathogenesis of microscopic colitis.

journal_name

Gut

journal_title

Gut

authors

Marteau P,Lavergne-Slove A,Lemann M,Bouhnik Y,Bertheau P,Becheur H,Galian A,Rambaud JC

doi

10.1136/gut.41.4.561

subject

Has Abstract

pub_date

1997-10-01 00:00:00

pages

561-4

issue

4

eissn

0017-5749

issn

1468-3288

journal_volume

41

pub_type

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