Adherence to a Mediterranean diet is associated with a lower risk of later-onset Crohn's disease: results from two large prospective cohort studies.

Abstract:

OBJECTIVE:To examine the relationship between Mediterranean diet and risk of later-onset Crohn's disease (CD) or ulcerative colitis (UC). DESIGN:We conducted a prospective cohort study of 83 147 participants (age range: 45-79 years) enrolled in the Cohort of Swedish Men and Swedish Mammography Cohort. A validated food frequency questionnaire was used to calculate an adherence score to a modified Mediterranean diet (mMED) at baseline in 1997. Incident diagnoses of CD and UC were ascertained from the Swedish Patient Register. We used Cox proportional hazards modelling to calculate HRs and 95% CI. RESULTS:Through December of 2017, we confirmed 164 incident cases of CD and 395 incident cases of UC with an average follow-up of 17 years. Higher mMED score was associated with a lower risk of CD (Ptrend=0.03) but not UC (Ptrend=0.61). Compared with participants in the lowest category of mMED score (0-2), there was a statistically significant lower risk of CD (HR=0.42, 95% CI 0.22 to 0.80) but not UC (HR=1.08, 95% CI 0.74 to 1.58). These associations were not modified by age, sex, education level, body mass index or smoking (all Pinteraction >0.30). The prevalence of poor adherence to a Mediterranean diet (mMED score=0-2) was 27% in our cohorts, conferring a population attributable risk of 12% for later-onset CD. CONCLUSION:In two prospective studies, greater adherence to a Mediterranean diet was associated with a significantly lower risk of later-onset CD.

journal_name

Gut

journal_title

Gut

authors

Khalili H,Håkansson N,Chan SS,Chen Y,Lochhead P,Ludvigsson JF,Chan AT,Hart AR,Olén O,Wolk A

doi

10.1136/gutjnl-2019-319505

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

1637-1644

issue

9

eissn

0017-5749

issn

1468-3288

pii

gutjnl-2019-319505

journal_volume

69

pub_type

杂志文章

相关文献

GUT文献大全
  • Hepatitis C virus: epidemiology and genotypes in the north east of England.

    abstract::The epidemiology of hepatitis C virus (HCV) infection was studied in an English teaching hospital over an 18 month period. A total of 104 HCV antibody positive patients were referred for further investigation. They were divided into those diagnosed through screening (blood donors and intravenous drug abusers) and thos...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.38.2.269

    authors: Watson JP,Brind AM,Chapman CE,Bates CL,Gould FK,Johnson SJ,Burt AD,Ferguson J,Simmonds P,Bassendine MF

    更新日期:1996-02-01 00:00:00

  • Massive hepatic resection for the carcinoid syndrome.

    abstract::Removal of the right lobe of the liver which was occupied largely by metastases, together with resection of ileal primary tumours, brought about complete remission of symptoms and signs in a 43-year-old man with a six-year history of the carcinoid syndrome. Investigations should be orientated toward surgery. When prac...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.10.8.617

    authors: Zeegen R,Rothwell-Jackson R,Sandler M

    更新日期:1969-08-01 00:00:00

  • The prognostic value of TP53 mutations in oesophageal adenocarcinoma: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To clarify the prognostic role of tumour protein 53 (TP53) mutations in patients with oesophageal adenocarcinoma (OAC) as there is a need for biomarkers that assist in guiding management for patients with OAC. DESIGN:A systematic review was conducted using MEDLINE, Embase, PubMed and Current Contents Connect...

    journal_title:Gut

    pub_type: 杂志文章,meta分析,评审

    doi:10.1136/gutjnl-2015-310888

    authors: Fisher OM,Lord SJ,Falkenback D,Clemons NJ,Eslick GD,Lord RV

    更新日期:2017-03-01 00:00:00

  • Interchange between collagenous and lymphocytic colitis in severe disease with autoimmune associations requiring colectomy: a case report.

    abstract:BACKGROUND:Collagenous colitis and lymphocytic colitis present with a similar clinical picture. Whether these conditions are separate entities or whether they represent different pathological stages of the same condition is an unresolved issue. PATIENT:This is a case of collagenous colitis following a fulminant course...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.38.5.788

    authors: Bowling TE,Price AB,al-Adnani M,Fairclough PD,Menzies-Gow N,Silk DB

    更新日期:1996-05-01 00:00:00

  • Personalised surveillance for serrated polyposis syndrome: results from a prospective 5-year international cohort study.

    abstract:BACKGROUND AND AIMS:Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC). International guidelines recommend surveillance intervals of 1-2 years. However, yearly surveillance likely leads to overtreatment for many. We prospectively assessed a surveillance protocol aiming to ...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1136/gutjnl-2018-318134

    authors: Bleijenberg AG,IJspeert JE,van Herwaarden YJ,Carballal S,Pellisé M,Jung G,Bisseling TM,Nagtegaal ID,van Leerdam ME,van Lelyveld N,Bessa X,Rodríguez-Moranta F,Bastiaansen B,de Klaver W,Rivero L,Spaander MC,Koornstra JJ,B

    更新日期:2020-01-01 00:00:00

  • Hepatocellular carcinoma: clinical frontiers and perspectives.

    abstract::Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death and is currently the main event leading to death in patients with cirrhosis. Evolving information suggests that the metabolic syndrome with non-alcoholic liver disease may be an important cause of HCC in addition to viral hepatitis and...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gutjnl-2013-306627

    authors: Bruix J,Gores GJ,Mazzaferro V

    更新日期:2014-05-01 00:00:00

  • Glucagon-like peptide-1: a potent regulator of food intake in humans.

    abstract:BACKGROUND/AIMS:Studies in animals suggest a physiological role for glucagon-like peptide-1-(7-36)-amide (GLP-1) in regulating satiety. The role of GLP-1 in regulating food intake in man has, however, not been investigated. Subjects-Sixteen healthy male subjects were examined in a double blind placebo controlled fashio...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/gut.44.1.81

    authors: Gutzwiller JP,Göke B,Drewe J,Hildebrand P,Ketterer S,Handschin D,Winterhalder R,Conen D,Beglinger C

    更新日期:1999-01-01 00:00:00

  • GATA6 regulates EMT and tumour dissemination, and is a marker of response to adjuvant chemotherapy in pancreatic cancer.

    abstract:BACKGROUND AND AIMS:The role of GATA factors in cancer has gained increasing attention recently, but the function of GATA6 in pancreatic ductal adenocarcinoma (PDAC) is controversial. GATA6 is amplified in a subset of tumours and was proposed to be oncogenic, but high GATA6 levels are found in well-differentiated tumou...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-311256

    authors: Martinelli P,Carrillo-de Santa Pau E,Cox T,Sainz B Jr,Dusetti N,Greenhalf W,Rinaldi L,Costello E,Ghaneh P,Malats N,Büchler M,Pajic M,Biankin AV,Iovanna J,Neoptolemos J,Real FX

    更新日期:2017-09-01 00:00:00

  • No harm from five year ingestion of oats in coeliac disease.

    abstract:BACKGROUND:Six to 12 months of ingestion of moderate amounts of oats does not have a harmful effect in adult patients with coeliac disease. As the safety of long term intake of oats in coeliac patients is not known, we continued our previous 6-12 month study for five years. AIM:To assess the safety of long term ingest...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/gut.50.3.332

    authors: Janatuinen EK,Kemppainen TA,Julkunen RJ,Kosma VM,Mäki M,Heikkinen M,Uusitupa MI

    更新日期:2002-03-01 00:00:00

  • Fine needle aspiration cytology of rectal masses.

    abstract::This paper describes the results of transproctoscopic fine needle aspiration cytology in the diagnosis of rectal lesions. Fifty one consecutive patients referred with a presumptive diagnosis of rectal mass were subjected to proctoscopic examination when fine needle aspiration cytology, brush cytology and biopsy sample...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.3.334

    authors: Kochhar R,Rajwanshi A,Wig JD,Gupta NM,Kesiezie V,Bhasin DK,Malik AK,Gupta SK,Mehta SK

    更新日期:1990-03-01 00:00:00

  • Serum gastrin in duodenal ulcer. I. Basal levels and effect of food and atropine.

    abstract::Fasting serum gastrin has been measured by radioimmunoassay in 72 patients with duodenal ulcer and compared with that in normals, patients with gastric ulcer, and with the Zollinger-Ellison syndrome. The mean (+/- SEM) gastrin levels were 15.7 +/- 1.5 pg/ml in the duodenal ulcer group, 32.1 +/- 4.3 pg/ml in normals, 1...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.12.11.899

    authors: Korman MG,Soveny C,Hansky J

    更新日期:1971-11-01 00:00:00

  • Oesophageal hiatus hernia in three generations of one family.

    abstract::A family is described in which eight members in three successive generations had a sliding type of oesophageal hiatus hernia (or partial thoracic stomach) as a sole anomaly. The trait in this family behaved as a strict dominant, manifesting the segregation of a single abnormal autosomal gene. Other possible aetiologie...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.11.1.51

    authors: Carré IJ,Froggatt P

    更新日期:1970-01-01 00:00:00

  • Managing radical surgery: notes from the patient's viewpoint.

    abstract::Based on a diary which was kept while preparing for and undergoing pan-proctocolectomy, the paper describes the process of coming to terms with an ileostomy. A number of stages in the process are identified: anticipation, reorientation, trauma, maintenance of selfimage and accommodation. The social-psychological strat...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.28.1.81

    authors: Kelly MP

    更新日期:1987-01-01 00:00:00

  • Reversible effect of phytohaemagglutinin on the growth and metabolism of rat gastrointestinal tract.

    abstract::The lectin, phytohaemagglutinin, present in beans survives passage through the gastrointestinal tract in a biologically and immunologically intact form. It is known that by binding to the brush border membranes of the small intestine phytohaemagglutinin induces its hyperplastic growth. However, its effect on the other...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.37.3.353

    authors: Bardocz S,Grant G,Ewen SW,Duguid TJ,Brown DS,Englyst K,Pusztai A

    更新日期:1995-09-01 00:00:00

  • Plasma insulin, serum lipids and lipoproteins in gall stone disease in non-insulin dependent diabetic subjects: a case control study.

    abstract::Fasting insulin, lipids and lipoproteins were measured in 22 middle aged female non-insulin dependent diabetics with gall stone disease (cases) and in 22 non-insulin dependent diabetics without gall stone disease (controls). The groups were matched for sex, age, obesity, and fasting glucose concentrations. No differen...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.3.344

    authors: Laakso M,Suhonen M,Julkunen R,Pyörälä K

    更新日期:1990-03-01 00:00:00

  • Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection.

    abstract:BACKGROUND AND AIMS:CD8 T cells are central to the control of hepatitis C virus (HCV) although the key features of a successful CD8 T cell response remain to be defined. In a cohort of Irish women infected by a single source, a strong association between viral clearance and the human lecucocyte (HLA)-A*03 allele has be...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2010.228403

    authors: Fitzmaurice K,Petrovic D,Ramamurthy N,Simmons R,Merani S,Gaudieri S,Sims S,Dempsey E,Freitas E,Lea S,McKiernan S,Norris S,Long A,Kelleher D,Klenerman P

    更新日期:2011-11-01 00:00:00

  • High frequency of helicobacter negative gastritis in patients with Crohn's disease.

    abstract::The frequency of gastric Crohn's disease has been considered low. This study was undertaken to determine the prevalence of chronic gastritis and Helicobacter pylori infection in patients with Crohn's disease. Oesophagogastroduodenoscopy was performed on 62 consecutive patients suffering from ileocolonic Crohn's diseas...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.38.3.379

    authors: Halme L,Kärkkäinen P,Rautelin H,Kosunen TU,Sipponen P

    更新日期:1996-03-01 00:00:00

  • Effect of intragastric pH on antral gastrin and somatostatin release in anaesthetised, atropinised duodenal ulcer patients and controls.

    abstract::The synchronous change in the antral release of gastrin and somatostatin into a vein draining the stomach was studied during acidic and alkaline intragastric pH in six anaesthetised duodenal ulcer patients and six controls after atropinisation. No differences in the basal secretion of gastrin and somatostatin were obs...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.28.2.206

    authors: Jensen SL,Holst JJ,Christiansen LA,Shokouh-Amiri MH,Lorentsen M,Beck H,Jensen HE

    更新日期:1987-02-01 00:00:00

  • Echo enhanced ultrasound: a new valid initial imaging approach for severe acute pancreatitis.

    abstract:AIM:This prospective study aimed to compare the accuracy of echo enhanced ultrasound with spiral computed tomography (CT) in assessing acute pancreatitis and to explore the correlation between ultrasound findings and clinical outcome. METHODS:Thirty one patients (24 men and 7 women, median age 39 years, range 19-67 ye...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2005.070276

    authors: Rickes S,Uhle C,Kahl S,Kolfenbach S,Monkemuller K,Effenberger O,Malfertheiner P

    更新日期:2006-01-01 00:00:00

  • Evaluation of colonic myoelectrical activity in health and functional disorders.

    abstract::Electrical activity of the colon was investigated in six healthy volunteers and 22 patients presenting functional colonic disorders associated with pain, constipation, or diarrhoea. Myoelectrical activity during 10 hours, including two daily meals, was recorded from eight groups of nickel-chrome electrodes using a 1.5...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.21.6.480

    authors: Bueno L,Fioramonti J,Ruckebusch Y,Frexinos J,Coulom P

    更新日期:1980-06-01 00:00:00

  • HIV enteropathy: comparative morphometry of the jejunal mucosa of HIV infected patients resident in the United Kingdom and Uganda.

    abstract:AIMS:To compare jejunal mucosal morphometry in HIV infected patients resident in London and Uganda. PATIENTS:Twenty HIV positive patients from London and 16 from Uganda were studied, and compared with HIV negative control subjects from both sites. METHODS:Stools and biopsy specimens were examined for enteropathogens....

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.43.3.350

    authors: Batman PA,Kapembwa MS,Miller AR,Sedgwick PM,Lucas S,Sewankambo NK,Serwadda D,Pudney J,Moody A,Harris JR,Griffin GE

    更新日期:1998-09-01 00:00:00

  • Properties of strains of Escherichia coli carried in different phases of ulcerative colitis.

    abstract::Strains of E. coli from the faeces of patients with active ulcerative colitis and with colitis in remission were examined for haemolysin and necrotoxin production. Cultures from 63 patients with active colitis grew haemolytic E. coli in 23 (37%) as compared with 24 (21%) from 115 patients whose disease was in remissio...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.15.2.143

    authors: Cooke EM,Ewins SP,Hywel-Jones J,Lennard-Jones JE

    更新日期:1974-02-01 00:00:00

  • Imaging of the common bile duct in patients undergoing laparoscopic cholecystectomy.

    abstract::Options for managing the common bile duct during laparoscopic cholecystectomy include routine peroperative cholangiography and selected preoperative endoscopic retrograde cholangiopancreatography (ERCP). The use of these methods was reviewed in 350 patients with symptomatic gall stones referred for laparoscopic cholec...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究

    doi:10.1136/gut.35.7.991

    authors: Hainsworth PJ,Rhodes M,Gompertz RH,Armstrong CP,Lennard TW

    更新日期:1994-07-01 00:00:00

  • Distribution of prostaglandins in gastric and duodenal mucosa of healthy subjects and duodenal ulcer patients: effects of aspirin and paracetamol.

    abstract::The distribution of mucosal PGE2-like activity was determined by bioassay technique in the body and antrum of the stomach and in the duodenum of healthy subjects and duodenal ulcer patients before and after administration of aspirin, paracetamol, or histamine. In healthy subjects, the oxyntic, antral and duodenal muco...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.22.4.283

    authors: Konturek SJ,Obtulowicz W,Sito E,Oleksy J,Wilkon S,Kiec-Dembinska A

    更新日期:1981-04-01 00:00:00

  • Periodontitis induced by Porphyromonas gingivalis drives periodontal microbiota dysbiosis and insulin resistance via an impaired adaptive immune response.

    abstract:OBJECTIVE:To identify a causal mechanism responsible for the enhancement of insulin resistance and hyperglycaemia following periodontitis in mice fed a fat-enriched diet. DESIGN:We set-up a unique animal model of periodontitis in C57Bl/6 female mice by infecting the periodontal tissue with specific and alive pathogens...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-309897

    authors: Blasco-Baque V,Garidou L,Pomié C,Escoula Q,Loubieres P,Le Gall-David S,Lemaitre M,Nicolas S,Klopp P,Waget A,Azalbert V,Colom A,Bonnaure-Mallet M,Kemoun P,Serino M,Burcelin R

    更新日期:2017-05-01 00:00:00

  • Effect of secretogogues on mucosal blood flow in the antrum and corpus of the stomach.

    abstract::Gastric mucosal blood flow in the rat was determined by the indicator fractionation technique of Sapirstein using Rb86Cl. Antral and corpus flow rates were determined in response to increasing doses of pentagastrin and histamine and the effect of vagotomy was determined. With progressive stimulation the antral:corpus ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.19.1.14

    authors: Taylor TV,Pullan BR,Goddard J,Torrance B

    更新日期:1978-01-01 00:00:00

  • Enterochromaffin cell and 5-hydroxytryptamine responses to the same infectious agent differ in Th1 and Th2 dominant environments.

    abstract:BACKGROUND/AIM:5-Hydroxytryptamine (5-HT) released from enterochromaffin cells influences intestinal homeostasis by altering gut physiology and is implicated in the pathophysiology of various gut disorders. The mechanisms regulating 5-HT production in the gut remain unclear. This study investigated the T helper (Th) 1/...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2007.129296

    authors: Motomura Y,Ghia JE,Wang H,Akiho H,El-Sharkawy RT,Collins M,Wan Y,McLaughlin JT,Khan WI

    更新日期:2008-04-01 00:00:00

  • Gastrin studies in gastric ulcer.

    abstract::Basal serum gastrin in 40 patients with benign gastric ulcer was 103 +/- 10.7 pg/ml, a level significantly higher than corresponding estimations in normal subjects and patients with duodenal ulcer. Following stimulation by a protein meal, a mean rise of 124 pg/ml was achieved at 75 minutes and prior atropinization ind...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.13.3.166

    authors: Korman MG,Soveny C,Hansky J

    更新日期:1972-03-01 00:00:00

  • Long-term performance of colorectal cancerscreening programmes based on the faecal immunochemical test.

    abstract:BACKGROUND:The long-term performance of colorectal cancer (CRC) screening programmes based on a 2-year faecal immunochemical test (FIT) is still unclear. METHODS:In a sample of 50 to 69-year-olds repeatedly screened with the FIT (OC-Hemodia latex agglutination test; cut-off: 20 µg haemoglobin/g faeces), we examined: (...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2017-314753

    authors: Zorzi M,Hassan C,Capodaglio G,Fedato C,Montaguti A,Turrin A,Rosano A,Monetti D,Stocco C,Baracco S,Russo F,Repici A,Rugge M

    更新日期:2018-12-01 00:00:00

  • Relationship between pancreatic secretion and pancreatic blood flow.

    abstract::An indicator fractionation technique using radioactive rubidium has been used to measure pancreatic blood flow after infusions of secretin, pancreozymin, urecholine, and pentagastrin. Secretin resulted in the production of a large volume of low viscous pancreatic juice and was associated with an increase in the cardia...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.11.1.62

    authors: Goodhead B,Himal HS,Zanbilowicz J

    更新日期:1970-01-01 00:00:00