Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers.

abstract：:Basal serum gastrin in 40 patients with benign gastric ulcer was 103 +/- 10.7 pg/ml, a level significantly higher than corresponding estimations in normal subjects and patients with duodenal ulcer. Following stimulation by a protein meal, a mean rise of 124 pg/ml was achieved at 75 minutes and prior atropinization ind...

journal_title：Gut

authors： Korman MG,Soveny C,Hansky J

更新日期：1972-03-01 00:00:00

abstract：:By prolonged immunization of an inbred rat strain with isologous liver homogenate in Freund's complete adjuvant a low grade autoimmune ;cholangitis' with periductular fibrosis has been demonstrated. The lesion could be transferred to isogeneic animals by serial spleen cell injections and was associated with mild but v...

journal_title：Gut

authors： Maclaurin BP

更新日期：1971-06-01 00:00:00

abstract：:The induction of adenocarcinomas in the glandular stomach of the adult male Wistar rat by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was used as a model to study the expression of the growth promoting peptide, transforming growth factor alpha (TGF alpha), during experimental gastric carcinogenesis. TGF alpha was iden...

journal_title：Gut

authors： Livingstone JI,Filipe MI,Wastell C

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Oligodeoxynucleotides (ODNs) containing unmethylated cytosine-guanosine (CpG) sequence motifs constitute the immunostimulatory components of bacterial DNA which potently activate innate immunity. Administration of CpG-ODNs before the onset of experimental colitis prevents intestinal inflammation by induction...

journal_title：Gut

authors： Hofmann C,Dunger N,Grunwald N,Hämmerling GJ,Hoffmann P,Schölmerich J,Falk W,Obermeier F

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:"Probiotic" bacteria are effective in treating some inflammatory bowel diseases. However which bacteria confer benefit and mechanisms of action remain poorly defined. Dendritic cells, which are pivotal in early bacterial recognition, tolerance induction, and shaping of T cell responses, may be central in med...

journal_title：Gut

authors： Hart AL,Lammers K,Brigidi P,Vitali B,Rizzello F,Gionchetti P,Campieri M,Kamm MA,Knight SC,Stagg AJ

更新日期：2004-11-01 00:00:00

abstract：:The variability in the orocaecal transit time as measured by the lactulose/breath hydrogen method has been studied for three conditions: lactulose given with a meal, subjects sitting; lactulose given with a meal, subjects semirecumbent; lactulose given in aqueous solution, subjects semirecumbent. Thirty three healthy ...

journal_title：Gut

authors： Staniforth DH,Rose D

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Small bowel transplantation remains a difficult therapeutic option endangered by a high rate of rejection and infectious complications. To improve these clinical results, it is mandatory to set up animal models to test alternative immunosuppressive regimens which may lead to immunotolerance. AIMS:To determi...

journal_title：Gut

authors： Sarnacki S,Auber F,Crétolle C,Camby C,Cavazzana-Calvo M,Müller W,Wagner N,Brousse N,Révillon Y,Fischer A,Cerf-Bensussan N

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:The postinfectious irritable bowel syndrome (PI-IBS) suggests that impaired resolution of inflammation could cause IBS symptoms. The authors hypothesised that polymorphisms in genes whose expression were altered by gastroenteritis might be linked to IBS with diarrhoea (IBS-D) which closely resembles PI-IBS. ...

journal_title：Gut

authors： Swan C,Duroudier NP,Campbell E,Zaitoun A,Hastings M,Dukes GE,Cox J,Kelly FM,Wilde J,Lennon MG,Neal KR,Whorwell PJ,Hall IP,Spiller RC

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Many neuroendocrine gastrointestinal tumours express receptors for the regulatory peptide somatostatin. Among the five existing somatostatin receptor (sst) subtypes, sst2A is the most frequently expressed in these tumours. However, little information is available about the cellular location of sst2A...

journal_title：Gut

authors： Gugger M,Waser B,Kappeler A,Schonbrunn A,Reubi JC

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:Surveillance colonoscopy is widely recommended in patients with longstanding and extensive ulcerative colitis (UC) in order to detect colorectal neoplasia at an early stage. However, it still remains questionable whether surveillance colonoscopy effectively enables early detection of UC associated neoplasia....

journal_title：Gut

authors： Fujii S,Tominaga K,Kitajima K,Takeda J,Kusaka T,Fujita M,Ichikawa K,Tomita S,Ohkura Y,Ono Y,Imura J,Chiba T,Fujimori T

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:Colorectal cancer is the second most common cause of cancer death in Europe and North America. Alarm features are used to prioritize access to urgent investigation, but there is little information concerning their utility in the diagnosis of colorectal cancer. METHODS:A systematic review and meta-analysis of...

journal_title：Gut

authors： Ford AC,Veldhuyzen van Zanten SJ,Rodgers CC,Talley NJ,Vakil NB,Moayyedi P

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Pancreatic cancer is among the most dismal of human malignancies. Current therapeutic strategies are virtually ineffective in controlling advanced, metastatic disease. Recent evidence suggests that the Hedgehog signalling pathway is aberrantly reactivated in the majority of pancreatic cancers, and t...

journal_title：Gut

authors： Feldmann G,Habbe N,Dhara S,Bisht S,Alvarez H,Fendrich V,Beaty R,Mullendore M,Karikari C,Bardeesy N,Ouellette MM,Yu W,Maitra A

更新日期：2008-10-01 00:00:00

abstract：OBJECTIVES:Lipid mediators in the GI tract regulate satiation and satiety. Bile acids (BAs) regulate the absorption and metabolism of dietary lipid in the intestine, but their effects on lipid-regulated satiation and satiety are completely unknown. Investigating this is challenging because introducing excessive BAs or ...

journal_title：Gut

authors： Higuchi S,Ahmad TR,Argueta DA,Perez PA,Zhao C,Schwartz GJ,DiPatrizio NV,Haeusler RA

更新日期：2020-09-01 00:00:00

abstract：:Coeliac disease is triggered by ingestion of wheat gliadin and is probably immune mediated. There is evidence by light microscopy that expression of class II major histocompatibility complex (MHC) molecules is increased in the small intestinal epithelium of patients with untreated coeliac disease and that gliadin can ...

journal_title：Gut

authors： Zimmer KP,Poremba C,Weber P,Ciclitira PJ,Harms E

更新日期：1995-05-01 00:00:00

abstract：:The prevalence of colorectal adenoma in 23 affected patients with hereditary non-polyposis colorectal cancer (HNPCC) was compared with that in an age matched forensic autopsy population. The mean ages at diagnosis of colorectal cancer in men (13) and women (10) were 39 and 37 years respectively. In HNPCC patients who ...

journal_title：Gut

authors： Jass JR,Stewart SM

更新日期：1992-06-01 00:00:00

abstract：:Single angiodysplasias were demonstrated by preoperative angiography in four patients. In two cases the lesions were in the terminal ileum, and were situated just above the caecum in the other two patients. In three patients, contrast medium was extravasated into the bowel lumen. Histological verification was obtained...

journal_title：Gut

authors： Whitehouse GH

更新日期：1973-12-01 00:00:00

abstract：BACKGROUND AND AIMS:Gastrokine 1 (GKN1) is a stomach-specific protein that is normally expressed in gastric mucosa but not in primary tumours and cell lines. Based on this evidence, it was presumed that GKN1 might play a role in gastric cancer development; however, its function and molecular mechanism are not clear. A ...

journal_title：Gut

authors： Xing R,Li W,Cui J,Zhang J,Kang B,Wang Y,Wang Z,Liu S,Lu Y

更新日期：2012-01-01 00:00:00

abstract：:Aspirin is generally regarded as a cause of gastric ulcer but the role of non-steroidal anti-inflammatory agents and paracetamol in the aetiology of peptic ulcer is unclear. To investigate this we conducted a case control study of 180 matched pairs of peptic ulcer patients and controls obtained from surgical and derma...

journal_title：Gut

authors： Duggan JM,Dobson AJ,Johnson H,Fahey P

更新日期：1986-08-01 00:00:00

abstract：:A case of adenocarcinoma of the ileum, occurring in an area concomitantly the site of Crohn's disease, is described. Examination of the literature suggests that there are certain characteristics of the small bowel carcinoma which arises in Crohn's disease. These include invisibility of the tumour on macroscopic inspec...

journal_title：Gut

authors： Fleming KA,Pollock AC

更新日期：1975-07-01 00:00:00

abstract：:A family is described in which eight members in three successive generations had a sliding type of oesophageal hiatus hernia (or partial thoracic stomach) as a sole anomaly. The trait in this family behaved as a strict dominant, manifesting the segregation of a single abnormal autosomal gene. Other possible aetiologie...

journal_title：Gut

authors： Carré IJ,Froggatt P

更新日期：1970-01-01 00:00:00

abstract：BACKGROUND:The detection of hepatocellular cancers (HCC) is a major role of preoperative imaging in patients with end stage liver disease being considered for orthotopic liver transplantation (OLT). AIMS:To assess the sensitivity of iodised oil computed tomography (IOCT). PATIENTS AND METHODS:A prospective evaluation...

journal_title：Gut

authors： Saada J,Bhattacharya S,Dhillon AP,Dick R,Burroughs AK,Rolles K,Davidson BR

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Several inflammatory disorders of the intestine are characterised by enhanced expression of tumour necrosis factor alpha (TNF-alpha). Monocytes and macrophages have been suggested as a major cellular source of TNF-alpha in human gut, whereas mast cells, although known to be capable of producing TNF-alpha, ha...

journal_title：Gut

authors： Bischoff SC,Lorentz A,Schwengberg S,Weier G,Raab R,Manns MP

更新日期：1999-05-01 00:00:00

abstract：:It is well known that chronic encephalopathy may be a major complication after the establishment of a surgical portal caval shunt for an episode of variceal haemorrhage. In an effort to minimise this problem Warren and colleagues developed the distal splenorenal shunt where the portal and mesenteric blood flow to the ...

journal_title：Gut

authors： Bleasel AF,Waugh RC,McCaughan GW

更新日期：1989-10-01 00:00:00

abstract：BACKGROUND:Sodium butyrate, a product of colonic bacterial fermentation, is able to inhibit cell proliferation and to stimulate cell differentiation of colonic epithelial cell lines. It has been proposed that these cellular effects could be linked to its ability to cause hyperacetylation of histone through the inhibiti...

journal_title：Gut

authors： Siavoshian S,Segain JP,Kornprobst M,Bonnet C,Cherbut C,Galmiche JP,Blottière HM

更新日期：2000-04-01 00:00:00

abstract：OBJECTIVE:Liver injury impacts hepatic inflammation in part via Toll-like receptor (TLR) signalling. Triggering receptor expressed on myeloid cells 2 (TREM-2) modulates TLR4-mediated inflammation in bone marrow (BM)-derived macrophages but its function in liver injury is unknown. Here we hypothesised that the anti-infl...

journal_title：Gut

authors： Perugorria MJ,Esparza-Baquer A,Oakley F,Labiano I,Korosec A,Jais A,Mann J,Tiniakos D,Santos-Laso A,Arbelaiz A,Gawish R,Sampedro A,Fontanellas A,Hijona E,Jimenez-Agüero R,Esterbauer H,Stoiber D,Bujanda L,Banales JM,K

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:To develop gene expression profiles that characterise KRAS-, BRAF- or PIK3CA-activated- tumours, and to explore whether these profiles might be helpful in predicting the response to the epidermal growth factor receptor (EGFR) pathway inhibitors better than mutation status alone. DESIGN:Fresh frozen tumour sa...

journal_title：Gut

authors： Tian S,Simon I,Moreno V,Roepman P,Tabernero J,Snel M,van't Veer L,Salazar R,Bernards R,Capella G

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:We aimed at the identification of genetic alterations that may functionally substitute for CTNNB1 mutation in ß-catenin-activated hepatocellular adenomas (HCAs) and hepatocellular carcinoma (HCC). DESIGN:Large cohorts of HCA (n=185) and HCC (n=468) were classified using immunohistochemistry. The mutational s...

journal_title：Gut

authors： Longerich T,Endris V,Neumann O,Rempel E,Kirchner M,Abadi Z,Uhrig S,Kriegsmann M,Weiss KH,Breuhahn K,Mehrabi A,Weber TF,Wilkens L,Straub BK,Rosenwald A,Schulze F,Brors B,Froehling S,Pellegrino R,Budczies J,Schirmac

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVE:Persistent colonisation by Helicobacter pylori, and especially by cagA-positive strains, has been related to several health outcomes with effects in opposite directions. Thus, it is important to evaluate its influence on total and category-specific mortality. DESIGN:We conducted prospective cohort analyses i...

journal_title：Gut

authors： Chen Y,Segers S,Blaser MJ

更新日期：2013-09-01 00:00:00

abstract：:To determine the significance of the endoscopic classification of gastritis proposed by a working party at the World Congress of Gastroenterology in Sydney 1990, 167 patients undergoing upper alimentary endoscopy were prospectively assessed by comprehensive endoscopic and histological methods. Ninety eight patients ha...

journal_title：Gut

authors： Khakoo SI,Lobo AJ,Shepherd NA,Wilkinson SP

更新日期：1994-09-01 00:00:00

abstract：:The role of biliary deoxycholate as an endogenous colon carcinogen and the possible association between cholelithiasis and/or cholecystectomy and the subsequent development of large bowel cancer is unclear. This paper describes biliary bile acids analysis performed on 13 patients undergoing cholecystectomy for gall st...

journal_title：Gut

authors： Castleden WM,Detchon P,Misso NL

更新日期：1989-06-01 00:00:00