An investigation into the enzyme histochemistry of adenocarcinomas of human large intestine and of the transitional epithelium immediately adjacent to them.

abstract：:A case of adenocarcinoma of the ileum, occurring in an area concomitantly the site of Crohn's disease, is described. Examination of the literature suggests that there are certain characteristics of the small bowel carcinoma which arises in Crohn's disease. These include invisibility of the tumour on macroscopic inspec...

journal_title：Gut

authors： Fleming KA,Pollock AC

更新日期：1975-07-01 00:00:00

abstract：:Vagal and spinal afferents represent the information superhighways that convey sensory information from the gut to the central nervous system. These afferents are sensitive to both mechanical and chemical stimuli. Vagal afferents terminate in the muscle layers and in the mucosa. Muscle afferents are activated at physi...

journal_title：Gut

authors： Grundy D

更新日期：2004-03-01 00:00:00

abstract：:Small intestinal mucosa obtained from six fasting patients with cholera by a peroral biopsy technique was studied with the electron microscope. The cultures of their rectal swabs were all positive for Vibrio cholerae. In the absorptive cells, large pseudopod-like cytoplasmic processes with deformed microvilli or witho...

journal_title：Gut

authors： Asakura H,Tsuchiya M,Watanabe Y,Enomoto Y,Morita A

更新日期：1974-07-01 00:00:00

abstract：BACKGROUND AND AIMS:Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC). International guidelines recommend surveillance intervals of 1-2 years. However, yearly surveillance likely leads to overtreatment for many. We prospectively assessed a surveillance protocol aiming to ...

journal_title：Gut

authors： Bleijenberg AG,IJspeert JE,van Herwaarden YJ,Carballal S,Pellisé M,Jung G,Bisseling TM,Nagtegaal ID,van Leerdam ME,van Lelyveld N,Bessa X,Rodríguez-Moranta F,Bastiaansen B,de Klaver W,Rivero L,Spaander MC,Koornstra JJ,B

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Micrometastases within bone marrow have been shown to indicate a poor prognosis in patients with epithelial tumours. However, the degree to which micrometastases represent true residual disease or cell shedding and metastatic potential, is unclear. AIM:To explore whether micrometastases represent residual d...

journal_title：Gut

authors： O'Sullivan GC,Collins JK,Kelly J,Morgan J,Madden M,Shanahan F

更新日期：1997-04-01 00:00:00

abstract：BACKGROUND:Intrasphincteric injection of botulinum toxin (Botx) has been proposed as treatment for oesophageal achalasia. However, the predictors of response and optimal dose remain unclear. AIMS:To compare the effect of different doses of Botx and to identify predictors of response. PATIENTS/METHODS:A total of 118 a...

journal_title：Gut

authors： Annese V,Bassotti G,Coccia G,Dinelli M,D'Onofrio V,Gatto G,Leandro G,Repici A,Testoni PA,Andriulli A

更新日期：2000-05-01 00:00:00

abstract：:The present study was undertaken to investigate the possibility that central nervous system monoaminergic pathways may play a role in the control of gastric acid and gastrin secretion in man. Submaximal pentagastrin stimulated (0.25 micrograms/kg/h) gastric acid secretion, as well as basal gastrin concentrations were ...

journal_title：Gut

authors： Caldara R,Barbieri C,Piepoli V,Borzio M,Masci E

更新日期：1985-10-01 00:00:00

abstract：BACKGROUND:The mechanisms of aspirin induced gastroduodenal injury are not fully understood. Aspirin induces the release of reactive oxygen metabolites in animal models, which may contribute to mucosal injury. AIMS:To investigate the effects of aspirin administered with placebo or antioxidants on gastric mucosal react...

journal_title：Gut

authors： McAlindon ME,Muller AF,Filipowicz B,Hawkey CJ

更新日期：1996-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Juvenile polyps occur in several Mendelian disorders, whether in association with gastrointestinal cancer alone (juvenile polyposis syndrome, JPS) or as part of known syndromes (Cowden, Gorlin, and Bannayan-Zonana) in association with developmental abnormalities, dysmorphic features, or extraintesti...

journal_title：Gut

authors： Bevan S,Woodford-Richens K,Rozen P,Eng C,Young J,Dunlop M,Neale K,Phillips R,Markie D,Rodriguez-Bigas M,Leggett B,Sheridan E,Hodgson S,Iwama T,Eccles D,Bodmer W,Houlston R,Tomlinson I

更新日期：1999-09-01 00:00:00

abstract：:A case is described of primary biliary cirrhosis in a 59 year old woman who initially presented with a rash over her lower legs 18 months before diagnosis. Skin biopsy examination showed non-caseating granulomas of the sarcoid type. It is believed that this is the first reported case of primary biliary cirrhosis prese...

journal_title：Gut

authors： Jardine DL,Chambers ST,Hart DJ,Chapman BA

更新日期：1994-04-01 00:00:00

abstract：:Early carcinoma of the gastric remnant was diagnosed in 19 patients between January 1976 and January 1986. In all patients early cancer was suspected at endoscopy and confirmed by biopsy and histology. The main reason for endoscopic examination was diffuse epigastric pain suggestive of stump gastritis. The surgical pr...

journal_title：Gut

authors： Pointner R,Schwab G,Königsrainer A,Bodner E,Schmid KW

更新日期：1988-03-01 00:00:00

abstract：:Rapid growth of a transplantable insulinoma in rats over a 14 day period results in hyperphagia together with a selective increase in the weight and enteroglucagon (GLI) concentration of the small intestine. Measurement of serotonin concentrations by an HPLC/fluorometric method demonstrated an increase in blood (91%; ...

journal_title：Gut

authors： Conlon JM,Bailey CJ,Flatt PR

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Little is known about the epidemiology of malignant digestive endocrine tumours. The aim of this study was to report on their incidence and management in a well defined population. METHODS:Data were obtained from the population based Digestive Cancer Registry of Burgundy (France) over a 24 year per...

journal_title：Gut

authors： Lepage C,Bouvier AM,Phelip JM,Hatem C,Vernet C,Faivre J

更新日期：2004-04-01 00:00:00

abstract：:An endoscopical and histological study was carried out in 114 patients, treated by 'curative' resection of the terminal ileum and part of the colon for Crohn's disease, in order to study the natural history of recurrent Crohn's disease. The recurrence rate of Crohn's disease in patients examined within one year of the...

journal_title：Gut

authors： Rutgeerts P,Geboes K,Vantrappen G,Kerremans R,Coenegrachts JL,Coremans G

更新日期：1984-06-01 00:00:00

abstract：BACKGROUND:Targeting tumour necrosis factor alpha (TNF-alpha) has demonstrated efficacy in Crohn's disease. AIM:To evaluate CDP571, a humanised antibody to TNF-alpha, for treating active Crohn's disease. PATIENTS:A total of 396 patients with moderate to severe Crohn's disease. METHODS:In a 28 week, randomised, doubl...

journal_title：Gut

authors： Sandborn WJ,Feagan BG,Radford-Smith G,Kovacs A,Enns R,Innes A,Patel J

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND:A high prevalence of osteoporosis is reported in Crohn's disease. The pathogenesis is not completely understood but is probably multifactorial. Longstanding Crohn's disease is associated with a deficiency of fat soluble vitamins, among them vitamin K. Vitamin K is a cofactor in the carboxylation of osteocalc...

journal_title：Gut

authors： Schoon EJ,Müller MC,Vermeer C,Schurgers LJ,Brummer RJ,Stockbrügger RW

更新日期：2001-04-01 00:00:00

abstract：BACKGROUND:Sulfhydryl (SH) compounds are essential in maintaining mucosal integrity in the gastrointestinal tract. A decrease in colonic mucosal SH compounds affects the redox status of the mucosa, resulting in vulnerability to further attacks. Therefore, there is a strong need for in vivo evaluation of SH compounds in...

journal_title：Gut

authors： Togashi H,Oikawa K,Adachi T,Sugahara K,Ito J,Takeda T,Watanabe H,Saito K,Saito T,Fukui T,Takeda H,Ohya H,Kawata S

更新日期：2003-09-01 00:00:00

abstract：OBJECTIVE:Most colorectal cancer (CRC) screening programmes are nowadays based on faecal immunochemical testing (FIT). Eligible subjects often use oral anticoagulants (OACs) or non-steroidal anti-inflammatory drugs (NSAIDs), which could possibly stimulate bleeding from both benign and premalignant lesions in the colon....

journal_title：Gut

authors： Nieuwenburg SAV,Vuik FER,Kruip MJHA,Kuipers EJ,Spaander MCW

更新日期：2019-05-01 00:00:00

abstract：:The effect of increasing the calcium, magnesium and sodium concentration in gall bladder bile samples from 21 patients with gall stones and nine controls on the in vitro rate of formation of cholesterol microcrystals and numbers of cholesterol microcrystals formed was examined. Addition of these cations to raise the m...

journal_title：Gut

authors： Neithercut WD

更新日期：1989-05-01 00:00:00

abstract：BACKGROUND:Helicobacter pylori affects gastric epithelium integrity by acceleration of apoptosis. However, it remains unclear what product of the bacteria causes apoptosis, or whether or not the apoptosis is involved in the development of ulcers. AIMS:To elucidate the factor from H pylori that causes acceleration of a...

journal_title：Gut

authors： Kohda K,Tanaka K,Aiba Y,Yasuda M,Miwa T,Koga Y

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:Gastric cancer is the third leading cause of cancer death worldwide and infection by Helicobacter pylori is the strongest risk factor. We have reported increased epidermal growth factor receptor (EGFR) phosphorylation in the H. pylori-induced human carcinogenesis cascade, and association with DNA damage. Our ...

journal_title：Gut

authors： Sierra JC,Asim M,Verriere TG,Piazuelo MB,Suarez G,Romero-Gallo J,Delgado AG,Wroblewski LE,Barry DP,Peek RM Jr,Gobert AP,Wilson KT

更新日期：2018-07-01 00:00:00

abstract：:A 22 year old woman presenting with recurrent intestinal pseudo-obstruction is reported. Jejunal biopsy showed subtotal villous atrophy which improved markedly during a period of total parenteral nutrition and with steroid treatment. It did not relapse on a gluten free diet. The reasons why this patient represents a c...

journal_title：Gut

authors： Dawson DJ,Sciberras CM,Whitwell H

更新日期：1984-09-01 00:00:00

abstract：:The purpose of this single blind controlled multicentre trial was to compare the relative effectiveness of pirenzepine and cimetidine in healing endoscopically proven duodenal ulcers. One hundred and twenty six patients with duodenal ulcer were treated with a daily dose of 100 mg pirenzepine (50 mg each before breakfa...

journal_title：Gut

authors： Brunner H,Dittrich H,Kratochvil P,Brandstätter G,Hentschel E,Schütze K,Tragl KH,Kern H,Löffelmann K,Zeiler H

更新日期：1984-02-01 00:00:00

abstract：:Octreotide has been proposed for the treatment of variceal bleeding. The effects on portal pressure, however, have been variable in published studies. As bleeding is more directly related to pressure in the varices, this study investigated the effect on variceal pressure of octreotide and terlipressin, a vasoactive dr...

journal_title：Gut

authors： Nevens F,Van Steenbergen W,Yap SH,Fevery J

更新日期：1996-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Pancreatic cancer is among the most dismal of human malignancies. Current therapeutic strategies are virtually ineffective in controlling advanced, metastatic disease. Recent evidence suggests that the Hedgehog signalling pathway is aberrantly reactivated in the majority of pancreatic cancers, and t...

journal_title：Gut

authors： Feldmann G,Habbe N,Dhara S,Bisht S,Alvarez H,Fendrich V,Beaty R,Mullendore M,Karikari C,Bardeesy N,Ouellette MM,Yu W,Maitra A

更新日期：2008-10-01 00:00:00

abstract：:The endothelins are a group of three related peptides with two receptor subtypes, ET(A) and ET(B). Following the discovery of endothelin 1 as a potent vasoconstrictor, there has been intense interest in the role of endothelin on vascular function in liver disease. Speculation on the role of endothelin in the pathogene...

journal_title：Gut

authors： Moore K

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:The gut microbiota, which is considered a causal factor in metabolic diseases as shown best in animals, is under the dual influence of the host genome and nutritional environment. This study investigated whether the gut microbiota per se, aside from changes in genetic background and diet, could sign different...

journal_title：Gut

authors： Serino M,Luche E,Gres S,Baylac A,Bergé M,Cenac C,Waget A,Klopp P,Iacovoni J,Klopp C,Mariette J,Bouchez O,Lluch J,Ouarné F,Monsan P,Valet P,Roques C,Amar J,Bouloumié A,Théodorou V,Burcelin R

更新日期：2012-04-01 00:00:00

abstract：:Cimetidine 200 mg three times daily and 400 mg at night was given to 10 subjects for four weeks. Apparent liver blood flow was measured by indocyanine green clearance and microsomal enzyme activity by antipyrine clearance, before and after cimetidine. There was no reduction in indocyanine green clearance but antipyrin...

journal_title：Gut

authors： Daneshmend TK,Ene MD,Parker G,Roberts CJ

更新日期：1984-02-01 00:00:00

abstract：:A case is described of a life threatening vasculitis of the small bowel leading to massive gastrointestinal haemorrhage which was apparently due to cytomegalovirus inclusion disease. Reactivation of cytomegalovirus probably followed the treatment of Wegener's granulomatosis with corticosteroids and azathioprine. This ...

journal_title：Gut

authors： Sackier JM,Kelly SB,Clarke D,Rees AJ,Wood CB

更新日期：1991-11-01 00:00:00

abstract：:In 18 patients intermediary anabolic metabolites of 5-FU were measured in normal colonic mucosa and colorectal cancer tissue of intravenous bolus injection or continuous infusion. Higher total concentrations of 5-FU products were found in the cancers when compared with normal colonic tissue. There appeared to be no ev...

journal_title：Gut

authors： Giles GR,Woodhouse L,Finan PJ,Chisholm EM

更新日期：1986-02-01 00:00:00