Abstract:
:Rapid growth of a transplantable insulinoma in rats over a 14 day period results in hyperphagia together with a selective increase in the weight and enteroglucagon (GLI) concentration of the small intestine. Measurement of serotonin concentrations by an HPLC/fluorometric method demonstrated an increase in blood (91%; p less than 0.05) and in extracts of colon (22%; p less than 0.05) but no change in extracts of the small intestine and caecum. The data support the hypothesis that the rise in enteroglucagon is related directly to the growth of the small intestine and is not a non-specific effect of hyperphagia.
journal_name
Gutjournal_title
Gutauthors
Conlon JM,Bailey CJ,Flatt PRdoi
10.1136/gut.28.suppl.213subject
Has Abstractpub_date
1987-01-01 00:00:00pages
213-6eissn
0017-5749issn
1468-3288journal_volume
28 Supplpub_type
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