Abstract:
:Distal duodenal biopsy specimens taken from 30 white, 35 Indian, and 20 Afro-Caribbean residents of West Birmingham during routine endoscopy for dyspepsia, were assessed by dissecting microscopy and morphometry. Finger-shaped villi were significantly less frequent in the Indian and Afro-Caribbean subjects than in the white subjects when assessed by dissecting microscopy (p less than 0.005), and both immigrant groups had decreased mucosal thickness (p less than 0.01), villous height (p less than 0.001), villous:crypt ratios (p less than 0.01) and enterocyte height (p less than 0.05) compared with the white group. In the Indian subjects, villous height and villous:crypt ratios correlated significantly with the time since the last visit to the Indian subcontinent (p less than 0.005). Serum alkaline phosphatase values were significantly higher in the Indian subjects compared with the whites (p less than 0.02), and serum globulins were increased in both the Afro-Caribbean and Indian subjects (p less than 0.01). There were no correlations between morphometric indices and body habitus or biochemical or haematological indices and the long term effect of the morphological changes is not clear.
journal_name
Gutjournal_title
Gutauthors
Wood GM,Gearty JC,Cooper BTdoi
10.1136/gut.32.3.256subject
Has Abstractpub_date
1991-03-01 00:00:00pages
256-9issue
3eissn
0017-5749issn
1468-3288journal_volume
32pub_type
杂志文章相关文献
GUT文献大全abstract:OBJECTIVE:To develop gene expression profiles that characterise KRAS-, BRAF- or PIK3CA-activated- tumours, and to explore whether these profiles might be helpful in predicting the response to the epidermal growth factor receptor (EGFR) pathway inhibitors better than mutation status alone. DESIGN:Fresh frozen tumour sa...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2012-302423
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND:Murine postoperative ileus results from intestinal inflammation triggered by manipulation-induced mast cell activation. As its extent depends on the degree of handling and subsequent inflammation, it is hypothesised that the faster recovery after minimal invasive surgery results from decreased mast cell acti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2007.120238
更新日期:2008-01-01 00:00:00
abstract::Lymphangiomas are rare tumours of lymphatic vessels, most commonly found in children. We present the unusual case of small bowel obstruction caused by benign lymphangioma in a middle aged woman. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.12.1568
更新日期:1991-12-01 00:00:00
abstract:BACKGROUND:The relation of demographic and psychological factors to the presence and extent of gut transit impairment in the functional gastrointestinal disorders has received little attention. AIMS:To compare the psychosocial and demographic features of patients with functional gastrointestinal disorders and delayed ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.46.1.83
更新日期:2000-01-01 00:00:00
abstract::Tumour cell membrane fatty acid composition was investigated using an animal model of colorectal carcinogenesis. Eighty six male Wistar rats were fed experimental diets containing either 5% saturated fat or 20% saturated fat. Colorectal tumours were induced by intraperitoneal injection of azoxymethane, and control rat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.4.413
更新日期:1991-04-01 00:00:00
abstract:OBJECTIVE:The risk of developing adenocarcinoma in non-dysplastic Barrett's oesophagus is low and difficult to predict. Accurate tools for risk stratification are needed to increase the efficiency of surveillance. We aimed to develop a prediction model for progression using clinical variables and genetic markers. METH...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309642
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:Visceral hyperalgesia has been implicated as a factor contributing to symptom generation in irritable bowel syndrome (IBS). However, previous studies using intestinal balloon distension have used psychophysical procedures which do not provide adequate and unbiased measures of visceral sensitivity. METHODS:T...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.4.505
更新日期:1997-10-01 00:00:00
abstract::In a prospective study we compared the diagnostic accuracy of endoscopic fine needle aspiration cytology with that of brush cytology and forceps biopsy in relation to gross tumour pattern and site in 265 confirmed consecutive cases of malignancy of the oesophagus, stomach, colon, and rectum. Aspiration cytology gave t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.7.745
更新日期:1991-07-01 00:00:00
abstract:BACKGROUND AND AIMS:The authors' goal was to measure pH at the gastric surface (pH₀) to understand how acid secretion affects the repair of microscopic injury to the gastric epithelium. METHODS:Microscopic gastric damage was induced by laser light, during confocal/two-photon imaging of pH-sensitive dyes (Cl-NERF, BCEC...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2011-300420
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:The gut-brain axis is considered as a major regulatory checkpoint in the control of glucose homeostasis. The detection of nutrients and/or hormones in the duodenum informs the hypothalamus of the host's nutritional state. This process may occur via hypothalamic neurons modulating central release of nitric oxi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-310230
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND AND AIMS:Juvenile polyps occur in several Mendelian disorders, whether in association with gastrointestinal cancer alone (juvenile polyposis syndrome, JPS) or as part of known syndromes (Cowden, Gorlin, and Bannayan-Zonana) in association with developmental abnormalities, dysmorphic features, or extraintesti...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.45.3.406
更新日期:1999-09-01 00:00:00
abstract::Recent discoveries of trypsinogen and trypsin inhibitor mutations in patients with chronic pancreatitis (CP) support the hypothesis that an inappropriate activation of pancreatic zymogens to active enzymes within the pancreatic parenchyma starts the inflammatory process. Current data suggest that CP may be inherited d...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.52.suppl_2.ii31
更新日期:2003-05-01 00:00:00
abstract::The behaviour of basal and stimulated acid secretion, gastrin release, serum pepsinogen I, and gastric emptying of liquids was studied in 19 consecutive patients with Helicobacter pylori positive duodenal ulcer, over a follow up period of six months. Eleven patients were studied before and at three and six months afte...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.2.210
更新日期:1995-08-01 00:00:00
abstract::This paper describes four patients whose chief symptoms were steatorrhoea and loss of weight. Despite the absence of a history of abdominal pain investigations showed that these patients had chronic pancreatitis, which responded to medical treatment. The pathological findings in two of these cases and in six which cam...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.3.3.252
更新日期:1962-09-01 00:00:00
abstract::Circulating immune complexes were determined in 59 consecutive patients with Crohn's disease and 100 blood donors by a double method based on the inhibition of the agglutinating activity of CIq and/or rheumatoid factor on the IgG-coated polystyrene particles. In patients, the incidence of positive immune complexes was...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.7.611
更新日期:1978-07-01 00:00:00
abstract:OBJECTIVE:To identify a causal mechanism responsible for the enhancement of insulin resistance and hyperglycaemia following periodontitis in mice fed a fat-enriched diet. DESIGN:We set-up a unique animal model of periodontitis in C57Bl/6 female mice by infecting the periodontal tissue with specific and alive pathogens...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-309897
更新日期:2017-05-01 00:00:00
abstract::The effects of low power (1-2 Watts), long exposure (30-400 seconds), interstitial Nd YAG laser therapy on dimethylhydrazine induced rat colonic neoplasms and normal rat colon have been studied. After a single exposure with appropriate laser parameters, dimethylhydrazine induced rat colonic neoplasms underwent coagula...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.29.1.27
更新日期:1988-01-01 00:00:00
abstract::The host's humoral immune response to Helicobacter pylori has been used in the diagnosis of active infection with these organisms. Several commercial tests are available but there are few and unconfirmed reports of their efficacy. This study aimed to assess and compare the efficacy of the following H pylori serologica...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.4.461
更新日期:1993-04-01 00:00:00
abstract::The free primary amines present in the faeces of 44 infants (1-18 months) with gastroenteritis have been examined by field desorption mass spectrometry of the lactone form of their fluorescamine derivatives without their prior separation. p-Tyramine, 2-phenylethylamine, the diamines, putrescine and cadaverine and seve...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.10.1173
更新日期:1986-10-01 00:00:00
abstract::An elderly woman with chronic ulcerative colitis who developed proximal muscle weakness, increased serum creatine phosphokinase activity, and histological and electromyographic abnormalities characteristic of polymyositis is described. Treatment with corticosteroids and 5-acetylsalicylic acid was followed by a remissi...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.34.4.567
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND:Cirrhotic patients with hepatocellular carcinoma (HCC) frequently have impaired glucose metabolism. AIMS:To investigate whether impaired glucose metabolism affects the growth rate of the tumour. PATIENTS AND METHODS:Tumour doubling time (DT), assessed by ultrasound imaging analysis, was measured in 60 pati...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.1.100
更新日期:2002-07-01 00:00:00
abstract::Caeruloplasmin is an alpha 2 protein produced in the liver that is responsible for transporting copper in the blood. Caeruloplasmin values are usually high in patients with chronic liver diseases, including chronic active hepatitis: low values, however, are characteristic of Wilson's disease. The case of a 17 year old...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.5.549
更新日期:1991-05-01 00:00:00
abstract::Glucagon-like peptide 1 does not comfortably fulfil the criterion of a gut derived factor responsible for an enhanced meal related insulin response; it appears logical to add the definition of a "physiological incretin hormone". ...
journal_title:Gut
pub_type: 评论,杂志文章
doi:10.1136/gut.2005.071787
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:Nicotinamide phosphoribosyltransferase (NAMPT, also referred to as pre-B cell colony-enhancing factor or visfatin) is critically required for the maintenance of cellular nicotinamide adenine dinucleotide (NAD) supply catalysing the rate-limiting step of the NAD salvage pathway. NAMPT is strongly upregulated i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-314241
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND AND AIMS:The early responses of the oesophageal mucosa to acid perfusion may predict subsequent pathology. Mucosal responses to luminal acid may result either from acid permeating through the mucosa or from other unknown transduction mechanisms. In order to better understand the dynamics of acid permeation i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.6.775
更新日期:2003-06-01 00:00:00
abstract::A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and management of adult coeliac disease (CD). This paper presents the recommendations of the British Society of Gastroenterolo...
journal_title:Gut
pub_type: 杂志文章,实务指引
doi:10.1136/gutjnl-2013-306578
更新日期:2014-08-01 00:00:00
abstract::The benzimidazole anthelmintics mebendazole and fenbendazole have been shown to be much less effective against Nippostrongylus brasiliensis infections in the rat on a combined iron and protein deficient diet. In the present experiments it was shown that the anthelmintic efficacy of mebendazole was significantly impair...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.4.305
更新日期:1979-04-01 00:00:00
abstract:OBJECTIVE:Lynch syndrome is caused by germline mutations in DNA mismatch repair genes leading to microsatellite instability (MSI) and colorectal cancer. Mesalazine, commonly used for the treatment of UC, reduces MSI in vitro. Here, we tested natural compounds for such activity and applied mesalazine and thymoquinone in...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-307663
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:The normal intestinal microflora plays an important role in host metabolism and provides a natural defence mechanism against invading pathogens. Although the microbiota in adults has been extensively studied, little is known of the changes that occur in the microflora with aging. These may have important con...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.2.198
更新日期:2001-02-01 00:00:00
abstract::The present study was undertaken to investigate the possibility that central nervous system monoaminergic pathways may play a role in the control of gastric acid and gastrin secretion in man. Submaximal pentagastrin stimulated (0.25 micrograms/kg/h) gastric acid secretion, as well as basal gastrin concentrations were ...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.26.10.1014
更新日期:1985-10-01 00:00:00