Use of an inert marker (phenol red) to improve accuracy in gastric secretion studies.

Abstract:

:Gastric secretion from 24 subjects was collected by continuous nasogastric aspiration during the plateau of secretion evoked by intravenous histamine diphosphate, 0.01 mg/kg/hr. Simultaneously, phenol red was instilled at a constant rate into the proximal part of the stomach. Concentrations of phenol red in 15-minute aspirates were measured, and used to deduce pyloric losses and the reasons for random variation in the volumes aspirated. The average coefficient of variation in the volume was 26%, irrespective of the nature of the nasogastric tube. Correction by phenol red reduced this value to 21%. The coefficient of variation of volume diminished as secretion rate increased. Pyloric losses amounted to 7 ml/15 min, and were independent of the secretion rate. The quantitative effect of these errors upon the assessment of gastric secretion was minimal at high secretion rates but important at low rates.

journal_name

Gut

journal_title

Gut

authors

Hobsley M,Silen W

doi

10.1136/gut.10.10.787

subject

Has Abstract

pub_date

1969-10-01 00:00:00

pages

787-95

issue

10

eissn

0017-5749

issn

1468-3288

journal_volume

10

pub_type

杂志文章

相关文献

GUT文献大全
  • Bacterial adhesion and disease activity in Helicobacter associated chronic gastritis.

    abstract::Ultrastructural examination of biopsies showing Helicobacter pylori associated chronic gastritis reveals close attachment between gastric surface epithelial cells and the organism. The finding of 'adhesion pedestals', which represents a cellular response to the presence of the organism, is analogous to the response of...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.2.134

    authors: Hessey SJ,Spencer J,Wyatt JI,Sobala G,Rathbone BJ,Axon AT,Dixon MF

    更新日期:1990-02-01 00:00:00

  • Abnormalities of lipid metabolism in hepatitis C virus infection.

    abstract::Hepatitis C virus (HCV) is a human pathogen responsible for acute and chronic liver disease, infecting an estimated 130-170 million persons worldwide. An intriguing feature of HCV infection is its peculiar relationship with lipids: (1) HCV virions circulate in serum bound to lipoproteins; (2) lipids have been shown to...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.2009.192732

    authors: Negro F

    更新日期:2010-09-01 00:00:00

  • Systematic review of bariatric surgery liver biopsies clarifies the natural history of liver disease in patients with severe obesity.

    abstract:OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is a frequent complication of morbid obesity, but its severity varies greatly and thus there is a strong need to better define its natural history in these patients. DESIGN:Liver biopsies were systematically performed in 798 consecutive patients with severe obesity u...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gutjnl-2016-312238

    authors: Bedossa P,Tordjman J,Aron-Wisnewsky J,Poitou C,Oppert JM,Torcivia A,Bouillot JL,Paradis V,Ratziu V,Clément K

    更新日期:2017-09-01 00:00:00

  • U.K. guidelines on the management of variceal haemorrhage in cirrhotic patients.

    abstract::These updated guidelines on the management of variceal haemorrhage have been commissioned by the Clinical Services and Standards Committee (CSSC) of the British Society of Gastroenterology (BSG) under the auspices of the liver section of the BSG. The original guidelines which this document supersedes were written in 2...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-309262

    authors: Tripathi D,Stanley AJ,Hayes PC,Patch D,Millson C,Mehrzad H,Austin A,Ferguson JW,Olliff SP,Hudson M,Christie JM,Clinical Services and Standards Committee of the British Society of Gastroenterology.

    更新日期:2015-11-01 00:00:00

  • Intestinal function and intestinal blood supply: a 20 year surgical study.

    abstract::The experience of The Middlesex Hospital in the investigation and management of chronic intestinal arterial occlusion (IAO) over a 20 year period is presented. Of some 100 patients referred only 28 were found to have IAO and these were critically evaluated in terms of insorptive and exsorptive function. No relation wa...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.26.7.656

    authors: Marston A,Clarke JM,Garcia Garcia J,Miller AL

    更新日期:1985-07-01 00:00:00

  • Relationship of hepatic iron concentration to histochemical grading and to total chelatable body iron in conditions associated with iron overload.

    abstract::A simple method based on atomic absorption spectrophotometry and using protein concentration as the reference standard was used for measuring the total tissue iron concentration in needle liver biopsy specimens from 47 patients with varying levels of body iron stores. The values obtained showed a close correlation ove...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.12.12.1011

    authors: Walker RJ,Miller JP,Dymock IW,Shilkin KB,Williams R

    更新日期:1971-12-01 00:00:00

  • B-cell clonality and infection with Helicobacter pylori: implications for development of gastric lymphoma.

    abstract:BACKGROUND:Although Helicobacter pylori has been implicated in the pathogenesis of gastric mucosa associated lymphoid tissue (MALT) and MALT lymphoma, it is not known how it may trigger these lesions and whether there is an identifiable pre-neoplastic stage. AIMS:To investigate the relation between MALT, H pylori infe...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.38.6.837

    authors: Sorrentino D,Ferraccioli GF,DeVita S,Avellini C,Beltrami CA,Labombarda A,Bernardis V,De Biase F,Trevisi A,Pivetta B,Boiocchi M,Bartoli E

    更新日期:1996-06-01 00:00:00

  • Effect of Helicobacter pylori eradication on the treatment of gastro-oesophageal reflux disease.

    abstract::The important issue of whether Heliobacter pylori eradication leads to increased reflux has been the subject of many apparently contradictory publications, but when we asked two leading authorities to give us their views, there turned out to be considerable consensus, as you can read below. ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2003.019844

    authors: Richter JE

    更新日期:2004-02-01 00:00:00

  • Periampullary cyst: a surgically remediable cause of pancreatitis.

    abstract::We report two patients with periampullary cysts associated with recurrent attacks of acute pancreatitis. In both patients the diagnosis was made preoperatively by upper gastrointestinal endoscopy and ERCP, which was also useful in determining the relationship of the cysts to the biliary and pancreatic ductal systems. ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.28.3.358

    authors: Kalvaria I,Bornman PC,Girdwood AH,Marks IN

    更新日期:1987-03-01 00:00:00

  • Management of achalasia of the cardia by forced pneumatic dilatation.

    abstract::Eighteen patients with achalasia of the cardia diagnosed by radiography, endoscopy, and manometry were subjected to forced pneumatic dilatation under fluoroscopic control. The procedure was uneventful in all but one patient who developed a pneumomediastinum which resolved on conservative management. A satisfactory res...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.23.6.541

    authors: Lishman AH,Dellipiani AW

    更新日期:1982-06-01 00:00:00

  • Chronic immune colitis in rabbits.

    abstract::A chronic colitis has been induced in rabbits having many of the histological features of human ulcerative colitis. Animals were first immunised with the common enterobacterial antigen of Kunin and haemagglutinating antibodies demonstrated in high titre. An immune complex colitis was then established by the injection ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.20.1.1

    authors: Mee AS,McLaughlin JE,Hodgson HJ,Jewell DP

    更新日期:1979-01-01 00:00:00

  • Molecular testing for antibiotic resistance in Helicobacter pylori.

    abstract::An estimated 7.5 million individuals in England and Wales are actively infected with Helicobacter pylori and hence knowledge of local resistance rates is of growing importance. Also, information on strain resistance following treatment failure is crucial in selecting an appropriate regimen as the development of bacter...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.50.3.285

    authors: Owen RJ

    更新日期:2002-03-01 00:00:00

  • A multicentre randomised study of intrasphincteric botulinum toxin in patients with oesophageal achalasia. GISMAD Achalasia Study Group.

    abstract:BACKGROUND:Intrasphincteric injection of botulinum toxin (Botx) has been proposed as treatment for oesophageal achalasia. However, the predictors of response and optimal dose remain unclear. AIMS:To compare the effect of different doses of Botx and to identify predictors of response. PATIENTS/METHODS:A total of 118 a...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1136/gut.46.5.597

    authors: Annese V,Bassotti G,Coccia G,Dinelli M,D'Onofrio V,Gatto G,Leandro G,Repici A,Testoni PA,Andriulli A

    更新日期:2000-05-01 00:00:00

  • Factor VII levels as a guide to prognosis in fulminant hepatic failure.

    abstract::Levels of clotting factors II, V, and VII were measured on admission and then daily in 12 patients with grade IV hepatic coma due to fulminant hepatic failure. Factor VII levels obtained within 36 hours of the development of grade IV coma were not of value in predicting which patients would subsequently recover consci...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.17.7.489

    authors: Gazzard BG,Henderson JM,Williams R

    更新日期:1976-07-01 00:00:00

  • Sweet-talk: role of host glycosylation in bacterial pathogenesis of the gastrointestinal tract.

    abstract::Glycosylation is a key modification of proteins and lipids and is involved in most intermolecular and intercellular interactions. The gastrointestinal mucus gel is continuous and can be divided into two layers: a secreted loosely associated layer and a layer firmly attached to the mucosa. In addition, the membrane-bou...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.2010.212704

    authors: Moran AP,Gupta A,Joshi L

    更新日期:2011-10-01 00:00:00

  • Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces hepatic steatosis in viral hepatitis and after alcohol intake.

    abstract:BACKGROUND AND AIMS:Tumour necrosis factor related apoptosis inducing ligand (TRAIL) induces apoptosis in transformed cells and is considered as an agent for cancer therapy. As there is evidence that TRAIL is also essential for apoptosis in animal models of liver injury, we investigated the role of TRAIL in viral hepat...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2004.056929

    authors: Mundt B,Wirth T,Zender L,Waltemathe M,Trautwein C,Manns MP,Kühnel F,Kubicka S

    更新日期:2005-11-01 00:00:00

  • Reduced mucosal antimicrobial activity in Crohn's disease of the colon.

    abstract:OBJECTIVES:In order to maintain the mucosal barrier against luminal microorganisms the intestinal epithelial cells synthesise various broad-spectrum antimicrobial peptides including defensins and cathelicidins. Recent studies indicate that both may be deficient in Crohn's disease. To elucidate the possible functional c...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2006.118646

    authors: Nuding S,Fellermann K,Wehkamp J,Stange EF

    更新日期:2007-09-01 00:00:00

  • Oral budesonide is as effective as oral prednisolone in active Crohn's disease. The Global Budesonide Study Group.

    abstract:BACKGROUND:The use of corticosteroids in active Crohn's disease often becomes limited by side effects. Budesonide is a potent corticosteroid with low systemic bioavailability due to an extensive first pass liver metabolism. AIMS:To compare the efficacy and safety of two dosage regimens of budesonide and prednisolone i...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1136/gut.41.2.209

    authors: Campieri M,Ferguson A,Doe W,Persson T,Nilsson LG

    更新日期:1997-08-01 00:00:00

  • Phenotype and function of HBV-specific T cells is determined by the targeted epitope in addition to the stage of infection.

    abstract:OBJECTIVE:Chronic HBV infection affects more than 250 million people worldwide and remains a global healthcare problem in part because we lack curative treatment. Sustained viral control requires HBV-specific T cells, but these become functionally impaired in chronic infection. Clinical evidence indicates that function...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2018-316644

    authors: Hoogeveen RC,Robidoux MP,Schwarz T,Heydmann L,Cheney JA,Kvistad D,Aneja J,Melgaço JG,Fernandes CA,Chung RT,Boonstra A,Kim AY,Baumert TF,Timm J,Lewis-Ximenez LL,Tonnerre P,Lauer GM

    更新日期:2019-05-01 00:00:00

  • Blocking VCAM-1 inhibits pancreatic tumour progression and cancer-associated thrombosis/thromboembolism.

    abstract:OBJECTIVE:Pancreatic ductal adenocarcinoma (PDAC) is the deadliest cancer. Cancer-associated thrombosis/thromboembolism (CAT), frequently observed in PDAC, is known as a poor prognostic factor. Here, we investigated the underlying mechanisms between PDAC and CAT, and performed a trial of therapeutic approach for PDAC u...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2020-320608

    authors: Sano M,Takahashi R,Ijichi H,Ishigaki K,Yamada T,Miyabayashi K,Kimura G,Mizuno S,Kato H,Fujiwara H,Nakatsuka T,Tanaka Y,Kim J,Masugi Y,Morishita Y,Tanaka M,Ushiku T,Nakai Y,Tateishi K,Ishii Y,Isayama H,Moses HL,

    更新日期:2020-10-21 00:00:00

  • Detection of gluten immunogenic peptides in the urine of patients with coeliac disease reveals transgressions in the gluten-free diet and incomplete mucosal healing.

    abstract:OBJECTIVE:Gluten-free diet (GFD) is the only management for coeliac disease (CD). Available methods to assess GFD compliance are insufficiently sensitive to detect occasional dietary transgressions that may cause gut mucosal damage. We aimed to develop a method to determine gluten intake and monitor GFD compliance in p...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2015-310148

    authors: Moreno ML,Cebolla Á,Muñoz-Suano A,Carrillo-Carrion C,Comino I,Pizarro Á,León F,Rodríguez-Herrera A,Sousa C

    更新日期:2017-02-01 00:00:00

  • Non-steroidal anti-inflammatory drug (NSAID) therapy in patients with hypertension, cardiovascular, renal or gastrointestinal comorbidities: joint APAGE/APLAR/APSDE/APSH/APSN/PoA recommendations.

    abstract:BACKGROUND:Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly prescribed medications, but they are associated with a number of serious adverse effects, including hypertension, cardiovascular disease, kidney injury and GI complications. OBJECTIVE:To develop a set of multidisciplinary recommenda...

    journal_title:Gut

    pub_type: 杂志文章,实务指引

    doi:10.1136/gutjnl-2019-319300

    authors: Szeto CC,Sugano K,Wang JG,Fujimoto K,Whittle S,Modi GK,Chen CH,Park JB,Tam LS,Vareesangthip K,Tsoi KKF,Chan FKL

    更新日期:2020-04-01 00:00:00

  • Faecal fat excretion after truncal, selective, and highly selective vagotomy for duodenal ulcer.

    abstract::Faecal fat excretion was measured on a metabolic ward in 16 patients with duodenal ulcer before operation, and in patients who were in good health more than one year after truncal vagotomy and pyloroplasty (n = 11), bilateral selective vagotomy and pyloroplasty (n = 9), or highly selective vagotomy without a drainage ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.15.7.521

    authors: Edwards JP,Lyndon PJ,Smith RB,Johnston D

    更新日期:1974-07-01 00:00:00

  • Gastric microbial community profiling reveals a dysbiotic cancer-associated microbiota.

    abstract:OBJECTIVE:Gastric carcinoma development is triggered by Helicobacter pylori. Chronic H. pylori infection leads to reduced acid secretion, which may allow the growth of a different gastric bacterial community. This change in the microbiome may increase aggression to the gastric mucosa and contribute to malignancy. Our a...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2017-314205

    authors: Ferreira RM,Pereira-Marques J,Pinto-Ribeiro I,Costa JL,Carneiro F,Machado JC,Figueiredo C

    更新日期:2018-02-01 00:00:00

  • Serum carcinoembryonic antigen in clinical disorders.

    abstract::Carcinoembryonic antigen (CEA) levels have been measured in the serum of 490 patients and 93 normal controls using the double antibody radioimmunoassay technique. Levels were elevated in 71 of patients with carcinomata of the gastrointestinal tract and in 42% with other types of malignancy. In patients with non-neopla...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.14.10.794

    authors: Booth SN,King JP,Leonard JC,Dykes PW

    更新日期:1973-10-01 00:00:00

  • High expression levels of putative hepatic stem/progenitor cell biomarkers related to tumour angiogenesis and poor prognosis of hepatocellular carcinoma.

    abstract:BACKGROUND/AIMS:To investigate the prognostic values of putative hepatic stem/progenitor cell (HSC/HPC) biomarkers in patients with hepatocellular carcinoma (HCC). METHODS:Fourteen biomarkers related to HSCs/HPCs or tumour angiogenesis were assessed by qRT-PCR and then validated by tissue microarrays (TMAs) in three i...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2008.176271

    authors: Yang XR,Xu Y,Yu B,Zhou J,Qiu SJ,Shi GM,Zhang BH,Wu WZ,Shi YH,Wu B,Yang GH,Ji Y,Fan J

    更新日期:2010-07-01 00:00:00

  • Progress towards the comprehensive control of hepatitis B in Africa: a view from South Africa.

    abstract::The carrier rate of hepatitis B virus (HBV) in black Africans averages 10.4% throughout the continent. Even within each country, however, there may be wide variations. HBV carriage in black Africans is largely established in early childhood, mostly through horizontal transmission. Perinatal transmission also occurs bu...

    journal_title:Gut

    pub_type: 杂志文章,评审

    doi:10.1136/gut.38.suppl_2.s31

    authors: Kew MC

    更新日期:1996-01-01 00:00:00

  • Perforation of an adenocarcinoma of the small bowel affected by regional enteritis.

    abstract::This report is of a patient with long-term small bowel regional enteritis who presented with a perforation of an adenocarcinoma involving a diseased portion of ileum. Adenocarcinoma of the small bowel is rare. The incidence of small bowel adenocarcinoma may be higher in patients with regional enteritis, but a definite...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.21.12.1093

    authors: Heathcote J,Knauer CM,Oakes D,Archibald RW

    更新日期:1980-12-01 00:00:00

  • Effects of phenobarbital and rose bengal on the ATPases of plasma membranes of rat and rabbit liver.

    abstract::The effects of drugs which change the bile-salt-independent fraction of bile flow on Na(+)K(a+) and Mg(2+) activated ATPases were studied in membrane fractions rich in bile canaliculi. The administration of phenobarbital caused no induction of these enzymes which could explain the increased bile flow observed in the r...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.13.11.920

    authors: Laperche Y,Launay A,Oudéa P

    更新日期:1972-11-01 00:00:00

  • Haemolysis in experimental cholestasis: possible role of erythrocyte sialic acid.

    abstract::Because previous studies have suggested that red cell membrane sialic acid might be a determinant of survival in vivo, we examined the relationship between haemolysis, erythrocyte membrane sialic acid, and hepatic neuraminidase (sialidase) levels in experimental cholestatic jaundice in rats. Treatment of normal rat er...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.15.10.794

    authors: Powell LW,LaMont JT,Isselbacher KJ

    更新日期:1974-10-01 00:00:00