Abstract:
BACKGROUND AND AIMS:The intestinal microbiota play a pivotal role in the inflammation associated with Crohn's disease through their interaction with the mucosal immune system. Some bifidobacteria species are immunoregulatory and induce increased dendritic cell interleukin 10 (IL-10) release in vitro. Fructo-oligosaccharides (FOS) increase faecal and mucosal bifidobacteria in healthy volunteers. The aim of this study was to assess the effect of FOS administration on disease activity, bifidobacteria concentrations, and mucosal dendritic cell function in patients with moderately active Crohn's disease. PATIENTS AND METHODS:Ten patients with active ileocolonic Crohn's disease received 15 g of FOS for three weeks. Disease activity was measured using the Harvey Bradshaw index. Faecal and mucosal bifidobacteria were quantified by fluorescence in situ hybridisation, and mucosal dendritic cell IL-10 and Toll-like receptor (TLR) expression were assessed by flow cytometry of dissociated rectal biopsies. RESULTS:FOS induced a significant reduction in the Harvey Bradshaw index from 9.8 (SD 3.1) to 6.9 (3.4) (p<0.01). There was a significant increase in faecal bifidobacteria concentration from 8.8 (0.9) log(10) to 9.4 (0.9) log(10) cells/g dry faeces (p<0.001). The percentage of IL-10 positive dendritic cells increased from 30 (12)% to 53 (10)% (p=0.06). Finally, the percentage of dendritic cells expressing TLR2 and TLR4 increased from 1.7 (1.7)% to 36.8 (15.9)% (p=0.08) and from 3.6 (3.6)% to 75.4 (3.4)% (p<0.001), respectively. CONCLUSIONS:FOS supplementation increases faecal bifidobacteria concentrations and modifies mucosal dendritic cell function. This novel therapeutic strategy appears to decrease Crohn's disease activity in a small open label trial and therefore warrants further investigation.
journal_name
Gutjournal_title
Gutauthors
Lindsay JO,Whelan K,Stagg AJ,Gobin P,Al-Hassi HO,Rayment N,Kamm MA,Knight SC,Forbes Adoi
10.1136/gut.2005.074971keywords:
subject
Has Abstractpub_date
2006-03-01 00:00:00pages
348-55issue
3eissn
0017-5749issn
1468-3288pii
gut.2005.074971journal_volume
55pub_type
临床试验,杂志文章相关文献
GUT文献大全abstract:OBJECTIVE AND DESIGN:The goal of the study was to determine whether the mutational profile of early colorectal polyps correlated with growth behaviour. The growth of small polyps (6-9 mm) that were first identified during routine screening of patients was monitored over time by interval imaging with CT colonography. Mu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-312232
更新日期:2017-12-01 00:00:00
abstract::Primary biliary cholangitis (formerly known as primary biliary cirrhosis, PBC) is an autoimmune liver disease in which a cycle of immune mediated biliary epithelial cell injury, cholestasis and progressive fibrosis can culminate over time in an end-stage biliary cirrhosis. Both genetic and environmental influences are...
journal_title:Gut
pub_type: 指南,杂志文章,实务指引
doi:10.1136/gutjnl-2017-315259
更新日期:2018-09-01 00:00:00
abstract::A simple method based on atomic absorption spectrophotometry and using protein concentration as the reference standard was used for measuring the total tissue iron concentration in needle liver biopsy specimens from 47 patients with varying levels of body iron stores. The values obtained showed a close correlation ove...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.12.12.1011
更新日期:1971-12-01 00:00:00
abstract::A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and management of adult coeliac disease (CD). This paper presents the recommendations of the British Society of Gastroenterolo...
journal_title:Gut
pub_type: 杂志文章,实务指引
doi:10.1136/gutjnl-2013-306578
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:The response of subjects to preventive intervention is heterogeneous. The goal of this study was to determine if the efficacy of a chemopreventive agent differs in non-tumour-bearing animals versus those with colorectal tumours. Sulindac and/or atorvastatin was administered to Apc+/Min-FCCC mice with known tu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-313942
更新日期:2018-07-01 00:00:00
abstract::Probiotic administration may exert a protective effect in colitis by preventing mucosal barrier disruption and influencing the extent of mucosal injury. ...
journal_title:Gut
pub_type: 评论,杂志文章,评审
doi:10.1136/gut.2004.060640
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:Hepatocellular adenomas (HCAs) classically develop in women who are taking oral contraceptives and have a risk of malignant transformation into hepatocellular carcinoma (HCC). HCA with malignant transformation is, however, an ill-defined entity thought to be an anecdotic pathway to HCC. The objective of this ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2010.222109
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Although polypoid lesions of the gall bladder are frequently observed in asymptomatic subjects, the natural history of these lesions has never been studied using ultrasonography. AIM:The natural history of polypoid lesions of the gall bladder was investigated using ultrasonography. SUBJECTS:Among 4343 pati...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.39.6.860
更新日期:1996-12-01 00:00:00
abstract:BACKGROUND:Motor disturbances are sometimes associated with diarrhoea by unknown mechanisms. AIM:To determine if there is a quantitative link between intestinal motility and epithelial secretion. SUBJECTS:Experiments were performed in 21 healthy volunteers and three patients with villus atrophy. METHODS:Duodenal and...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.46.3.376
更新日期:2000-03-01 00:00:00
abstract:BACKGROUND AND AIMS:Independent component analysis (ICA) of the electroencephalogram (EEG) overcomes many of the classical problems in EEG analysis. We used ICA to determine the brain responses to painful stimulation of the oesophagus. METHODS:Twelve subjects with a median age of 41 years were included. With a nasal e...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.2005.068460
更新日期:2006-05-01 00:00:00
abstract::Spontaneous basal rectal activity, recorded after resection of the sigmoid colon for diverticular disease, was more than twice the normal. The rectum of post-resection cases yielded a markedly exaggerated overall response to prostigmine, in addition to producing abundant fast wave patterns. The response to stretch of ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.2.121
更新日期:1970-02-01 00:00:00
abstract::There is no universally available laboratory test to diagnose bile acid diarrhoea (BAD). OBJECTIVE:To conduct a systematic review and meta-analysis to identify a biomarker for idiopathic BAD in patients with functional bowel disorder (FBD) with diarrhoea. DESIGN:We searched multiple databases through 15 May 2015. Da...
journal_title:Gut
pub_type: 杂志文章,meta分析,评审
doi:10.1136/gutjnl-2015-309889
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:A high prevalence of osteoporosis is reported in Crohn's disease. The pathogenesis is not completely understood but is probably multifactorial. Longstanding Crohn's disease is associated with a deficiency of fat soluble vitamins, among them vitamin K. Vitamin K is a cofactor in the carboxylation of osteocalc...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.4.473
更新日期:2001-04-01 00:00:00
abstract::The prevalence of methane production in an adult population of 256 subjects was 41%, but it was significantly higher in females (49%), than males (33%). When the population was subdivided into ethnic groups. Caucasians (48%) and Black (45%) had significantly more methane producers than Orientals (24%) and Indians (32%...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.11.951
更新日期:1980-11-01 00:00:00
abstract::Despite mass population screening and an incidence of EGC in Japan that is at least double that of the West, there seem to be no genuine differences in the clinicopathological features of the disease between the two regions. The macroscopic appearance, size, depth of invasion, frequency of lymph node invasion, and his...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.41.2.142
更新日期:1997-08-01 00:00:00
abstract::Effects of [Asu1,7]-eel calcitonin on gastric somatostatin and gastrin secretion were studied by using the isolated perfused rat stomach. [Asu1,7]-eel calcitonin (10(-9)--10(-7)M) caused a simultaneous dose-dependent increase of gastric somatostatin release and decrease of gastrin secretion, with a significant correla...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.2.94
更新日期:1980-02-01 00:00:00
abstract:BACKGROUND:Somatostatin has been used to prevent pancreatitis after endoscopic retrograde cholangiopancreatography but its effect on acute non-biliary pancreatitis is still unclear. AIM:The purpose of this study was to evaluate the function of the sphincter of Oddi (SO) and the effect of somatostatin on patients with ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.49.6.843
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Non-selective cyclooxygenase (COX) inhibitors (non-steroidal anti-inflammatory drugs) inhibit large bowel carcinogenesis in patients with familial adenomatous polyposis (FAP). Their role in the duodenum of these patients is less certain. The disease modifying activity of specific COX-2 inhibitors has not bee...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.50.6.857
更新日期:2002-06-01 00:00:00
abstract::Diverticulitis affects the right side of the colon more commonly than the left side in the Far East. A consecutive series of 35 patients (mean age 44 years) with right sided diverticulitis seen at this hospital is presented. All had localised pain in the right iliac fossa but systemic upset was uncommon. All but one w...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.4.547
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:The prevalence of portopulmonary hypertension (PPHTN) in patients with cirrhosis and refractory ascites is unknown. Its presence may preclude patients from receiving a transjugular intrahepatic portosystemic shunt or liver transplantation as a definitive treatment for their end stage cirrhosis. PURPOSE:To d...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.9.1355
更新日期:2003-09-01 00:00:00
abstract::The disposition of antipyrine following oral administration of 1200 mg has been investigated in 10 patients with histologically confirmed hepatosplenic schistosomiasis and 11 normal subjects living in Sudan. Drug metabolising activity as assessed by antipyrine clearance was similar in patients when compared with norma...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.19.9.808
更新日期:1978-09-01 00:00:00
abstract::Thirty two patients with empyema of the gall bladder were identified among 1327 cases of gall-bladder disease presenting to one hospital over a six year period. Abdominal pain had been present for a median of eight days and, in eight cases, for between one and four months. In a few cases, the disease was painless and ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.12.1183
更新日期:1983-12-01 00:00:00
abstract::Although the development of endoscopic methods of treatment for biliary obstruction has proceeded rapidly in recent years, endoscopic retrograde cholangiopancreatographic (ERCP) services are patchily distributed. A recent survey by the British Society of Gastroenterology has shown that almost half the district general...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.10.1150
更新日期:1990-10-01 00:00:00
abstract::Of 279 patients admitted to a specialist unit with acute pancreatitis, 210 were admitted directly and 69 were transferred for treatment of local or systemic complications. Outcome was assessed in terms of mortality and morbidity and in relation to aetiology, predicted severity of disease (modified Glasgow score), orga...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.1.121
更新日期:1995-07-01 00:00:00
abstract::Eighteen patients with fulminant liver failure were studied, 10 with normal renal function (group A) and eight with renal failure (group B, plasma creatinine greater than 200 mumol/l). Renal function was assessed by standard clearance techniques and patients in group B had a marked reduction compared with group A in b...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.12.1643
更新日期:1987-12-01 00:00:00
abstract::An estimated 7.5 million individuals in England and Wales are actively infected with Helicobacter pylori and hence knowledge of local resistance rates is of growing importance. Also, information on strain resistance following treatment failure is crucial in selecting an appropriate regimen as the development of bacter...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.50.3.285
更新日期:2002-03-01 00:00:00
abstract::The feasibility of surgery in amoebic colitis is presented by illustrative case histories in two patients. Subtotal colectomy and ileostomy were carried out for fulminating colitis in the one and exteriorization, excision, and subsequent re-anastomosis of a localized perforated area of bowel in the other. It is sugges...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.11.941
更新日期:1970-11-01 00:00:00
abstract:OBJECTIVE:Shortage of organ donors, a critical challenge for treatment of end-stage organ failure, has motivated the development of alternative strategies to generate organs in vitro. Here, we aim to describe the hepatorganoids, which is a liver tissue model generated by three-dimensional (3D) bioprinting of HepaRG cel...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2019-319960
更新日期:2020-05-20 00:00:00
abstract:OBJECTIVE:The natural course of chronic hepatitis C varies widely. To improve the profiling of patients at risk of developing advanced liver disease, we assessed the relative contribution of factors for liver fibrosis progression in hepatitis C. DESIGN:We analysed 1461 patients with chronic hepatitis C with an estimat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-306997
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:Many patients with irritable bowel syndrome IBS not only have abdominal pain but also may suffer from visceral hypersensitivity and heighted visceral nociception. Moreover, IBS has few effective therapeutic agents and mechanisms of disease are unclear. Our goals were to (i) identify microRNA (miRNA) expressio...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2013-306464
更新日期:2016-05-01 00:00:00