Hydrogen sulphide and the hyperdynamic circulation in cirrhosis: a hypothesis.


:Cirrhosis is associated with the development of a hyperdynamic circulation, which is secondary to the presence of systemic vasodilatation. Several mechanisms have been postulated to be involved in the development of systemic vasodilatation, including increased synthesis of nitric oxide, hyperglucagonaemia, increased carbon monoxide synthesis, and activation of K(ATP) channels in vascular smooth muscle cells in the systemic and splanchnic arterial circulation. Hydrogen sulphide (H2S) has recently been identified as a novel gaseous transmitter that induces vasodilatation through activation of K(ATP) channels in vascular smooth muscle cells. In this brief review, we comment on what is known about H2S, vascular and neurological function, and postulate its role in the pathogenesis of the vascular abnormalities in cirrhosis.






Ebrahimkhani MR,Mani AR,Moore K





Has Abstract


2005-12-01 00:00:00
















  • Duodenal involvement in Schistosoma mansoni infection.

    abstract::Intestinal involvement in Schistosoma mansoni infection is usually confined to the ileum and colon. Duodenal infestation was diagnosed in a patient with recurrent schistosomiasis despite treatment who presented with a postoperative small bowel fistula. Duodenal schistosomiasis can be suspected on endoscopy, but must a...


    pub_type: 杂志文章


    authors: Contractor QQ,Benson L,Schulz TB,Contractor TQ,Kasturi N

    更新日期:1988-07-01 00:00:00

  • Effect of glucocorticoid on liver regeneration after partial hepatectomy in the rat.

    abstract::The increase in activities of hepatic thymidylate synthetase (EC and thymidine kinase (EC, which catalyse the formation of thymidylate through the de novo and salvage pathways, respectively, were significantly suppressed during liver regeneration in rats which were given glucocorticoids (hydrocorti...


    pub_type: 杂志文章


    authors: Tsukamoto I,Kojo S

    更新日期:1989-03-01 00:00:00

  • TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms.

    abstract:OBJECTIVE:Hepatocellular carcinoma (HCC) is a prevalent and aggressive cancer usually arising on a background of chronic liver injury involving inflammatory and hepatic regenerative processes. The triggering receptor expressed on myeloid cells 2 (TREM-2) is predominantly expressed in hepatic non-parenchymal cells and i...


    pub_type: 杂志文章


    authors: Esparza-Baquer A,Labiano I,Sharif O,Agirre-Lizaso A,Oakley F,Rodrigues PM,Zhuravleva E,O'Rourke CJ,Hijona E,Jimenez-Agüero R,Riaño I,Landa A,La Casta A,Zaki MYW,Munoz-Garrido P,Azkargorta M,Elortza F,Vogel A,Schabbaue

    更新日期:2020-09-09 00:00:00

  • NAD metabolism fuels human and mouse intestinal inflammation.

    abstract:OBJECTIVE:Nicotinamide phosphoribosyltransferase (NAMPT, also referred to as pre-B cell colony-enhancing factor or visfatin) is critically required for the maintenance of cellular nicotinamide adenine dinucleotide (NAD) supply catalysing the rate-limiting step of the NAD salvage pathway. NAMPT is strongly upregulated i...


    pub_type: 杂志文章


    authors: Gerner RR,Klepsch V,Macheiner S,Arnhard K,Adolph TE,Grander C,Wieser V,Pfister A,Moser P,Hermann-Kleiter N,Baier G,Oberacher H,Tilg H,Moschen AR

    更新日期:2018-10-01 00:00:00

  • Evaluation of laser doppler flowmetry for the study of benign and malignant gastric blood flow in vivo.

    abstract:BACKGROUND:Tumour vascularisation is a determinant of the development of metastases. AIMS:To measure blood flow in normal stomach and gastric adenocarcinomas by laser Doppler flowmetry and correlate blood flow with vascularisation after immunohistochemical staining of resected specimens for CD31 and von Willebrand fac...


    pub_type: 临床试验,杂志文章


    authors: Schilling MK,Redaelli C,Friess H,Blum B,Signer C,Maurer CA,Büchler MW

    更新日期:1999-09-01 00:00:00

  • Mucosal 5-aminosalicylic acid concentration inversely correlates with severity of colonic inflammation in patients with ulcerative colitis.

    abstract:BACKGROUND AND AIM:The treatment of ulcerative colitis (UC) with 5-aminosalicylic acid (5-ASA) does not have the same therapeutic effect in all patients. We tested the hypothesis that the effectiveness of the drug is related to its mucosal concentration. PATIENTS:Twenty one UC patients receiving oral 5-ASA (2.4-3.2 g/...


    pub_type: 杂志文章


    authors: Frieri G,Giacomelli R,Pimpo M,Palumbo G,Passacantando A,Pantaleoni G,Caprilli R

    更新日期:2000-09-01 00:00:00

  • Extrapancreatic necrosis without pancreatic parenchymal necrosis: a separate entity in necrotising pancreatitis?

    abstract:OBJECTIVE:In the revised Atlanta classification of acute pancreatitis, the term necrotising pancreatitis also refers to patients with only extrapancreatic fat necrosis without pancreatic parenchymal necrosis (EXPN), as determined on contrast-enhanced CT (CECT). Patients with EXPN are thought to have a better clinical o...


    pub_type: 杂志文章,多中心研究


    authors: Bakker OJ,van Santvoort H,Besselink MG,Boermeester MA,van Eijck C,Dejong K,van Goor H,Hofker S,Ahmed Ali U,Gooszen HG,Bollen TL,Dutch Pancreatitis Study Group.

    更新日期:2013-10-01 00:00:00

  • The effects of corticotrophin and corticoids on secretion from denervated gastric pouches in dogs.

    abstract::The effects of corticotrophin and of cortisone, methyl prednisolone, and of aldosterone on the gastric secretion of dogs have been investigated. Juice was collected from dogs with denervated pouches under basal conditions and when stimulated with meat extract and with histamine. For each secretion the volume, viscosit...


    pub_type: 杂志文章



    更新日期:1960-03-01 00:00:00

  • Yellowish lesions in the oesophagus.

    abstract::CLINICAL PRESENTATION: A 51-year-old man, who had no previous disease, underwent a screening oesophagogastroduodenoscopy, which revealed multiple yellowish lesions in the middle thoracic oesophagus. All lesions were ≤3 mm in size and slightly elevated. Each lesion showed one or two white protrusions on the surface (fi...


    pub_type: 杂志文章


    authors: Hamada K,Yamasaki Y,Kubota JI,Okada H

    更新日期:2019-01-01 00:00:00

  • Meat intake and risk of diverticulitis among men.

    abstract:OBJECTIVE:Diverticulitis is a common disease with a substantial clinical and economic burden. Besides dietary fibre, the role of other foods in the prevention of diverticulitis is underexplored. DESIGN:We prospectively examined the association between consumption of meat (total red meat, red unprocessed meat, red proc...


    pub_type: 杂志文章


    authors: Cao Y,Strate LL,Keeley BR,Tam I,Wu K,Giovannucci EL,Chan AT

    更新日期:2018-03-01 00:00:00

  • Studies of the effect of metoclopramide and apomorphine on gastric emptying and secretion in man.

    abstract::With oral and intravenous doses of metoclopramide there was no constant effect on the gastric emptying of test meals of glucose or sodium citrate, nor was secretion of acid by the stomach in response to test meals of glucose or sodium citrate affected. Apomorphine, in subnauseous doses (0.25 mg intravenously) slowed t...


    pub_type: 杂志文章


    authors: Ramsbottom N,Hunt JN

    更新日期:1970-12-01 00:00:00

  • Decreased plasma isoleucine concentrations after upper gastrointestinal haemorrhage in humans.

    abstract:BACKGROUND:A decrease in arterial isoleucine values after intragastric blood administration in pigs has been observed. This contrasted with increased values of most other amino acids, ammonia, and urea. After an isonitrogenous control meal in these pigs all amino acids including isoleucine increased, and urea increased...


    pub_type: 杂志文章


    authors: Dejong CH,Meijerink WJ,van Berlo CL,Deutz NE,Soeters PB

    更新日期:1996-07-01 00:00:00

  • Analgesic ingestion and other factors preceding relapse in ulcerative colitis.

    abstract::To investigate factors which predispose to relapse in patients with ulcerative colitis, we conducted a survey to compare the events occurring in the four weeks preceding the clinic attendance of 62 outpatients in remission with those taking place in the same period before the onset of relapse in 21 patients attending ...


    pub_type: 杂志文章


    authors: Rampton DS,McNeil NI,Sarner M

    更新日期:1983-03-01 00:00:00

  • The prognostic value of TP53 mutations in oesophageal adenocarcinoma: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To clarify the prognostic role of tumour protein 53 (TP53) mutations in patients with oesophageal adenocarcinoma (OAC) as there is a need for biomarkers that assist in guiding management for patients with OAC. DESIGN:A systematic review was conducted using MEDLINE, Embase, PubMed and Current Contents Connect...


    pub_type: 杂志文章,meta分析,评审


    authors: Fisher OM,Lord SJ,Falkenback D,Clemons NJ,Eslick GD,Lord RV

    更新日期:2017-03-01 00:00:00

  • Endothelin and vascular function in liver disease.

    abstract::The endothelins are a group of three related peptides with two receptor subtypes, ET(A) and ET(B). Following the discovery of endothelin 1 as a potent vasoconstrictor, there has been intense interest in the role of endothelin on vascular function in liver disease. Speculation on the role of endothelin in the pathogene...


    pub_type: 杂志文章


    authors: Moore K

    更新日期:2004-02-01 00:00:00

  • Decreased miR-199 augments visceral pain in patients with IBS through translational upregulation of TRPV1.

    abstract:OBJECTIVE:Many patients with irritable bowel syndrome IBS not only have abdominal pain but also may suffer from visceral hypersensitivity and heighted visceral nociception. Moreover, IBS has few effective therapeutic agents and mechanisms of disease are unclear. Our goals were to (i) identify microRNA (miRNA) expressio...


    pub_type: 杂志文章


    authors: Zhou Q,Yang L,Larson S,Basra S,Merwat S,Tan A,Croce C,Verne GN

    更新日期:2016-05-01 00:00:00

  • Infliximab for the treatment of pyoderma gangrenosum: a randomised, double blind, placebo controlled trial.

    abstract:BACKGROUND:Pyoderma gangrenosum (PG) is a chronic ulcerating skin condition that often occurs in association with inflammatory bowel disease. There have been a number of reports of PG responding to infliximab, a monoclonal antibody against tumour necrosis factor alpha. AIM:In the first randomised placebo controlled tr...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Brooklyn TN,Dunnill MG,Shetty A,Bowden JJ,Williams JD,Griffiths CE,Forbes A,Greenwood R,Probert CS

    更新日期:2006-04-01 00:00:00

  • Biliary bile acids in cholelithiasis and colon cancer.

    abstract::The role of biliary deoxycholate as an endogenous colon carcinogen and the possible association between cholelithiasis and/or cholecystectomy and the subsequent development of large bowel cancer is unclear. This paper describes biliary bile acids analysis performed on 13 patients undergoing cholecystectomy for gall st...


    pub_type: 杂志文章


    authors: Castleden WM,Detchon P,Misso NL

    更新日期:1989-06-01 00:00:00

  • Constipation in early childhood: patient characteristics, treatment, and longterm follow up.

    abstract::Little is known about chronic constipation in infants, toddlers, and preschool children and longterm outcome after treatment. The symptoms of 174 children < or = 4 years of age, who were evaluated for chronic constipation, are reported in this study together with the long-term outcome in 90 of them. Initial symptoms w...


    pub_type: 杂志文章


    authors: Loening-Baucke V

    更新日期:1993-10-01 00:00:00

  • Comparison of the Rome IV criteria with the Rome III criteria for the diagnosis of irritable bowel syndrome in secondary care.

    abstract:OBJECTIVES:Despite being proposed 4 years ago, there has been no independent validation study of the Rome IV criteria for IBS. We assessed their performance for the diagnosis of IBS in secondary care and compared them with the previous iteration, the Rome III criteria. DESIGN:We collected complete symptom data from co...


    pub_type: 杂志文章


    authors: Black CJ,Craig O,Gracie DJ,Ford AC

    更新日期:2020-09-24 00:00:00

  • Gastrokine 1 induces senescence through p16/Rb pathway activation in gastric cancer cells.

    abstract:BACKGROUND AND AIMS:Gastrokine 1 (GKN1) is a stomach-specific protein that is normally expressed in gastric mucosa but not in primary tumours and cell lines. Based on this evidence, it was presumed that GKN1 might play a role in gastric cancer development; however, its function and molecular mechanism are not clear. A ...


    pub_type: 杂志文章


    authors: Xing R,Li W,Cui J,Zhang J,Kang B,Wang Y,Wang Z,Liu S,Lu Y

    更新日期:2012-01-01 00:00:00

  • Reduction of gastrointestinal protein loss by elemental diet in Crohn's disease of the small bowel.

    abstract::Seven patients with hypoalbuminaemia and extensive jejunoileal Crohn's disease were treated with an elemental diet for 28 to 56 days. Over this time there was an increase in total plasma proteins from mean of 49.1 to 59.0 g/l and a mean rise in serum albumin from 20.7 to 30.0 g/l (P less than 0.05). In addition, there...


    pub_type: 杂志文章


    authors: Logan RF,Gillon J,Ferrington C,Ferguson A

    更新日期:1981-05-01 00:00:00

  • Liver damage associated with perhexiline maleate.

    abstract::Two patients who developed biochemical and histological evidence of hepatitis while taking the anti-anginal drug perhexiline maleate are described. The pathological changes were those of mild to moderate fatty change together with a hepatitis which resembled alcoholic hepatitis, including in one patient the presence o...


    pub_type: 杂志文章


    authors: Lewis D,Wainwright HC,Kew MC,Zwi S,Isaacson C

    更新日期:1979-03-01 00:00:00

  • Down regulation of epidermal growth factor receptors in liver proliferation induced by a mixture of triiodothyronine, amino acids, glucagon, and heparin (TAGH).

    abstract::This study investigated the mechanisms by which TAGH solution (a mixture of triiodothyronine, amino acids, glucagon, and heparin) induces DNA synthesis in hepatocytes in the liver of intact rats, with particular reference to events at the epidermal growth factor (EGF) receptor. Both partial hepatectomy and infusion of...


    pub_type: 杂志文章


    authors: Vesey DA,Selden AC,Hodgson HJ

    更新日期:1993-11-01 00:00:00

  • Helicobacter pylori: a risk and severity factor of non-steroidal anti-inflammatory drug induced gastropathy.

    abstract::This prospective study aimed to determine the prevalence of Helicobacter pylori infection in relation to the occurrence and severity of NSAIDs induced gastropathy. A total of 111 patients were studied-66 were taking NSAIDs and 45 were control patients. All patients underwent endoscopy during which antral biopsy specim...


    pub_type: 杂志文章


    authors: Heresbach D,Raoul JL,Bretagne JF,Minet J,Donnio PY,Ramée MP,Siproudhis L,Gosselin M

    更新日期:1992-12-01 00:00:00

  • Computed tomography in predicting gall stone solubility: a prospective trial.

    abstract::This prospective study was undertaken to evaluate the correlation between densitometric values of gall stones assessed by computed tomography and the success rate of litholytic therapy in 28 patients eligible for oral treatment. A densitometric study of the stones was performed in all patients before treatment. A cut ...


    pub_type: 杂志文章


    authors: Caroli A,Del Favero G,Di Mario F,Spigariol F,Scalon P,Meggiato T,Zambelli C,Naccarato R

    更新日期:1992-05-01 00:00:00

  • Psychological stress and corticotropin-releasing hormone increase intestinal permeability in humans by a mast cell-dependent mechanism.

    abstract:OBJECTIVE:Intestinal permeability and psychological stress have been implicated in the pathophysiology of IBD and IBS. Studies in animals suggest that stress increases permeability via corticotropin-releasing hormone (CRH)-mediated mast cell activation. Our aim was to investigate the effect of stress on intestinal perm...


    pub_type: 杂志文章


    authors: Vanuytsel T,van Wanrooy S,Vanheel H,Vanormelingen C,Verschueren S,Houben E,Salim Rasoel S,Tόth J,Holvoet L,Farré R,Van Oudenhove L,Boeckxstaens G,Verbeke K,Tack J

    更新日期:2014-08-01 00:00:00

  • The CCR5-delta32 mutation: impact on disease outcome in individuals with hepatitis C infection from a single source.

    abstract:BACKGROUND AND AIMS:Chemokines are small polypeptides, a major function of which is lymphocyte recruitment and trafficking. The aim of this study was to assess the involvement of inherited variations in CCR2, CCR5, and the ligand RANTES in determining disease outcome in hepatitis C virus (HCV) infected individuals. ME...


    pub_type: 杂志文章


    authors: Goulding C,McManus R,Murphy A,MacDonald G,Barrett S,Crowe J,Hegarty J,McKiernan S,Kelleher D

    更新日期:2005-08-01 00:00:00

  • Substantial and sustained improvement of serrated polyp detection after a simple educational intervention: results from a prospective controlled trial.

    abstract:OBJECTIVE:Serrated polyps (SPs) are an important cause of postcolonoscopy colorectal cancers (PCCRCs), which is likely the result of suboptimal SP detection during colonoscopy. We assessed the long-term effect of a simple educational intervention focusing on optimising SP detection. DESIGN:An educational intervention,...


    pub_type: 杂志文章


    authors: Bleijenberg AGC,van Leerdam ME,Bargeman M,Koornstra JJ,van Herwaarden YJ,Spaander MC,Sanduleanu S,Bastiaansen BAJ,Schoon EJ,van Lelyveld N,Dekker E,IJspeert JEG

    更新日期:2020-12-01 00:00:00

  • Epidermal growth factor reduces multiorgan failure induced by thioacetamide.

    abstract:BACKGROUND:Multiorgan failure is a severe life threatening state where present therapeutic approaches are suboptimal. Epidermal growth factor (EGF) is a potent stimulant of repair in in vitro and in vivo models. We therefore examined its potential beneficial effect in reducing mortality and injury induced by the noxiou...


    pub_type: 杂志文章


    authors: Caballero ME,Berlanga J,Ramirez D,Lopez-Saura P,Gozalez R,Floyd DN,Marchbank T,Playford RJ

    更新日期:2001-01-01 00:00:00