Abstract:
:Cirrhosis is associated with the development of a hyperdynamic circulation, which is secondary to the presence of systemic vasodilatation. Several mechanisms have been postulated to be involved in the development of systemic vasodilatation, including increased synthesis of nitric oxide, hyperglucagonaemia, increased carbon monoxide synthesis, and activation of K(ATP) channels in vascular smooth muscle cells in the systemic and splanchnic arterial circulation. Hydrogen sulphide (H2S) has recently been identified as a novel gaseous transmitter that induces vasodilatation through activation of K(ATP) channels in vascular smooth muscle cells. In this brief review, we comment on what is known about H2S, vascular and neurological function, and postulate its role in the pathogenesis of the vascular abnormalities in cirrhosis.
journal_name
Gutjournal_title
Gutauthors
Ebrahimkhani MR,Mani AR,Moore Kdoi
10.1136/gut.2004.056556keywords:
subject
Has Abstractpub_date
2005-12-01 00:00:00pages
1668-71issue
12eissn
0017-5749issn
1468-3288pii
gut.2004.056556journal_volume
54pub_type
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