Abstract:
:In order to examine the relationship of various haemodynamic parameters in two different liver diseases, 10 patients with cirrhosis of liver and 14 patients with non-cirrhotic portal fibrosis were studied. In cirrhotics, mean (+/- SD) wedged hepatic (25.8 +/- 6.4 mmHg), intrahepatic (24.5 +/- 6.2 mmHg) and intrasplenic (25.0 +/- 5.6 mmHg) pressures correlated significantly (p less than 0.001) with intravariceal (25.2 +/- 6.7) pressure measurements. In patients with NCPF, mean (+/- SD) wedged hepatic (9.1 +/- 3.7 mmHg) and intraphepatic (15.4 +/- 5.8 mmHg) pressures were significantly (p less than 0.01) lower than the intrasplenic (24.5 +/- 4.2 mmHg) and intravariceal (23.96 +/- 5.6 mmHg) pressures. Two independent pressure gradients, one between intrasplenic and intrahepatic pressure (8.9 +/- 6.5 mmHg) and another between intrahepatic and wedged hepatic venous pressure (6.2 +/- 5.6 mmHg) were seen in non-cirrhotic portal fibrosis patients, indicating the likelihood of both pre- and perisinusoidal resistance to flow of portal venous blood in these patients. A highly significant (p less than 0.001) correlation between intravariceal and intrasplenic pressures was found in patients with cirrhosis of liver (r = 0.93), as well as in patients with non-cirrhotic portal fibrosis (r = 0.85). No correlation was found between the size of oesophageal varices and wedged hepatic and intrahepatic pressures. Patients with grade 4 varices had significantly higher intravariceal (p less than 0.01) and intrasplenic (p less than 0.05) pressure than patients with grade 2 varices. It can be concluded that intravariceal pressure is representative of portal pressure in patients with cirrhosis of liver as well as in non-cirrhotic portal fibrosis patients and it can be recommended as the single haemodynamic investigation in patients with portal hypertension and oesophageal varices.
journal_name
Gutjournal_title
Gutauthors
Sarin SK,Sethi KK,Nanda Rdoi
10.1136/gut.28.3.260subject
Has Abstractpub_date
1987-03-01 00:00:00pages
260-6issue
3eissn
0017-5749issn
1468-3288journal_volume
28pub_type
杂志文章相关文献
GUT文献大全abstract:AIMS:To evaluate the clinical utility of two new tests for serum trypsinogen 2 and trypsin 2-alpha 1 antitrypsin complex (trypsin 2-AAT) in diagnosing and assessing the severity of acute pancreatitis (AP) induced by endoscopic retrograde cholangiopancreatography (ERCP). PATIENTS:Three hundred and eight consecutive pat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.41.5.690
更新日期:1997-11-01 00:00:00
abstract::The results of bile salt treatment in patients with radiolucent stones and a functioning gall bladder have been poor. In 42 of these patients awaiting cholecystectomy we determined the value of duodenal bile examination in predicting gall stone composition, and thus identifying those less likely to respond to bile sal...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.1.112
更新日期:1994-01-01 00:00:00
abstract::One hundred patients who had undergone operation for duodenal ulcer (68 vagotomy and gastroenterostomy; seven vagotomy and pyloroplasty; 22 gastrectomy and three gastroenterostomy) 10 or more years previously each underwent endoscopy. Biopsies were taken and gastric juice aspirated for measurement of pH and nitrite co...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.3.246
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:Appendicectomy reduces the risk of having ulcerative colitis. However, its effect on the natural history of ulcerative colitis remains uncertain. AIM:To determine whether appendicectomy reduces the overall severity of ulcerative colitis. PATIENTS AND METHODS:Appendicectomy status and smoking habits were sp...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.6.803
更新日期:2002-12-01 00:00:00
abstract::In order to establish whether alcohol in amounts in amounts customarily imbibed during social drinking causes gastro-oesophageal reflux, 12 healthy young individuals, without symptoms of gastro-oesophageal reflux, were studied twice. Each time, distal oesophageal pH was monitored continuously for three hours after a s...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.19.4.336
更新日期:1978-04-01 00:00:00
abstract:BACKGROUND:Interleukin 8 (IL-8) has recently been proposed to have an important role in mediating the development of the systemic sequelae associated with severe acute pancreatitis. AIMS:To define the role of IL-8 in acute pancreatitis by neutralising its effects with a monoclonal anti-IL-8 antibody (WS-4), in a rabbi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.43.2.232
更新日期:1998-08-01 00:00:00
abstract::With oral and intravenous doses of metoclopramide there was no constant effect on the gastric emptying of test meals of glucose or sodium citrate, nor was secretion of acid by the stomach in response to test meals of glucose or sodium citrate affected. Apomorphine, in subnauseous doses (0.25 mg intravenously) slowed t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.11.12.989
更新日期:1970-12-01 00:00:00
abstract::The endothelins are a group of three related peptides with two receptor subtypes, ET(A) and ET(B). Following the discovery of endothelin 1 as a potent vasoconstrictor, there has been intense interest in the role of endothelin on vascular function in liver disease. Speculation on the role of endothelin in the pathogene...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2003.024703
更新日期:2004-02-01 00:00:00
abstract::Microalbuminuria independently predicts the development of nephropathy and increased cardiovascular morbidity and mortality in diabetic patients, but it may be an indicator of the acute phase response. This study examined microalbuminuria as a marker of the acute phase response in patients with inflammatory bowel dise...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.11.1599
更新日期:1994-11-01 00:00:00
abstract::Gastric acid secretion, pepsin secretion, and fasting serum gastrin levels were measured in 23 patients with duodenal ulcer disease, divided into three groups which received either cimetidine 800 mg daily, cimetidine 1600 mg daily, or ranitidine hydrochloride 300 mg daily for eight weeks. Pentagastrin tests were carri...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.24.1.61
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVES:IBDs have an increased risk for development of colorectal cancer (CRC). Here, we aimed at the characterisation of the functional role of Th17-associated transcription factors in sporadic and colitis-associated colon cancer in vivo. DESIGN:We used mice deficient or transgenic for the activating protein 1 fam...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308227
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Patients with liver cirrhosis are at increased risk of serious bacterial infections carrying a high case fatality rate. Case reports have suggested an association between liver cirrhosis and pyogenic liver abscess. AIMS:To estimate the risk and case fatality rate of pyogenic liver abscess in Danish patients...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.48.2.260
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:Gastric cancer is the third leading cause of cancer death worldwide and infection by Helicobacter pylori is the strongest risk factor. We have reported increased epidermal growth factor receptor (EGFR) phosphorylation in the H. pylori-induced human carcinogenesis cascade, and association with DNA damage. Our ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-312888
更新日期:2018-07-01 00:00:00
abstract::The absorption of short chain fatty acids by the human rectum in the absence of chloride has been studied using a dialysis bag technique. Absorption rates of sodium, water, and short chain fatty acids were unchanged on replacing chloride with sulphate. Final concentrations of bicarbonate were 35.4 +/- 3.4 mmol/l in th...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.20.5.400
更新日期:1979-05-01 00:00:00
abstract::The prevalence of antibodies against hepatitis C virus (anti-HCV) among intravenous drug users (IVDU) has consistently been very high. Cross challenge studies in chimpanzees provide evidence that reinfection with different HCV strains may occur. In humans, reinfection with different HCV strains has been reported in mu...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.52.6.900
更新日期:2003-06-01 00:00:00
abstract::Three cases are presented of lymphocytic colitis with chronic diarrhoea concurrent with longterm use of Cyclo 3 Fort, a phlebotonic drug used in France. The histological and immunopathological features of lymphocytic colitis are described. We show that lymphocytic colitis is drug induced, particularly in one patient w...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.3.426
更新日期:1994-03-01 00:00:00
abstract::In a double-blind controlled trial amylopectin sulphate (Depepsen) had no significant advantage over placebo in the symptomatic treatment of duodenal ulcer. ...
journal_title:Gut
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1136/gut.18.9.723
更新日期:1977-09-01 00:00:00
abstract::The distribution of the endoplasmic reticulum in human hepatocytes is defined in quantitative terms using the techniques of morphometry. The subjects of the study are liver biopsies from normal, untreated subjects and patients being treated with various drugs. In contrast to rat hepatocytes, the amount of smooth endop...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.15.9.737
更新日期:1974-09-01 00:00:00
abstract::The extent to which defects in protein synthesis occurred in an experimental indomethacin induced rat model of nonsteroidal enteropathy has been examined. Male rats (nine) were fed indomethacin (8 mg/kg/day) for three days mixed with a powdered form of chow. The control group of rats (nine) were fed the same diet for ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.33.2.242
更新日期:1992-02-01 00:00:00
abstract::A case of spontaneous partial rupture of the normal large bowel causing a haemoperitoneum is described. No similar case appears to have been reported previously. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.1.4.321
更新日期:1960-12-01 00:00:00
abstract:OBJECTIVE:To elucidate the association between antiviral therapy and extrahepatic outcomes in individuals infected with HCV. METHODS:This nationwide cohort study screened 293,480 Taiwanese residents with HCV infection and excluded those with substantial comorbidity. A total of 12,384 eligible patients who had received...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-308163
更新日期:2015-03-01 00:00:00
abstract::The effects of intravenous N-acetylcysteine on hepatic and systemic haemodynamics were investigated in 11 patients with stable cirrhosis (eight alcohol; two primary biliary cirrhosis; one cryptogenic). N-acetylcysteine administration had no effect on the mean heart rate or mean arterial blood pressure despite a signif...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.35.9.1290
更新日期:1994-09-01 00:00:00
abstract:BACKGROUND AND AIMS:Helicobacter pylori (H pylori) infection is a major risk factor in the development of distal gastric adenocarcinoma. Development of the invasive phenotype is associated with the phenomenon of epithelial:mesenchymal transition (EMT). Soluble heparin-binding epidermal growth factor (HB-EGF) has been i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.199794
更新日期:2010-08-01 00:00:00
abstract:OBJECTIVE:Silibinin is a flavonolignan that is well established for its robust antiviral activity against HCV infection and has undergone several clinical trials for the management of hepatitis C. Despite its potency, silibinin suffers from poor solubility and bioavailability, restricting its clinical use. To overcome ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2016-312019
更新日期:2017-10-01 00:00:00
abstract::Patients with functional gastrointestinal disorders may have visceral sensory dysfunction so that physiological stimuli induce their symptoms. The clinical significance of altered perception-that is, its relation to clinical symptoms-remains unclear. Data indicate that sensory dysfunction is associated with altered re...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.51.suppl_1.i25
更新日期:2002-07-01 00:00:00
abstract::A Syrian family is described with three children who had inherited selective vitamin B12 malabsorption associated with proteinuria. (Imerslund-Grasbeck syndrome). Although inherited the defect was apparently not present at birth. A third child had less severe vitamin B12 malabsorption, was not vitamin B12 deficient an...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.3.311
更新日期:1985-03-01 00:00:00
abstract::Options for managing the common bile duct during laparoscopic cholecystectomy include routine peroperative cholangiography and selected preoperative endoscopic retrograde cholangiopancreatography (ERCP). The use of these methods was reviewed in 350 patients with symptomatic gall stones referred for laparoscopic cholec...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.35.7.991
更新日期:1994-07-01 00:00:00
abstract::Cimetidine 200 mg three times daily and 400 mg at night was given to 10 subjects for four weeks. Apparent liver blood flow was measured by indocyanine green clearance and microsomal enzyme activity by antipyrine clearance, before and after cimetidine. There was no reduction in indocyanine green clearance but antipyrin...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.25.2.125
更新日期:1984-02-01 00:00:00
abstract:OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is a frequent complication of morbid obesity, but its severity varies greatly and thus there is a strong need to better define its natural history in these patients. DESIGN:Liver biopsies were systematically performed in 798 consecutive patients with severe obesity u...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2016-312238
更新日期:2017-09-01 00:00:00
abstract:OBJECTIVE:Corticosteroid has been established as the standard therapy for autoimmune pancreatitis (AIP), but the requirement for maintenance corticosteroid therapy is controversial. We conducted a randomised controlled trial to clarify the efficacy of maintenance corticosteroid therapy in patients with AIP. DESIGN:We ...
journal_title:Gut
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1136/gutjnl-2016-312049
更新日期:2017-03-01 00:00:00