Abstract:
:A 60 year old man developed steatorrhoea, weight loss, mild diabetes mellitus, labile hypertension and limb cramps. Raised plasma concentrations of catecholamines, particularly noradrenaline and a computed tomography-scan showing an adrenal tumour strongly suggested a pheochromocytoma. Adrenoreceptor blockade reversed the symptoms, decreased faecal fat, and increased duodenal trypsin to normal concentrations. After adrenalectomy the patient was asymptomatic and there was no steatorrhoea. The blood glucose concentrations became normal. Immunocytochemistry revealed the tumour cells to store large amounts of enkephalin and somatostatin reactive material and moderate amounts of immunoreactive beta-endorphin and dynorphin.
journal_name
Gutjournal_title
Gutauthors
Thesleff P,Benoni C,Mårtensson H,Nilsson A,Sundler F,Akesson Bdoi
10.1136/gut.28.10.1298subject
Has Abstractpub_date
1987-10-01 00:00:00pages
1298-301issue
10eissn
0017-5749issn
1468-3288journal_volume
28pub_type
杂志文章相关文献
GUT文献大全abstract:OBJECTIVE:The natural course of chronic hepatitis C varies widely. To improve the profiling of patients at risk of developing advanced liver disease, we assessed the relative contribution of factors for liver fibrosis progression in hepatitis C. DESIGN:We analysed 1461 patients with chronic hepatitis C with an estimat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2014-306997
更新日期:2015-10-01 00:00:00
abstract::Gastric cancer is a major health burden worldwide and prevention is the most promising strategy to control the disease. The available scientific evidence indicates that curing Helicobacter pylori infection results in a modest retardation of the precancerous process but does not prevent all cancers. Individuals at the ...
journal_title:Gut
pub_type: 评论,杂志文章,评审
doi:10.1136/gut.2004.039834
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:The prevalence of duodenal carcinoma is much higher in familial adenomatous polyposis (FAP) than in the background population, and duodenal adenomatosis is found in most polyposis patients. AIMS:To describe the long term natural history of duodenal adenomatosis in FAP and evaluate if cancer prophylactic sur...
journal_title:Gut
pub_type: 杂志文章,多中心研究
doi:10.1136/gut.2003.027771
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor (VEGF) is a therapeutic target in gastrointestinal cancer (GiC). However, its in vivo visualisation could not be achieved to date with endoscopic techniques. Confocal laser endomicroscopy (CLE) is a novel imaging technique for gastrointestinal endoscopy providing in vivo mi...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.2009.202986
更新日期:2010-08-01 00:00:00
abstract::Though amoebic liver abscess and liver cirrhosis occur very commonly in hospital practice in the tropics, they have not to the knowledge of the present authors hitherto been reported to occur simultaneously in the same patient. The patient described here, who had clear-cut clinical and histological features of chronic...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.21.2.161
更新日期:1980-02-01 00:00:00
abstract::A simple evocative test has been used to study pancreatic function. Serial estimations of amylase and lipase in blood serum are made at intervals up to six hours and again at 24 hours after injecting intravenously standard doses of secretin and pancreozymin. The results of 213 tests on a normal group, in pancreatic di...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.1.2.125
更新日期:1960-06-01 00:00:00
abstract:BACKGROUND:Almost 4% of the population suffer from food allergy which is an adverse reaction to food with an underlying immunological mechanism. AIMS:To characterise one of the most frequent IgE defined food allergens, fish parvalbumin. METHODS:Tissue and subcellular distribution of carp parvalbumin was analysed by i...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.46.5.661
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:Non-alcoholic fatty liver disease (NAFLD) is a frequent complication of morbid obesity, but its severity varies greatly and thus there is a strong need to better define its natural history in these patients. DESIGN:Liver biopsies were systematically performed in 798 consecutive patients with severe obesity u...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2016-312238
更新日期:2017-09-01 00:00:00
abstract:BACKGROUND:Interstitial cells of Cajal (ICC) are required for normal intestinal motility. ICC are found throughout the human colon and are decreased in the sigmoid colon of patients with slow transit constipation. AIMS:The aims of this study were to determine the normal distribution of ICC within the human colon and t...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.51.4.496
更新日期:2002-10-01 00:00:00
abstract:BACKGROUND:Bovine immunoglobulin concentrate (BIC)-Clostridium difficile is prepared from the colostrum of cows immunised against C difficile toxins and contains high concentrations of neutralising IgG antitoxin. AIMS:To determine the proportion of BIC-C difficile which survives passage through the human stomach and s...
journal_title:Gut
pub_type: 临床试验,杂志文章
doi:10.1136/gut.44.2.212
更新日期:1999-02-01 00:00:00
abstract::Lymphocytic gastritis is a new histopathological entity characterised by a dense lymphocytic infiltration of surface and pit gastric epithelium. Previous retrospective work has suggested that lymphocytic gastritis is related to an endoscopic form of gastropathy comprising enlarged folds, nodules and erosions, commonly...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.31.3.282
更新日期:1990-03-01 00:00:00
abstract::Ten patients in whom cystic dystrophy developed in a heterotopic pancreas of the duodenal (nine patients) or gastric (one patient) wall are reported. All were young or middle aged white men, only two of whom were alcoholic. The symptoms were caused by intestinal or biliary stenosis, or both, secondary to the inflammat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.34.3.343
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Dyspepsia and irritable bowel syndrome are suitable conditions for assessment of quality of life. Their similarities justify the elaboration of a single specific questionnaire for the two conditions. AIMS:To examine the process leading to the validation of the psychometric properties of the functional diges...
journal_title:Gut
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1136/gut.44.4.527
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:Hepatitis D virus (HDV) is a defective virus that completes its life cycle only with hepatitis B virus (HBV). The HBV with HDV super-infection has been considered as one of the most severe forms of the chronic viral hepatitis. However, there is a scarcity of data on the global burden of HDV infection. DESIGN...
journal_title:Gut
pub_type: 杂志文章,meta分析
doi:10.1136/gutjnl-2018-316601
更新日期:2019-03-01 00:00:00
abstract::The role of Helicobacter pylori infection in the pathogenesis of functional dyspepsia is debated. It is known that a substantial fraction of dyspeptic patients manifest a low discomfort threshold to gastric distension. This study investigated the symptomatic pattern in 27 H pylori positive and 23 H pylori negative pat...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.37.1.47
更新日期:1995-07-01 00:00:00
abstract:OBJECTIVE:Adherent-invasive Escherichia coli (AIEC) are a leading candidate bacterial trigger for Crohn's disease (CD). The AIEC pathovar is defined by in vitro cell-line assays examining specific bacteria/cell interactions. No molecular marker exists for their identification. Our aim was to identify a molecular proper...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2015-311059
更新日期:2017-08-01 00:00:00
abstract::Gastric antral vascular ectasia ('water melon stomach') is a poorly documented cause of occult upper gastrointestinal blood loss. We describe a case which emphasises the clinical and pathological difficulties that can be encountered in making this elusive diagnosis. ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.8.954
更新日期:1991-08-01 00:00:00
abstract::The value of lactulose treatment in hepatic encephalopathy is widely recognised but its mode of action remains controversial. Much evidence supports a role for gamma-aminobutyric acid in hepatic encephalopathy, and lactulose could alter its bacterial production in the gut. Using the rat synaptic membrane assay and gas...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.32.9.1007
更新日期:1991-09-01 00:00:00
abstract::In a prospective survey positive antimitochondrial antibodies have been detected in 69/4200 (1.64%) of all sera submitted to a routine immunology laboratory. Of the 69, only nine patients had uniquivocal primary biliary cirrhosis, six others had chronic active hepatitis, 10 had abnormal liver function tests without ev...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.23.10.814
更新日期:1982-10-01 00:00:00
abstract:BACKGROUND:Treatment cessation in chronic HBV infection may be durable in certain patient subgroups before hepatitis B surface antigen (HBsAg) seroclearance. The role of serum HBV RNA in determining treatment cessation suitability has not been well-investigated. METHODS:Nucleos(t)ide analogue (NUC) treatment was disco...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2020-321116
更新日期:2020-08-05 00:00:00
abstract::Intestinal protein loss in chronic inflammatory bowel diseases may be easily determined by measurement of alpha-1-antitrypsin (alpha 1-AT) stool concentration and alpha 1-AT clearance. Both parameters were significantly raised in 36 and 34 patients respectively with chronic inflammatory bowel diseases, compared with e...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.4.386
更新日期:1987-04-01 00:00:00
abstract:BACKGROUND:Endoscopic diagnosis of short segments of Barrett's epithelium (SSBE)' is difficult and its meaning in terms of the presence of specialised columnar epithelium (SCE) has not been prospectively evaluated. AIMS:To evaluate the prevalence of SCE in patients with an endoscopic diagnosis of SSBE and in individua...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.42.5.659
更新日期:1998-05-01 00:00:00
abstract::Neurotensin is a tridecapeptide located mainly in the distal small intestine. The present study was carried out in order to investigate the neurotensin response after proximal small intestinal resection in the rat. After resection, the median plasma concentration of neurotensin like immunoreactivity (NTLI) was unchang...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.28.9.1107
更新日期:1987-09-01 00:00:00
abstract::The relationship between the adaptive response and plasma PYY concentrations after small bowel resection has been investigated. Seventy five per cent proximal small bowel resection resulted in a rise in plasma PYY at six days from 28 +/- 3.1 to 85 +/- 12.3 pmol/l (p less than 0.001) and this difference was maintained ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.26.12.1353
更新日期:1985-12-01 00:00:00
abstract::Heartburn is a common symptom affecting 21-44% of the adult population on a monthly basis. Oesophagitis is less common, affecting 2% of individuals. Epidemiological studies have shown that patients with gastro-oesophageal reflux disease (GORD) have similar incidence rates of Helicobacter pylori infection as do control...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.45.2008.i13
更新日期:1999-07-01 00:00:00
abstract::Although colorectal cancer (CRC) is a common cause of cancer-related death, it is fortunately amenable to screening with faecal tests for occult blood and endoscopic tests. Despite the evidence for the efficacy of guaiac-based faecal occult blood tests (gFOBT), they have not been popular with primary care providers in...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gutjnl-2014-308074
更新日期:2015-08-01 00:00:00
abstract::Psychological treatments are increasingly being used to help patients with the irritable bowel syndrome (IBS), but the efficacy of such treatments is still debated. This review indicates that there are three ways in which they might have been effective in published studies to date; relating bowel symptoms to stress, s...
journal_title:Gut
pub_type: 杂志文章,评审
doi:10.1136/gut.30.11.1601
更新日期:1989-11-01 00:00:00
abstract:BACKGROUND:Helicobacter pylori infection is associated with a marked infiltration of the gastric epithelium by neutrophils, macrophages, lymphocytes, and plasma cells. Despite the presence of phagocytes in close vicinty to H pylori microbes a great number of people are unable to eradicate bacteria. AIMS:To investigate...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.40.1.20
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVE:As the current therapeutic strategies for human hepatocellular carcinoma (HCC) have been proven to have limited effectiveness, immunotherapy becomes a compelling way to tackle the disease. We aim to provide humanised mouse (humice) models for the understanding of the interaction between human cancer and immun...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gutjnl-2017-315201
更新日期:2018-10-01 00:00:00
abstract::The oral administration of loxtidine to mice at doses of 600, 250, and 50 mg/kg/day for 746 days produced carcinoid tumours of the gastric fundus. The fundic mucosa also showed marked atypical hyperplasia with changes in foveolar cells similar to those seen in early incomplete metaplasia. These effects may be related ...
journal_title:Gut
pub_type: 杂志文章
doi:10.1136/gut.27.11.1338
更新日期:1986-11-01 00:00:00