Abstract:
:Epithelial cells shed from the intestinal villus in starved rats were trapped in mucus which the goblet cells were stimulated to secrete; the number of trapped cells per villus was counted in whole mounts of fixed Feulgen-stained specimens from three sites in the small intestine. Increase in the interval between stimulation and fixation caused an increase in the number of shed cells per villus; the rate of this increase was postulated to represent the rate of cell shedding. The rate of cell production per crypt was measured with Colcemid; this rate, multiplied by the number of crypts per villus, gave the rate of cell production per villus. There was good agreement between these estimates of cell production and cell shedding.
journal_name
Gutjournal_title
Gutauthors
Clarke RMdoi
10.1136/gut.11.12.1015subject
Has Abstractpub_date
1970-12-01 00:00:00pages
1015-9issue
12eissn
0017-5749issn
1468-3288journal_volume
11pub_type
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