Meat intake and risk of diverticulitis among men.

Abstract:

OBJECTIVE:Diverticulitis is a common disease with a substantial clinical and economic burden. Besides dietary fibre, the role of other foods in the prevention of diverticulitis is underexplored. DESIGN:We prospectively examined the association between consumption of meat (total red meat, red unprocessed meat, red processed meat, poultry and fish) with risk of incident diverticulitis among 46 461 men enrolled in the Health Professionals Follow-Up Study (1986-2012). Cox proportional hazards models were used to compute relative risks (RRs) and 95% CIs. RESULTS:During 651 970 person-years of follow-up, we documented 764 cases of incident diverticulitis. Compared with men in the lowest quintile (Q1) of total red meat consumption, men in the highest quintile (Q5) had a multivariable RR of 1.58 (95% CI 1.19 to 2.11; p for trend=0.01). The increase in risk was non-linear, plateauing after six servings per week (p for non-linearity=0.002). The association was stronger for unprocessed red meat (RR for Q5 vs Q1: 1.51; 95% CI 1.12 to 2.03; p for trend=0.03) than for processed red meat (RR for Q5 vs Q1: 1.03; 95% CI 0.78 to 1.35; p for trend=0.26). Higher consumption of poultry or fish was not associated with risk of diverticulitis. However, the substitution of poultry or fish for one serving of unprocessed red meat per day was associated with a decrease in risk of diverticulitis (multivariable RR 0.80; 95% CI 0.63 to 0.99). CONCLUSIONS:Red meat intake, particularly unprocessed red meat, was associated with an increased risk of diverticulitis. The findings provide practical dietary guidance for patients at risk of diverticulitis.

journal_name

Gut

journal_title

Gut

authors

Cao Y,Strate LL,Keeley BR,Tam I,Wu K,Giovannucci EL,Chan AT

doi

10.1136/gutjnl-2016-313082

subject

Has Abstract

pub_date

2018-03-01 00:00:00

pages

466-472

issue

3

eissn

0017-5749

issn

1468-3288

pii

gutjnl-2016-313082

journal_volume

67

pub_type

杂志文章

相关文献

GUT文献大全
  • Bacterial and fungal microbiota in relation to probiotic therapy (VSL#3) in pouchitis.

    abstract:BACKGROUND:The intestinal microbiota plays a critical role in the pathophysiology of pouchitis, a major complication after ileal pouch anal anastomosis in patients with ulcerative colitis. Recently, controlled trials have demonstrated that probiotics are effective in maintenance of remission in pouchitis patients. Howe...

    journal_title:Gut

    pub_type: 杂志文章,随机对照试验

    doi:10.1136/gut.2005.078303

    authors: Kühbacher T,Ott SJ,Helwig U,Mimura T,Rizzello F,Kleessen B,Gionchetti P,Blaut M,Campieri M,Fölsch UR,Kamm MA,Schreiber S

    更新日期:2006-06-01 00:00:00

  • Motor activity recorded in the unprepared colon of healthy humans.

    abstract::A manometric method was developed to study the motor activity in the unprepared human colon, and the results in eight healthy subjects were compared with those obtained in the same subjects after bowel cleansing with a non-absorbable solution containing polyethylene glycol 4000 (PEG). A tube assembly (4.5 m long, 12 l...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.37.5.649

    authors: Lémann M,Flourié B,Picon L,Coffin B,Jian R,Rambaud JC

    更新日期:1995-11-01 00:00:00

  • Lipid peroxidation in rats chronically fed ethanol.

    abstract::Chronic alcohol consumption induces cytochrome P450IIE1, enabling habitual abusers to consume far greater quantities of alcohol than normal subjects. This pathway of metabolism leads to the production of free radical species, which cause tissue damage through peroxidation of cell membranes. Groups of Wistar rats of eq...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.35.11.1644

    authors: Teare JP,Greenfield SM,Watson D,Punchard NA,Miller N,Rice-Evans CA,Thompson RP

    更新日期:1994-11-01 00:00:00

  • Copper kinetics in liver disease.

    abstract::The plasma clearance and the liver uptake of intravenously administered (64)Cu were significantly impaired in four patients with Wilson's disease. These defects were unlikely to be simply expressions of the high liver copper concentration as the plasma clearance and hepatic uptake of (64)Cu were normal in four patient...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.12.2.139

    authors: Smallwood RA,McIlveen B,Rosenoer VM,Sherlock S

    更新日期:1971-02-01 00:00:00

  • Non-steroidal anti-inflammatory drugs as a risk factor for acute diarrhoea: a case crossover study.

    abstract:BACKGROUND AND AIMS:Several cases of acute colitis induced by non-steroidal anti-inflammatory drugs (NSAIDs) have been reported but the general role of recent NSAID intake as a risk factor for acute diarrhoea has not been studied to date. The aim of our study was to determine whether the risk of acute diarrhoea is incr...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.52.2.260

    authors: Etienney I,Beaugerie L,Viboud C,Flahault A

    更新日期:2003-02-01 00:00:00

  • miR-150 as a potential biomarker associated with prognosis and therapeutic outcome in colorectal cancer.

    abstract:BACKGROUND:MicroRNAs (miRNA) have potential as prognostic biomarkers and therapeutic targets in cancer. A study was undertaken to investigate the association between miRNA expression patterns and the prognosis and therapeutic outcome of colorectal cancer (CRC). METHODS:miRNA expression profiling in tumour, adenoma and...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2011-301122

    authors: Ma Y,Zhang P,Wang F,Zhang H,Yang J,Peng J,Liu W,Qin H

    更新日期:2012-10-01 00:00:00

  • Ambulatory small intestinal motility in 'diarrhoea' predominant irritable bowel syndrome.

    abstract::Dysmotility of the duodenum and proximal jejunum has been reported in patients with irritable bowel syndrome. This study extended these findings by recording fasting ambulatory motility from electronic strain gauge sensors sited in the jejunum and ileum of eight diarrhoea predominant irritable bowel syndrome patients ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.35.2.203

    authors: Gorard DA,Libby GW,Farthing MJ

    更新日期:1994-02-01 00:00:00

  • Cerebral processing of painful oesophageal stimulation: a study based on independent component analysis of the EEG.

    abstract:BACKGROUND AND AIMS:Independent component analysis (ICA) of the electroencephalogram (EEG) overcomes many of the classical problems in EEG analysis. We used ICA to determine the brain responses to painful stimulation of the oesophagus. METHODS:Twelve subjects with a median age of 41 years were included. With a nasal e...

    journal_title:Gut

    pub_type: 临床试验,杂志文章

    doi:10.1136/gut.2005.068460

    authors: Drewes AM,Sami SA,Dimcevski G,Nielsen KD,Funch-Jensen P,Valeriani M,Arendt-Nielsen L

    更新日期:2006-05-01 00:00:00

  • Comparison of faecal bile acid profiles between patients with adenomatous polyps of the large bowel and healthy subjects in Japan.

    abstract::Faecal bile acid excretion was examined in 13 patients with adenomatous polyps of the large bowel and compared with a series of matched healthy subjects. Bile acids were analysed in detail with respect to the composition of individual bile acids and their mode of conjugation. The total excretion of bile acids by the p...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.25.8.824

    authors: Tanida N,Hikasa Y,Shimoyama T,Setchell KD

    更新日期:1984-08-01 00:00:00

  • Intestinal absorption of two dipeptides in Hartnup disease.

    abstract::The results of oral tolerance tests of two dipeptides and of their constitutent amino acids are compared in normal subjects and in a case of Hartnup disease. In the control subjects the rate of absorption of phenylalanine from phenylalanyl-phenylalanine and of tryptophan from glycyl-tryptophan was slower than after th...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.11.5.380

    authors: Asatoor AM,Cheng B,Edwards KD,Lant AF,Matthews DM,Milne MD,Navab F,Richards AJ

    更新日期:1970-05-01 00:00:00

  • Screening SMAD1, SMAD2, SMAD3, and SMAD5 for germline mutations in juvenile polyposis syndrome.

    abstract:BACKGROUND AND AIMS:Juvenile polyps occur in several Mendelian disorders, whether in association with gastrointestinal cancer alone (juvenile polyposis syndrome, JPS) or as part of known syndromes (Cowden, Gorlin, and Bannayan-Zonana) in association with developmental abnormalities, dysmorphic features, or extraintesti...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.45.3.406

    authors: Bevan S,Woodford-Richens K,Rozen P,Eng C,Young J,Dunlop M,Neale K,Phillips R,Markie D,Rodriguez-Bigas M,Leggett B,Sheridan E,Hodgson S,Iwama T,Eccles D,Bodmer W,Houlston R,Tomlinson I

    更新日期:1999-09-01 00:00:00

  • A search for persistent virus infection in Crohn's disease.

    abstract::Cell cultures derived from Crohn's disease and control tissues were subjected to a series of tests designed to detect persistent, non-cytocidal virus infection. No evidence for any such infection was found, and it is concluded that persistent viral infection of gut tissues is unlikely to play a significant role in the...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.21.3.202

    authors: Phillpotts RJ,Hermon-Taylor J,Teich NM,Brooke BN

    更新日期:1980-03-01 00:00:00

  • Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling.

    abstract:BACKGROUND AND AIMS:Emerging evidence suggests that highly treatment-resistant tumour-initiating cells (TICs) play a central role in the pathogenesis of pancreatic cancer. Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) is considered to be a novel anticancer agent; however, recent studies have shown th...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2008.149039

    authors: Kallifatidis G,Rausch V,Baumann B,Apel A,Beckermann BM,Groth A,Mattern J,Li Z,Kolb A,Moldenhauer G,Altevogt P,Wirth T,Werner J,Schemmer P,Büchler MW,Salnikov AV,Herr I

    更新日期:2009-07-01 00:00:00

  • Direct measurement of acid permeation into rat oesophagus.

    abstract:BACKGROUND AND AIMS:The early responses of the oesophageal mucosa to acid perfusion may predict subsequent pathology. Mucosal responses to luminal acid may result either from acid permeating through the mucosa or from other unknown transduction mechanisms. In order to better understand the dynamics of acid permeation i...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.52.6.775

    authors: Tanaka S,Chu S,Hirokawa M,Montrose MH,Kaunitz JD

    更新日期:2003-06-01 00:00:00

  • Increased intestinal permeability in ankylosing spondylitis--primary lesion or drug effect?

    abstract::We have found increased small intestinal permeability to 51Cr-ethylenediaminetetra acetate in patients with ankylosing spondylitis compared with controls. There is no significant difference between patients with ankylosing spondylitis and patients with rheumatoid arthritis taking non-steroidal anti-inflammatory drugs ...

    journal_title:Gut

    pub_type: 临床试验,杂志文章

    doi:10.1136/gut.32.12.1470

    authors: Morris AJ,Howden CW,Robertson C,Duncan A,Torley H,Sturrock RD,Russell RI

    更新日期:1991-12-01 00:00:00

  • Detection of subclinical autonomic neuropathy in constipated patients using a sweat test.

    abstract::Chronic idiopathic constipation may be the result of an autonomic neuropathy. This hypothesis was tested in 23 constipated patients and 17 age matched controls, using the acetylcholine sweat spot test devised to test autonomic integrity in diabetes. Acetylcholine (0.01%) was injected in the dorsum of the foot painted ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.33.11.1539

    authors: Altomare D,Pilot MA,Scott M,Williams N,Rubino M,Ilincic L,Waldron D

    更新日期:1992-11-01 00:00:00

  • TPX2 and AURKA promote 20q amplicon-driven colorectal adenoma to carcinoma progression.

    abstract:BACKGROUND AND OBJECTIVE:Progression of a colorectal adenoma to invasive cancer occurs in a minority of adenomas and is the most crucial step in colorectal cancer pathogenesis. In the majority of cases, this is associated with gain of a substantial part of chromosome 20q, indicating that multiple genes on the 20q ampli...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2011-301153

    authors: Sillars-Hardebol AH,Carvalho B,Tijssen M,Beliën JA,de Wit M,Delis-van Diemen PM,Pontén F,van de Wiel MA,Fijneman RJ,Meijer GA

    更新日期:2012-11-01 00:00:00

  • Measurement of vitamin D levels in inflammatory bowel disease patients reveals a subset of Crohn's disease patients with elevated 1,25-dihydroxyvitamin D and low bone mineral density.

    abstract:OBJECTIVES:Many patients with Crohn's disease (CD) have low bone mineral density (BMD) that may not be solely attributable to glucocorticoid use. We hypothesised that low BMD in patients with CD is associated with elevated circulating levels of the active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)(2)D). We fu...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.2003.036657

    authors: Abreu MT,Kantorovich V,Vasiliauskas EA,Gruntmanis U,Matuk R,Daigle K,Chen S,Zehnder D,Lin YC,Yang H,Hewison M,Adams JS

    更新日期:2004-08-01 00:00:00

  • Peutz-Jeghers syndrome associated with gastrointestinal carcinoma. Report of two cases in a family.

    abstract::Patients with the Peutz-Jeghers syndrome carry a slight, though definite, increased risk of gastrointestinal carcinoma. The malignant potentiality of Peutz-Jeghers hamartomatous polyps, generally considered benign, is supported by this report. Two cases of metastasising gastrointestinal carcinoma associated with the P...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.20.2.169

    authors: Cochet B,Carrel J,Desbaillets L,Widgren S

    更新日期:1979-02-01 00:00:00

  • Role of the enteric nervous system in the maintained hypersecretion induced by enterotoxin STa in the nutritionally deprived intestine.

    abstract::Electrogenic (Cl-) secretion was measured as the short circuit current (Isc, microA/cm2) across muscle-stripped sheets of jejunum and ileum incubated in vitro after removal from fed rats, rats starved for three days, and chronically undernourished rats (50% of fed control intake for 21 days). Concentration and Isc res...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.35.9.1237

    authors: Nzegwu HC,Levin RJ

    更新日期:1994-09-01 00:00:00

  • Personalised surveillance for serrated polyposis syndrome: results from a prospective 5-year international cohort study.

    abstract:BACKGROUND AND AIMS:Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC). International guidelines recommend surveillance intervals of 1-2 years. However, yearly surveillance likely leads to overtreatment for many. We prospectively assessed a surveillance protocol aiming to ...

    journal_title:Gut

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1136/gutjnl-2018-318134

    authors: Bleijenberg AG,IJspeert JE,van Herwaarden YJ,Carballal S,Pellisé M,Jung G,Bisseling TM,Nagtegaal ID,van Leerdam ME,van Lelyveld N,Bessa X,Rodríguez-Moranta F,Bastiaansen B,de Klaver W,Rivero L,Spaander MC,Koornstra JJ,B

    更新日期:2020-01-01 00:00:00

  • Antiproliferative effects of interferon alpha on human pancreatic carcinoma cell lines are associated with differential regulation of protein kinase C isoenzymes.

    abstract:BACKGROUND:The molecular mechanisms mediating the antiproliferative effects of interferon alpha on human pancreatic carcinoma cells are poorly understood. AIM:To characterise the effects of interferon alpha on protein kinase C isoenzyme expression in interferon alpha sensitive and resistant human pancreatic tumour cel...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.39.2.255

    authors: Rosewicz S,Weder M,Kaiser A,Riecken EO

    更新日期:1996-08-01 00:00:00

  • Duodenal ulcer and refined carbohydrate intake: a case-control study assessing dietary fibre and refined sugar intake.

    abstract::An association between duodenal ulceration and a low fibre intake and a high refined carbohydrate diet has been reported. We therefore compared the current diet, smoking habits, social class, and possible other risk factors of 78 patients with duodenal ulcer and a community control group matched for age and sex. Logis...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.9.993

    authors: Katschinski BD,Logan RF,Edmond M,Langman MJ

    更新日期:1990-09-01 00:00:00

  • Immunological features of lung lavage cells from patients with primary biliary cirrhosis may reflect those seen in pulmonary sarcoidosis.

    abstract::To investigate the basis of subclinical alveolitis in patients with primary biliary cirrhosis, 10 primary biliary cirrhosis patients were studied by bronchoalveolar lavage. Both bronchoalveolar lavage lymphoid and non-lymphoid cell populations were analysed using immunocytological methods to determine their proportion...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.2.208

    authors: Spiteri MA,Johnson M,Epstein O,Sherlock S,Clarke SW,Poulter LW

    更新日期:1990-02-01 00:00:00

  • Growth differentiation factor 11 attenuates liver fibrosis via expansion of liver progenitor cells.

    abstract:OBJECTIVE:Liver fibrosis and cirrhosis resulting from chronic liver injury represent a major healthcare burden worldwide. Growth differentiation factor (GDF) 11 has been recently investigated for its role in rejuvenation of ageing organs, but its role in chronic liver diseases has remained unknown. Here, we investigate...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gutjnl-2019-318812

    authors: Dai Z,Song G,Balakrishnan A,Yang T,Yuan Q,Möbus S,Weiss AC,Bentler M,Zhu J,Jiang X,Shen X,Bantel H,Jaeckel E,Kispert A,Vogel A,Saborowski A,Büning H,Manns M,Cantz T,Ott M,Sharma AD

    更新日期:2020-06-01 00:00:00

  • Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study.

    abstract:BACKGROUND:Epigenetic alterations accumulate in normal-appearing tissues of patients with cancer, producing an epigenetic field defect. Cross-sectional studies show that the degree of the defect may be associated with risk in some types of cancer, especially cancers associated with chronic inflammation. OBJECTIVE:To d...

    journal_title:Gut

    pub_type: 杂志文章,多中心研究

    doi:10.1136/gutjnl-2014-307094

    authors: Asada K,Nakajima T,Shimazu T,Yamamichi N,Maekita T,Yokoi C,Oda I,Ando T,Yoshida T,Nanjo S,Fujishiro M,Gotoda T,Ichinose M,Ushijima T

    更新日期:2015-03-01 00:00:00

  • A ne method for studying gut transit times using radioopaque markers.

    abstract::A simple technique for measuring gastrointestinal transit times using radioopaque pellets of barium-impregnated polythene has been developed and validated. A normal range has been established by studying 25 normal subjects; all passed the first marker within three days and most passed 80% of the markers within five da...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.10.10.842

    authors: Hinton JM,Lennard-Jones JE,Young AC

    更新日期:1969-10-01 00:00:00

  • Pan-colonic decrease in interstitial cells of Cajal in patients with slow transit constipation.

    abstract:BACKGROUND:Interstitial cells of Cajal (ICC) are required for normal intestinal motility. ICC are found throughout the human colon and are decreased in the sigmoid colon of patients with slow transit constipation. AIMS:The aims of this study were to determine the normal distribution of ICC within the human colon and t...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.51.4.496

    authors: Lyford GL,He CL,Soffer E,Hull TL,Strong SA,Senagore AJ,Burgart LJ,Young-Fadok T,Szurszewski JH,Farrugia G

    更新日期:2002-10-01 00:00:00

  • Dermatogenic enteropathy.

    abstract::Steatorrhoea has been found in a large proportion of patients with inflammatory dermatoses, especially eczema and psoriasis. It is due to the rash itself and disappears rapidly after topical treatment of the skin. This particular enteropathy, unlike that associated with dermatitis herpetiformis, is not accompanied by ...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.11.4.292

    authors: Marks J,Shuster S

    更新日期:1970-04-01 00:00:00

  • Plasma insulin, serum lipids and lipoproteins in gall stone disease in non-insulin dependent diabetic subjects: a case control study.

    abstract::Fasting insulin, lipids and lipoproteins were measured in 22 middle aged female non-insulin dependent diabetics with gall stone disease (cases) and in 22 non-insulin dependent diabetics without gall stone disease (controls). The groups were matched for sex, age, obesity, and fasting glucose concentrations. No differen...

    journal_title:Gut

    pub_type: 杂志文章

    doi:10.1136/gut.31.3.344

    authors: Laakso M,Suhonen M,Julkunen R,Pyörälä K

    更新日期:1990-03-01 00:00:00