Relationship between pancreatic secretion and pancreatic blood flow.

abstract：OBJECTIVE:Corticosteroid has been established as the standard therapy for autoimmune pancreatitis (AIP), but the requirement for maintenance corticosteroid therapy is controversial. We conducted a randomised controlled trial to clarify the efficacy of maintenance corticosteroid therapy in patients with AIP. DESIGN:We ...

journal_title：Gut

authors： Masamune A,Nishimori I,Kikuta K,Tsuji I,Mizuno N,Iiyama T,Kanno A,Tachibana Y,Ito T,Kamisawa T,Uchida K,Hamano H,Yasuda H,Sakagami J,Mitoro A,Taguchi M,Kihara Y,Sugimoto H,Hirooka Y,Yamamoto S,Inui K,Inatomi O,

更新日期：2017-03-01 00:00:00

abstract：:All cases of Crohn's disease in the Nottingham area were ascertained and the date and place of domicile and work at the time of onset of symptoms noted. Applying the Knox and Pike and Smith tests for clustering of patients in time and space, no significant results were observed. Further analysis of differences in time...

journal_title：Gut

authors： Miller DS,Keighley A,Smith PG,Hughes AO,Langman MJ

更新日期：1975-06-01 00:00:00

abstract：BACKGROUND:Dyspepsia and irritable bowel syndrome are suitable conditions for assessment of quality of life. Their similarities justify the elaboration of a single specific questionnaire for the two conditions. AIMS:To examine the process leading to the validation of the psychometric properties of the functional diges...

journal_title：Gut

authors： Chassany O,Marquis P,Scherrer B,Read NW,Finger T,Bergmann JF,Fraitag B,Geneve J,Caulin C

更新日期：1999-04-01 00:00:00

abstract：:The two major forms of inflammatory bowel disease (IBD), encompassing Crohn's disease (CD) and ulcerative colitis (UC), are chronic immune-mediated conditions characterised by an increased production of pro-inflammatory cytokines that act as critical drivers of intestinal inflammation. Anti-cytokine therapy has been s...

journal_title：Gut

authors： Danese S,Argollo M,Le Berre C,Peyrin-Biroulet L

更新日期：2019-10-01 00:00:00

abstract：:A previous cohort study suggested that there might be an association between use of cimetidine and motor neurone disease. The Oxford Record Linkage Study was used to explore this hypothesis. In the analysis the presence of a peptic ulcer in patients after 1976 was taken as a proxy for cimetidine (and ranitidine) use. ...

journal_title：Gut

authors： Vessey MP,Goldacre MJ,Seagroatt V,Yeates D

更新日期：1993-12-01 00:00:00

abstract：:The possibility that proliferative instability around a healing anastomosis promotes carcinogenesis was tested in 234 male Sprague-Dawley rats. Animals received the first of five weekly injections of azoxymethane (total dose 50 mg/kg) either immediately after transection of the descending colon or at 2, 4, 8, and 12 w...

journal_title：Gut

authors： Roe R,Fermor B,Williamson RC

更新日期：1987-07-01 00:00:00

abstract：:Pregnancy and contraceptive steroids are associated with a raised incidence of cholesterol gall stone disease. In pregnancy there is an increase in the size of the gall bladder. Investigation of hepatobiliary function in man and mammals has not established if the enlarged gall bladder is simply dilated, or if the abso...

journal_title：Gut

authors： Rådberg G,Svanvik J

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND AND AIMS:The early responses of the oesophageal mucosa to acid perfusion may predict subsequent pathology. Mucosal responses to luminal acid may result either from acid permeating through the mucosa or from other unknown transduction mechanisms. In order to better understand the dynamics of acid permeation i...

journal_title：Gut

authors： Tanaka S,Chu S,Hirokawa M,Montrose MH,Kaunitz JD

更新日期：2003-06-01 00:00:00

abstract：:The effect of peritoneal lavage with the addition of camostate to the lavage fluid on the outcome of taurocholate pancreatitis in rats was studied. Camostate is a low molecular weight protease inhibitor which has been developed recently. Peritoneal lavage was performed for 12 hours and camostate was added to the lavag...

journal_title：Gut

authors： Leonhardt U,Seidensticker F,Fussek M,Stöckmann F,Creutzfeldt W

更新日期：1990-08-01 00:00:00

abstract：:Visceral hypersensitivity has been recognised as a characteristic of patients with irritable bowel syndrome (IBS). It may be involved in the pathogenesis of abdominal pain/discomfort, and seems to result from the sensitisation of nerve afferent pathways originating from the gastrointestinal tract. From a clinical poin...

journal_title：Gut

authors： Delvaux M

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Although evidence points to a role for histamine and serotonin in visceral hypersensitivity, activation of calcium channels such as transient receptor potential vanilloid 4 (TRPV4) also causes visceral hypersensitivity. We hypothesised that TRPV4 is important for the generation of hypersensitivity, mediating...

journal_title：Gut

authors： Cenac N,Altier C,Motta JP,d'Aldebert E,Galeano S,Zamponi GW,Vergnolle N

更新日期：2010-04-01 00:00:00

abstract：:This paper describes the construction and use of "radio pills" which transmit changes in intraluminar pressure. ...

journal_title：Gut

authors： CONNELL AM,ROWLANDS EN

更新日期：1960-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Independent component analysis (ICA) of the electroencephalogram (EEG) overcomes many of the classical problems in EEG analysis. We used ICA to determine the brain responses to painful stimulation of the oesophagus. METHODS:Twelve subjects with a median age of 41 years were included. With a nasal e...

journal_title：Gut

authors： Drewes AM,Sami SA,Dimcevski G,Nielsen KD,Funch-Jensen P,Valeriani M,Arendt-Nielsen L

更新日期：2006-05-01 00:00:00

abstract：AIMS:To determine the harm that ensues from faecal occult blood (FOB) screening for colorectal cancer. METHODS:150 251 people were randomly allocated either to receive biennial Haemoccult FOB tests (n =75 253) or not to be contacted (n=74 998). Study group patients returning positive tests were offered colonic investi...

journal_title：Gut

authors： Robinson MH,Hardcastle JD,Moss SM,Amar SS,Chamberlain JO,Armitage NC,Scholefield JH,Mangham CM

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:Reports on the effects of bone marrow-derived cells on hepatic fibrosis are contradictory. Impaired fibrosis but increased inflammation has recently been demonstrated 10 weeks after bone marrow transplantation (BM-Tx) in Abcb4-/- mice. It is hypothesised that BM-Tx might have long-term therapeutic potential b...

journal_title：Gut

authors： Roderfeld M,Rath T,Pasupuleti S,Zimmermann M,Neumann C,Churin Y,Dierkes C,Voswinckel R,Barth PJ,Zahner D,Graf J,Roeb E

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Crohn's disease (CD) ileal lesions are colonised by pathogenic adherent-invasive Escherichia coli (AIEC) producing outer membrane vesicles (OMVs) that contribute to the bacterial invasion process. In addition, increased expression of endoplasmic reticulum (ER)-localised stress response proteins, due...

journal_title：Gut

authors： Rolhion N,Barnich N,Bringer MA,Glasser AL,Ranc J,Hébuterne X,Hofman P,Darfeuille-Michaud A

更新日期：2010-10-01 00:00:00

abstract：:An elderly woman with chronic ulcerative colitis who developed proximal muscle weakness, increased serum creatine phosphokinase activity, and histological and electromyographic abnormalities characteristic of polymyositis is described. Treatment with corticosteroids and 5-acetylsalicylic acid was followed by a remissi...

journal_title：Gut

authors： Chugh S,Dilawari JB,Sawhney IM,Dang N,Radotra BD,Chawla YK

更新日期：1993-04-01 00:00:00

abstract：:Three cases of apparent primary villous atrophy of the terminal ileum in women with chronic diarrhoea are reported. Eight cases have previously been reported in the literature. Clinical characteristics are the presence of severe chronic secretory diarrhoea with episodes of hypokalaemia combined with signs of ileal mal...

journal_title：Gut

authors： Marteau P,Lavergne-Slove A,Lemann M,Bouhnik Y,Bertheau P,Becheur H,Galian A,Rambaud JC

更新日期：1997-10-01 00:00:00

abstract：:p53 mutations are a common genetic finding in hepatocellular carcinoma from areas of high aflatoxin exposure. Recent small studies have shown that p53 gene mutations may be less common in areas with a low prevalence of hepatocellular carcinoma such as Great Britain. The protein product of mutant p53 can be detected im...

journal_title：Gut

authors： Collier JD,Carpenter M,Burt AD,Bassendine MF

更新日期：1994-01-01 00:00:00

abstract：BACKGROUND:The normal intestinal microflora plays an important role in host metabolism and provides a natural defence mechanism against invading pathogens. Although the microbiota in adults has been extensively studied, little is known of the changes that occur in the microflora with aging. These may have important con...

journal_title：Gut

authors： Hopkins MJ,Sharp R,Macfarlane GT

更新日期：2001-02-01 00:00:00

abstract：:Proximal diversion has commonly been used for severe perianal Crohn's disease in an attempt to relieve local symptoms, whether the primary intestinal disease is in the colon or small bowel. Two patients are presented in whom diversion led to severe symptomatic disease in the previously normal defunctioned bowel. In ea...

journal_title：Gut

authors： Williamson ME,Hughes LE

更新日期：1994-08-01 00:00:00

abstract：:Serumfolate folate levels and the bacteriology of the small intestine were studied in 13 patients with jejunal diverticulosis, 29 patients with partial gastrectomy, and five patients with ileal disease. The mean serum folate level in the patients with partial gastrectomy (7.2 mmug/ml) was similar to that of control su...

journal_title：Gut

authors： Hoffbrand AV,Tabaqchali S,Booth CC,Mollin DL

更新日期：1971-01-01 00:00:00

abstract：BACKGROUND:Despite intent to cure surgery with negative resection margins, locoregional recurrence is common in pancreatic cancer. AIMS:To determine whether detection of K-ras gene mutation in the histologically negative surgical margins of pancreatic cancer reflects unrecognised disease. PATIENTS:Seventy patients wh...

journal_title：Gut

authors： Kim J,Reber HA,Dry SM,Elashoff D,Chen SL,Umetani N,Kitago M,Hines OJ,Kazanjian KK,Hiramatsu S,Bilchik AJ,Yong S,Shoup M,Hoon DS

更新日期：2006-11-01 00:00:00

abstract：BACKGROUND:The reported cumulative risk of developing pouchitis in ulcerative colitis (UC) patients undergoing ileal pouch-anal anastomosis (IPAA) approaches 50% after 10 years. To date, no preoperative serological predictor of pouchitis has been found. AIMS:To assess whether preoperative perinuclear antineutrophil cy...

journal_title：Gut

authors： Fleshner PR,Vasiliauskas EA,Kam LY,Fleshner NE,Gaiennie J,Abreu-Martin MT,Targan SR

更新日期：2001-11-01 00:00:00

abstract：:Bran, ispaghula (Fybogel), and lactulose were given to three groups of patients with diverticular disease for four weeks. Faecal weights, bile acids, fat and electrolytes, transit time, and colonic motility were estimated before and after treatment. Stool weight increased, notably with Fybogel. Cereal bran had the gre...

journal_title：Gut

authors： Eastwood MA,Smith AN,Brydon WG,Pritchard J

更新日期：1978-12-01 00:00:00

abstract：BACKGROUND:Gastric carcinogenesis is a multifactorial, multistep process, in which chronic inflammation plays a major role. AIMS:In order to ascertain whether free radical mediated oxidative DNA damage is involved in such a process, concentrations of 8-hydroxydeoxyguanosine (8OHdG), a mutagenic/carcinogenic adduct, an...

journal_title：Gut

authors： Farinati F,Cardin R,Degan P,Rugge M,Mario FD,Bonvicini P,Naccarato R

更新日期：1998-03-01 00:00:00

abstract：:This paper describes four patients whose chief symptoms were steatorrhoea and loss of weight. Despite the absence of a history of abdominal pain investigations showed that these patients had chronic pancreatitis, which responded to medical treatment. The pathological findings in two of these cases and in six which cam...

journal_title：Gut

authors： GOULSTON SJ,GALLAGHER ND

更新日期：1962-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Untreated coeliac disease in the mother is associated with lower birth weight. We examined the risk of adverse neonatal outcome when the infant's mother, father, or other relative suffered from known coeliac disease. METHODS:Mothers answered a questionnaire a few days after the birth of their infan...

journal_title：Gut

authors： Ludvigsson JF,Ludvigsson J

更新日期：2001-08-01 00:00:00

abstract：OBJECTIVE:A high body mass index (BMI) is associated with an increased risk for severe liver disease. It is unclear if this risk differs across BMI categories, and if the association is partially attributed to development of type 2 diabetes mellitus (T2DM). DESIGN:We used register data from more than 1.2 million Swedi...

journal_title：Gut

authors： Hagström H,Tynelius P,Rasmussen F

更新日期：2018-08-01 00:00:00

abstract：:Some patients with diarrhoea predominant irritable bowel syndrome have increased rectal sensitivity. It is uncertain, however, whether the diarrhoea is a consequence of the rectal sensitivity or if it is sensitising the rectum in some way. The aim of this study was to assess whether inducing diarrhoea in normal health...

journal_title：Gut

authors： Houghton LA,Wych J,Whorwell PJ

更新日期：1995-08-01 00:00:00