Gastrokine 1 induces senescence through p16/Rb pathway activation in gastric cancer cells.

abstract：BACKGROUND:In hereditary pancreatitis mutations of exons 2 (N21I) and 3 (R117H) of the cationic trypsinogen gene have been described. AIMS:To investigate whether the same mutations can also be found in patients with chronic alcoholic pancreatitis. METHODS:Leucocyte DNA was prepared from 23 patients with chronic alcoh...

journal_title：Gut

authors： Teich N,Mössner J,Keim V

更新日期：1999-03-01 00:00:00

abstract：:Using immune electron microscopy, an attempt has been made to visualise viral particles in Crohn's disease tissue and faeces. No particles resembling viruses were observed, but in the absence of a specific antiserum a negative result does not exclude the presence of a virus, particularly if it is sparsely distributed....

journal_title：Gut

authors： Whorwell PJ,Baldwin RC,Wright R

更新日期：1976-09-01 00:00:00

abstract：:The secretory response of gastric acid to pure ethanol and alcoholic beverages may be different because the action of the non-ethanolic contents of the beverage may overwhelm that of ethanol. Pure ethanol in low concentrations (< 5% vol/vol) is a mild stimulant of acid secretion whereas at higher concentrations it has...

journal_title：Gut

authors： Chari S,Teyssen S,Singer MV

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Pyoderma gangrenosum (PG) is a chronic ulcerating skin condition that often occurs in association with inflammatory bowel disease. There have been a number of reports of PG responding to infliximab, a monoclonal antibody against tumour necrosis factor alpha. AIM:In the first randomised placebo controlled tr...

journal_title：Gut

authors： Brooklyn TN,Dunnill MG,Shetty A,Bowden JJ,Williams JD,Griffiths CE,Forbes A,Greenwood R,Probert CS

更新日期：2006-04-01 00:00:00

abstract：:Ten patients in whom cystic dystrophy developed in a heterotopic pancreas of the duodenal (nine patients) or gastric (one patient) wall are reported. All were young or middle aged white men, only two of whom were alcoholic. The symptoms were caused by intestinal or biliary stenosis, or both, secondary to the inflammat...

journal_title：Gut

authors： Fléjou JF,Potet F,Molas G,Bernades P,Amouyal P,Fékété F

更新日期：1993-03-01 00:00:00

abstract：:A group of 80 patients with diseases of the small intestine were given a standardized psychiatric assessment every time they attended the outpatients' department over a period of a year. Forty-six patients with idiopathic steatorrhoea, 23 patients with Crohn's disease, and 11 patients with alactasia were interviewed o...

journal_title：Gut

authors： Goldberg D

更新日期：1970-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Gastric acid secretion is downregulated by Helicobacter pylori infection and upregulated after its eradication, but the mechanisms are still unclear. We examined the effects of H pylori eradication on the number of parietal cells and on expression of molecules functioning in acid secretion in the hu...

journal_title：Gut

authors： Osawa H,Kita H,Ohnishi H,Hoshino H,Mutoh H,Ishino Y,Watanabe E,Satoh K,Sugano K

更新日期：2006-02-01 00:00:00

abstract：:Serum zinc concentrations and urine zinc excretion have been studied in 10 patients with severe Crohn's disease before and during 59 patient-weeks of intravenous nutrition. Before serum zinc concentrations (9.9 +/- 1.0 mumol/l: mean +/- SEM) and urine zinc excretion (3-3 +/- 0.6 mumol/24h) were less than controls (p l...

journal_title：Gut

authors： Main AN,Hall MJ,Russell RI,Fell GS,Mills PR,Shenkin A

更新日期：1982-11-01 00:00:00

abstract：:Eight patients with traumatic transverse lesions of the spinal cord and eight healthy controls were examined with respect to the function of the anal sphincters. Continuous recordings of anal pressure and electromyograms from the striated sphincter muscles were obtained during gradual rectal distension by means of an ...

journal_title：Gut

authors： Frenckner B

更新日期：1975-08-01 00:00:00

abstract：:Lymphocytic gastritis and primary gastric lymphoma are rare conditions with unknown aetiology. It has recently been suggested that Helicobacter pylori has a role in the pathogenesis of both of them. The occurrence of lymphocytic gastritis and H pylori was studied in a series of patients with primary gastric lymphoma. ...

journal_title：Gut

authors： Miettinen A,Karttunen TJ,Alavaikko M

更新日期：1995-10-01 00:00:00

abstract：BACKGROUND:Hereditary pancreatitis (HP) is a rare autosomal dominant disorder with variable expression and an overall lifetime penetrance of 80%. We hypothesised that (1) monozygotic twins within similar environments would develop the typical signs of HP at a similar age, and (2) if penetrance were due to modifier gene...

journal_title：Gut

authors： Amann ST,Gates LK,Aston CE,Pandya A,Whitcomb DC

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, may play a critical role in many chronic pain conditions. The possible involvement of BDNF in the altered gut sensation in patients with irritable bowel syndrome (IBS) was investigated in the present study. METHODS:Rectosigmoid bi...

journal_title：Gut

authors： Yu YB,Zuo XL,Zhao QJ,Chen FX,Yang J,Dong YY,Wang P,Li YQ

更新日期：2012-05-01 00:00:00

abstract：OBJECTIVE:Lesogaberan (AZD3355) is a novel γ-aminobutyric acid B-type receptor agonist designed to treat gastro-oesophageal reflux disease (GERD) by inhibiting transient lower oesophageal sphincter relaxations. A randomised, double-blind, placebo-controlled, multi-centre phase IIb study was performed to assess the effi...

journal_title：Gut

authors： Shaheen NJ,Denison H,Björck K,Karlsson M,Silberg DG

更新日期：2013-09-01 00:00:00

abstract：:Ileal disease or resection causes bile salt malabsorption and a reduction in the bile salt content of bile. Since cholesterol solubility requires adequate bile salt concentrations, depletion of the bile salt content of bile might, therefore, jeopardize cholesterol solubility and predispose to cholesterol gallstone for...

journal_title：Gut

authors： Dowling RH,Bell GD,White J

更新日期：1972-06-01 00:00:00

abstract：:The free primary amines present in the faeces of 44 infants (1-18 months) with gastroenteritis have been examined by field desorption mass spectrometry of the lactone form of their fluorescamine derivatives without their prior separation. p-Tyramine, 2-phenylethylamine, the diamines, putrescine and cadaverine and seve...

journal_title：Gut

authors： Murray KE,Adams RF,Earl JW,Shaw KJ

更新日期：1986-10-01 00:00:00

abstract：:Sex differences exist in the site specific incidences of colorectal cancer. The increased incidence of colonic cancer in women with breast cancer and the protective effect of increasing parity suggest a role for sex hormones. To explore the molecular basis, the expression of messenger RNA for oestrogen and progesteron...

journal_title：Gut

authors： Singh S,Sheppard MC,Langman MJ

更新日期：1993-05-01 00:00:00

abstract：OBJECTIVE:miR-21 was found to be overexpressed in the colon tissues and serum of patients with UC and colorectal cancer (CRC); however, the exact roles of miR-21 in colitis-associated CRC remain unclear. The aim of our study was to investigate the biological mechanisms of miR-21 in colitis-associated colon cancer (CAC)...

journal_title：Gut

authors： Shi C,Yang Y,Xia Y,Okugawa Y,Yang J,Liang Y,Chen H,Zhang P,Wang F,Han H,Wu W,Gao R,Gasche C,Qin H,Ma Y,Goel A

更新日期：2016-09-01 00:00:00

abstract：:Helicobacter pylori is present worldwide but few large population studies exist on the epidemiology of the infection. A random cross sectional study was performed of H pylori infection in the adult population of San Marino, a European country with high gastric cancer rate, to assess its prevalence and to evaluate its ...

journal_title：Gut

authors： Gasbarrini G,Pretolani S,Bonvicini F,Gatto MR,Tonelli E,Mégraud F,Mayo K,Ghironzi G,Giulianelli G,Grassi M

更新日期：1995-06-01 00:00:00

abstract：:The experience of The Middlesex Hospital in the investigation and management of chronic intestinal arterial occlusion (IAO) over a 20 year period is presented. Of some 100 patients referred only 28 were found to have IAO and these were critically evaluated in terms of insorptive and exsorptive function. No relation wa...

journal_title：Gut

authors： Marston A,Clarke JM,Garcia Garcia J,Miller AL

更新日期：1985-07-01 00:00:00

abstract：:This presentation describes interim findings in a series of 319 patients referred from 41 hospitals on the basis of histopathological findings of 'early gastric cancer', 'dysplasia', or 'worrying mucosal appearances'. Data were recorded using a predefined proforma, and histopathological material circulated amongst a '...

journal_title：Gut

authors： de Dombal FT,Price AB,Thompson H,Williams GT,Morgan AG,Softley A,Clamp SE,Unwin BJ

更新日期：1990-01-01 00:00:00

abstract：:Proximal diversion has commonly been used for severe perianal Crohn's disease in an attempt to relieve local symptoms, whether the primary intestinal disease is in the colon or small bowel. Two patients are presented in whom diversion led to severe symptomatic disease in the previously normal defunctioned bowel. In ea...

journal_title：Gut

authors： Williamson ME,Hughes LE

更新日期：1994-08-01 00:00:00

abstract：BACKGROUND AND AIMS:Serrated polyposis syndrome (SPS) is associated with an increased risk of colorectal cancer (CRC). International guidelines recommend surveillance intervals of 1-2 years. However, yearly surveillance likely leads to overtreatment for many. We prospectively assessed a surveillance protocol aiming to ...

journal_title：Gut

authors： Bleijenberg AG,IJspeert JE,van Herwaarden YJ,Carballal S,Pellisé M,Jung G,Bisseling TM,Nagtegaal ID,van Leerdam ME,van Lelyveld N,Bessa X,Rodríguez-Moranta F,Bastiaansen B,de Klaver W,Rivero L,Spaander MC,Koornstra JJ,B

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:The normal intestinal microflora plays an important role in host metabolism and provides a natural defence mechanism against invading pathogens. Although the microbiota in adults has been extensively studied, little is known of the changes that occur in the microflora with aging. These may have important con...

journal_title：Gut

authors： Hopkins MJ,Sharp R,Macfarlane GT

更新日期：2001-02-01 00:00:00

abstract：:A method of in vivo calculation of liver volume using a gamma camera and a 1600 or 4096 channel analyser is described. Topographically, the maximum thickness giving the highest counts in matrix data in the right anterior oblique projection is measured as the maximum breadth in the right posterior oblique projection. T...

journal_title：Gut

authors： Fujii M,Mukai T,Yamamoto T,Wakisaka G

更新日期：1976-04-01 00:00:00

abstract：OBJECTIVE:Blood vessel epicardial substance (BVES) is a tight junction-associated protein that regulates epithelial-mesenchymal states and is underexpressed in epithelial malignancy. However, the functional impact of BVES loss on tumourigenesis is unknown. Here we define the in vivo role of BVES in colitis-associated c...

journal_title：Gut

authors： Parang B,Kaz AM,Barrett CW,Short SP,Ning W,Keating CE,Mittal MK,Naik RD,Washington MK,Revetta FL,Smith JJ,Chen X,Wilson KT,Brand T,Bader DM,Tansey WP,Chen R,Brentnall TA,Grady WM,Williams CS

更新日期：2017-05-01 00:00:00

abstract：:The frequency of gastric Crohn's disease has been considered low. This study was undertaken to determine the prevalence of chronic gastritis and Helicobacter pylori infection in patients with Crohn's disease. Oesophagogastroduodenoscopy was performed on 62 consecutive patients suffering from ileocolonic Crohn's diseas...

journal_title：Gut

authors： Halme L,Kärkkäinen P,Rautelin H,Kosunen TU,Sipponen P

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Vascular endothelial growth factor (VEGF) is a therapeutic target in gastrointestinal cancer (GiC). However, its in vivo visualisation could not be achieved to date with endoscopic techniques. Confocal laser endomicroscopy (CLE) is a novel imaging technique for gastrointestinal endoscopy providing in vivo mi...

journal_title：Gut

authors： Foersch S,Kiesslich R,Waldner MJ,Delaney P,Galle PR,Neurath MF,Goetz M

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Visceral hyperalgesia has been implicated as a factor contributing to symptom generation in irritable bowel syndrome (IBS). However, previous studies using intestinal balloon distension have used psychophysical procedures which do not provide adequate and unbiased measures of visceral sensitivity. METHODS:T...

journal_title：Gut

authors： Naliboff BD,Munakata J,Fullerton S,Gracely RH,Kodner A,Harraf F,Mayer EA

更新日期：1997-10-01 00:00:00

abstract：OBJECTIVES:COVID-19 has rapidly become a major health emergency worldwide. Patients with IBD are at increased risk of infection, especially when they have active disease and are taking immunosuppressive therapy. The characteristics and outcomes of COVID-19 in patients with IBD remain unclear. DESIGN:This Italian prosp...

journal_title：Gut

authors： Bezzio C,Saibeni S,Variola A,Allocca M,Massari A,Gerardi V,Casini V,Ricci C,Zingone F,Amato A,Caprioli F,Lenti MV,Viganò C,Ascolani M,Bossa F,Castiglione F,Cortelezzi C,Grossi L,Milla M,Morganti D,Pastorelli L,R

更新日期：2020-07-01 00:00:00

abstract：:We have determined the relative importance of day and night time gastric acid inhibition for duodenal ulcer healing by comparing the anti-ulcer efficacy of a single morning with that of a single bedtime dose of ranitidine. One hundred and thirty patients with active duodenal ulcer were randomly assigned to a double-bl...

journal_title：Gut

authors： Bianchi Porro G,Parente F,Sangaletti O

更新日期：1990-04-01 00:00:00