abstract：:This study aimed to determine applicable value of DWIBS in diagnosis of solitary pulmonary lesions. This study involved 32 solitary lung disease patients. T1W1, T2W1, T2WI-SPAIR were examined using MRI scanner and analyzed with View-forum 6.0 workstation. Imaging characteristics of pulmonary solitary lesions on DWIBS ...

journal_title：American journal of translational research

authors： Zhao C,Deng D,Ye W,Long L,Lu Y,Wei Y

更新日期：2021-01-15 00:00:00

abstract：:Skin flap ischemia-reperfusion (IR) injury is the key factor to the success rate of skin transplantation, the molecular mechanism of flap IR injury needs to be continuously explored to provide new ideas for its clinical treatment. G protein-coupled receptor kinase 2 (GRK2) was reported to be involved in regulating mit...

journal_title：American journal of translational research

authors： Wang Y,Wu Y,Zhou M,Wang P,Luo J,Rui Y

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:Radiotherapy has been widely used in the treatment of hepatocellular carcinoma (HCC). However, whether the patients should receive radiotherapy before or after surgical treatment has not been studied. The objective of the study was to compare the efficacy of the treatment in HCC patients who received pre-sur...

journal_title：American journal of translational research

authors： Chen L,Guo X,Chen S,Ren Y,Sun T,Yang F,Zheng C

更新日期：2021-01-15 00:00:00

abstract：:Coronavirus disease 2019 (COVID-19) infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic disease with high morbidity and mortality. Inflammatory and thrombosis are its main manifestations. As an important organ of hemofiltration metabolism, the kidney is prone to blocka...

journal_title：American journal of translational research

authors： Chen X,Yu C,Jing H,Wang C,Zhao X,Zhang J,Zhang S,Liu H,Xie R,Shi J

更新日期：2020-12-15 00:00:00

abstract：BACKGROUND:Cancer/testis antigens (CTAs) are attractive therapeutic targets for tumor immunotherapy due to their restrictive expression in normal testis but excessive in majority of tumor types. ACTL8, CTCFL, OIP5 and XAGE3 are members of the CTAs family. Currently, the data of ACTL8, CTCFL, OIP5 and XAGE3 expression i...

journal_title：American journal of translational research

authors： Li X,Ning L,Zhang Q,Ge Y,Liu C,Bi S,Zeng X,Nong W,Wu S,Guo G,Xiao S,Luo B,Xie X

更新日期：2020-12-15 00:00:00

abstract：OBJECTIVE:This study aimed to explore the function and mechanism of Cytochrome P450 2J2 (CYP2J2) epoxygenase and epoxyeicosatrienoic acids (EETs) in the malignant development of hepatocellular carcinoma (HCC). METHOD:The expressional levels of EETs and CYP2J2 in HCC tissues and cell lines were quantified by ELISA, wes...

journal_title：American journal of translational research

authors： Gui L,Xu Q,Huang J,Wu G,Tang H,Hui L,Hua P,Zhang L,Zhu Y

更新日期：2020-12-15 00:00:00

abstract：PURPOSE:To introduce a novel transverse tunnel (TT) in anterior talofibular ligament (ATFL) reconstruction, and assess whether it was superior to the tunnels currently used. METHODS:Thirteen fresh cadaveric lower extremities were perfused with lead-based contrast. Talar tunnels were drilled from the ATFL insertion in ...

journal_title：American journal of translational research

authors： Wang D,Shen Z,Yang S,Zhang B,Li Y,Fang Y,Jiao C,Guo Q,Zhang W,Jiang D

更新日期：2020-12-15 00:00:00

abstract：:Concerns about the potential neurotoxicity of general anesthesia to the developing brain have been increasing in recent years. Animal studies have shown that neonatal exposure to general anesthesia causes both acute neurotoxicity and behavioral abnormalities later in life. In the present study, we observed over-activa...

journal_title：American journal of translational research

authors： Li H,Li J,Yu Q,Dai C,Gu J,Peng S,Iqbal K,Liu F,Gong CX

更新日期：2020-12-15 00:00:00

abstract：:Regenerative medicine has been shown to hold enormous potential to treat traumatic and degenerative diseases, and substantial advancements have been made in the recent decades. In particular, different cell types were evaluated in basic research and preclinical studies on cell-based therapy applications. Despite the e...

journal_title：American journal of translational research

authors： Chen Z,Hong F,Wang Z,Hao D,Yang H

更新日期：2020-11-15 00:00:00

abstract：:The benefits of using a surgical microscope in periodontal therapy were mainly based on subjective statements made by patients or periodontists. We aimed to provide laboratory evidence for the advantages of using a surgical microscope during root scaling on periodontitis teeth. In the present study, the extracted teet...

journal_title：American journal of translational research

authors： Liao H,Zhang H,Xiang J,Chen G,Cao Z

更新日期：2020-11-15 00:00:00

abstract：BACKGROUND:Single-cell RNA sequencing (scRNA-seq) was recently adopted for exploring molecular programmes and lineage progression patterns of pathogenesis of important diseases. In this study, scRNA-seq was used to identify potential markers for chondrocytes in osteoarthritis (OA) and to explore the function of differe...

journal_title：American journal of translational research

authors： Zhang X,Huang N,Huang R,Wang L,Ke Q,Cai L,Wu S

更新日期：2020-11-15 00:00:00

abstract：:Macrophages participate in all stages of sepsis and affect immune homeostasis and inflammatory processes. Small ubiquitin-like modifier (SUMO) protease SENP1 plays an important role in cellular inflammation by regulating proteins in SUMOylation. However, the roles and related mechanisms of SENP1 in macrophage inflamma...

journal_title：American journal of translational research

authors： Zheng C,Li D,Zhan W,He K,Yang H

更新日期：2020-11-15 00:00:00

abstract：BACKGROUND:The association between LINC01305, a newly discovered long non-coding RNA (lncRNA), and cervical cancer (CC) has been poorly analyzed. In the present study, we revealed high expression of LINC01305 in CC by the cancer genome atlas (TCGA) and Gene Expression Omnibus (GEO), and dissected the related mechanisms...

journal_title：American journal of translational research

authors： Xu Y,Zhu H,Ma H,Yuan L,Hu Q,Yang L

更新日期：2020-11-15 00:00:00

abstract：:The heart is an organ with extremely high energy expenditure, and cardiac performance is consistent with its metabolic level. Under pathological situations, the heart adjusts its metabolic pattern through mitochondrial regulation and substrate selection to maintain energy homeostasis. Heart failure is associated with ...

journal_title：American journal of translational research

authors： Li J,Xie S,Guo L,Jiang J,Chen H

更新日期：2020-10-15 00:00:00

abstract：:The purpose of this study was to construct and validate a model for predicting nonalcoholic fatty liver disease (NAFLD) in the non-obese Chinese population. A total of 13240 NAFLD-free individuals at baseline from a 4-y longitudinal study were allocated to a training cohort (n=8872) and a validation cohort (n=4368). T...

journal_title：American journal of translational research

authors： Wang J,Tang Y,Peng K,Liu H,Xu J

更新日期：2020-10-15 00:00:00

abstract：:Severe acute pancreatitis (SAP) contributes to multiple organ dysfunction and intestine is one of the most susceptible targets. This study aims to explore the role of C3a/C3aR axis in SAP-induced intestinal barrier injury. Adult male Sprague Dawley rats were randomly divided into control, SAP, C3aRA (0.06 mg/kg) and C...

journal_title：American journal of translational research

authors： Ye J,Dai H,Liu Y,Yu B,Yang J,Fei A

更新日期：2020-10-15 00:00:00

abstract：:Recent research found that sodium selenite (Na2SeO3) could ameliorate oxidative damage in patients with Hashimoto's thyroiditis (HT). Additionally, the effects of adipose-derived mesenchymal stem cells (AMSCs) in an animal model of HT were also reported. However, the effects of AMSCs combined with Na2SeO3 on HT are un...

journal_title：American journal of translational research

authors： Che K,Liu X,Chi J,Li P,Gao J,Fu Z,Yan S,Xing X,Hu J

更新日期：2020-10-15 00:00:00

abstract：:The coronavirus disease 2019 (COVID-19) pandemic has spread to almost all countries. The currently reported epidemiological statistics show that age, gender, and type of comorbidities may be high-risk factors for critically ill patients with COVID-19. However, there is no comprehensive analysis of these risk factors. ...

journal_title：American journal of translational research

authors： Mi J,Zhong W,Huang C,Zhang W,Tan L,Ding L

更新日期：2020-10-15 00:00:00

abstract：:Depression is prevalence in patients with laryngeal cancer. In this study, we aim to investigate whether psychological intervention could reduce the depression of patients receiving cancer treatment. In this study, 258 patients with laryngeal cancer were assigned into two groups with or without psychological intervent...

journal_title：American journal of translational research

authors： Zhang S,Chen H,Zhang M,Sun X,Liu X

更新日期：2020-10-15 00:00:00

abstract：:Clinicopathologic data of 16 cases of DLBCL, NOS after CD19-targeted CAR T-cell therapy were retrospectively reviewed. Statistical analyses were performed to investigate the diagnostic agreement and indicate the relationship of the given types or their alterations (Group I versus Group II) to the prognosis. A total of...

journal_title：American journal of translational research

authors： Zhou J,Zhang W,Zhang Y,Zheng S,Zhou L,Yang X,Wang C

更新日期：2020-10-15 00:00:00

abstract：:As a dual-acting neurotransmitter, glycine plays critical roles in cerebral ischemia by activating both glycine receptors (GlyRs) and N-methyl-D-aspartate acid receptors (NMDARs). However, the involvement of glycine receptor alpha 2 (GlyRa2) in cerebral ischemia has not been explored. The objective of this study was t...

journal_title：American journal of translational research

authors： Chen Z,Wang X,Liao H,Sheng T,Chen P,Zhou H,Pan Y,Liu W,Yao H

更新日期：2020-10-15 00:00:00

abstract：:The purpose of this study is to explore the expression and clinical significance of KIF23 in ovarian cancer (OV) and identify potential targets for clinical treatment. Oncomine, GEO, and TCGA databases were used to analysis the expression of KIF23 in OV. The prognostic value of KIF23 gene was analyzed by the Kaplan-Me...

journal_title：American journal of translational research

authors： Hu Y,Zheng M,Wang C,Wang S,Gou R,Liu O,Li X,Liu J,Lin B

更新日期：2020-09-15 00:00:00

abstract：:Urine-derived stem cells (USCs) are autologous stem cells that exhibit self-renewal ability and multi-lineage differentiation potential. These characteristics make USCs an ideal cell source for hepatocellular transplantation. Here, we investigated the biological characteristics of USCs and their potential use for the ...

journal_title：American journal of translational research

authors： Hu C,He Y,Fang S,Tian N,Gong M,Xu X,Zhao L,Wang Y,He T,Zhang Y,Bi Y

更新日期：2020-09-15 00:00:00

abstract：:Geranylgeranylation (GGylation) is a lipid modification process of signaling proteins. Currently, very little is known about the GGylation signaling for gastric cancer cell proliferation and migration. In this report, we found that inhibition of GGylation by the mevalonate pathway inhibitor atorvastatin and the gerany...

journal_title：American journal of translational research

authors： Wei J,Peng K,Zhu J,Wang L,Han T,Sun A,Shao G,Liu H,Yang W,Lin Q

更新日期：2020-09-15 00:00:00

abstract：AIMS:This study was to investigate the effect of TUG1 on apoptosis and ECM degradation of human degenerative intervertebral disc nucleus pulposus cells (NPCs) and its mechanism. METHODS:Human degenerative intervertebral disc NP tissues were obtained from 10 patients with lumbar disc herniation (LDH) who underwent lumb...

journal_title：American journal of translational research

authors： Tang N,Dong Y,Xiao T,Zhao H

更新日期：2020-09-15 00:00:00

abstract：:Endothelial barrier dysfunction is a critical pathophysiological process of pulmonary ischemia/reperfusion (I/R) injury in patients scheduled for cardiopulmonary bypass. Impaired actin cytoskeleton dynamics and cell-cell junctions are the main causes of endothelial dysfunction. Statins have protective effects on I/R-i...

journal_title：American journal of translational research

authors： Han D,Sun J,Fan D,Zhang C,Du S,Zhang W

更新日期：2020-09-15 00:00:00

abstract：:Spinal cord injury (SCI) can lead to different levels of paraplegia. Studies have shown that exercise exerts wide protective effects against various diseases, and microRNAs (miRNAs) are involved in its beneficial effects. However, the specific role of miRNAs in the protective effects of exercise against SCI remains un...

journal_title：American journal of translational research

authors： Li M,Jiang WT,Li J,Ji WC

更新日期：2020-09-15 00:00:00

abstract：:Severe air pollution has raised concerns about the adverse effects of particulate matters 2.5 μm in size (PM2.5) on human health. However, the mechanisms elucidating how PM2.5 affects lungs, especially in COPD, remain unclear. In this study, we examined the concentration changes of environmental PM2.5 from 2013 to 201...

journal_title：American journal of translational research

authors： Li H,Yan X,Feng S,Li S,Zhang H,Li J,Qi T

更新日期：2020-09-15 00:00:00

abstract：:This study aimed to investigate the intercorrelation among long noncoding RNA MALAT1 (lnc-MALAT1), microRNA-125b (miR-125b), FOXQ1, PTGS2 and CDK5, as well as their correlations with disease risk, severity and progression of Alzheimer's disease (AD). In total, 120 AD patients, 120 Parkinson's disease (PD) patients and...

journal_title：American journal of translational research

authors： Zhuang J,Cai P,Chen Z,Yang Q,Chen X,Wang X,Zhuang X

更新日期：2020-09-15 00:00:00

abstract：:Clostridium difficile colitis is caused by a cytotoxin produced by the anaerobic bacteria C. difficile on the epithelial cells of the large intestine, particularly C. difficile toxin B (Tcd B). Current C. difficile toxin assays have proven to be insensitive and have thus been ruled out from diagnostic purposes. Theref...

journal_title：American journal of translational research

authors： Qi H,Wang Y,Wu P,Ma Y,Wang J

更新日期：2020-08-15 00:00:00

abstract：:Acute mercury poisoning, involving a number of organs, leads to severe dysfunctions, such as acute renal failure (ARF), and even threatens patients' lives. A case of acute severe mercuric chloride (HgCl2) poisoning with multiple organ failure was reported in this study. A 38-year-old woman orally took about 50 g HgCl2...

journal_title：American journal of translational research

authors： Bai L,Peng X,Liu Y,Sun Y,Zheng L,Liu Z,Wan K,Wang J,Zhao J,Qiu Z

更新日期：2020-08-15 00:00:00

abstract：:Myocardial ischemia/reperfusion (I/R) injury is a common cardiovascular disease with high morbidity and mortality globally, which derives from acute myocardial infarction and coronary artery disease. Elabela has been proved to bind to apelin receptors in the heart. The present study aimed to investigate the protective...

journal_title：American journal of translational research

authors： Yu P,Ma S,Dai X,Cao F

更新日期：2020-08-15 00:00:00

abstract：:This study was designed to assess the levels of human serum amyloid A (SAA) and C-reactive protein (CRP) in patients with coronavirus disease 2019 (COVID-19) to determine their prognostic value in predicting the severity of disease. Patients with COVID-19 who presented with acute respiratory distress syndrome (ARDS) s...

journal_title：American journal of translational research

authors： Chen M,Wu Y,Jia W,Yin M,Hu Z,Wang R,Li W,Wang G

更新日期：2020-08-15 00:00:00

abstract：:Glioblastoma multiforme (GBM) is the most common and invasive tumor of the central nervous system. Growth factors and cytokines (GFCKs) play a crucial role in tumor invasion. In the present study, GFCK expression profiles from GBM patients in the Chinese Glioma Genome Atlas were used to perform sample clustering with ...

journal_title：American journal of translational research

authors： Hu B,Ruan Y,Wei F,Qin G,Mo X,Wang X,Zou D

更新日期：2020-08-15 00:00:00

abstract：:The use of perforator flaps is a common surgical technique in wound repair. However, the area surrounding the multiterritory perforating flap often becomes necrotic due to ischemia. Hydroxysafflor yellow A (HSYA), a traditional Chinese medicine extracted from edible safflower, can be used medicinally to promote angiog...

journal_title：American journal of translational research

authors： Zhang C,Shao Z,Chen Z,Lin C,Hu S,Lou Z,Li J,Zheng X,Lin N,Gao W

更新日期：2020-08-15 00:00:00

abstract：:This study aims to reveal the biological relevancy between melanosis coli (MC) with colon cancer by analyzing the proteomics differences of tissues of melanosis coli, colon cancer, and normal ones to probe into the causes and development mechanisms of MC from the perspective of biomolecules. Fourteen differential prot...

journal_title：American journal of translational research

authors： Yuan S,Wang P,Zhou X,Xu J,Lu S,Chen Y,Zhang Y

更新日期：2020-07-15 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Salvianolic acid A (SAA) is a main component derived from Salvia miltiorrhiza and has been revealed to protect against cerebral ischemia/reperfusion injury (CIRI). The present study was designed to evaluate the neuroprotective role of SAA in CIRI and explore its underlying mechanism in vivo an...

journal_title：American journal of translational research

authors： Zhao J,Li L,Fang G

更新日期：2020-07-15 00:00:00

abstract：:Curcumin is a safe, cost-effective natural agent with multiple targets that displays therapeutic potential in cancer. Recently, we reported a novel curcumin analog, Da0324, which exhibited significantly improved stability and anti-cancer activity. However, the molecular mechanism underlying the anti-cancer activity of...

journal_title：American journal of translational research

authors： Xu F,Ji Z,He L,Chen M,Chen H,Feng Q,Dong B,Yang X,Jiang L,Jin R

更新日期：2020-07-15 00:00:00

abstract：:Cholangiocarcinoma (CCA) is an aggressive tumour with a poor prognosis due to its late clinical presentation and the lack of effective non-surgical therapies. Previous studies have reported that platelets are implicated in tumour invasion and metastasis, while their role and the underlying mechanism in CCA remain uncl...

journal_title：American journal of translational research

authors： Pan S,Hu Y,Hu M,Jian H,Chen M,Gan L,Zheng P,He Y,Wang J

更新日期：2020-07-15 00:00:00

abstract：BACKGROUND:Experiments were conducted on the assumption that vivid chondrogenesis would be boosted in vivo following previously preliminary chondrogenesis in a mesenchymal stem cell (MSC)-rich entire umbilical cord (UC) in vitro. METHODS:Virtual 3-D tracheal grafts were generated by using a profile obtained by scannin...

journal_title：American journal of translational research

authors： Shai SE,Lai YL,Hung YW,Hsieh CW,Huang BJ,Su KC,Wang CH,Hung SC

更新日期：2020-07-15 00:00:00