Abstract：
:Cholangiocarcinoma (CCA) is an aggressive tumour with a poor prognosis due to its late clinical presentation and the lack of effective non-surgical therapies. Previous studies have reported that platelets are implicated in tumour invasion and metastasis, while their role and the underlying mechanism in CCA remain unclear. Here, we show that platelets are hyperactivated in patients with CCA and that platelet-derived growth factor (PDGF) promotes the migration of CCA tumour cells both in vitro and in vivo. Further investigations revealed that PDGF can upregulate the expression of MMP2/MMP9 and induce epithelial-mesenchymal transition (EMT) by activating the p38/MAPK signalling pathway in CCA cells. In addition, the expression of MMP2/MMP9 was associated with lymph node metastasis and poor prognosis in CCA patients after surgical resection. In conclusion, our findings demonstrate that platelets play an important role in facilitating the invasion and metastasis of CCA cells by secreting PDGF, which may provide a novel target for CCA treatment.
journal_name
Am J Transl Resjournal_title
American journal of translational researchauthors
Pan S,Hu Y,Hu M,Jian H,Chen M,Gan L,Zheng P,He Y,Wang Jsubject
Has Abstractpub_date
2020-07-15 00:00:00pages
3577-3595issue
7issn
1943-8141journal_volume
12pub_type
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journal_title：American journal of translational research
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