abstract：:Epidermal growth factor receptor (EGFR) is considered as a valid target in the clinical trials of anticancer therapy and tyrosine kinase inhibitors (TKIs) of EGFR are approved for cancer treatments. In present work, cucurbitacin IIb (CuIIb) was confirmed to exhibit the proliferation inhibitory activity in A549 cells. ...

journal_title：Environmental toxicology and pharmacology

authors： Liang Y,Zhang T,Ren L,Jing S,Li Z,Zuo P,Li T,Wang Y,Zhang J,Wei Z

更新日期：2021-01-01 00:00:00

abstract：:Juvenile Oncorhynchus mykiss (average weight: 22.3 g) were fed one of five selenomethionine diets (1.09, 8.79, 15.37, 30.79, or 61.58 mg Se/kg diet). After 4 weeks, hepatic catalase activity over 15.37 mg Se/kg diets was significantly decreased, and the glutathione peroxidase activity over 30.79 mg Se/kg diets was ele...

journal_title：Environmental toxicology and pharmacology

authors： Lee JW,Deng DF,Lee J,Kim K,Jung HJ,Choe Y,Park SH,Yoon M

更新日期：2020-11-01 00:00:00

abstract：:The present armamentarium of commercially available antidotes provides limited protection against the neurological effects of organophosphate exposure. Hence, there is an urgent need to design and develop molecules that can protect and reactivate inhibited-AChE in the central nervous system. Some natural compounds lik...

journal_title：Environmental toxicology and pharmacology

authors： Sharma R,Upadhyaya K,Gupta B,Ghosh KK,Tripathi RP,Musilek K,Kuca K

更新日期：2020-11-01 00:00:00

abstract：:Quantitative structure - activity relationships (QSARs) which are obtained with a representation of the molecular architecture via simplified molecular input-line entry system (SMILES) are applied to build up predictive models of acute toxicity of pesticides towards Daphnia magna. The acute toxicity towards Daphnia ma...

journal_title：Environmental toxicology and pharmacology

authors： Cappelli CI,Toropov AA,Toropova AP,Benfenati E

更新日期：2020-11-01 00:00:00

abstract：:Juveniles of the shrimp Litopenaeus vannamei (3.3 ± 0.4 g) were exposed separately to nitrite (0.0, 1.1, 2.6, and 5.3 mg/L nitrogen as nitrite [NO2--N]) and nitrate (0, 90, 225 and 400 mg/L nitrogen as nitrate [NO3--N]) concentrations equivalent to 0, 10, 25, and 50% of the LC50-96 h value of NO2--N and NO3--N in low ...

journal_title：Environmental toxicology and pharmacology

authors： Valencia-Castañeda G,Frías-Espericueta MG,Vanegas-Pérez RC,Chávez-Sánchez MC,Páez-Osuna F

更新日期：2020-11-01 00:00:00

abstract：:Bisphenol A (BPA), a well-recognized anthropogenic xenoestrogen, has been identified as a causative agent responsible for inducing carcinogenicity, cognitive impairment, neurotoxicity, oxidative stress, etc. However, BPA-induced neurotoxicity and its possible amelioration through natural compound intervention remain e...

journal_title：Environmental toxicology and pharmacology

authors： Sahoo PK,Pradhan LK,Aparna S,Agarwal K,Banerjee A,Das SK

更新日期：2020-11-01 00:00:00

abstract：:In the new drugs, greater than 90 % of active pharmaceutical ingredients (APIs) or marketed drugs have poor solubility and bioavailability, which restrict the development of pharmaceutical preparations. The use of crystalline molecular complexes (CMCs) involving API and biocompatible precursors to improve solubility h...

journal_title：Environmental toxicology and pharmacology

authors： Wang H,Li S,Liu L,Wang J,Wang Y,Guo W

更新日期：2020-11-01 00:00:00

abstract：:The results of the current study investigated the chemo-preventive effect of crocin against hepatocarcinogenesis in rats with particular focus on the evaluation of the modulatory impact of crocin on apoptotic and nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways. Thioacetamide (TAA) (200 mg/kg, I.P...

journal_title：Environmental toxicology and pharmacology

authors： Elsherbiny NM,Eisa NH,El-Sherbiny M,Said E

更新日期：2020-11-01 00:00:00

abstract：:Increasing prevalence of herbal and dietary supplement-induced hepatotoxicity has been reported worldwide. Usnic acid (UA) is a well-known hepatotoxin derived from lichens. Since 2000, more than 20 incident reports have been received by the US Food and Drug Administration after intake of UA containing dietary suppleme...

journal_title：Environmental toxicology and pharmacology

authors： Kwong SP,Wang C

更新日期：2020-11-01 00:00:00

abstract：:In this study, we report the antioxidant and antitoxic potential of chemically synthesized 4-oxo-2-phenyl-4H-chromene-7,8-diyl bis((1-amino-2-hydroxypropyl)carbamate) (DHF-BAHPC) compound using in vitro and in vivo assays. The DHF-BAHPC was synthesized by linking 7,8-Dihydroxyflavone (DHF) with two molecules of Fmoc-t...

journal_title：Environmental toxicology and pharmacology

authors： Mohankumar T,Lalithamba HS,Manigandan K,Muthaiyan A,Elangovan N

更新日期：2020-10-01 00:00:00

abstract：:Ulcerative colitis (UC) is a disease of increased worldwide prevalence. UC progression is associated with serious complications that leave the patient with considerable health burdens. Nifuroxazide is an oral nitrofuran antibiotic used as antidiarrheal medication. The current study places an emphasis on investigating ...

journal_title：Environmental toxicology and pharmacology

authors： El-Far YM,Elsherbiny NM,El-Shafey M,Said E

更新日期：2020-10-01 00:00:00

abstract：:The effects of obesity and smoking in the coronavirus disease 2019 (COVID-19) pandemic remain controversial. Angiotensin converting enzyme 2 (ACE2), a component of the renin-angiotensin system (RAS), is the human cell receptor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVI...

journal_title：Environmental toxicology and pharmacology

authors： Engin AB,Engin ED,Engin A

更新日期：2020-08-01 00:00:00

abstract：:Triazine herbicide atrazine is considered to be moderately toxic to various aquatic animals. The aim of our study was to evaluate the acute embryotoxicity of atrazine and its two degradation products, desisopropylatrazine and desethylatrazine, and their mixture to the early life stages of zebrafish (Danio rerio) by me...

journal_title：Environmental toxicology and pharmacology

authors： Blahova J,Cocilovo C,Plhalova L,Svobodova Z,Faggio C

更新日期：2020-07-01 00:00:00

abstract：:Lead (Pb) is recognized as a potent inducer of synaptic toxicity generally associated with reduced synaptic transmission and increased neuronal fiber excitability, becoming an environmental risk for neurodegenerative processes. Despite numerous toxicological studies on Pb have been directed to the developing brain, at...

journal_title：Environmental toxicology and pharmacology

authors： Wu Z,Bai L,Tu R,Zhang L,Ba Y,Zhang H,Li X,Cheng X,Li W,Huang H

更新日期：2020-05-01 00:00:00

abstract：:In our previous study we demonstrated that the fruit ripening retardant Daminozide or Alar causes change in life history traits, distortion of adult wing structure, DNA damage in brain cells and mutagenic effects in fruit fly Drosophila melanogaster. As a continuation of the previous study the present work is designed...

journal_title：Environmental toxicology and pharmacology

authors： Roy SS,Ghosh S

更新日期：2020-04-01 00:00:00

abstract：:Prednisolone is a synthetic glucocorticoid used clinically for treating allergies, inflammation, and autoimmune diseases. Long-term prednisolone use has been shown to have negative effects on physiology and mood. We aimed to study the pharmacology and toxicology of glucocorticoid-like drugs by investigating behavioral...

journal_title：Environmental toxicology and pharmacology

authors： Xin N,Jiang Y,Liu S,Zhou Y,Cheng Y

更新日期：2020-04-01 00:00:00

abstract：BACKGROUND:Exposure to arsenic has been reported to affect the nervous system in a number of ways. Various epidemiological studies suggest cognitive impairment in subjects following exposure to environmental arsenic. The goal of the present study was to determine if supplementation of exogenous α-lipoic acid (ALA) coul...

journal_title：Environmental toxicology and pharmacology

authors： Dixit S,Mehra RD,Dhar P

更新日期：2020-04-01 00:00:00

abstract：:To identify the effect of hOGG1 methylation, Ser326Cys polymorphism and their interactions on the risk of coal-borne arsenicosis, 113 coal-borne arsenicosis subjects and 55 reference subjects were recruited. Urinary arsenic contents were analyzed with ICP-MS. hOGG1 methylation and Ser326Cys polymorphism was measured b...

journal_title：Environmental toxicology and pharmacology

authors： Ma L,Liang B,Yang Y,Chen L,Liu Q,Zhang A

更新日期：2020-04-01 00:00:00

abstract：:The European City Fish project aimed to develop a generic methodology for ecological risk assessment for urban rivers. Since traditional methods only consider a small fraction of substances present in the water cycle, biological effect monitoring is required for a more reliable assessment of the pollution status. A ma...

journal_title：Environmental toxicology and pharmacology

authors： van der Oost R,McKenzie DJ,Verweij F,Satumalay C,van der Molen N,Winter MJ,Chipman JK

更新日期：2020-02-01 00:00:00

abstract：:The environmental contaminants pentachlorophenol (PCP) and 4, 4'-dichlorodiphenyltrichloroethane (DDT) are detected in some human blood samples at levels as high as 5 μM (PCP) and 260 nM (DDT). Several cancers are associated with exposures to these contaminants. IL-6 is a pro-inflammatory cytokine that when dysregulat...

journal_title：Environmental toxicology and pharmacology

authors： Martin TJ,Gabure S,Maise J,Snipes S,Peete M,Whalen MM

更新日期：2019-11-01 00:00:00

abstract：:Cleft palate(CP) is a widely studied congenital malformation. However, its etiology and pathogenesis still remain unclear. Proteins are fundamental molecules that participate in every biological process within cells. In this study, we established CP mouse models induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) an...

journal_title：Environmental toxicology and pharmacology

authors： Wang C,Zhai SN,Yuan XG,Zhang DW,Jiang H,Qiu L,Fu YX

更新日期：2019-11-01 00:00:00

abstract：:The aim of this study was to investigate the sensitivity of the marine scallop Mizuhopecten yessoensis to different copper concentrations (10 and 30 μgl-1) in the prespawning period. Reaction of the scallop to this effect was evaluated by a set of biomarkers, including general metabolism enzymes (acid and alkaline pho...

journal_title：Environmental toxicology and pharmacology

authors： Istomina A,Chelomin V,Kukla S,Zvyagintsev A,Karpenko A,Slinko E,Dovzhenko N,Slobodskova V,Kolosova L

更新日期：2019-08-01 00:00:00

abstract：:Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts glucose to sorbitol. It plays a vital role as a glucose reducing agent and is involved in the pathophysiology of diabetic complications. In this st...

journal_title：Environmental toxicology and pharmacology

authors： Demir Y,Özaslan MS,Duran HE,Küfrevioğlu Öİ,Beydemir Ş

更新日期：2019-08-01 00:00:00

abstract：:Species-specific in vitro epithelial barriers represent interesting predictive tools for risk assessment evaluation in toxicological studies. Moreover, these models could be applied either as stand-alone methods for the study of absorption, bioavailability, excretion, transport, effects of xenobiotics, or through an I...

journal_title：Environmental toxicology and pharmacology

authors： Bertero A,Augustyniak J,Buzanska L,Caloni F

更新日期：2019-08-01 00:00:00

abstract：:Indole-3-carbinol (I3C) is extracted from cruciferous vegetables and is well known for its anti-cancer, antioxidant and anti-inflammatory effects. This study investigated the protective effect of I3C in hyperlipidemia zebrafish larvae and early life stage toxicity of I3C on zebrafish embryos/larvae. Zebrafish larvae w...

journal_title：Environmental toxicology and pharmacology

authors： Jiang Y,Yang G,Liao Q,Zou Y,Du Y,Huang J

更新日期：2019-08-01 00:00:00

abstract：:The aim of this research was to investigate circulating expression levels of three miRNAs (miR-126, miR-155, and miR-145) proposed as predictive CVD biomarkers in Mexican women exposed to inorganic arsenic via drinking water. Mean UAs concentration of 19.5 ± 14.0 μg/g creatinine was found after urine samples were anal...

journal_title：Environmental toxicology and pharmacology

authors： Ruíz-Vera T,Ochoa-Martínez ÁC,Zarazúa S,Carrizales-Yáñez L,Pérez-Maldonado IN

更新日期：2019-04-01 00:00:00

abstract：:One of the consequence of municipal waste deposition is the production of landfill leachate. Its volume and composition is determined by numerous factors, including waste composition, landfill age and the volume of precipitation. Leachate may contain a number of mineral and organic compounds, the volume of which must ...

journal_title：Environmental toxicology and pharmacology

authors： Przydatek G

更新日期：2019-04-01 00:00:00

abstract：:In the present study, the status of antioxidant response and molecular regulation in Chinese mitten crab, Eriocheir sinensis under the exposure of synthetic pyrethroid deltamethrin were investigated by means of measuring the antioxidative enzyme activity and relative mRNA expression of heat shock proteins (HSPs) in he...

journal_title：Environmental toxicology and pharmacology

authors： Hong Y,Huang Y,Yan G,Huang Z

更新日期：2019-02-01 00:00:00

abstract：:Both β-amyloid (Aβ) catabolism and epigenetic regulation play critical roles in the onset of neurodegeneration. The latter also contribute to Pb neurotoxicity. The present study explored the role of epigenetic modifiers and Aβ degradation enzymes in Pb-induced latent effects on Aβ overproduction in vitro. Our results ...

journal_title：Environmental toxicology and pharmacology

authors： Wang Y,Hu Y,Wu Z,Su Y,Ba Y,Zhang H,Li X,Cheng X,Li W,Huang H

更新日期：2019-02-01 00:00:00

abstract：:The present study was aimed to analyze the effect of ZnO and TiO2 nanoparticles (NPs) on Haemato-immunological parameters in adult Tilapia, Oreochromis mossambicus. The nanoparticles size found as 47 nm and 30 nm for ZnO and TiO2 respectively. The acute toxicity (96 h) of ZnO (LC50: 100-110 ppm) and TiO2 (LC50: 80-90 ...

journal_title：Environmental toxicology and pharmacology

authors： Suganthi P,Murali M,Athif P,Sadiq Bukhari A,Syed Mohamed HE,Basu H,Singhal RK

更新日期：2019-02-01 00:00:00

abstract：:Recently, electromagnetic fields around ultra-high voltage transmission lines have received considerable attentions for their potential biological effects. This study aimed to investigate the effects of static electric field (SEF) and power frequency electric field (PFEF) on cognition. Mice were exposed to SEF and PFE...

journal_title：Environmental toxicology and pharmacology

authors： Di G,Kim H,Xu Y,Kim J,Gu X

更新日期：2019-02-01 00:00:00

abstract：:Genetic variations in the glutathione S-transferase genes GSTT1 and GSTM1 have been widely studied, and homozygous deletions or null genotypes have been reported in different populations. Previous studies suggest that individuals who are homozygous-null at the GSTM1 or GSTT1 locus may have an increased risk of environ...

journal_title：Environmental toxicology and pharmacology

authors： Prayuni K,Razari I,Yuliwulandari R

更新日期：2019-01-01 00:00:00

abstract：:Safrole is a natural compound categorized as a group 2B carcinogen extracted from betel quid chewing, which is a common practice of psychoactive habits integrated into social and cultural ceremonies among serveral million people, especially in Southern or Southeastern Asia. Safrole is one of the major risk compunds fo...

journal_title：Environmental toxicology and pharmacology

authors： Chien KJ,Yang ML,Tsai PK,Su CH,Chen CH,Horng CT,Yeh CH,Chen WY,Lin ML,Chen CJ,Chian CY,Kuan YH

更新日期：2018-12-01 00:00:00

abstract：:Although neurotoxicity and hepatotoxicity have long been associated with exposure to polychlorinated biphenyls (PCBs), less is known about the selective toxicity of those hydroxylated PCBs (OH-PCBs) and PCB sulfates that are metabolites derived from exposure to PCBs found in indoor air. We have examined the toxicity o...

journal_title：Environmental toxicology and pharmacology

authors： Rodriguez EA,Vanle BC,Doorn JA,Lehmler HJ,Robertson LW,Duffel MW

更新日期：2018-09-01 00:00:00

abstract：:4-tert-octylphenol (4t-OP) is a well-known xenoestrogen. Our objective was to explore the effects and molecular mechanisms of 4t-OP on human sperm. Sperm samples were exposed to 0, 0.1, or 0.3 mM 4t-OP for two hours. Results showed that both sperm viability and motility were significantly injured by 0.3 mM 4t-OP. We a...

journal_title：Environmental toxicology and pharmacology

authors： Huang S,Cao S,Zhou T,Kong L,Liang G

更新日期：2018-09-01 00:00:00

abstract：:The influence of prenatal alcohol exposure on the serotoninergic system in the brain has been well studied, however its influence on the serotoninergic system in the gastrointestinal system remains unknown. The objective of the study was to use a mouse model of prenatal alcohol exposure to investigate the effects on s...

journal_title：Environmental toxicology and pharmacology

authors： Dylag KA,Fidalgo SVS,Gard PR,Patel BA

更新日期：2018-07-01 00:00:00

abstract：:Iran is one of the main suppliers of pistachio for the European market accounting for over 90% of its demands; hence, efficient analytical methods are required for detection of mycotoxins contamination in pistachio kernels before exporting them. In this study, aflatoxin B1 (AFB1) and ochratoxin A (OTA) levels in five ...

journal_title：Environmental toxicology and pharmacology

authors： Taghizadeh SF,Rezaee R,Davarynejad G,Asili J,Nemati SH,Goumenou M,Tsakiris I,Tsatsakis AM,Shirani K,Karimi G

更新日期：2018-07-01 00:00:00

abstract：:Organophosphate flame retardants (OPFRs) are increasingly produced and used as alternatives of brominated flame-retardants (BFRs) and have become emerging marine environmental contaminants. So far, however, little is known regarding the biological effects of OPFRs in marine organisms. In this study, the biological eff...

journal_title：Environmental toxicology and pharmacology

authors： Wu H,Zhong M,Lu Z,Shan X,Li F,Ji C,Cong M

更新日期：2018-07-01 00:00:00

abstract：:DNA damage caused by environmental agents often lead to many chronic diseases, including cancer. The present study aimed to understand the relative toxicity possessed by Bisphenol A (BPA) and Bisphenol S (BPS) on human bronchial epithelial cells (BEAS-2B). The cells were exposed to either BPA or BPS and evaluated for ...

journal_title：Environmental toxicology and pharmacology

authors： George VC,Rupasinghe HPV

更新日期：2018-06-01 00:00:00

abstract：:Radiation-induced inflammation plays an important role in radiation-induced tissue injury. 18β-glycyrrhetinic acid (18β-GA) has shown an anti-inflammatory activity. This study aimed to assess the activity of 18β-GA against radiation-induced skin damage, and explore the underlying mechanisms. In vitro assay revealed 18...

journal_title：Environmental toxicology and pharmacology

authors： Su L,Wang Z,Huang F,Lan R,Chen X,Han D,Zhang L,Zhang W,Hong J

更新日期：2018-06-01 00:00:00