abstract：:The intertwining between epilepsy, sleep disorders and beta amyloid pathology has been progressively highlighted, as early identification and stratification of patients at high risk of cognitive decline is the need of the hour. Modification of the sleep-wake activity, such as sleep impairment or excessive daytime slee...

journal_title：Mechanisms of ageing and development

authors： Liguori C,Spanetta M,Romoli M,Placidi F,Nardi Cesarini E,Mercuri NB,Costa C

更新日期：2021-01-11 00:00:00

abstract：:The number of senescent cells in the skin is increasing with age. Numerous studies have attempted to elucidate the role of these cells in normal aging of the skin as well as in age-related skin conditions. In recent years, attempts have also been made to find treatments that aim either to cleanse the skin tissues of s...

journal_title：Mechanisms of ageing and development

authors： Georgakopoulou EA,Valsamidi C,Veroutis D,Havaki S

更新日期：2021-01-01 00:00:00

abstract：:The present review focuses on the effect of aging on flow-mediated outward remodeling (FMR) via alterations in estrogen metabolism, oxidative stress and inflammation. In ischemic disorders, the ability of the vasculature to adapt or remodel determines the quality of the recovery. FMR, which has a key role in revascula...

journal_title：Mechanisms of ageing and development

authors： Chehaitly A,Vessieres E,Guihot AL,Henrion D

更新日期：2020-12-14 00:00:00

abstract：:Senescence is a biological process that induces a permanent cell cycle arrest and a specific gene expression program in response to various stressors. Following studies over the last few decades, the concept of senescence has evolved from an antiproliferative mechanism in cancer (oncogene-induced senescence) to a crit...

journal_title：Mechanisms of ageing and development

authors： Engler M,Fidan M,Nandi S,Cirstea IC

更新日期：2020-12-09 00:00:00

abstract：:This cross-sectional study was conducted among a rural elderly population of 725 individuals aged over 60 years from Eastern India to assess the association of multiple chronic diseases with frailty and dependence. Multimorbidity, frailty, and dependence were assessed using prevalidated tools. Regression models were u...

journal_title：Mechanisms of ageing and development

authors： Kshatri JS,Palo SK,Bhoi T,Barik SR,Pati S

更新日期：2020-12-01 00:00:00

abstract：:Multimorbidity and depression are complex multifactorial conditions with major implications for older individuals, their families, and healthcare providers. In this scoping review, we aimed to 1) review findings from longitudinal epidemiological studies investigating the association between multimorbidity and depressi...

journal_title：Mechanisms of ageing and development

authors： Triolo F,Harber-Aschan L,Belvederi Murri M,Calderón-Larrañaga A,Vetrano DL,Sjöberg L,Marengoni A,Dekhtyar S

更新日期：2020-12-01 00:00:00

abstract：:Several laboratory animal models have shown that dietary energy restriction (ER) can promote longevity and improve various health aspects in old age. However, whether the entire spectrum of ER-induced short- and long-term physiological and metabolic adaptions is translatable to humans remains to be determined. In this...

journal_title：Mechanisms of ageing and development

authors： Xie K,Kapetanou M,Sidiropoulou K,Bano D,Gonos ES,Djordjevic AM,Ehninger D

更新日期：2020-12-01 00:00:00

abstract：:Social isolation (SI) is a major health risk in older people leading to cognitive decline. This study examined how SI and age influence performance in the novel object recognition (NOR) and elevated plus maze (EPM) tasks in C57BL/6 mice aged 3 or 24 months. Mice were group-housed (groups of 2-3) or isolated for 2 week...

journal_title：Mechanisms of ageing and development

authors： Panossian A,Cave MW,Patel BA,Brooks EL,Flint MS,Yeoman MS

更新日期：2020-10-01 00:00:00

abstract：:Hematopoietic stem cell performance and identity, crucial for homeostasis of the blood-forming system, is governed by extrinsic factors found in the bone marrow microenvironment. Communication within hematopoietic stem cell niches occurs via soluble factors or cell-to-cell contacts between niche and blood-forming cell...

journal_title：Mechanisms of ageing and development

authors： Böhm L,Helbing DL,Oraha N,Morrison H

更新日期：2020-10-01 00:00:00

abstract：:Age is the only one non-modifiable risk of cerebral ischemia. Advances in stroke medicine and behavioral adaptation to stroke risk factors and comorbidities was successful in decreasing stroke incidence and increasing the number of stroke survivors in western societies. Comorbidities aggravates the outcome after cereb...

journal_title：Mechanisms of ageing and development

authors： Popa-Wagner A,Petcu EB,Capitanescu B,Hermann DM,Radu E,Gresita A

更新日期：2020-09-01 00:00:00

abstract：:Vascular tree development depends on the timely differentiation of endothelial and vascular smooth muscle cells. These latter are key players in the formation of the vascular scaffold that offers resistance to the blood flow. This review aims at providing an overview on the role of PDE5, the cGMP-specific phosphodiest...

journal_title：Mechanisms of ageing and development

authors： Cesarini V,Guida E,Campolo F,Crescioli C,Di Baldassarre A,Pisano C,Balistreri CR,Ruvolo G,Jannini EA,Dolci S

更新日期：2020-09-01 00:00:00

abstract：:Hypertension is a common age-related disease, along with vascular and neurodegenerative diseases. Vascular ageing increases during hypertension, but hypertension itself accelerates vascular ageing, thus creating a vicious circle. Vascular stiffening, endothelial dysfunction, impaired contractility and vasorelaxation a...

journal_title：Mechanisms of ageing and development

authors： Forte M,Stanzione R,Cotugno M,Bianchi F,Marchitti S,Rubattu S

更新日期：2020-07-01 00:00:00

abstract：:Mice with an overall deletion of the sensory neuropeptide α-calcitonin gene-related peptide (α-CGRP) develop an age-dependent osteopenic bone phenotype. Underlying molecular mechanisms of how αCGRP affects bone cell metabolism are not well understood. This study aims to characterize differences in metabolic parameters...

journal_title：Mechanisms of ageing and development

authors： Niedermair T,Schirner S,Lasheras MG,Straub RH,Grässel S

更新日期：2020-07-01 00:00:00

abstract：:Aging is known to affect adversely the corticosterone status and the brain function including cognition. Calorie restricted (CR) diet has been found to improve brain aging. The objective of the present investigation is to study the effect of short-term CR diet without any food deprivation on aging-induced impairment o...

journal_title：Mechanisms of ageing and development

authors： Chakraborty A,Banerjee S,Mukherjee B,Poddar MK

更新日期：2020-07-01 00:00:00

abstract：:Aging causes changes in body composition and energy balance. Estrogen plays an important role in body's metabolism. The aim of this study was to determine whether estrogen has beneficial effects on leptin responsiveness in aged mice. Young 4 months and aged 19-21 female mice fed High Fat Diet (HFD) or Standard Diet (S...

journal_title：Mechanisms of ageing and development

authors： Farhadi Z,Khaksari M,Azizian H,Dabiri S,Fallah H,Nozari M

更新日期：2020-03-01 00:00:00

abstract：:Aging results in functional and structural changes in the cardiovascular system, translating into a progressive increase of mechanical vessel stiffness, due to a combination of changes in micro-RNA expression patterns, autophagy, arterial calcification, smooth muscle cell migration and proliferation. The two pivotal m...

journal_title：Mechanisms of ageing and development

authors： Piccirillo F,Carpenito M,Verolino G,Chello C,Nusca A,Lusini M,Spadaccio C,Nappi F,Di Sciascio G,Nenna A

更新日期：2019-12-01 00:00:00

abstract：:In most species, females live longer than males. An understanding of this female longevity advantage will likely uncover novel anti-aging therapeutic targets. Here we investigated the transcriptomic responses in the hypothalamus - a key organ for somatic aging control - to the introduction of a simple aging-related mo...

journal_title：Mechanisms of ageing and development

authors： van Gastel J,Cai H,Cong WN,Chadwick W,Daimon C,Leysen H,Hendrickx JO,De Schepper R,Vangenechten L,Van Turnhout J,Verswyvel J,Becker KG,Zhang Y,Lehrmann E,Wood WH 3rd,Martin B,Maudsley S

更新日期：2019-12-01 00:00:00

abstract：:Structural changes of glycans are observed in different (patho)physiological conditions. Human placental membrane (glyco)proteins were isolated from the first and third trimester placentas of mothers at different ages. By using lectin microarray, we demonstrated that the placental membrane N-glycome contains several N...

journal_title：Mechanisms of ageing and development

authors： Robajac D,Masnikosa R,Nemčovič M,Križáková M,Belická Kluková Ľ,Baráth P,Katrlík J,Nedić O

更新日期：2019-10-01 00:00:00

abstract：:The identification of predictive markers of life span would help to unravel the underlying mechanisms influencing ageing and longevity. For this aim, 30 variables including immune functions, inflammatory-oxidative stress state and behavioural characteristics were investigated in ICR-CD1 female mice at the adult age (N...

journal_title：Mechanisms of ageing and development

authors： Martínez de Toda I,Vida C,Sanz San Miguel L,De la Fuente M

更新日期：2019-09-01 00:00:00

abstract：:Gut microbiota is among the factors that may be involved in healthy aging. Broader and geographically spread studies on gut microbiota of centenarians can help in identifying a common signature of longevity. We identified an endogamous Indian population with high centenarian prevalence. Here, we compared the gut micro...

journal_title：Mechanisms of ageing and development

authors： Tuikhar N,Keisam S,Labala RK,Imrat,Ramakrishnan P,Arunkumar MC,Ahmed G,Biagi E,Jeyaram K

更新日期：2019-04-01 00:00:00

abstract：:Caloric restriction (CR) is the most effective intervention to improve health span and extend lifespan in preclinical models. This anti-aging effect of CR is related to attenuation of oxidative damage in various tissues, with divergent results in the brain. We addressed how brain oxidoreductive balance would be modula...

journal_title：Mechanisms of ageing and development

authors： Moyse E,Arsenault M,Gaudreau P,Ferland G,Ramassamy C

更新日期：2019-04-01 00:00:00

abstract：:Cellular senescence is a phenomenon of irreversible growth arrest in mammalian somatic cells in culture. Various stresses induce cellular senescence and indeed, we have found that excess thymidine effectively induces cellular senescence in human cells. Further, many reports indicate the implication of chromatin protei...

journal_title：Mechanisms of ageing and development

authors： Arai R,En A,Takauji Y,Maki K,Miki K,Fujii M,Ayusawa D

更新日期：2019-03-01 00:00:00

abstract：:Aging is characterized by a progressive loss of several physiological functions that can cause various age-related disorders. Several factors have been identified as causes of aging to elucidate the decline in functions. Various aspects of physiological deterioration are controlled by the hypothalamus, a critical brai...

journal_title：Mechanisms of ageing and development

authors： Kim K,Choe HK

更新日期：2019-01-01 00:00:00

abstract：:The extracellular matrix (ECM) is an intricate network that provides structural and anchoring support to cells in order to stabilize cell morphology and tissue architecture. The ECM also controls many aspects of the cell's dynamic behavior and fate through its ongoing, bidirectional interaction with cells. These inter...

journal_title：Mechanisms of ageing and development

authors： De Luca M

更新日期：2019-01-01 00:00:00

abstract：:While deviations from the optimal phenotype are deleterious, increased variation can prevent population extinction under severe stresses. Cell division asymmetry is an important source of microbial phenotypic heterogeneity. A consecutive set of asymmetric divisions can cause the gradual accumulation of deleterious fac...

journal_title：Mechanisms of ageing and development

authors： Knorre DA,Azbarova AV,Galkina KV,Feniouk BA,Severin FF

更新日期：2018-12-01 00:00:00

abstract：:Developments in medicine have led to a significant increase in the average human lifespan. This increase in aging is most readily apparent in the case of HIV where antiretroviral therapy has shifted infection from a terminal to a chronic but manageable disease. Despite this advance, patients suffer from co-morbidities...

journal_title：Mechanisms of ageing and development

authors： Cohen J,D'Agostino L,Tuzer F,Torres C

更新日期：2018-10-01 00:00:00

abstract：:Endogenous retroelements, transposons that mobilize through RNA intermediates, include some of the most abundant repetitive sequences of the human genome, such as Alu and LINE-1 sequences, and human endogenous retroviruses. Recent discoveries demonstrate that these mobile genetic elements not only act as intragenomic ...

journal_title：Mechanisms of ageing and development

authors： Cardelli M

更新日期：2018-09-01 00:00:00

abstract：:Epigenetic modifications, including changes in DNA methylation, have been implicated in a wide range of diseases including neurological diseases such as Alzheimer's. The role of dietary folate in providing methyl groups required for maintenance and modulation of DNA methylation makes it a nutrient of interest in Alzhe...

journal_title：Mechanisms of ageing and development

authors： Robinson N,Grabowski P,Rehman I

更新日期：2018-09-01 00:00:00

abstract：:Here we show that a labyrinth channel compartment and slit diaphragms, which are the histological structures enabling insect nephrocytes ultrafiltration, are established during embryogenesis first by the garland nephrocytes (GCNs). The later pericardial nephrocytes, which represent the majority of functional nephrocyt...

journal_title：Mechanisms of ageing and development

authors： Psathaki OE,Dehnen L,Hartley PS,Paululat A

更新日期：2018-07-01 00:00:00

abstract：:Tumor cells express NADPH oxidase-1 (NOX1) in their membrane and control NOX1-based intercellular reactive oxygen and nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling through membrane-associated catalase and superoxide dismutase. TREATMENT:of tumor cells with high concentrations of H2O2, peroxnitrite...

journal_title：Mechanisms of ageing and development

authors： Bauer G

更新日期：2018-06-01 00:00:00

abstract：:Scavenger receptor B1 (SR-B1) is a trans-membrane protein, involved in tissue reverse cholesterol transport. Several studies have demonstrated that SR-B1 is also implicated in other physiological processes, such as bacteria and apoptotic cells recognition and regulation of intracellular tocopherol and carotenoids leve...

journal_title：Mechanisms of ageing and development

authors： Muresan XM,Sticozzi C,Belmonte G,Savelli V,Evelson P,Valacchi G

更新日期：2018-06-01 00:00:00

abstract：:The process of epithelial-mesenchymal transition (EMT) of lens epithelial cells (LECs) after cataract surgery contributes to tissue fibrosis, wound healing and lens regeneration via a mechanism not yet fully understood. Here, we show that tropomyosin 2 (Tpm2) plays a critical role in wound healing and lens aging. Post...

journal_title：Mechanisms of ageing and development

authors： Shibata T,Shibata S,Ishigaki Y,Kiyokawa E,Ikawa M,Singh DP,Sasaki H,Kubo E

更新日期：2018-04-01 00:00:00

abstract：:Cellular senescence is a fundamental trait of many eukaryotic organisms. Senescent cells participate both in the developmental program and in normal ageing and age-related diseases. Senescence of proliferation-prone cells is a state of permanent cell cycle arrest accompanied by metabolic activity manifested by high se...

journal_title：Mechanisms of ageing and development

authors： Bielak-Zmijewska A,Mosieniak G,Sikora E

更新日期：2018-03-01 00:00:00

abstract：:Aging is accompanied by the accumulation of cellular damage over time in response to stress, lifestyle and environmental factors ultimately leading to age-related diseases and death. Additionally, the number of senescent cells increases with age. Senescence is most likely not a static endpoint, it represents a series ...

journal_title：Mechanisms of ageing and development

authors： Ott C,Jung T,Grune T,Höhn A

更新日期：2018-03-01 00:00:00

abstract：:The present study aimed to reveal aging-related changes in the skeletal muscle of SD rats by comparing transcriptome analysis, integrated with muscle physiological parameters. Ten rats aged 25 months were set as the old group (OG) and ten rats aged 6 months were set as the young group (YG). After 6 weeks of feeding, t...

journal_title：Mechanisms of ageing and development

authors： Zhou J,Liao Z,Chen J,Zhao K,Xiao Q

更新日期：2018-01-01 00:00:00

abstract：:Antioxidants and telomere length are potential biomarkers for individuals' exposure and ability to cope with environmental stressors. However, intraspecific variations in antioxidant alterations due to natural, life cycle related stress, have been rarely estimated. We investigated those changes in wild-derived house m...

journal_title：Mechanisms of ageing and development

authors： Stauffer J,Panda B,Ilmonen P

更新日期：2018-01-01 00:00:00

abstract：:Perceived age is an easily accessible biomarker of aging. Here, we studied its relation to DNA methylation age (DNAm age) as introduced in (Horvath, 2013) in 180 elderly Danish twins. We found perceived age and DNAm age to be associated with chronological age (P=0.04 resp. P=2.2e-10) when correcting for gender, but di...

journal_title：Mechanisms of ageing and development

authors： Debrabant B,Soerensen M,Christiansen L,Tan Q,McGue M,Christensen K,Hjelmborg J

更新日期：2018-01-01 00:00:00

abstract：:DNA methylation (DNAm) is a fundamental biochemical modification which occurs over the lifespan of an individual and it is a significant component in the aging process. Methylation level of CpG sites plays an important role in finding the age of a person. Different approaches were used to extract age-related CpG (AR-C...

journal_title：Mechanisms of ageing and development

authors： Goel N,Karir P,Garg VK

更新日期：2017-09-01 00:00:00

abstract：:An increasing body of data is progressively indicating that the comprehension of the epigenetic landscape, actively integrated with the genetic elements, is crucial to delineate the molecular basis of the inter-individual complexity of ageing process. Indeed, it has emerged that DNA methylation changes occur during ag...

journal_title：Mechanisms of ageing and development

authors： Bacalini MG,D'Aquila P,Marasco E,Nardini C,Montesanto A,Franceschi C,Passarino G,Garagnani P,Bellizzi D

更新日期：2017-07-01 00:00:00

abstract：:The presence of damaged and microbial DNA can pose a threat to the survival of organisms. Cells express various sensors that recognize specific aspects of such potentially dangerous DNA. Recognition of damaged or microbial DNA by sensors induces cellular processes that are important for DNA repair and inflammation. He...

journal_title：Mechanisms of ageing and development

authors： Gasser S,Zhang WYL,Tan NYJ,Tripathi S,Suter MA,Chew ZH,Khatoo M,Ngeow J,Cheung FSG

更新日期：2017-07-01 00:00:00